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X-WR-CALNAME:Cancer Epigenetics Society
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X-WR-CALDESC:Events for Cancer Epigenetics Society
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DTSTART:20180325T010000
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DTSTART:20181028T010000
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DTSTART;VALUE=DATE:20180918
DTEND;VALUE=DATE:20181020
DTSTAMP:20260730T125631
CREATED:20180918T171857Z
LAST-MODIFIED:20180918T172235Z
UID:20679-1537228800-1539993599@ces.b2sg.org
SUMMARY:Research Scientist - T Cell Metabolism
DESCRIPTION:Poseida Therapeutics\, Inc. is seeking an outstanding candidate to join our immuno-oncology team at La Jolla\, San Diego\, CA. The T Cell Metabolism Scientist will design and perform experiments optimizing the manufacture of chimeric antigen receptor (CAR)-T cell therapies of the T stem cell memory subset (TSCM)\, which are an ideal cell population for adoptive immunotherapy since they are long-lived\, self-renewing and multi-potent. The hypothetical attributes of a CAR-T product with a high percentage of TSCM include enhanced durability\, as well as potency against solid tumors. Investigation will focus on immunometabolism for understanding and optimizing the non-viral piggyBac™ CAR-Tscm manufacturing process via the use of in vitro human cell-based assays assessing T cell proliferation\, phenotype and function. The position will play a critical role in the evaluation and identification of manufacturing strategies for enhancing metabolic fitness and bioenergetic profile of CAR-T products.  The successful candidate will demonstrate excellent oral and written communication skills\, work well both independently and as part of a team\, and be able to work on multiple projects/product candidates simultaneously.  Broad expertise in cellular metabolism\, key regulatory pathways\, T cell culture\, and flow cytometry is required for this role.  The position is a hands-on\, laboratory-based role with the possibility of direct reports. \nPoseida Therapeutics is translating best-in-class gene engineering technologies into lifesaving cell therapies. The company is developing CAR T-cell immunotherapies for multiple myeloma\, prostate and other cancer types\, as well as gene therapies for orphan diseases. P-BCMA-101 is Poseida’s lead CAR-T therapy currently in Phase 1 clinical development for the treatment of multiple myeloma. Poseida has assembled a suite of industry-leading gene engineering technologies\, including the piggyBac™ DNA Modification System\, TAL-CLOVER™ and Cas-CLOVER™ site-specific nucleases\, and Footprint-Free™ Gene Editing (FFGE). For more information\, visit www.poseida.com. \nQualifications\nRequired Experience and Skills: \n\nPhD or equivalent in cell biology\, immunology\, or related field\nExpertise in metabolic pathways supporting T cell proliferation and differentiation (glycolysis\, fatty acid\, mitochondrial metabolism\, etc.)\nA detailed knowledge of lipid metabolism and salvage pathways used in nutrient-limiting\, solid tumor microenvironments\nUnderstanding of key T cell regulatory and differentiation pathways (PI3K-Akt-mTOR pathway in differentiation and memory formation\, etc.)\nExperience in the characterization\, culture\, expansion\, and manipulation of T cells\nAssessment of mitochondrial mass\, activity\, and spare respiratory capacity (Seahorse XF\, etc.)\nKnowledge of cellular and/or tumor immunology principles\, technologies\, and experimental techniques (cell culture\, in vitro cellular assays\, flow cytometry\, etc.)\nMulti-parameter flow cytometry and proficiency in FACS data analysis programs\nExperience designing\, executing\, and interpreting genomics and transcriptome assays (NGS\, RNA-Seq\, Single Cell RNA-Seq\, AmpliSeq\, etc.)\nCell separation technologies (e.g.\, Miltenyi AutoMACS) and FACS sorting\nAbility to organize\, communicate\, and present complex data sets to key stakeholders from diverse backgrounds\nExcellent oral and communication skills\n\nPreferred Experience and Skills: \n\nUnderstanding of epigenetic control of T cell differentiation\nExperience developing\, testing\, and/or utilizing CAR-T products\nFunctional assays measuring cellular activation\, cytokine release\, proliferation\, and killing\nWork with external academic\, biotechnology\, and contract research organizations
URL:https://ces.b2sg.org/event/poseida-18sept18/
LOCATION:Poseida Therapeutics\, 4242 Campus Point Court\, Suite 700\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/09/Poseida-Therapeutics.jpg
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