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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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DTSTART:20180325T010000
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DTSTART:20181028T010000
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DTSTART;VALUE=DATE:20181029
DTEND;VALUE=DATE:20181201
DTSTAMP:20260730T073838
CREATED:20181029T081957Z
LAST-MODIFIED:20181029T081957Z
UID:20778-1540771200-1543622399@ces.b2sg.org
SUMMARY:Principal Scientist
DESCRIPTION:We seek an accomplished Principal Scientist level oncologist/immunologist to join the in vivo pharmacology group within the Oncology Research Unit (ORU) of Pfizer’s Worldwide Research & Development (WRD) division in La Jolla\, California. The successful candidate will join a dynamic team of scientists in the Oncology In Vivo Pharmacology Group\, playing a leading role in the development of models of cancer and evaluating new drug candidates. \n\nParticipate in pre-clinical drug discovery and development projects with a focus on targeted therapeutics\, epigenetics and immune-oncology. Characterize and develop small molecules in close collaboration with partner lines as an integral member of drug discovery teams. Evaluate anti-tumor effects in combination with biologics. Employ and develop new cutting-edge in vivo mouse and human cancer models. Provide technical and scientific expertise in in vivo pharmacology to the tumor cell biology department to enable target identification\, validation\, prioritization and efficient drug discovery of small molecules. Ideal applicants will possess excellent communication\, leadership and organizational skills\, critical problem-solving abilities\, and a commitment to excellence. \n\nROLE RESPONSIBILITIES \n\nEstablish scientific in vivo strategy for drug discovery projects.\nServe as the in vivo pharmacology lead for several drug discovery projects. Work within multi-functional teams to support small molecule drug discovery and combination therapy.\nDevelop and characterize new in vivo mouse models\, including syngeneic tumor and genetically engineered mouse (GEM) models\, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.\nDesign and conduct in vivo studies to evaluate and establish efficacy\, PK/PD relationship\, combination strategy\, biomarker identification and analysis.\nSupervision and scientific guidance of 3-5 experienced scientists.\nInterpretation\, presentation and documentation of experiments as well as preparation of reports. Responsible for in vivo section of i.e. IND filings.\nWritten and verbal presentation of results within a multidisciplinary team environment. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.\nPublication of results in scientific peer-reviewed journals and presentations at internal\, national\, and international meetings.\n\n\nQUALIFICATIONS \n\nPh.D. in Cancer Biology\, Immunology\, Biochemistry\, Genetics or equivalent experience in a related discipline.\nPreferred > 5 years industry experience\nExpertise in in vivo pharmacology and experience with animal models of human cancers as well as strong publication record or evidence of equivalent achievements in industry are desired.\nHands on in vivo skills (IV\, PO dosing)\, blood/tissue collection\nProven ability to make important contributions to cancer biology\, immuno-oncology or related fields\nAbility to follow novel scientific or technological developments\, and to implement them in the laboratory.\nCurrent knowledge of oncology research\, drug discovery and development\, with emphasis on drug combinations\, immuno-oncology.\nTechnical and scientific experience in drug discovery and preclinical development.\nExcellent written and oral communication and presentation skills in English. Proficiency in all common office and scientific software.\nStrong ability to multi-task and work productively in a fast-paced\, highly collaborative\, and diverse team environment. Capability to contribute to a vivid and challenging intellectual environment.\n\n\nA plus: \n\nExperience in leading Oncology drug discovery programs\nSupervisory experience\nExperience in immune-modulatory research\, flow cytometry\nExpertise with GEM and humanized models\nExperience with biomarker development
URL:https://ces.b2sg.org/event/pfizer-29oct18/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/05/pfizer_new_logo.jpg
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