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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;VALUE=DATE:20190521
DTEND;VALUE=DATE:20190623
DTSTAMP:20260730T000435
CREATED:20190521T124310Z
LAST-MODIFIED:20190521T124310Z
UID:21264-1558396800-1561247999@ces.b2sg.org
SUMMARY:Scientist- Functional Genomics
DESCRIPTION:The successful candidate will work independently or as part of a research team that is focused on developing and running functional genomic screens and identifying new targets for the OTD department. Use of shRNA or CRISPR technology platforms to screen and identify targets regulating oncology and or immune related disease pathways is essential. He/she will also provide weekly assay development \, cell culture\, and molecular biology support for different projects and programs. \nROLE SUMMARY \nPfizer Integrative Biotechnology Group (IBG) located in Pearl River\, NY is within the Oncology division of Pfizer Worldwide Research & Development. IBG is dedicated to developing the next generation oncology therapeutics and therapeutic combinations by employing a multidisciplinary approach to target cancer cell cycle and modulate tumor microenvironment. We are seeking a qualified candidate at the Scientist level to join the group to contribute to drug discovery efforts by applying functional genomics and advanced molecular biology strategies to study novel cellular mechanisms underlying synthetic lethality with Pfizer’s preclinical and clinical assets. Primary responsibility of this role includes generating data packages to support advancement of late stage projects and publications in top-tiered research journals. \nThe qualified candidate for this position will be a highly motivated and collaborative scientist with strong interest in cancer biology\, epigenetics\, cell cycle progression and/or senescence response. \nS/he will demonstrate clear and professional verbal and written communication skills\, maintain an electronic notebook\, and can present scientific results to collaborators and at team meetings. \nROLE RESPONSIBILITIES  \n\nPerform experiments to study genetic and epigenetic factors that promote tumor growth and maintenance\nDevelop cellular and molecular assays to define mechanism of action relevant to target inhibition either by genetic approaches or compound treatment\nPerform cell-based assays for drug response alone or in combination to identify drug synergy\nPerform RNAi/CRISPR-based functional genomics screens for target discovery and validate novel drug targets both in vitro and in vivo\nPresent experiment results in group meetings\nMaintain experimental records in electronic lab notebook\nShare common lab responsibilities such as lab supply order and inventory management\nContribute to a dynamic\, exciting culture that embraces teamwork and innovation.\n\nBASIC QUALIFICATIONS  \n\nB.S. degree with 6+ years of experience or M.S. degree with 5+ years of experience in molecular biology\, cell biology\, genetics or related discipline\nMinimum 5 years of hands-on laboratory research\nAbility to plan and execute in vitro and/or ex vivo experiments with minimal supervision\nExperience in cell culture\, flow cytometry\, cell-based assays and standard molecular biology techniques such as SDS-PAGE\, ELISA\, Western Blot\, DNA/RNA purification\, PCR/RT-PCR\, and lentiviral packaging & transduction\nExperience with data processing software including Excel and Prism\nExcellent organization and planning skills\, the ability to work independently or as part of a team\, good verbal & written communication and interpersonal skills\, and strong motivation with a pro-active attitude and dedicated work ethic\nAbility and desire to learn new techniques\n\nPREFERRED QUALIFICATIONS \n\nExperience in cancer biology especially in cell cycle regulation and cancer epigenetics\nKnowledge of RNAi technology and experience in pooled RNAi-based screens\nExperience in use of CRISPR-based techniques for gene knockout\, gene editing as well as working knowledge of pooled CRISPR-based screening approaches\nExperience with NextGen sequencing\nExperience with tumor cell dissociation and processing
URL:https://ces.b2sg.org/event/p-21may19/
LOCATION:Pfizer – Pearl River\, NY\, 401 North Middletown Road\, Pearl River\, NY\, 10965\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/05/pfizer_new_logo.jpg
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