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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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DTSTART:20180325T010000
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DTSTART:20181028T010000
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DTSTART;VALUE=DATE:20181015
DTEND;VALUE=DATE:20181117
DTSTAMP:20260730T054328
CREATED:20181015T065008Z
LAST-MODIFIED:20181015T065008Z
UID:20748-1539561600-1542412799@ces.b2sg.org
SUMMARY:Scientist II
DESCRIPTION:The key therapeutic platforms currently under investigation leverage a broad range of biological activities that allow for the development of novel paradigm-changing therapeutics. Our discovery research teams are organized into four Thematic Centers of Excellence (TCoE)\, including Protein Homeostasis (PH)\, Epigenetics\, Immuno-oncology and Inflammation & Immunology. Within each these areas\, discovery research\, translational research\, and early clinical development are integrated into a single team.  \nSummary/Scope:\nThe PH TCoE is built on our legacy IMiD drugs\, which exhibited therapeutic efficacy in erythema nodosum leprosum\, myelodysplastic syndrome\, and multiple myeloma. This class of drugs hijack the cereblon E3 ubiquitin ligase to eliminate disease-driving proteins that are otherwise considered “undruggable”. The early drug discovery team in the PH TCoE is now seeking a motivated PhD scientist to assist the development of cereblon modulating agents that target novel cereblon neosubstrates for ubiquitination and degradation for the treatment of a variety of human diseases. The successful candidate will develop and utilize state-of-art biotechnology tools to identify novel substrates and perform target validation for the relevant disease indication. The successful candidate will work collaboratively in a multi-disciplinary environment\, and w ill have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.  \nResponsibilities will include\, but are not limited to\, the following:  \nGenerate testable hypotheses\, design research protocols and execute experiments \nLead genome-wide and focused CRISPR screens \nUtilize CRISPR and RNAi to determine the disease relevance of novel cereblon substrates \nPerform cellular experiments to help define the SAR of cereblon modulators \nUtilize genetic and pharmacological approaches to define the MOA of candidate agents \nDesign and develop novel assays \nDocument\, interpret and troubleshoot results \nConvey data analysis and interpretation to supervisor and colleagues \nCommunicate with peers and supervisors and foster teamwork \nContribute to collaborative efforts \nStrong commitment to quality and reproducibility \nDemonstrate adaptability \nSupervise or guide research staffs  \nQualifications:\nPh.D. in Molecular and Cell Biology\, Biochemistry or related scientific discipline with at least 4 years of relevant work experience. Strong publication record in major scientific journals is required.  \nSkills/Knowledge Required :\nExtensive wet-lab experience with routine molecular\, cellular and genetic biology tools \nExperience with CRISPR-Cas9 mediated gene editing \nExperience with genome-wide CRISPR screens is preferred \nExtensive training in cancer biology \nResearch experience in hematologic malignancies is preferred \nHighly motivated and strong team player with a high degree of independence \nInnovative and critical thinking \nExcellent time management and organizational skills \nStrong communication skills\, both written and oral 
URL:https://ces.b2sg.org/event/celgene-15oct18/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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