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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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DTSTART;VALUE=DATE:20180420
DTEND;VALUE=DATE:20180522
DTSTAMP:20260729T140347
CREATED:20180420T102949Z
LAST-MODIFIED:20180420T102949Z
UID:19902-1524182400-1526947199@ces.b2sg.org
SUMMARY:Director - Sequencing Research
DESCRIPTION:We seek a talented\, collaborative inter-disciplinary scientist to lead innovative application of next-generation sequencing (NGS) methods in close collaboration with Celgene colleagues and strategic research & development partners. \nThis individual will play a key scientific role in the development of internal sequencing resources and the optimization of Celgene NGS assays with focus on novel protocols to elucidate disease and therapeutic mechanisms during the early stages of drug discovery. \nThe role presents an exciting opportunity to build a scientific team that partners and collaborates with laboratory and analytical research colleagues to drive new experimental and data capture strategies\, alongside assessment and selection of external NGS groups to procure well-established assays at scale. \nKey collaborators and stakeholders include researchers in our thematic centers of excellence (TCoEs) and colleagues in the Research Informatics and Knowledge Utilization (RIKU) department\, engaged in work towards key objectives for Celgene Research and Early Development (R&ED). Scientific focus is on development of novel therapies for patients with diseases of unmet need in cancer\, autoimmune and neurological indications. \nAs part of the RIKU organization\, an additional component of the role will be to partner with bioinformatics and data science colleagues to align data generation with computational infrastructure\, and novel experimental methods with innovative analysis and data integration strategies that enable full leverage of NGS output towards research across the R&ED organization and beyond. \nThe position would suit an individual with demonstrated scientific leadership experience and excellent communication and collaboration skills. Keen interest in inter-disciplinary application of high-throughput molecular profiling methods to life sciences data is imperative. Applications are encouraged from those looking to impact delivery of truly innovative and life-changing therapies for complex diseases of unmet medical need. \nResponsibilities include but are not limited to: \n\nLead development of novel NGS approaches\, experiments and protocols aligned to key scientific research objectives\, including adoption of cutting-edge methods from the field.\nWork alongside laboratory and analytical scientists to map NGS approaches to investigational hypotheses and optimize experimental designs.\nAdvise on sample extraction\, library preparation and QC\, and guide collection of supporting metadata across Celgene research groups.\nAssess and select new technologies and external NGS vendors to procure well-established assays at scale\, including design and execution of pilot studies.\nManage the operation of internal next-generation sequencing resources.\nSupervise staff dedicated to NGS core activities and collaboratively develop supporting infrastructures\, including LIMS.\nPresent strategies\, approaches\, results and conclusions to Celgene colleagues and external audiences.\nContribute to enable strategic collaborations with academic and commercial collaborators to benefit therapeutic programs.\n\nQualifications \n\nPh.D. in Biochemistry\, Biology or related field from a recognized higher-education establishment with at least 16 years of relevant work experience\, required.\n10+ years research experience of NGS-focused molecular/chemical biology in university\, hospital or biotechnology environment\nWide-ranging experience in application of NGS platforms to complex biological research questions\, particularly in the areas of cancer and immune biology required.\n\n\nExpertise in the design and procurement of molecular profiling data using contemporary platforms for genomic\, transcriptional and epigenetic profiling and including single-cell profiling techniques required.\nProven ability to lead core activities\, supervise research staff\, and collaborate successfully with laboratory and analytical research groups required.\nBackground in development of novel NGS protocols that enable investigation of scientific hypotheses and elucidation of biological mechanisms required.\nEngagement with and assessment of external technology providers\, including design of pilot experiments\, to guide and inform selection required.\nIn-depth knowledge of contemporary NGS technologies and experimental design considerations\, including assessment of 3rd party capabilities.\nExcellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.\n\nBackground experience & complementary knowledge: \n\nPublication track-record in use of NGS methods to answer complex research questions in cancer biology\, autoimmune disease and/or epigenetics preferable.\nProven experience in development and application of novel NGS protocols that enable investigation of research hypotheses.\nHands-on experience of sample and library preparation\, operation and maintenance of high- and low-throughput NGS apparatus (Illumina preferable).\nExpertise in standard molecular and cell biology techniques including (at least) real-time PCR\, WGS\, WGBS\, ChIP-seq\, ATAC-seq\, mRNA-seq\, total RNA-seq\, and single cell RNA-seq.\nPrevious experience of staff supervision and operations management in a progressive core NGS facility preferable.\nAwareness of contemporary LIMS schema\, open-source bioinformatics tools and database structures.\nProven problem-solving skills\, collaborative nature and adaptability across disciplines.
URL:https://ces.b2sg.org/event/celgene-20apr18/
LOCATION:Celgene\, 86 Morris Ave\, Summit\, NJ\, 07901\, United States
CATEGORIES:Jobs
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