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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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DTSTART:20170326T010000
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DTSTART:20171029T010000
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DTSTART;VALUE=DATE:20170916
DTEND;VALUE=DATE:20171017
DTSTAMP:20260729T205248
CREATED:20170916T135947Z
LAST-MODIFIED:20170916T140054Z
UID:19060-1505520000-1508198399@ces.b2sg.org
SUMMARY:Staff Scientist - Assay Development
DESCRIPTION:At Freenome\, you will help develop the assay technology analyzing patient samples to contribute to our mission of early detection and intervention in human disease. As a Staff Scientist\, you will be the internal subject matter expert in DNA/RNA assay technology for the development of both existing and new or complementary techniques. You will work closely with Computational Biologists to rapidly iterate on improvements to the core analytical method and to evaluate new technologies that can drive improvements in our end-to-end test performance. \nResponsibilities \n\n\nApply expert knowledge of molecular biology and biochemistry to refine existing and develop new next-generation sequencing-based assay protocols.\nOptimize protocols and workflow upstream of sequencing\, including sample collection\, extraction\, and quantitation.\nCollaborate with Computational Biologists to evaluate the cost/benefit of integrating new molecular technologies into our analytical workflow.\nCollaborate with clinical laboratory members to transition development protocols into clinical production\, including design of validation experiments and collaboration on SOP development.\n\nWhat We’re Looking For\n\n\n\nPhD or equivalent research and development experience in molecular biology\, biochemistry\, genetics\, chemistry\, or a related field.\n5+ years post-PhD experience in NGS-based DNA or RNA assay development.\nExpert-level knowledge of next-generation sequencing assay development\, including both general nucleic acid biochemistry as well as specifics of optimization for different applications\, platforms\, and analytes.\nProven track record of building robust assays for large-scale use by third parties: you don’t just use the kit\, you designed the kit.\nAbility to perform basic data analysis for experimental iteration independent of external support.\nUnderstanding of the biology of nucleic acids in humans\, especially cell-free nucleic acid (cfDNA\, cfRNA) biology.\nExperience managing scientific teams and mentoring junior scientists.\nClear communications skills and ability to work with team members in the same and adjacent disciplines.\n\n\n\nNice to Haves\n\nExperience implementing and optimizing methods beyond germline DNA-seq of organisms with clean reference genomes: RNA-seq\, epigenetics\, single-cell sequencing\, sequencing of ancient/archaic DNA\, metagenomics\, de novo genome sequencing.\nAbility to design for automated implementation: you’ve optimized for plate-based\, low-volume formats and/or microfluidics and have used automated liquid handlers.\nUnderstanding of bioinformatics tools in NGS and ability to independently perform advanced analyses of sequencing data.\nComputing skills: expertise in Linux and a general-purpose or scientific programming language: Python\, R\, Java\, C\, C++.\nHands-on proficiency in managing technology transfer requirements\, including guard-banding and stability studies\, in-process quality control\, etc.\nExperience working in a regulated laboratory environment (CLIA\, GLP/GCLP\, IVD development).
URL:https://ces.b2sg.org/event/freenome-sept17/
LOCATION:Freenome\, 259 East Grand Avenue\, South San Francisco\, CA\, 94080\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/09/Freenome.jpg
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