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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;VALUE=DATE:20190221
DTEND;VALUE=DATE:20190325
DTSTAMP:20260729T224036
CREATED:20190221T180326Z
LAST-MODIFIED:20190221T180326Z
UID:21079-1550707200-1553471999@ces.b2sg.org
SUMMARY:Sr. Scientist - Sequencing Research
DESCRIPTION:We are seeking a talented highly motivated research scientist to join our new Sequencing Research capability in San Diego. The successful candidate will work on novel NGS profiling approaches to elucidate disease state from patient biospecimens\, PDX and organoid models\, and multi-cellular pre-clinical disease models. Work performed will contribute to therapeutic discovery and early translational research programs in oncology\, autoimmune and neurological indications. \nThe role will involve extensive partnership with scientist colleagues from across Celgene Research & Early Development (R/ED) to drive new experimental\, data capture and sample rescue strategies\, and will include inter-disciplinary collaboration with analytical research colleagues to maximize the depth and robustness of insights derived from transcriptional\, mutational and epigenetic profiling datasets. Areas of technical research focus include the successful profiling of rare\, damaged or low-yield samples\, and collaborative pursuit and assessment of diagnostic assay hypotheses. \nKey stakeholders include researchers in our thematic centers of excellence (TCoEs)\, our Translational Development and Diagnostics (TDD) function\, and colleagues in the Research Informatics and Knowledge Utilization (RIKU) department\, engaged in work towards key objectives for Celgene Research and Early Development (R/ED). \nThis position suits an individual with demonstrated scientific talent and future leadership potential\, with excellent communication and collaboration skills. Keen interest in inter-disciplinary application of high-throughput molecular profiling methods to life sciences data is imperative.\nApplications are encouraged from those looking to impact delivery of truly innovative and life-changing therapies for complex diseases of unmet medical need. \nResponsibilities will include\, but are not limited to\, the following: \n\nCollaborative design and execution of NGS profiling experiments to elucidate disease state and therapeutic response\, with focus on successful profiling of rare\, damaged or low-yield samples\, and collaborative pursuit and assessment of diagnostic assay hypotheses.\nResearch at the leading edge of NGS sample preparation and profiling technologies\, including implementation of novel protocols drawn from the literature\, Celgene academic collaborators\, and/or in-house efforts\, aligned to Celgene scientific research objectives.\nAdvise on sample extraction\, library preparation and QC\, guide collection of supporting metadata\, liaise with computational research colleagues during analytical research\, and translational scientists involved in diagnostics research.\nDesign and perform pilot experiments to test new protocols\, and assess new profiling platforms and external vendor capabilities.\nContribute to the operation of internal next-generation sequencing resources and development of supporting infrastructures\, including documentation of protocols developed and supervision of technical support staff as required.\nPresent strategies\, approaches\, results and conclusions to Celgene colleagues and external audiences to a publishable standard.\nContribute to enable strategic collaborations with academic and commercial collaborators to benefit therapeutic programs.\n\n\nSkills/Knowledge Required: \n\nPh.D. in biology\, biochemistry or related discipline at a recognized higher-education establishment.\nAt least 6 years of inter-disciplinary research experience with focus on cell or molecular profiling for elucidation of human disease in university\, hospital or biotechnology research scenarios.\nExpertise in performing state of the art NGS studies with demonstrable record of innovative protocol development and peer-reviewed publication in relevant areas.\nExpertise in the generation of robust molecular profiling datasets from low-yield\, damaged or contaminated human samples for translational research objectives. \nExperience in use of NGS profiling methods to answer complex research questions in cancer biology\, autoimmune disease\, epigenetics and/or immune biology.\nHands-on experience of sample and library preparation\, operation and maintenance of high- and low-throughput NGS apparatus (Illumina preferable).\nIn-depth knowledge of contemporary NGS technologies and experimental design considerations\, and familiarity with downstream bioinformatics approaches applied to process\, analyze\, visualize and interpret NGS datasets.\nAwareness of contemporary LIMS schema\, open-source bioinformatics tools and database structures.\nExperience in performing functional assays to validate experimental findings.\nExcellent time management and organizational skills\, proven problem-solving skills\, collaborative nature and adaptability across disciplines\nExcellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.
URL:https://ces.b2sg.org/event/cel-21feb19/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/png:https://ces.b2sg.org/wp-content/uploads/2017/08/celgene-1-e1503843775806.png
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