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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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TZID:Europe/Paris
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DTSTART:20180325T010000
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DTSTART:20181028T010000
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DTSTART;VALUE=DATE:20180624
DTEND;VALUE=DATE:20180726
DTSTAMP:20260730T013503
CREATED:20180624T084841Z
LAST-MODIFIED:20180624T085018Z
UID:20401-1529798400-1532563199@ces.b2sg.org
SUMMARY:Associate Scientist
DESCRIPTION:Pfizer’s Oncology Research Unit (ORU) in La Jolla\, California is seeking an Associate Scientist focused on translating basic discoveries in the field of cancer epigenetics into novel therapeutics. \nOur ideal candidate will work within in a collaborative team environment to perform laboratory-based research. The candidate employ genetic and pharmacological to discover and confirm candidates for novel cancer therapeutics. As a member of the group\, you will also be involved in mechanism-of-action studies\, the interpretation and presentation of data\, and will function as an integral member of the team to advance new targets. The successful candidate will have experience in state-of-the-art techniques in epigenomic profiling (ATAC-seq\, ChIP-seq) as well as a basic understanding of epigenetic regulation in the tumor microenvironment. \nROLE RESPONSIBILITIES \nWill report into a team leader within the Epigenetics group. Expected to collaborate with scientists within the Oncology Research Division and across partner lines including Chemistry\, Global Business Technology\, Pharmacokinetics\, Dynamics &Metabolism\, Drug Safety R&D\, Pharmaceutical Science\, and compound management. \nPrimary Duties: \nWork as part of project teams to design\, execute\, analyze/interpret\, and refine experiments ranging from: biochemical and molecular assays\, target modulation\, biomarker assay development. \nDepending upon the stage of project\, specific duties to include: \n\nApplication of genetic and pharmacologic approaches to modulate drug targets in vitro\, and assess functional impact on cancer initiation and progression. This will include functional genomics techniques\, viral vector delivery\, transfection\, antibodies\, small molecules and other pharmacologic approaches to modulate targets in vitro.\nDevelop\, optimize\, and implement assays that constitute the compound screening funnel.\nGenerate engineered cell lines for primary and secondary pharmacology.\nExecute secondary cell-based assays across various technology platforms – qPCR\, ChIP\, RNA-seq\, ATAC-seq\, FACS\, immunofluorescence\, western blotting\, ELISA\, high content screening\, etc.\nApply complex in vitro assays for target validation and secondary pharmacology: spheroid models\, colony forming assays\, 3D co-culture systems.\nCollaborate with in vivo pharmacology group for efficacy testing\, PK/PD and pre-clinical PoC experiments.\nIn addition to efficacy testing\, carry out supporting assays (ELISA\, western blot\, gene expression analysis of tissue lysates) to assess target modulation levels and downstream effects.\nUse electronic data capture/analysis tools such as Excel\, GraphPad\, Biobook\, Spotfire and PowerPoint for experimental documentation and data analysis/presentations.\nPresent research results and methodologies at weekly meetings with immediate supervisor\, at Epigenetic team meetings\, and with members of the oncology research unit as appropriate (example: project team meetings).\nContribute to building a culture that embraces scientific excellence\, urgency\, continuous learning and improvement\, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.\n\nBASIC QUALIFICATIONS \n\nB.S. in Cell Biology\, Molecular Biology (or a comparable biological science) with 0-3 years of related work experience.\nHands on experience with cell-based assays to monitor and analyze effects of target modulation (ELISA\, ICW\, FRET\, Luminescence based assays).\nExperience in functional genomics techniques (CRISPR\, RNAi) for target assessment and generation of cell lines.\nExperience in molecular biology techniques for analysis of chromatin structure/function (ATAC-seq\, ChIP-seq)\, gene expression\, and protein expression\nMust be able to work in a team environment\, have excellent communication skills and be able to present data at project team meetings.\nAbility to master new concepts and techniques quickly.\nStrong attention to detail and organizational skills to manage projects in parallel
URL:https://ces.b2sg.org/event/pfizer-24jun18/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/05/pfizer_new_logo.jpg
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