The Exceptional Published Investigations (Epi) Awards are bestowed to the best cancer epigenetics research published in Research Articles, Cutting-edge Communications, Technical Reports, Technical Sheets, and Databases & Large Datasets articles published in the Cancer Epigenetics Society journals. Only Society professional members are eligible to nominate (including to self-nominate) papers for the Epi Awards during a 3-month nomination period that is communicated to all members via email. The top 10 most nominated papers are then debated by the Society journal editorial board members to select the most significant published research work. Announcement of the Award winners is made each year at the Cancer Epigenetics Society annual meeting.