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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20180325T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20181028T010000
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END:VTIMEZONE
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180130
DTEND;VALUE=DATE:20180304
DTSTAMP:20260819T182441
CREATED:20180130T142854Z
LAST-MODIFIED:20180224T062119Z
UID:19628-1517270400-1520121599@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:The Faber laboratory has an opening for a postdoctoral fellow to study the rational combinations of epigenetic drugs for solid tumor therapies. The successful candidate will have a Ph.D. and a strong background in cancer biology. \nJob Type: Full-time \nRequired experience: \n\ncancer biology: 4 years
URL:https://ces.b2sg.org/event/vcu-30jan18/
LOCATION:Virginia Commonwealth University\, 907 Floyd Ave\, Richmond\, VA\, 23284\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/09/VCU-virginia-commonwealth-e1506279590219.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180208
DTEND;VALUE=DATE:20180309
DTSTAMP:20260819T182441
CREATED:20180208T152549Z
LAST-MODIFIED:20180208T152549Z
UID:19640-1518048000-1520553599@ces.b2sg.org
SUMMARY:Assistant Scientist
DESCRIPTION:The Department of Psychiatry is seeking an Assistant Scientist.  The Assistant Scientist will independently perform research involving neuroscience\, cancer\, epigenetics\, and molecular biology directed by the goals of the Principle Investigator Dr. Wahlestedt\, will collect\, analyze\, and summarize data\, prepare manuscripts and grant applications\, and supervise and train students and postdoctoral fellows in the laboratory.  \n \nThe minimum requirements are: Ph.D. in Cancer biology or Neuroscience. One (1) year of post doctoral experience required.  Five (5) years of relevant post-doctoral research experience – highly preferred. Experience as a teaching assistant – highly preferred. 
URL:https://ces.b2sg.org/event/umiami-8feb18/
LOCATION:University of Miami\, 1320 S Dixie Hwy\, Coral Gables\, FL\, 33146\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/07/u-miami-health.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180208
DTEND;VALUE=DATE:20180309
DTSTAMP:20260819T182441
CREATED:20180208T154034Z
LAST-MODIFIED:20180208T154059Z
UID:19642-1518048000-1520553599@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:Purpose Perform research in the lab and program of Dr. Song (Stephen) Yi\, Principal Investigator and Assistant Professor of Oncology at the LIVESTRONG Cancer Institutes.  \nEssential Functions Use systems and computational biology\, bioinformatics\, and proteomics approaches to identify genetic and epigenetic biomarkers\, and synthetic lethal mechanisms underlying cancer and immunity for personalized medicine. Perform bioinformatics data analyses and integrative mechanistic studies in a collaborative environment. Perform projects utilizing functional data from cell lines\, Patient Derived Xenograft (PDX) models and cancer patients. Perform data analysis include genomics\, proteomics\, network biology\, epigenetics and next-generation sequencing. Publish manuscripts\, write and edit grants\, progress reports. Participate in the design of a project. Lead a research effort in the direction set forth by the PI and the specific project.  \nMarginal/Incidental functions Other related functions as assigned.  \nRequired qualifications Ph.D. degree in bioinformatics\, systems and computational biology\, cancer biology\, immunology\, or relevant field within the last three years. The Dell Medical School is especially interested in qualified candidates who can contribute to diversity and excellence within the learning health system. At the Dell Medical School we strive to create a vital\, inclusive health ecosystem. To ensure alignment\, we follow these fundamental values: https://dellmed.utexas.edu/culture.  \nPreferred Qualifications Experience with cancer genomics\, CRISPR screens and next-generation sequencing analysis. 
URL:https://ces.b2sg.org/event/ut-8feb18/
LOCATION:University of Texas at Austin in Austin\, Austin\, TX\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/02/UT-Austin-texas-uni-austin-e1518104103469.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180208
DTEND;VALUE=DATE:20180309
DTSTAMP:20260819T182441
CREATED:20180208T155029Z
LAST-MODIFIED:20180208T155043Z
UID:19648-1518048000-1520553599@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:The Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine has an exciting opportunity for a Postdoctoral Associate for Ovarian Cancer Research. This position will have major responsibilities in all aspects of study conception\, design\, execution\, and analysis within a cancer epigenetics and genomics research laboratory.  \n \nThe minimum qualifications for this position are as follows: Ph.D.\, M.D./Ph.D.\, or M.D. in Genetics\, Biochemistry\, Molecular/Cell Biology\, Cancer Genetics\, Oncology\, or a closely related field of study. Computer skills with experience using Microsoft PowerPoint\, Excel\, Photoshop or Illustrator or other graphics software preferred. Excellent verbal and written communication skills with a strong command of the English language. 
URL:https://ces.b2sg.org/event/umiami2-8feb18/
LOCATION:University of Miami\, 1320 S Dixie Hwy\, Coral Gables\, FL\, 33146\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180208
DTEND;VALUE=DATE:20180310
DTSTAMP:20260819T182441
CREATED:20180208T203038Z
LAST-MODIFIED:20180208T203038Z
UID:19650-1518048000-1520639999@ces.b2sg.org
SUMMARY:Research Assistant
DESCRIPTION:GW’s Department of Microbiology\, Immunology\, and Tropical Medicine is searching for a full-time Research Assistant for Dr.Chiappinelli’s laboratory at the George Washington Cancer Center (https://smhs.gwu.edu/cancercenter/) and the Department of Microbiology\, Immunology\, & Tropical Medicine. Dr. Chiappinelli’s laboratory focuses on the epigenetic control of gene expression in cancer\, specifically of immune signaling in and from tumor cells. Our goal is to use epigenetic therapies to harness the power of the immune system to fight cancer.  \nThe Research Assistant will be responsible for performing experiments under the direction of the principal investigator in a biomedical research laboratory and contributing to general maintenance of the laboratory\, equipment and supplies. The individual will conduct experiments under the direct supervision of a postdoctoral fellow and will also receive mentoring and direct guidance from Dr. Chiappinelli in order to advance his/her career in academic research.  \nResponsibilities include: \n\nProvide assistance to research scientist\, postdoctoral scientists and lab manager\nOptimize\, develop\, qualify and execute the following assays: basic tissue culture\, PCR \, quantitative RT- PCR \, western blots\, and flow cytometry.\nGeneral maintenance of the laboratory. Maintain Good Laboratory Practice\, comply with biosafety guidelines\, keep inspection records and generate SOPs and reports.\nMaintain and troubleshoot equipment\nWork closely with graduate students\nParticipate in group meetings and present data\nOther duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position.\n\nIncumbent is expected to work well as part of a team and have enthusiasm for the practice of science.  \nMinimum Qualifications:\nQualified candidates will hold a BA/BS in a related discipline. Degree must be conferred by the start date of the position.  \nAdditional Required Licenses/Certifications/Posting Specific Minimum Qualifications:  \nPreferred Qualifications:\nEducation: Bachelor’s degree in biology\, chemistry\, or related field.  \nExperience: Previous laboratory experience (during undergraduate education or post-undergraduate).  \nPreferred qualifications include: experience handling laboratory animals\, experience in immunology-based and molecular biology techniques including flow cytometry\, quantitative RT- PCR \, nucleic acid extractions\, cell culture\, and aseptic technique. 
URL:https://ces.b2sg.org/event/gwu-8feb18/
LOCATION:George Washington University\, 2121 I St NW\, Washington\, DC\, 20052\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/gwu-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180208
DTEND;VALUE=DATE:20180310
DTSTAMP:20260819T182441
CREATED:20180208T204543Z
LAST-MODIFIED:20180208T204911Z
UID:19655-1518048000-1520639999@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:The Simone Laboratory in the Radiation Oncology Department at Thomas Jefferson University Hospital in Philadelphia\, PA is seeking an outstanding post-doctoral fellow to work in the area of cancer and radiation biology. Our laboratory focuses on using metabolic manipulation such as dietary alterations\, to improve standard cancer therapy such as radiation and chemotherapy. Mechanistically\, our focus is on microRNA alterations and downstream effectors. Our laboratory has a focus on hormonally responsive cancers such as breast and prostate cancer using both in vitro and in vivo models. From the pre-clinical data generated in the Simone Laboratory\, we have now opened multiple clinical trials with hormone-driven cancer patients which allows for the laboratory to evaluate translational endpoints of our basic science research. \nExperience Required : The candidate must be highly motivated\, independent and interested in our projects. The candidate must have PhD in molecular biology\, cell biology or a cancer related field. Although not absolutely necessary\, the ideal candidate will preferably have some experience with caloric restriction\, epigenetics\, microRNA or radiation biology. Expertise in microarray analysis\, RT-PCR\, ChIP\, cloning\, mouse husbandry\, in vivo tumor experiments are also a plus. The successful candidate will of course have mentoring so that career goals can be achieved\, but must be able to independently generate hypotheses\, design experiments to test the hypothesis\, performs routine and more difficult procedures\, analyze data and coherently present results in the form of presentations\, abstracts\, manuscripts and the basis for grant writing\, preparation and submission. In addition\, qualified candidates should have strong verbal and written communication skills\, and a demonstrated record of scientific achievement through peer-reviewed publications. Successful\, well-motivated candidates will join a highly interactive\, interdisciplinary team of researchers with diverse backgrounds and expertise in a collaborative scientific environment. Preference will be given to individuals with these skill sets who are now completing their thesis work and have at least one high-impact publication.
URL:https://ces.b2sg.org/event/tju-8feb18/
LOCATION:Thomas Jefferson University Hospital\, Philadelphia\, PA\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180208
DTEND;VALUE=DATE:20180310
DTSTAMP:20260819T182441
CREATED:20180208T211115Z
LAST-MODIFIED:20180208T215042Z
UID:19661-1518048000-1520639999@ces.b2sg.org
SUMMARY:Research Fellow
DESCRIPTION:Postdoctoral position is available in Prof. Jolanta Grembecka laboratory\, University of Michigan\, Ann Arbor\, to carry out an interdisciplinary project to study the effect of small molecules in in vitro and in vivo models of cancers and to pursue target validation studies using genetic approaches. We are seeking for a highly motivated postdoctoral fellow with extensive experience in cancer cell biology. The research will be focused on evaluation of the activity and the mechanism of action of novel small molecules blocking epigenetic proteins in cancer. This position requires the expertise in cell biology and molecular biology techniques\, including PCR\, qRT-PCR\, Western Blotting\, co-Immunoprecipitation\, ChIP\, ChIPSeq\, flow cytometry\, fluorescence microscopy\, immunostaining. Prior work experience with animals such as transgenic mice and xenograft models of cancer would be desired. Successful candidate will be a part of an interdisciplinary team focused on development and pre-clinical evaluation of novel anti-cancer drug candidates. Required Qualifications* \nApplicant must have PhD in biology or related field. The candidates must be a first author on at least 2-3 publications. This position requires extensive experience in cell and molecular biology techniques. Furthermore\, excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations.
URL:https://ces.b2sg.org/event/umich-8feb18/
LOCATION:University of Michigan\, 500 S State St\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/uni-michigan.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180209
DTEND;VALUE=DATE:20180310
DTSTAMP:20260819T182441
CREATED:20180209T002613Z
LAST-MODIFIED:20180209T003129Z
UID:19669-1518134400-1520639999@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:  \nAccording to the National Institute of Health (NIH) and the National Science Foundation (NSF)\, a postdoc is an individual who has received a doctoral degree (or equivalent) and is engaged in a temporary and defined period of mentored advanced research training to enhance the professional skills and research independence needed to pursue his or her chosen career path. In addition\, according to the National Postdoc Association (NPA)\, Postdoctoral appointees can pursue basic\, clinical or translational projects so long as their primary effort is devoted toward their own scholarship. Postdocs are essential to the scholarly mission of the mentor and host institution\, and thus are expected to have the freedom to publish the results of their scholarship. \nCharacteristics of a postdoctoral appointment:  \nIt is expected that postdocs at MCW\, with the assistance of their supervisor\, will: \n\nTransition to career independence through the development of professional skills that enable the postdoc to actively pursue a career of his/her own choosing.\nBe supervised by at least one senior scholar who actively promotes the postdoc’s professional development.\nEstablish an individual development plan (IDP) that incorporates equally the postdoc’s career and training goals and the mentor’s research goals.\nPursue basic\, clinical\, or translational projects so long as effort is focused primarily on research.\nPublish results of the postdoc’s research and scholarship during their appointment.\nThe postdoctoral appointment is temporary by nature\, the aggregate amount of time spent as a postdoc is recommended to not exceed five years (not including family medical leave or maternity/paternity leave).\nAs postdocs are important members of the host institution’s community\, appropriate levels of compensation\, health care\, and other benefits commensurate with their essential status should be afforded\, independent of the postdoc’s source of funding.\n\n\nPrimary Functions \n \n\nPlan\, design and execute complex research studies\, procedures and protocols.\nParticipate in discovery projects.\nCoordinate research study activities; lead and manage projects.\nOversee organization\, synthesis and analysis of data and findings.\nPrepare scientific reports\, outcome findings and scientific manuscripts.\nParticipate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data\, develop methodologies\, and design and evaluate lab procedures.\nMaintain supplies\, may require negotiation with vendors\, and track purchase orders.\nMay oversee the work of laboratory personnel including training and development as well as daily work direction\, delegation and establishing priorities.\n\n\nKnowledge – Skills – Abilities  \nRequired knowledge: biology\, chemistry\, mathematics\, statistics\, documentation\, records management\, data utilization\, complex problem solving\, critical thinking\, resource management\, and writing skills \nSkills and abilities: Necessary research skills include standard molecular and cellular biology techniques. Qualified candidates should have outstanding critical thinking and problem-solving skills\, excellent written and oral skills\, as well as the ability to collaborate with others in a team-oriented environment. Experience in epigenetics and/or mouse models\, especially cancer-related\, would be an asset.
URL:https://ces.b2sg.org/event/mcw-8feb18/
LOCATION:Medical College of Wisconsin\, Milwaukee\, WI\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/02/MCW-medical-college-wisconsin-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180224
DTEND;VALUE=DATE:20180325
DTSTAMP:20260819T182441
CREATED:20180224T063337Z
LAST-MODIFIED:20180224T063413Z
UID:19678-1519430400-1521935999@ces.b2sg.org
SUMMARY:Postdoctoral Research Associate
DESCRIPTION:Preferred Education: \nPh.D. Biology\, Biochemistry\, Medicine\, or related field. \nPreferred Experience: \nExperience in physiology\, anatomy\, and surgery using preclinical models of colon cancer. Performed necropsies\, clinical and/or laboratory experience. Proficient in molecular biology techniques\, such as immunoblotting\, PCR\, RT-PCR\, or cell culture and cloning. Experience in performing rodent tumor bioassays following approved protocols using intra-oral and intra-peritoneal injections. \nRequired Special Knowledge\, Skills\, and Abilities: \nAbility to multi-task and work cooperatively with others. Ability to perform all tasks and job responsibilities safely without injury to self and others\, in compliance with A&M System and TAMHSC guidelines. Provide a safe environment that fosters respect\, inclusion\, and equality. \nJob Responsibilities \n\nPerform Procedures: Perform endoscopies and polypectomies on live study animals\, helping to develop/improve surgical resection protocols on rodent small intestine and colon.\nExperiments: Conduct cell culture\, molecular\, biochemical\, and animal studies to determine the action of chemopreventive compounds in cell culture and tumorigenicity assays. Perform cell culture experiments and molecular techniques such as PCR\, RT-PCR\, Western blotting\, RNA-seq\, and DNA methylation assays to investigate epigenetic mechanisms in GI lesions.\nResearch: Participate in joint projects involving faculty\, postdoctoral fellows\, and research assistants. Assist with research grant proposals and provide publishable reports for conference and journal presentation. This will include library research into new approaches\, the preparation of tables\, graphs\, photographs\, and figures\, and assist in manuscripts and grant proposals. Participate in weekly lab meetings within the center and in local/regional programs relevant to ongoing projects. Participate in joint projects involving faculty\, junior lab personnel\, and graduate students. Provides assistance to graduate students and junior lab personnel.
URL:https://ces.b2sg.org/event/tam-24feb18/
LOCATION:Texas A&M University Health Science Center\, 8441 Riverside Pkwy\, Bryan\, TX\, 77807\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180224
DTEND;VALUE=DATE:20180326
DTSTAMP:20260819T182441
CREATED:20180224T190655Z
LAST-MODIFIED:20180224T190655Z
UID:19684-1519430400-1522022399@ces.b2sg.org
SUMMARY:Research Assistant Professor
DESCRIPTION:An individual is sought to independently direct a project investigating molecular cross-talk between epigenetics and chromatin organization in normal and malignant hematopoiesis using molecular biology\, biochemistry\, fluorescence microscopy\, and NGS-based epigenome profiling methods. The goal of these studies is to identify novel targets and design therapeutic interventions to prevent or delay the development of\, and to treat acute myeloid leukemia.  \n\nDesign and coordinate projects to carry out experiments in animal models of myeloid malignancies and pre-leukemic conditions to evaluate potential therapeutic agents\nPerform epigenomic and chromatin profiling experiments such as ChIP-seq\, ATAC-seq\, MAPit-PATCH\, WGBS\nUse wide field fluorescence and and confocal microscopy to document dynamic changes in chromatin structure in live and fixed hematopoietic cells\nAnalyze\, interpret\, and visually organize data\nWrite manuscripts\nAssist with grant proposal preparation\nWrite technical reports\nTrain and supervise technical personnel\, assist with mentoring of graduate students\nPresent research results at meetings\n\n\nAdvertised Salary: \nCommensurate with education and experience  \nMinimum Requirements: \nPh.D. in molecular biology\, biochemistry\, cancer biology\, molecular genetics\, or related field  \nPreferred Qualifications: \n5+ years of research experience  \nExpertise in cancer epigenetics\, chromatin biology\, transcriptomics\, functional genomics\, and other NGS-based methods as demonstrated by published papers in peer reviewed scientific journals  \nSpecial Instructions to Applicants: \nInterested candidates must apply online. Please upload most recent CV\, Cover Letter of interest\, and three references with contact information. 
URL:https://ces.b2sg.org/event/unifl-24feb18/
LOCATION:University of Florida\, Gainesville\, FL\, 32611\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/06/uni-florida.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180224
DTEND;VALUE=DATE:20180326
DTSTAMP:20260819T182441
CREATED:20180224T193454Z
LAST-MODIFIED:20180224T193654Z
UID:19686-1519430400-1522022399@ces.b2sg.org
SUMMARY:Laboratory Coordinator
DESCRIPTION:We are seeking to recruit a Laboratory Coordinator in the laboratory of Dr. Kevin Gardner in the Department of Pathology and Cell Biology. The Gardner lab studies basic mechanisms of epigenetic gene regulation in breast cancer using both model systems and patient derived material (Proc Natl Acad Sci U S A. 2009 Nov 17;106(46): 19286-91; Nat Struct Mol Biol. 2010 Dec;17(12): 1406-13; Nat Commun. 2012 Jan 17;3:633; Nat Commun. 2013;4:1449).  \nResponsibilities include but are not limited to: \n\nManaging the day to day operations of the laboratory\nMaintenance of cell lines\nCarrying out immunoprecipitation assays\nOrdering and maintaining inventory of laboratory supplies.\nKeeping track of orders and confirming billing\nSetting up and performing experiments involving tissue culture\, western blot\, DNA\, RNA\, analysis\nMaintaining records pertaining to the laboratory\, including records of experimental results.\nOperating\, maintaining and troubleshooting complex equipment (e.g. ABI 7300 Real-Time PCR system)\nAssisting in the training of new hires\, Support Staff employees\, Students and Fellows in laboratory procedures\nImplementing safety regulations\nPerforming other related duties as necessary to the functioning of the laboratory.\n\nMinimum Qualifications for Grade \nApplicant MUST meet these minimum qualifications to be considered an applicant  \nRequires a bachelor’s degree plus two years of related experience or equivalent in education\, training and experience.  \nAdditional Position-Specific Minimum Qualifications \nApplicant MUST meet these minimum qualifications to be considered an applicant  \nThe successful candidate must have extensive common knowledge and skill with basic molecular and cell biology\, including mammalian tissue culture\, RNA isolation\, QPCR\, PCR\, recombinant DNA technology\, immunoblotting\, immunohistochemistry\, viral and plasmid vectors construction\, in situ hybridization\, fluorescence microscopy\, ELISA assay\, conventional reporter fluorescent and bioluminescent assays\, in situ hybridization and fluorescence microscopy.  \nMust be computer literate (MS Access\, MS Excel\, Windows and/or Mac).  \nAbility to work independently\, under minimal supervision.  \nMust demonstrate excellent interpersonal and communication skills.  \nThe incumbent should be able to work independently\, be very well organized and reliable and enjoy working in an interdisciplinary and highly collaborative atmosphere where technical support will be provided for all projects in the lab.  \nSpecial Instructions  \nPreferred Qualifications  \n\nFive years of related experience.\nBachelor’s degree in chemistry\, biology or related science
URL:https://ces.b2sg.org/event/cu-24feb18/
LOCATION:Columbia University Medical Center\, 630 W 168th St\, New York\, NY\, 10032\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/11/Columbia-University-Medical-Center.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180224
DTEND;VALUE=DATE:20180326
DTSTAMP:20260819T182441
CREATED:20180224T203901Z
LAST-MODIFIED:20180224T203919Z
UID:19689-1519430400-1522022399@ces.b2sg.org
SUMMARY:Post-Doctoral Fellow
DESCRIPTION:The Espinosa Laboratory in the Cancer Division of the Department of Pharmacology at the University of Colorado Denver | Anschutz Medical Campus is seeking independent and creative postdoctoral fellows. The Espinosa Lab utilizes an integrated system of functional genomics and mechanistic studies aimed at making biological discoveries with clear translational potential. Most of our current studies are focused on harnessing the power of pleiotropic transcription factors for cancer treatment Examples of ongoing projects are: \n\nElucidation of gene networks governed by transcription factors involved in cancer. We employ functional genomics tools to elucidate the signaling cascades driven by cancer-relevant transcription factors such as p53 and HIF1A across different cell types and stimuli. We aim to elucidate molecular mechanisms that control the cellular response upon activation of these transcription factors\, from enhancer priming to metabolic control\, with the ultimate goal of harnessing these mechanisms for therapeutic purposes (e.g. Galbraith et al.\, Cell 2013\, Allen et al.\, eLife 2014\, Andrysik et. al.\, Genome Res 2017).\nMechanistic studies of transcriptional coactivators and chromatin regulators with oncogenic and tumor suppressive functions. Using a multidimensional approach\, from biochemistry to functional genomics\, we investigate the role of specific transcriptional coactivators and chromatin factors in cancer development. We are particularly interested in the role of the Mediator Complex in oncogenesis and tumor suppression (e.g. Donner et al.\, Mol Cell 2007\, Donner et al.\, Nature Struct Mol Biol. 2010\, Galbraith et al.\, Cell 2013\, Perez-Perri et al. Cell Reports 2016).\nPharmacological manipulation of transcription factors and cofactors for therapeutic purposes. Our goal is to identify effective strategies to employ novel biologically targeted therapeutics modulating the activity of transcription factors\, cofactors and chromatin regulators for cancer treatment. Presently\, we are focused on several first-in-class drugs that modulate transcription factors\, Mediator-associated kinases\, and epigenetic readers (e.g. Sullivan et al.\, Nat Chem Biol. 2012\, Andrysik et al.\, Cell Reports 2013).\nRoles of Interferon signaling in Down syndrome and cancer. We are particularly interested in understanding how hyperactivation of Interferon signaling in people with Down syndrome may contribute to the clinical impacts of trisomy 21\, including the lower incidence of solid malignancies and higher incidence of leukemias observed in this population (e.g. Sullivan et al.\, eLIFE 2016; Sullivan et al.\, Scientific Reports 2017).\n\nOur hope is that these courses of study will lead to clinically actionable discoveries and ultimately improve patient outcomes as well as our understanding of human biology in general. All projects provide ample opportunity for gaining experience with genomic methods to study gene transcription\, expression\, and epigenetic regulation. We also frequently employ shRNA and CRISPR technology\, along with a host of additional advanced molecular\, biochemical\, and genomic techniques. \nQualifications \nMinimum Requirements: \n\nPh.D. in molecular biology or a related field\n\n\nExcellent written and verbal communication skills in English\n\n\nProven ability to work independently within a research lab\n\n\nExperience with mammalian tissue culture\n\nDesired or preferred: \nExperience with molecular biology methods\, such as: \n\nRT/quantitative PCR\nWestern blotting\nRNA interference\nCRISPR / genome editing\nLenti/retroviral production and transduction\nFlow cytometry\n3 years mammalian tissue culture experience\nExperience with rodent models\nExperience with generation and analysis of genomic sequence data\nExperience with standard bioinformatics tools\nExperience with statistical programming\, such as R
URL:https://ces.b2sg.org/event/unico-24feb18/
LOCATION:University of Colorado – School of Medicine\, Aurora\, CO\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180224
DTEND;VALUE=DATE:20180326
DTSTAMP:20260819T182441
CREATED:20180224T205805Z
LAST-MODIFIED:20180224T211233Z
UID:19693-1519430400-1522022399@ces.b2sg.org
SUMMARY:Senior Research Associate
DESCRIPTION:Constellation Pharmaceuticals is a premier epigenetics company\, focused on the discovery and development of novel\, small molecules targeting chromatin regulatory proteins in tumor and immune cells for therapeutic applications in oncology. Our unique discovery platform integrates our understanding of chromatin-regulatory mechanisms with cancer and immune pathways to optimize our drug discovery activities and fully enable the clinical translation of our programs. Our translational capabilities are being currently expanded to ensure the differentiated clinical development of our clinical and pre-clinical assets and we look for talented and experienced individuals who want to participate in developing novel cancer therapeutics. \nResponsibilities: \n\nWork closely with scientists to design and execute cell-based phenotypic and mechanism of action assays in a variety of assay platforms\nGenerate\, analyze\, and catalog data with database tools such as Genedata and software tools such as GraphPad Prism\nPerform standard molecular biology and biochemistry techniques according to established protocols\nDocument all work in electronic notebooks and present data internally at group meetings\nRequirements: \n\nBS/MS in biology or other relevant field\nA minimum of 2-3 years of postgraduate laboratory experience (industry setting preferred)\nExperience with mammalian cell culture and standard molecular biology techniques is essential\nExperience with a variety of cell-based assays (Cell Titer Glo\, ELISA\, flow cytometry) is essential\nAbility to adapt to new roles in a dynamic working environment\, detail oriented with excellent time management skills\nStrong oral and written communication skills and an ability to successfully work as part of an integrated\, interdisciplinary team
URL:https://ces.b2sg.org/event/constellation-24feb18/
LOCATION:Constellation Pharmaceuticals\, 215 First Street\, Cambridge\, MA\, 02142\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180228
DTEND;VALUE=DATE:20180330
DTSTAMP:20260819T182441
CREATED:20180228T120457Z
LAST-MODIFIED:20180228T120546Z
UID:19719-1519776000-1522367999@ces.b2sg.org
SUMMARY:Assistant Scientist
DESCRIPTION:The Sylvester Cancer Center is seeking an Assistant Scientist for the Cancer Epigenetics to work in a highly collaborative\, multi-researcher program investigating the molecular mechanisms of epigenetic regulation of cancer.  \nResponsibilities: We are seeking highly motivated individuals to develop and implement innovative computational approaches for analyzing high throughput genomic and epigenomic data\, including but not limited to\, integrated cancer risk prediction model\, cancer subtype discovery\, genomic and epi-genomic data integration\, single cell RNA-Seq data analysis\, non-coding RNA data analysis\, and other datasets. Projects will include next-generation sequencing based profiling studies of DNA methylation\, hydroxymethylation\, ChIP-seq\, ATAC-seq and RNA-seq to elucidate the role of epigenetic regulation in cancer biology. Applicants should hold a PhD and/or MD degree and have strong computational biology skills. Previous experience with epigenome-wide assays is preferred. The successful candidate will be working in a collaborative environment with multiple faculty members\, biostatisticians and bioinformaticians on translational cancer research.  \nMinimum Qualifications: Ph.D. in Bioinformatics\, Computational Biology\, Biostatistics\, Statistics\, Genetics\, Computer Science\, or a related field. Excellent communications skills in English (both verbal and written). Proficiency in using R/Bioconductor and Perl/Python for genomic data analysis is required. Solid training in quantitative sciences. Experience with R/Bioconductor. Experience with Next-generation sequencing data analysis. Understanding of epigenome biology. Strong programming skills. Strong oral and written communication skills. The ability to work both independently and in a team environment. Ability to write manuscripts independently. 
URL:https://ces.b2sg.org/event/umiami-28feb18/
LOCATION:University of Miami\, 1320 S Dixie Hwy\, Coral Gables\, FL\, 33146\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180228
DTEND;VALUE=DATE:20180330
DTSTAMP:20260819T182441
CREATED:20180228T121528Z
LAST-MODIFIED:20180228T121915Z
UID:19721-1519776000-1522367999@ces.b2sg.org
SUMMARY:Informatics Analyst II
DESCRIPTION:This position will work primarily with scientists and computational experts using Next Generation Sequencing (NGS) data\, such as RNA-sequencing\, miRNA-sequencing\, and Methylation arrays. This position focuses on applied bioinformatics skills in transcriptional profiling and epigenetic analyses in pediatric acute myeloid leukemia. \nResponsibilities \nSpecific Responsibilities Include \n\nProcess diverse NGS datasets prior to analysis.\nImplement standard data quality\, formatting and annotation processes.\nData management and organization for large “omics” datasets ( > 1000 samples).\nVisualization of “omics” data.\nContribution to on-going research projects\, including statistical and bioinformatics support for clinical research fellows\, and molecular biologists.\n\nQualifications \nBasic Qualifications \n\nEnrollment in an accredited graduate degree program.\nAbility to commit to a 9-month\, full-time position.\nProgramming skills in R.\nProgramming skills in Python.\nExperience with computing in a Unix/Linux environment.\nExperience with high performance computing clusters (HPC) and job scheduling systems (SLURM\, Torque\, etc).\n\nAdditional Skills/Preferences \n\nStrong verbal\, written\, and organizational skills.\nAbility to work both independently and in a team.\nCoursework in molecular biology\, algorithms\, and statistics.
URL:https://ces.b2sg.org/event/hutch-28feb18/
LOCATION:Fred Hutchinson Cancer Research Center\, 1100 Fairview Ave. N.\, Seattle\, WA\, 98109-1024\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180228
DTEND;VALUE=DATE:20180330
DTSTAMP:20260819T182441
CREATED:20180228T124534Z
LAST-MODIFIED:20180325T093647Z
UID:19724-1519776000-1522367999@ces.b2sg.org
SUMMARY:Senior Principal Scientist\, Receptor Biochemist
DESCRIPTION:The Pfizer Oncology Research & Development group in La Jolla is seeking a full-time employee to support the drug discovery process to create innovative cancer therapies. The successful candidate will provide expert scientific and technical expertise towards the discovery and pre-clinical development of innovative small molecule drugs for receptor-class protein targets (e.g. GPCR\, NHR\, SLC). The successful candidate will work with a high degree of independence to provide biochemical insight on receptor targets and ligands as well as impact drug discovery project teams at a high strategic level. \nResponsibilities \n\nProvide senior\, strategic\, and technical leadership for the cellular and molecular characterization of receptor targets (GPCR\, nuclear hormone receptors\, membrane transporters\, and ion channels) and the development of effective lead discovery testing-cascades that impact the oncology portfolio and advance innovative drugs through our preclinical pipeline\nLead/ contribute to the establishment of methods to characterize and understand the impact of receptor drug candidates – particularly with regard to assessment of targeted receptor agonist/antagonist interactions (on-/off-target occupancy) and efficacy for multiple preclinical oncology projects\nLead/ contribute to the establishment of programs to identify relevant biomarkers for oncology receptor drug candidates\nDemonstrate strong leadership\, personal accountability and interpersonal skills\, and capability for mentoring junior colleagues (direct reports and others)\, and establish safe\, high-quality lab practices\nEnsure high-quality\, timely documentation in electronic laboratory notebooks and Technical Reports\, and contribute to Regulatory Filings and responses to Regulatory questions as appropriate\nPresent data/ strategy to scientists and management in internal and external venues (technical meetings\, Project Team meetings\, conferences) and publish in peer-reviewed journals\, as appropriate\nMaintain current in relevant literature and innovative technologies and their application to receptor target characterization and understanding\, particularly in areas of tumor cell receptor signaling\, epigenetics\, and immune-oncology\n\nQualifications \n\nThe candidate must have a Ph.D. in biochemistry or cell biology (or related field) with 8+ years of experience in small molecule drug discovery with a strong track record of success.\nThe individual will be a recognized scientific and technical expert with cellular receptors (e.g. GPCR\, NHR) and highly experienced in methods to characterize agonists and antagonists and their biochemical and cellular function/activities.\nA well-established ability to develop robust\, functional in vitro assays for the discovery of small molecule agonist/antagonists of membrane receptors is required.\nCorresponding or senior-authored publications in top-tier journals is also a prerequisite.\nThe candidate must demonstrate strong leadership\, personal accountability and interpersonal skills\, and capability for mentoring junior colleagues (direct reports and others)\, and establish safe\, high-quality lab practices.\nIn addition\, the candidate should display a strong strategic understanding of small molecule drug discovery and have a broad understanding of cross-discipline drug discovery processes within a project team.\nA scientific background in oncology and/or immuno-oncology drug discovery is preferred.\nThe candidate should possess excellent communication skills (written\, verbal)\, proven leadership skills\, and the demonstrated ability to make good decisions and influence teams to advance projects and navigate the complexities of receptor-based drug discovery.
URL:https://ces.b2sg.org/event/pfizer-28feb18/
LOCATION:Pfizer – Pearl River\, NY\, 401 North Middletown Road\, Pearl River\, NY\, 10965\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180302
DTEND;VALUE=DATE:20180404
DTSTAMP:20260819T182441
CREATED:20180302T180057Z
LAST-MODIFIED:20180302T180355Z
UID:19728-1519948800-1522799999@ces.b2sg.org
SUMMARY:Institute Research Scientist - Translational Biology
DESCRIPTION:The Institute Research Scientist participates in cross-functional research to identify and validate novel oncology targets\, and applies deep biological insights to then translate these findings into novel oncology therapeutic agents to benefit patients.  \nSalary Range: Min $98\,000 – Mid $122\,500 – Max $147\,000  \nESSENTIAL FUNCTIONS  \n1. Apply and develop basic science tools and methodologies to develop complex strategies and enable advancement of Center projects through leadership and experimental activities.  \n2. Apply cutting edge functional genomics approaches to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.  \n3. Independently design\, execute and interpret in vitro\, ex-vivo and in vivo experiments to validate and explore therapeutic potential of drug targets.  \n4. Work with research and bioinformatics teams to utilize internal biological and oncogenomic data sets to generate and test biological hypotheses.  \n5. Work with medicinal chemistry and pharmacology teams as part of drug discovery efforts to validate targets and optimize novel small molecule therapeutics.  \n6. Lead drug discovery biology efforts to selection of lead candidate molecules and transition into clinical development.  \n7. Develop and implement biomarker strategies to guide early clinical development of drugs.  \n8. Design and develop cell and molecular assays to define mechanism of action for compounds\, identify pharmacodynamic assays to be used in pre-clinical and clinical setting and test patient selection strategies.  \n9. Develop extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or apoptosis.  \n10. Adapt to new technologies and find solutions to related program studies.  \n11. Interpret\, present and report research findings at internal meetings and external scientific conferences.  \nEducation  \nRequired: Bachelor’s degree in Biology\, Biochemistry\, molecular biology\, cell biology\, enzymology\, pharmacology\, chemistry or related field.  \nPreferred: PhD in Biological Science or Medical degree strongly preferred  \nExperience  \nRequired: Ten years of relevant research laboratory experience. With Master’s degree\, eight years of required experience and with PhD\, two years of required experience.  \nPreferred: At least two years of relevant experience in oncology research in biotech or pharmaceutical environment.  \n– Experience with genetic (ie RNAi and cDNAs) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study target biology utilizing state of the art molecular biology and biochemistry methods and assays essential to drive projects.  \n– Experience working with chemists\, in vitro and in vivo pharmacologists to develop and utilize assays in support of the development of small molecules for target validation and as part of compound lead optimization for the development of novel therapeutics is highly desirable.  \n– A demonstrated track record in the development and implementation of functional genomics strategies to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.  \n– Broad knowledge of cell culture techniques is required and knowledge of how to utilize in vivo oncology models is desirable. Hands-on experience utilizing genetically engineered mouse models and orthotopic or subcutaneous primary or established tumor cell line xenograft models is desirable.  \n– Extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or anti-apoptosis as evidenced by publication in peer-reviewed journals.  \n– Strong data analysis skills\, ability to interpret results and contribute to the design of follow-up experiments\, troubleshoot issues with assay performance\, and effectively present results and conclusions to co-workers\, collaborators and senior leadership.
URL:https://ces.b2sg.org/event/mda-2mar18/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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