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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
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TZNAME:CEST
DTSTART:20180325T010000
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TZNAME:CET
DTSTART:20181028T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180426
DTEND;VALUE=DATE:20180528
DTSTAMP:20260823T013357
CREATED:20180426T071206Z
LAST-MODIFIED:20180426T071206Z
UID:19933-1524700800-1527465599@ces.b2sg.org
SUMMARY:Senior Scientist
DESCRIPTION:Develop and drive tissue based biomarker assays including immunohistochemistry (IHC) and in-situ hybridization (ISH) biomarker assay development to support the AbbVie Oncology pipeline. Investigate\, identify\, develop\, and optimize novel methods and techniques for tissue based biomarkers. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific advances and integrate this knowledge into research or development programs. As an integral member of the Translational Oncology team\, the individual will interface with internal and external biology\, genomics/proteomics\, in vivo and toxicology teams to deliver translational biomarker assays for novel clinical candidates. Key Responsibilities Include: \nLead IHC assay development for chromogenic and multiplex fluorescence platforms. \nSupport target screening to identify biomarkers and indications for clinical development for multiple programs with internal and external collaborators. \nIntegrate complex data sets including DNA\, RNA\, protein evaluations (various platforms such as microarray\, ISH\, IHC etc) from preclinical models\, procured tissue and patient samples from exploratory clinical trials to support target validation and biomarker development efforts. \nCollaborate with a diverse set of scientists from histology/pathology\, in vivo\, molecular biology\, cancer biology\, biochemistry\, protein biochemistry\, biostatistics and clinical backgrounds to generate impactful hypotheses for biomarker development. \nManage multiple collaborations (internal and external work requests\, contracts\, etc). \nDemonstrate the ability to support key project questions/needs by effectively utilizing available information and technical expertise. \nProactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program. \nUnderstand and adhere to corporate standards regarding code of conduct\, safety\, appropriate handling of materials\, controlled drug\, GxP compliance\, and animal care where applicable. \nTechnical leadership skills to mentor team members and guide and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals.  \nGrade level and title commensurate with experience  \nBasic:\nBachelors or equivalent education and 10-12+ years of experience\, Master’s Degree or equivalent education and 8-10+ years of experience\, PhD and typically 0-4+ years of experience. \nIndustry experience is preferred. \nExpertise in immunohistochemistry assay development is required. It is highly desired to have experience in assay development with automated IHC staining platforms. Experience in chromogenic in-situ hybridization for both DNA and RNA\, fluorescent IHC and multiplexing is highly preferred. Familiarity with image analysis\, in vitro and/or in vivo assays\, genomic data and literature mining\, disease/biological pathway analysis\, and biomarker development is a plus. \nOncology experience in the areas of apoptosis\, DNA repair\, epigenetics\, ADC\, biologics therapies\, immuno-oncology desired. \nGood grasp of drug discovery\, clinical development\, biochemistry\, molecular biology\, cancer biology and related subjects. \nStrong communication skills with preparing and presenting data to people with diverse scientific backgrounds required. Excellent interpersonal skills\, able to work in a team-oriented environment. Research\, scientific and program management experience a plus. Key Leadership Competencies: \nBuilds strong relationships with peers and cross functionally with partners to enable higher performance. \nLearns fast\, grasps the “essence” and can change course quickly where indicated. \nRaises the bar and is never satisfied with the status quo. \nCreates a learning environment\, open to suggestions and experimentation for improvement. \nEmbraces the ideas of others\, nurtures innovation and manages innovation to reality. \nStrong interpersonal and communication skills with demonstrated ability to work within a team environment.
URL:https://ces.b2sg.org/event/abbvie-26apr18/
LOCATION:AbbVie – Lake County\, IL\, Lake County\, IL\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/11/abbvie-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180426
DTEND;VALUE=DATE:20180528
DTSTAMP:20260823T013357
CREATED:20180426T072408Z
LAST-MODIFIED:20180426T072534Z
UID:19935-1524700800-1527465599@ces.b2sg.org
SUMMARY:Post Doctoral Fellow (NCI)
DESCRIPTION:The Division of Cancer Treatment & Diagnosis (DCTD)\, National Cancer Institute is actively exploring drug molecular mechanisms in conjunction with tumor gene expression\, mutation and protein profiling to pair the development of newer anticancer agents with specific molecular vulnerabilities in the precision oncology medicine setting. The Leidos Biomedical program in molecular pharmacology at the Frederick National Laboratory for Cancer Research\, NCI-Frederick campus\, supports the Molecular Pharmacology Branch pursuit of this DCTD initiative in the Developmental Therapeutics Program (DTP). \nKEY ROLES/RESPONSIBILITIES \nThe Post Doctoral Fellow will: \n\nPlay a key role in evaluating the associations between aMOIs\, genes of interest\, and drug responses in the context of targeted clinical trials using cancer cell lines\, Patient Derived Xenografts (PDX) lines and organoid cultures\, by applying several molecular biology techniques to achieve gene modulation\nExecute experimental procedures according to project plans and as agreed with the Laboratory Head\nPerform knock-down (using siRNA and shRNA) as well over-expression experiments to evaluate the impact of genes of interest in the sensitivity or resistant to drug treatment\n\n\nQualifications: \nBASIC QUALIFICATIONS \nTo be considered for this position\, you must minimally meet the knowledge\, skills\, and abilities listed below: \n\nPossession of a Doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation in a field related to pharmacology\, molecular pharmacology\, experimental therapeutics\, cancer therapy or drug development. Foreign degrees will be evaluated for U.S. equivalency\nNo additional experience required for candidates with a Doctoral degree\nMust be able to obtain and maintain a security clearance\n\nPREFERRED QUALIFICATIONS \nCandidates with these desired skills will be given preferential consideration: \n\nExperience in epigenetics\nExperience applying molecular biological techniques including gene editing methodologies to the resolution of cancer drug mechanism of action questions\nExpertise using gene expression/mutations profiles to identify genes\, proteins and pathways that determine drug sensitivity\n\nExpected Competencies: \n\nThe candidate must have practical experience with basic molecular and cellular biology techniques including PCR cloning\, mutagenesis\, transient and stable expression methodologies and si/shRNA mediated gene knockdown\nAbility to effectively interpret experimental data and sufficient experience with molecular pharmacology and its methodologies to determine compounds mechanisms of action are required\nMust have a thorough understanding of genetics\, genomics and gene regulation\nExperience with viral expression systems is required
URL:https://ces.b2sg.org/event/leidos-26apr18/
LOCATION:Leidos Biomedical\, 5202 Presidents Ct\, Frederick\, MD\, 21703\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/04/leidos.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180426
DTEND;VALUE=DATE:20180528
DTSTAMP:20260823T013357
CREATED:20180426T091551Z
LAST-MODIFIED:20180426T091950Z
UID:19940-1524700800-1527465599@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:  \nA post-doctoral position is available in the laboratory of Alexey Terskikh\, Development\, Aging\, and Regeneration Program\, Sanford Burnham Prebys Medical Discovery Institute\, La Jolla\, California. The position focuses on the novel approaches to study epigenetics at a single cell level. A candidate will explore the capability of Microscopic Imaging of Epigenetic Landscape (MIEL) and fluorescence-based reporters enabling live imaging of epigenetic modifications at a single cell level. MIEL combines fluorescence detection of epigenetic marks with automated cell imaging and machine learning to profile and quantify the “epigenetic signatures” of individual cells. \nA candidate will investigate the epigenetic heterogeneity at the single cell level and the asymmetry during stem cell division in normal neurogenesis and in brain tumors. One of the long-term goals of this project is to determine whether the outcome of stem cell division is stochastic or deterministic and thus could be predicted based on the epigenetic signature of mother cell. \nRequired Experience \nThe candidate must have a Ph.D. degree in any discipline of Biological Sciences. Skills in tissue culture\, cell and molecular biology\, fluorescent microscopy\, computational biology and writing skills are required. Experience with transgenic mice model is highly desirable. \n 
URL:https://ces.b2sg.org/event/sbp-26apr18/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180426
DTEND;VALUE=DATE:20180528
DTSTAMP:20260823T013357
CREATED:20180426T102347Z
LAST-MODIFIED:20180426T102430Z
UID:19943-1524700800-1527465599@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:According to the National Institute of Health (NIH) and the National Science Foundation (NSF)\, a postdoc is an individual who has received a doctoral degree (or equivalent) and is engaged in a temporary and defined period of mentored advanced research training to enhance the professional skills and research independence needed to pursue his or her chosen career path. In addition\, according to the National Postdoc Association (NPA)\, Postdoctoral appointees can pursue basic\, clinical or translational projects so long as their primary effort is devoted toward their own scholarship. Postdocs are essential to the scholarly mission of the mentor and host institution\, and thus are expected to have the freedom to publish the results of their scholarship. \nCharacteristics of a postdoctoral appointment: \nIt is expected that postdocs at MCW\, with the assistance of their supervisor\, will: \n\nTransition to career independence through the development of professional skills that enable the postdoc to actively pursue a career of his/her own choosing.\nBe supervised by at least one senior scholar who actively promotes the postdoc’s professional development.\nEstablish an individual development plan (IDP) that incorporates equally the postdoc’s career and training goals and the mentor’s research goals.\nPursue basic\, clinical\, or translational projects so long as effort is focused primarily on research.\nPublish results of the postdoc’s research and scholarship during their appointment.\nThe postdoctoral appointment is temporary by nature\, the aggregate amount of time spent as a postdoc is recommended to not exceed five years (not including family medical leave or maternity/paternity leave).\nAs postdocs are important members of the host institution’s community\, appropriate levels of compensation\, health care\, and other benefits commensurate with their essential status should be afforded\, independent of the postdoc’s source of funding.\n\nPrimary Functions \n\nPlan\, design and execute complex research studies\, procedures and protocols.\nParticipate in discovery projects.\nCoordinate research study activities; lead and manage projects.\nOversee organization\, synthesis and analysis of data and findings.\nPrepare scientific reports\, outcome findings and scientific manuscripts.\nParticipate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data\, develop methodologies\, and design and evaluate lab procedures.\nMaintain supplies\, may require negotiation with vendors\, and track purchase orders.\nMay oversee the work of laboratory personnel including training and development as well as daily work direction\, delegation and establishing priorities.\n\nKnowledge – Skills – Abilities \nRequired knowledge: biology\, chemistry\, mathematics\, statistics\, documentation\, records management\, data utilization\, complex problem solving\, critical thinking\, resource management\, and writing skills \nSkills and abilities: Necessary research skills include standard molecular and cellular biology techniques. Qualified candidates should have outstanding critical thinking and problem-solving skills\, excellent written and oral skills\, as well as the ability to collaborate with others in a team-oriented environment. Experience in epigenetics and/or mouse models\, especially cancer-related\, would be an asset.
URL:https://ces.b2sg.org/event/mcw-26apr18/
LOCATION:Medical College of Wisconsin\, 8701 W Watertown Plank Rd\, Milwaukee\, WI\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180426
DTEND;VALUE=DATE:20180528
DTSTAMP:20260823T013357
CREATED:20180426T103405Z
LAST-MODIFIED:20180426T103534Z
UID:19945-1524700800-1527465599@ces.b2sg.org
SUMMARY:Professor
DESCRIPTION:Posting Summary\n\nThe Division of Experimental Pathology of the Department of Pathology and Laboratory Medicine (http://rwjms.rutgers.edu/departments_institutes/pathpweb/) seeks applicants for a tenure-track appointment at the Assistant or Associate Professor level. Applicants must hold a Ph.D. or M.D. degree. Physician/Board-certified pathologist scientists are strongly encouraged to apply. \n\n\n\n\n\n\n\nQualifications\n\n\nMinimum Education and Experience\n\nmust hold a Ph.D. or M.D. degree. \n\n\n\nRequired Knowledge\, Skills\, and Abilities\n\nThe successful candidate is expected to develop an independent basic research or translational research program in the fields of cell\, molecular or developmental biology\, immunology\, virology with strong relevance to cancer and organ specific diseases. Ideally\, the research program would integrate with existing programs in cell migration\, morphogenesis\, extracellular matrix\, cytoskeletal/motor protein dynamics\, viral hepatitis\, cancer genetics and epigenetics\, and cancer immunology.
URL:https://ces.b2sg.org/event/rutgers-26apr18/
LOCATION:Rutgers Cancer Institute of New Jersey\, 195 Little Albany St\, New Brunswick\, NJ\, 08903\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180426
DTEND;VALUE=DATE:20180528
DTSTAMP:20260823T013357
CREATED:20180426T104234Z
LAST-MODIFIED:20180426T104234Z
UID:19948-1524700800-1527465599@ces.b2sg.org
SUMMARY:Principal Institute Research Scientist
DESCRIPTION:The Principal Research Scientist applies extensive biology and drug development expertise to oversee cross-functionalresearch teams that are tasked with identifying and validating novel oncology targets\, and then apply deep biology insights to then translate these finding to position novel oncology therapeutic agents in contexts that maximally benefit patients.\n\nThe mission of The Center for Co-Clinical Trials (CCCT) is to integrate biological insights with drug discovery expertise to accelerate the development of innovative targeted cancer therapeutics. The CCCT is a ground-breaking translational research team that partners with world-class drug discovery scientists at the Institute for Applied Cancer Science (IACS) along with their industry-modelled in vivo pharmacology unit and state-of-the-art computational biology infrastructure. CCCT’s cross-functional teams aim to deliver biological insights regarding genetic and functional contributions that influence tumor response to novel therapeutic agents or regimens. As part of the MD Anderson Cancer Center Moon Shots initiative\, the capabilities of the CCCT\, in concert with IACS\, support the institution’s academic and clinical research programs to help us reach our goal of delivering safer\, more effective treatments to our patients.\n\nSalary Range Min $129\,000 – Mid $161\,000 – Max $193\,000\n\n\nKEY FUNCTIONS:\n\n1. Principal Research Scientist applies expert knowledge of tumor biology in areas such as immune oncology\, oncogenic signaling\, metabolism\, epigenetics and/or DNA damage to enable target discovery\, validation and drug development.\n\n2. Oversee and/or lead multiple cross-functional research drug discovery and development programs.\n\n3. Lead collaborations with computational biologists utilizing patient-centric –omic databases to identify deregulated contexts that inform on target discovery\, target validation and translational biology efforts in defined tumor contexts.\n\n4. Oversee the design\, execution\, analysis and interpretation of in vitro\, ex-vivo and in vivo experiments to validate targets\, optimize compound selection and explore therapeutic potential of drug targets.\n\n5. Apply knowledge of pharmacology to enable in vivo assessment of chemical matter and establishment of pharmacodynamics\, pharmacokinetic and efficacy relationships.\n\n6. Lead drug discovery biology efforts to enable selection of lead candidate molecules.\n\n7. Apply expertise to lead the discovery\, validation and development of cell and molecular assays to define mechanism of action\, measure pharmacodynamic changes and select patient responder populations.\n\n8. Lead program biology efforts to enable clinical positioning of developmental candidates.\n\n9. Develop and lead strong collaborative relationships with internal and external groups.\n\n10. Manage activity of direct reports and project teams.\n\n11. Interpret\, present and report research findings at internal meetings and external scientific conferences.\n\n12. Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential\n\n\nEducation \nRequired: PhD in one of the natural sciences or related field or Medical degree.\nExperience\nRequired: Seven years experience of relevant research experience in lab.\n\n\nIdeal Candidate will possess the following:\n\n1. MD or PhD with over 7 years of relevant post-degree experience in a pharmaceutical/biotech environment.\n2. Evidence of utilization of cancer genomics to inform on target discovery\, validation and/or clinical positioning of development drug candidates.\n3. Experience with genetic (ie RNAi and cDNAs) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study target biology utilizing biochemistry\, cellular and molecular biology methods and assays to drive program biology.\n4. Experience utilizing mouse models of cancer to enable target discovery\, validation\, drug development and/or translational biology.\n5. Experience working with chemists\, in vitro and in vivo pharmacologists to develop and utilize assays in support of the development of small molecules for target validation and as part of lead optimization.\n6. Extensive knowledge and experience in areas of tumor biology including\, but not limited to immune oncology\, oncogenic signaling\, cancer metabolism\, epigenetic deregulation\, apoptosis and/or DNA damage and repair as evidenced by publication in peer-reviewed journals.\n7. Strong data analysis skills\, ability to interpret results\, design of follow-up experiments\, troubleshoot issues with assay performance\, and effectively present results and conclusions to co-workers\, collaborators and senior leadership.\n8. Evidence of leading multi-functional teams of scientists to deliver on program objectives.\n9. Evidence of independent thinking and leadership skills.
URL:https://ces.b2sg.org/event/mdacc-26apr18/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180427
DTEND;VALUE=DATE:20180529
DTSTAMP:20260823T013357
CREATED:20180427T114433Z
LAST-MODIFIED:20180509T111016Z
UID:19950-1524787200-1527551999@ces.b2sg.org
SUMMARY:Research Assistant II
DESCRIPTION:SUMMARY\nThe Research Assistant II position provides technical and coordination skills to support laboratory research projects in the Department of Epigenetics and Molecular Carcinogenesis at the Houston campus.\n\nJOB SPECIFIC COMPETENCIES\nResearch Support\nProvide experimental and technical support for ongoing research projects. Perform duties in accordance with general and/or specific plans. Assists in the design of laboratory experiments\, techniques\, and protocols. Processes\, organizes and summarizes data\, reporting experiment results using a variety of scientific\, word processing\, spreadsheet or statistical software applications or program platforms. Preparation of tissues\, cell cultures\, blood samples\, and perform other laboratory duties\, such as the handling of laboratory animals. Assist in general laboratory operation\, ensures the laboratory is prepared for experiments\, performs related laboratory maintenance such as maintaining and cleaning equipment and assisting with monitoring and stocking supplies\, preparation of stock solutions and other reagents. Collect and analyze data from experimental procedures and discuss results with the principal investigator. Document experimental results and maintain an organized laboratory notebook. Prepare materials for submission to granting agencies and foundations. May instruct other staff and students in basic laboratory techniques.\n\nExpertise and Specialization\nApply basic background and experience in science to the application of laboratory techniques\, using judgment\, analysis and evaluation. Read literature and confer with superiors regarding new procedures\, and modify them according to the needs of the project. Master complex skills and techniques used in the Core laboratory. Learn new skills or technology.\n\nLaboratory Organization\nCoordinate procedures\, assemble materials and contribute to the Core laboratory. Participate in ongoing learning and demonstrate application of it in carrying out assignments. Follow Core guidelines regarding order processing\, handling of rush orders and special jobs. Alert superiors to problems with orders or with the queue. Interact with client user groups and alert superiors to problems/concerns. Perform other duties as assigned.\nOther duties as assigned.\n\n\n\n\nREQUIREMENTS\nEducation: Bachelor’s degree with major course works in one of the basic sciences.\nPreferred Education: Master’s Level Degree.\nCertification: None.\nPreferred Certification: None.\nExperience: Two years of experience in scientific or experimental research work. No experience required with preferred degree.
URL:https://ces.b2sg.org/event/mda-27apr18/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/MDAnderson.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180427
DTEND;VALUE=DATE:20180529
DTSTAMP:20260823T013357
CREATED:20180427T122342Z
LAST-MODIFIED:20180509T110218Z
UID:19952-1524787200-1527551999@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:Position Highlights:\nCharacterize and Develop Next Generation Therapeutics for Lethal Prostate and Breast Cancers\nProject 1: To characterize epigenetic regulators promoting survival\, adaptability and metastasis of lethal cancers\, particularly hormone refractory prostate and breast cancers and characterize novel small molecule inhibitors that we have recently developed.\nProject II. To characterize novel epigenetic regulators of genome stability and how these may be compromised as disease progresses to drug resistant stage.\n\nLabpage link: http://labpages2.moffitt.org/mahajank\nThe Ideal Candidate:\n\nPostdoctoral candidates should be highly proficient in utilizing a variety of biochemical\, cell biology and molecular biology techniques as well as mouse tumor models to address novel research questions.\n\n\nThe candidate should be able to work independently as well as in a team setting in the highly interdisciplinary environment at the Moffitt Cancer Center.\n\n\nExperience in developing assays to profile compounds using mechanistic and functional readouts is preferred. The candidate should have demonstrated ability to write original manuscripts and review articles.\n\nResponsibilities:\n\nDesign\, conduct original research\, analyze data\, write manuscripts.\n\n\nPresent at lab\, departmental meetings\, institute and international conferences.\n\n\nTrain other lab personnel.\n\n\nHighly organized\, motivated and self-driven.\n\nCredentials and Qualifications:\n\nM.D. and Ph.D. in Biochemistry/Molecular Biology/Cancer Biology with <1 year of post-doctoral\n\n\nat least 1-2 first author papers related to epigenetics\, long non-coding RNA biology and drug discovery and with a focus on cancer cell biology and drug discovery is preferred.\n\nA competitive salary and benefits package will be offered to the successful candidate. Interested applicants should send a single PDF file that includes a current CV with recent publications\, a personal statement of scientific interests and goals (2-page maximum) and contact information for three references to Dr. Kiran Mahajan Kiran.mahajan@moffitt.org
URL:https://ces.b2sg.org/event/moffitt-27apr18/
LOCATION:Moffitt Cancer Center Magnolia Campus\, 12902 USF Magnolia Drive\, Tampa\, FL\, 33612\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/Moffitt-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180427
DTEND;VALUE=DATE:20180529
DTSTAMP:20260823T013357
CREATED:20180427T135114Z
LAST-MODIFIED:20180507T090104Z
UID:19956-1524787200-1527551999@ces.b2sg.org
SUMMARY:Postdoctoral Associate - Cancer Research
DESCRIPTION:The Human Genetics Department at the University of Miami Miller School of Medicine has an exciting opportunity for a Postdoctoral Associate. This position will carry out advanced independent and/or directed research to achieve the objectives of the research project. Duties assigned to this position will require an in-depth knowledge of a specialized field\, process\, and discipline and may involve organizing and implementing complex research plans\, the development of methods of research\, testing and data collection\, analysis and evaluation\, and writing reports containing descriptive\, analytical\, and evaluative content. The duties will require the exercise of independent discretion and judgment in carrying out research activities within the predetermined research scope and methodology. The Postdoctoral Associate will assist the Principal Investigator\, who is also the Director of the Cancer Epigenetics Research Program. The Postdoctoral Associate will conduct research and ensure that all experiments are appropriately conducted following the policies and procedures of the University of Miami.  \nThe minimum qualifications for this position are as follows: Ph.D. in a relevant discipline involving cell/molecular biology\, immunology\, or stem cell. Must have experience in human cell/tissue culture\, molecular biological techniques\, experimental experience with studies in epigenetics and cancer research. Ability to plan\, organize\, and meet deadlines. Must be highly motivated. Ability to pay close attention to detail\, ensuring accuracy in work. Must be a self-starter with strong interpersonal skills. Proficiency and experience using Microsoft Word\, Excel\, and PowerPoint. Ability to manage multiple tasks simultaneously and independently. Ability to apply logic and demonstrate problem solving techniques. Excellent communication skills\, both verbal and written\, with strong presentation skills. 
URL:https://ces.b2sg.org/event/umiami-27apr18/
LOCATION:University of Miami\, 1320 S Dixie Hwy\, Coral Gables\, FL\, 33146\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180427
DTEND;VALUE=DATE:20180529
DTSTAMP:20260823T013357
CREATED:20180427T140400Z
LAST-MODIFIED:20180427T140621Z
UID:19959-1524787200-1527551999@ces.b2sg.org
SUMMARY:Research Assistant Professor or Postdoctoral Scientist
DESCRIPTION:We are seeking a motivated Research Assistant Professor or Postdoc who is interested in advancing his or her career in a vibrant and highly collaborative environment to join my interdisciplinary team at the Huntsman Cancer Institute. I am Dr. Neli Ulrich\, Senior Director for Population Sciences at the Huntsman Cancer Institute and have research projects available in: \n\nCancer prognosis\, molecular diagnostics\, and survivorship of colorectal cancer\n\nOur research includes transdisciplinary approaches to colorectal cancer prognosis\, utilizing health behavior information as well as metabolomics\, proteomics\, epigenetics and other molecular diagnostics. The position will involve participation in international consortia\, statistical analyses\, leadership on multiple publications\, project management\, and active participation in grant applications. The HCI is growing substantially and offers also perspectives for tenured faculty positions. \nWe are looking for a Assistant Research Professor or Postdoc with the following profile: \n\nA doctoral degree that qualifies you to work in molecular & translational epidemiology. For example a degree in epidemiology\, statistics\, biostatistics\, genetics\, nutritional sciences\, pharmacology or medicine.\nExcellent writing and communication skills and a solid publication record\nGood knowledge of epidemiology and biostatistics\nHighly motivated\, organized and intelligent\nExcellent team player and someone who enjoys working with scientists of diverse backgrounds\nBackground in colorectal cancer preferred\nFor Research Assistant Professor: 2 years of postdoctoral experience.
URL:https://ces.b2sg.org/event/utah-27apr18/
LOCATION:University of Utah\, 201 Presidents Cir\, Salt Lake City\, 84112\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180428
DTEND;VALUE=DATE:20180908
DTSTAMP:20260823T013357
CREATED:20180428T131558Z
LAST-MODIFIED:20180428T131558Z
UID:19962-1524873600-1536364799@ces.b2sg.org
SUMMARY:Postdoc Research Associate
DESCRIPTION:This position will employ a wide range of experimental systems and interdisciplinary approaches and provide broad training in 3 areas: a.) control of cell cycle and tumor suppression by the ubiquitin pathway\, b.) tumor metabolism\, and c.) epigenetic control during tumorigenesis and innate immunity with an emphasis on the regulation of DNA de/methylation. The incumbent will be employed to carry out advanced independent and/or directed research to achieve the objectives of the research project. The principal investigator will establish the professional objectives and performance standards for the incumbent and will make annual evaluations. \n\n\n\n\nMinimum Qualifications: \nThis position requires knowledge of the fields\, processes and disciplines of cell biology and cancer metabolism. The position will involve organizing and implementing research plans\, the development of methods of research\, testing and data collection\, analysis and evaluation\, and writing reports containing descriptive\, analytical and evaluative content. The duties require discretion and judgement in carrying out research activities within the predetermined research scope and methodology. A PhD degree in the appropriate biomedical science or related field or discipline\, or the recognized terminal degree\, is required.
URL:https://ces.b2sg.org/event/unc-28apr18/
LOCATION:University of North Carolina – UNC-Chapel Hill\, Chapel Hill\, NC\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180512
DTEND;VALUE=DATE:20180614
DTSTAMP:20260823T013357
CREATED:20180512T084407Z
LAST-MODIFIED:20180512T181333Z
UID:20054-1526083200-1528934399@ces.b2sg.org
SUMMARY:Research Scientist
DESCRIPTION:RESEARCH SCIENTIST\, Koch Institute (KI) for Integrative Cancer Research-J&J Lung Cancer Initiative Collaboration. \n\nJob Requirements\nREQUIRED: MD and/or Ph.D. in medicine and/or biomedical science; extensive knowledge of cancer biology and related fields; ability to conceptualize and write proposals and publishable manuscripts\, evaluate and train junior researchers\, innovate\, and conduct research; meticulous attention to detail; strong organizational\, documentation\, interpersonal\, and communication skills; comfort summarizing and reporting results; ability to work collaboratively\, follow safety procedures\, and maintain a safe work environment. Familiarity with physiology; cell and molecular biology; immunology; animal testing of biologics; materials science; and/or histological\, biochemical\, and mechanical analyses ideal. Job #15547 \nThis is a one-year\, term-limit appointment with an extension based on continued funding.
URL:https://ces.b2sg.org/event/ki-12may18/
LOCATION:Koch Institute MIT\, Cambridge\, MA\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180512
DTEND;VALUE=DATE:20180614
DTSTAMP:20260823T013357
CREATED:20180512T174404Z
LAST-MODIFIED:20180512T180657Z
UID:20057-1526083200-1528934399@ces.b2sg.org
SUMMARY:Post Doctoral Research Associate
DESCRIPTION:We are seeking a motivated Postdoctoral Scientist or Research Assistant Professor interested in advancing his or her career in a vibrant and highly collaborative environment to join an interdisciplinary team at the Huntsman Cancer Institute. \nDr. Ulrich is a Senior Director for Population Sciences at the Huntsman Cancer Institute and has research projects available in cancer prognosis\, molecular diagnostics\, and survivorship of colorectal cancer. \nThe University/Huntsman Cancer Institute is home to exceptional genetic epidemiologic resources\, including the Utah Population Database\, with >9 million records\, including extensive Utah genealogy records linked to the Utah SEER Cancer Registry\, as well as health records from the University of Utah Hospital and Clinics\, links to statewide cancer and other statewide health record database resources. The University’s excellent biostatistics and research design\, genomics resources\, and biospecimen repository\, as well as a strong research informatics core\, enable outstanding research in genetic and molecular epidemiology. Our Cancer Hospital provides superb resources for multidisciplinary collaborations in translational/clinical epidemiology. HCI is a NCI-designated comprehensive cancer center which supports a vibrant research enterprise in a highly collegial environment. We are currently doubling our research space and increasing our faculty in population sciences research. \nUtah is known for stunning natural wonders\, including 5 National Parks\, and world-class recreation for outdoor enthusiasts. Salt Lake City and the surrounding areas offer diverse neighborhoods\, great schools\, restaurants\, arts and entertainment\, and endless possibilities for sports and recreation. Learn more at: http://healthsciences.utah.edu/living_in_utah/index.php. \nThe University of Utah Health Sciences Center is a patient focused center distinguished by collaboration\, excellence\, leadership\, and Respect. The University of Utah HSC values candidates who are committed to fostering and furthering the culture of compassion\, collaboration\, innovation\, accountability\, diversity\, integrity\, quality\, and trust that is integral to the mission of the University of Utah Health Sciences Center. \nResponsibilities \nOur research includes transdisciplinary approaches to colorectal cancer prognosis\, utilizing health behavior information as well as metabolomics\, proteomics\, epigenetics and other molecular diagnostics. The position will involve participation in international consortia (GAME-ON\, CORECT\, ColoCare\, NIH-COMET)\, statistical analyses\, leadership on multiple publications\, project management\, and active participation in grant applications. \nMinimum Qualifications \n\nA doctoral degree in molecular & translational epidemiology or equivalent (Epidemiology\, Statistics\, Biostatistics\, Genetics\, Nutritional Sciences\, Pharmacology or Medicine)\nExcellent writing and communication skills and a solid publication record\nKnowledge of epidemiology and biostatistics\nHighly motivated\, organized and intelligent\nTeam player able to work with scientists of diverse backgrounds\n\nPreferences \n\nBackground in colorectal cancer preferred\n\n\nFor Research Assistant Professor: 2 years of postdoctoral experience\n\n\nThe HCI is growing substantially and also offers perspectives for tenured faculty positions.\n\nType Benefited Staff Special Instructions Summary \nInterested? Please contact Dr. Neli Ulrich\, neli.ulrich@hci.utah.edu\nCheck out our websites at: http://www.huntsmancancer.org/ulrich and https://healthcare.utah.edu/huntsmancancerinstitute/research/research-studies/colocare-consortium.php \nHCI is growing substantially and also offers perspectives for tenured faculty positions.
URL:https://ces.b2sg.org/event/utah-12may18/
LOCATION:University of Utah\, 201 Presidents Cir\, Salt Lake City\, 84112\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180515
DTEND;VALUE=DATE:20180617
DTSTAMP:20260823T013357
CREATED:20180515T175215Z
LAST-MODIFIED:20180515T175215Z
UID:20083-1526342400-1529193599@ces.b2sg.org
SUMMARY:Postdoctoral Scientist
DESCRIPTION:The Department of Biochemistry and Molecular Medicine (BMM) strives to deliver the highest quality of professional education and training\, and conduct cutting edge research in the areas of biochemistry\, molecular genetics and genomics with a goal to better understand human disease. Additionally\, the department continues to have a long and successful record in training undergraduate\, master and graduate students at the George Washington University School of Medicine and Health Sciences. \nOur Research Programs span from cancer biology\, hepatobiology\, autism\, vascular biology\, and computational genomics. Unlocking the mysteries of biologic processes at the molecular and genomic level is the common thread connecting all research programs. The overall research in the department continues to connect modern biochemistry and genomic discoveries to translational medicine\, leading to a unique multidisciplinary research program in biochemistry and molecular medicine. Find out more here: https://smhs.gwu.edu/biochemistry/ \nThe Biochemistry and Molecular Medicine department is looking for a candidate that will work under the direct supervision of Dr. Mei-Yi Wu. He or she will be responsible for carrying out the research experiments. He or she will also participate in the weekly lab meeting\, and present and discuss the progress of the project with Dr. Mei-Yi Wu. \nThe project focuses on two epigenetic modulators and members of the AT-rich interaction domain family\, ARID4A and ARID4B. Epigenetics plays an important role in human health and disease. Disruption of epigenetic modifications leads to dysregulation of gene function without altering the DNA sequence per se. A major challenge in understanding the importance of epigenetics in human health and diseases is to identify the specific epigenetic factors and the signaling involved. Currently\, we are investigating the role of ARID4A and ARID4B in development and cancer disease using state-of-the-art conditional knockout mouse models and genomic and proteomic approach. We also study the role of ARID4B in cancer stem cells that have been suggested as the major cause for therapy resistance and the driving force behind cancer metastasis and relapse. To investigate whether and how ARID4B drive cancer development\, we evalute the underlying molecular mechanisms by which ARID4B promotes therapy resistance and aggressive cancer. \nDuties include: \n\nCulture and transfection of mammial cells\nCollecting samples for reporter gene assays\nWestern blotting to analyze protein expression\nCancer cell migration and invasion assays\nHuman cancer xenogrant experiments using SCID/NOD mice\nThe postdoc will also work with genetically modified mice\nOrdering lab supplies\, lab maintenance and other duties as assigned\nThis position performs other duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position.\n\n\nMinimum Qualifications: \nQualified candidates will hold a PhD in a related discipline. Degree must be conferred by the start date of the position \nAdditional Required Licenses/Certifications/Posting Specific Minimum Qualifications: Preferred Qualifications: \nPh.D. degree\, with experience in molecular and cellular biology.
URL:https://ces.b2sg.org/event/gwu-15may18/
LOCATION:George Washington University\, 2121 I St NW\, Washington\, DC\, 20052\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180516
DTEND;VALUE=DATE:20180618
DTSTAMP:20260823T013357
CREATED:20180516T094155Z
LAST-MODIFIED:20180516T094942Z
UID:20091-1526428800-1529279999@ces.b2sg.org
SUMMARY:Associate Researcher - Oncological Sciences
DESCRIPTION:Dr. Amaia Lujambio´s research group studies mechanisms of liver cancer initiation and liver cancer maintenance. In particular\, we are interested in how genetic alterations in cancer cells contribute to tumorigenesis\, alter treatment response\, and create vulnerabilities that may be targeted therapeutically. In particular\, we are interested in understanding how genetic alterations in liver cancer cells affect mechanisms of immune escape and response to immunotherapies. \n \nOur research interests involve the establishment of in vitro and in vivo systems for the study of liver cancer\, as well as the rational use of shRNA and CRISPR libraries to identify drug targets for the disease. We utilize sophisticated mouse models of cancer\, RNAi and CRISPR technologies\, valuable human cancer samples\, and genetic and epigenetic profiling as key tools. \n \nThe ultimate goal is to improve our understanding of liver cancer and to identify novel strategies that can be exploited therapeutically to improve healthspan and longevity. \n \n \nRequirements:\n\nBachelor of Science in molecular biology\, cell biology\, immunology or a related topic\nThe candidate will be expected to work well in a collaborative environment\, and to have strong communication skills\nExperience in molecular biology\, cell culture\, flow cytometry is required. Computational skills\, immunology and mouse experience are a plus
URL:https://ces.b2sg.org/event/sinai-16may18/
LOCATION:Mount Sinai – Icahn School of Medicine\, 1468 Madison Ave\, New York\, NY\, 10029\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180518
DTEND;VALUE=DATE:20180620
DTSTAMP:20260823T013357
CREATED:20180518T090019Z
LAST-MODIFIED:20180522T120337Z
UID:20099-1526601600-1529452799@ces.b2sg.org
SUMMARY:Principal Scientist - Cancer Epigenetics
DESCRIPTION:Pfizer Oncology Research & Development (ORD) in La Jolla\, California\, is seeking a Principal Scientist focused on translating basic discoveries in the field of cancer epigenetics into novel therapeutics. \nOur ideal candidate will lead a team of motivated and scientifically rigorous scientists to perform laboratory-based research in a collaborative team environment. The candidate will lead biological target validation\, utilizing genetic and pharmacological approaches to discover and confirm candidates for novel cancer therapeutics. As a member of the group\, you will also be involved in mechanism-of-action studies\, interpretation and presentation of data\, and will function as an integral member of the team to advance new targets. The successful candidate will have experience in the integration of molecular profiling data including epigenomic (ATAC-seq\, ChIP-seq)\, transcriptomic\, proteomic\, and genomic datasets\, into a broader understanding of epigenetic regulation within the tumor and interactions between the tumor and the tumor microenvironment. \nRole Responsibilities \n\nLead a laboratory research group to study genetic and epigenetic mechanisms in tumor biology with the aim to identify new therapeutic targets that can be translated to the clinic\nUtilize expertise in epigenetic biology to design\, execute\, and analyze/interpret innovative approaches for epigenetic targeting in cancer.\nWork collaboratively with computational biology group to integrate complex data sets including epigenomic and other ‘omic’ data in pre-clinical settings for target discovery\, validation\, and advance mechanism of action target biology\nLead development of cell and molecular assays to define mechanism of action\, measure pharmacodynamic changes and select responder patient populations.\nInterface with discovery biology and computational biology groups to design\, develop\, and interpret datasets developed from genetic and pharmacological screens\nDevelop and apply complex in vitro assays including organoids to enable target discovery\, validation and drug development.\nProactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program.\nPresent research results and methodologies at weekly meetings with immediate supervisor and/or project leader\, and at meetings with members of the oncology research unit as appropriate.\nContribute to building a culture that embraces scientific excellence\, urgency\, partnerships with key stakeholders\, continuous learning and improvement\, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.\n\nBasic Qualifications \n\nPhD in Molecular Biology\, Pharmacology (or a comparable biological science) plus post doc and 4+ years of relevant experience in an academic or pharmaceutical/biotech environment.\nExpertise in chromatin biology\, epigenetics and mechanism of transcriptional regulation as evidenced by publication in peer-reviewed journals.\nExtensive knowledge and experience in areas of tumor biology including\, but not limited to immune oncology\, oncogenic signaling\, cancer metabolism\, apoptosis and/or DNA damage and repair\nDemonstrate proficiency in the use of software tools to support epigenomic data analysis including ATAC-seq\, ChIP-seq\, and RNA-seq.\nExperience in use of CRISPR-based techniques for gene knockout\, gene editing and as well as working knowledge of pooled CRISPR -based screening approaches\nAble to work in a team environment\, good communication skills and excellent leaderships skills.\nExperience managing scientists\n\nPreferred Qualifications \n\nPreference for candidates with a strong track record in cancer drug discovery and the targeting of epigenetic pathways by small-molecule inhibitors.
URL:https://ces.b2sg.org/event/pfizer-18may18/
LOCATION:Pfizer – Pearl River\, NY\, 401 North Middletown Road\, Pearl River\, NY\, 10965\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180519
DTEND;VALUE=DATE:20180715
DTSTAMP:20260823T013357
CREATED:20180519T171048Z
LAST-MODIFIED:20180519T171231Z
UID:20115-1526688000-1531612799@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:An exciting opportunity is available to join a cancer pharmacology lab that emphasizes pharmacokinetic (PK)\, pharmacodynamic (PD)\, and quantitative systems pharmacology (QSP) approaches to study brain tumors. The lab integrates experimental data with mathematical models or QSP models to characterize drug action and predict drug responses in patients. The ultimate goal is to bridge preclinical and clinical drug development paradigms and advance precision medicine. \nThe postdoctoral position is in the lab of James M. Gallo in the Department of Pharmaceutical Sciences\, School of Pharmacy and Pharmaceutical Sciences at the University at Buffalo. The department is a premier research unit with a storied tradition of excellence in PK/PD research. Ongoing projects are in anticancer drug development\, drug resistance\, cell state\, epigenetics and tumor heterogeneity. \nThe postdoctoral associate will join a highly interactive department with a central focus of PK/PD/QSP modeling\, and have opportunities to interact with highly talented graduate students\, and scientists within the university including Roswell Park Cancer Institute. Position responsibilities include: \n\nDevelop PK/PD/QSP models using a variety of computer programs.\nParticipate in lab meetings and contribute to the training of students and lab personnel in advanced modeling methods.\nInteract positively with scientific personnel across different disciplines to advance QSP.\nProvide expert support of computer systems used for the labs modeling efforts.\nMaintain abreast of current literature in the fields relevant to lab projects.\nProvide reports based on your work for scientific publications and extramural funding applications.\nAdvance your knowledge of QSP modeling methods and implement those as needed\n\n\n\n\nMinimum Qualifications\n\n\nPh.D. in Engineering\, Mathematics\, Pharmacometrics\, Systems Biology/Pharmacology or a related field.\nDemonstration of mathematical modeling & computer simulation experience; preferably related to biomedical/pharmaceutical applications.\nExpertise in Matlab/SimBiology/Simulink.\nAdditional familiarity with R\, JDesigner/Systems Biology Workbench and related programs desirable.
URL:https://ces.b2sg.org/event/buffalo-19may18/
LOCATION:University at Buffalo\, Buffalo\, NY\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180520
DTEND;VALUE=DATE:20180622
DTSTAMP:20260823T013357
CREATED:20180520T133216Z
LAST-MODIFIED:20180520T133216Z
UID:20129-1526774400-1529625599@ces.b2sg.org
SUMMARY:Research Associate- General Surgery
DESCRIPTION:Job Summary/Essential Job Functions:  Under the direction of the Principal Investigator\, the Research Associate will work independently and perform assigned research.  This position requires strong knowledge of biomedical science\, processing of samples for cellular studies\, including cell sorting\, immunophenotyping\, cell culture\, establishing and keeping mice models for validation of identified pathway\, among other laboratory techniques.  This position will also manage\, designs and carries out experiments\, analyzes\, interprets and present data analyses and interpretation \n  \nDUTIES AND RESPONSIBILITIES:\n \n\nPreparation of samples for cellular studies\, data analyses\, and interpretation.\nPerform cellular/immunological study design.\nPerforms research experiments focused on understanding the role of Id3 in local B cell immune responses before and during liver ischemia reperfusion injury and disease development.\nPerforms Epigenetics ischemia reperfusion injury experimental procedures.\nPerforms experiments related to liver donor quality and mechanistic studies in liver cancer.\n Studies mechanistic chronic kidney disease.\nResearches and develops strategies to minimize ischemia reperfusion injury and pump perfusion.\nMaintain liver biorepository collections of samples.\nDocument experimental processes and results for preparation of scientific reports.\nWorks in conjunction with the PI in preparation of manuscripts\, grants and research compliance documents.\nSubmits published papers and obtain grant funding.\nPerform other duties as required.  \n\n \n \n  \nJOB SPECIFICATIONS:\n\nPh.D. Biological Science; four (4) years cell biology\, molecular biology\, biochemistry techniques; including cell culture\, molecular biology techniques.  The ability to prioritize and coordinate activities of the lab. Laboratory experience\, ability to maintain confidentiality and make sound independent judgments\, excellent verbal/written communication and leadership skills.  Working knowledge of databases\, spreadsheets\, word processing and other special programs for data analysis.  
URL:https://ces.b2sg.org/event/utnhsc-20may18/
LOCATION:University of Tennessee Health Science Center\, Memphis\, TN\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180520
DTEND;VALUE=DATE:20180622
DTSTAMP:20260823T013357
CREATED:20180520T141606Z
LAST-MODIFIED:20180520T141606Z
UID:20133-1526774400-1529625599@ces.b2sg.org
SUMMARY:Postdoctoral Research Fellow
DESCRIPTION:The Thyroid Cancer Research Laboratory at MGH studies key genetic and epigenetic changes in those thyroid cancer patients who do poorly. We are seeking an experienced research fellow interested in pursuing innovative studies on pre-clinical mouse models of thyroid cancer and has an established interest and skillset that includes tumor immunology\, an understanding of mouse models of malignancy and a basic understanding of bio-informatics. \n\nPrincipal Duties & Responsibilities: The Research Fellow will join a collaborative group of scientists with expertise in studying the basic and translational biology of thyroid cancer. The research aims are to characterize the genetic changes in thyroid cancer that leads to proliferative\, immune and stromal alterations. This position provides outstanding opportunities for continued scientific development and for contributing to pioneering research with high translational impact. The scientific environment at MGH and surrounding institutions offers ample opportunity for productive collaborations. \n  \nJob Requirements: The candidate will have a solid foundation in experimental research with a strong record of publication. A PhD or MD/PhD degree is required. Expertise in molecular and immune cell biology is necessary. Experience working with rodents and immune assays as well the ability to work independently is preferred. Fundamental knowledge of signaling pathways\, tumor immunology and bioinformatics is important. Outstanding oral and written communication skills are important as well as willingness to work with collaborators and train students and residents. Those with a history of successful grant writing experience will be given preference. \n\nAdditional Information: Please include a cover letter with your resume which details your interests in thyroid cancer and 2-3 names of people who could immediately provide letters of reference. \n\nTo apply for this position\, please email or send your resume to: \nSareh Parangi\, MD \nProfessor of Surgery\, Harvard Medical School \n15 Parkman Street\, Wang 460\, Boston\, MA 02114 \nsparangi@mgh.harvard.edu
URL:https://ces.b2sg.org/event/mgh-20may18/
LOCATION:Massachusetts General Hospital Cancer Cente\, 55 Fruit St\, Boston\, MA\, 02114\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180520
DTEND;VALUE=DATE:20180622
DTSTAMP:20260823T013357
CREATED:20180520T172022Z
LAST-MODIFIED:20180520T172022Z
UID:20139-1526774400-1529625599@ces.b2sg.org
SUMMARY:Postdoc Research Fellow - Oncogenesis
DESCRIPTION:The Hackensack Meridian Health Center for Discovery and Innovation is offering a position for postdoctoral studies in the field of cancer signaling and gene expression in the laboratory of Dr. Byungwoo Ryu. The goal of the laboratory’s research program is to unravel the cancer epigenome regulating mechanisms which can be targeted for the sensitization to the precision therapies in the hope of translating these therapeutic modalities to have long-term clinical benefit. The Ryu laboratory focuses on investigating chromatin remodeling enzymes\, such as histone and DNA modifiers and gene transcription factors as potential targets for overcoming the resistance of oncogene-targeting therapies and enhancing the objective therapy response rate of immune check-point blockade therapies. The Ryu laboratory uses chemical genetics approaches including small molecule inhibitors\, genome/epigenome-wide profiling\, gene-editing technology\, and animal models. Successful postdoctoral candidate will have a strong interest in cancer biology\, epigenetics\, and immuno-oncology. The candidate will perform in vivo animal models and in vitro analyses. The postdoctoral fellow is expected to understand the project and work independently taking responsibilities in the development and execution of experimental procedures to successfully advance the research project. The successful candidate will be responsible for preparing data for presentations\, progress reports\, and the preparation of manuscripts and posters. The post-doctoral fellow is anticipated to have good communication and writing skills. The successful candidate will have a team-oriented mindset and will provide guidance to junior members. \n\n\n\nResponsibilities\n\n\n\n1. Proficient at most gold standard assays in molecular biology and genetics. 2. Design and conduct animal studies using a vast array of genetic models. 3. Perform data analysis and interpretation. 4. Present results in internal and external research forums. 5. Participate in grant and manuscript writing\, as appropriate. \n\n\n\nQualifications\n\n\n\nEducation\, Knowledge\, Skills and Abilities Required: 1. Hold a Ph.D. in Molecular Biology\, Biochemistry\, Cancer biology or equivalent from an accredited graduate level institution. 2. Minimum publication or in preparation of one article as first author in a reputable peer-reviewed scientific journal. 3. Excellent analytical and presentation skills. 4. Expertise in cell culture\, flow cytometry\, mouse handling\, and basic cellular and molecular biology techniques required. Education\, Knowledge\, Skills and Abilities Preferred: 1. Knowledge and experience with RNA/DNA extraction\, PCR and qPCR analysis\, and next generation sequencing/bioinformatics a plus. 
URL:https://ces.b2sg.org/event/hackensack-20may18/
LOCATION:Hackensack Meridian Health\, Hackensack\, NJ\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180521
DTEND;VALUE=DATE:20180623
DTSTAMP:20260823T013357
CREATED:20180521T065023Z
LAST-MODIFIED:20180521T065830Z
UID:20145-1526860800-1529711999@ces.b2sg.org
SUMMARY:Senior Scientist-In Vivo Pharmacology Oncology
DESCRIPTION:We seek an accomplished Senior Scientist level oncologist/immunologist to join the in vivo pharmacology group within the Oncology Research Unit (ORU) of Pfizer’s Worldwide Research & Development (WRD) division in La Jolla\, California. The successful candidate will join a dynamic team of scientists in the Oncology In Vivo Pharmacology Group\, playing a leading role in the characterization of models of cancer and evaluating new drug candidates. \nParticipate in pre-clinical drug discovery and development projects with a focus on targeted therapeutics\, epigenetics and the tumor microenvironment. Characterize and develop small molecules in close collaboration with partner lines as an integral member of drug discovery teams. Evaluate anti-tumor effects in combination with biologics. Employ and develop new cutting-edge in vivo mouse and human cancer models. Provide technical and scientific expertise in in vivo pharmacology to the tumor cell biology department to enable target identification\, validation\, prioritization and efficient drug discovery of small molecules. \nThe candidate must have a strong background in immunology with extensive hands-on experience in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20\, Cytobank\, FlowJo\, FACS\, MACS). \nIdeal applicants will have excellent communication\, leadership and organizational skills\, critical problem-solving abilities\, and a commitment to excellence.  \nROLE RESPONSIBILITIES \n\nPlan\, execute and analyze multi-parameter flow cytometric analysis studies of cells within the tumor microenvironment.\nResponsible for building and continuously updating flow panels based on recent scientific advances. Maintenance and upgrade of equipment (Fortessa-X20).\nDevelop and characterize new in vivo mouse models\, including syngeneic tumor and genetically engineered mouse (GEM) models\, to study biologic mechanisms and support exploration of novel therapies.\nDesign and conduct in vivo studies to evaluate and establish efficacy\, PK/PD relationship\, combination strategy\, biomarker identification and analysis.\nInterpretation\, presentation and documentation of experiments as well as preparation of reports.\nWritten and verbal presentation of results within a multidisciplinary team environment.\nPublication of results in scientific peer-reviewed journals and presentations at internal\, national\, and international meetings.\nMay manage a colleague\n\nBASIC QUALIFICATIONS \n\nPh.D. (or M.S. degree with 7+ years’\, or B.S. degree with 10+ years’\, relevant post-graduate experience) in Cancer Biology\, Immunology or related discipline.\nExtensive expertise in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20\, Cytobank\, FlowJo\, FACS\, MACS).\nExpertise in in vivo pharmacology and experience with animal models of human cancers as well as strong publication record or evidence of equivalent achievements in industry are desired.\nHands on in vivo skills (IV\, PO dosing)\, blood/tissue collection\nProven ability to make important contributions to cancer biology\, immuno-oncology or related fields\nAbility to follow novel scientific or technological developments\, and to implement them in the laboratory.\nCurrent knowledge of oncology research\, drug discovery and development.\nExcellent written and oral communication and presentation skills in English.\nStrong ability to multi-task and work productively in a fast-paced\, highly collaborative\, and diverse team environment. Capability to contribute to a vivid and challenging intellectual environment.
URL:https://ces.b2sg.org/event/pfizer-21may18/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180521
DTEND;VALUE=DATE:20180623
DTSTAMP:20260823T013357
CREATED:20180521T070643Z
LAST-MODIFIED:20180521T070753Z
UID:20149-1526860800-1529711999@ces.b2sg.org
SUMMARY:Computational Biologist
DESCRIPTION:Dr. Tim Triche Jr. is seeking a full-time Computational Biologist to join his research team. The Triche Lab focuses on developing statistical and mathematical methods to dissect pediatric and adult cancers\, with a focus on cancers of the blood in children. In pediatric tumors\, recurrent mutations alone are rarely sufficient to characterize a person’s disease\, and the role of inherited susceptibility is poorly understood. The lab seeks to improve both outcomes and quality of life by rational selection of positive (“Patients with X usually respond to A”) biomarkers for response and negative (“Patients with Y rarely respond to B”) biological markers for non-response over the course of disease. Particularly in rare tumors\, this approach is well suited to rapidly piloting clinical trials and re-purposing existing drugs; indeed\, one such regional DNA methylation marker is currently in a Phase III trial for front-line chemotherapy. \nWe collaborate broadly with clinical and basic scientists. The role of chromatin- and DNA-modifying proteins\, under the catchall term epigenetic regulators\, is a primary interest. Recent work characterizing genetic influences on transcription suggests that rare variants dominate the landscape\, motivating an alternate readout of regulatory aberrations. We are developing methods to improve both variant prioritization and interpretation of regulatory impacts by jointly analyzing both. To do so\, we make heavy use of high-throughput sequence analysis\, both in bulk and sorted cells\, often from clinical trials. \nOurs is a young lab. You will help determine its growth and direction\, and it will help determine yours. \nIn this role\, you will be responsible for the following tasks: \n\nHandle data management and reproducible analysis for a variety of experimental designs\nDevelop\, maintain\, and support computational biology pipelines\nPerform data mining at scale on both local and (where feasible) cloud pilot resources\nPre-print and publish results and novel methods\, serving as primary or contributing author\, while ensuring compliance with data sharing plans\, and wherever possible\, unsupervised replication\nAnticipate and keep abreast of new developments in bioinformatics and works to ensure the availability of state-of-the-art methods\, resources\, and data sources to support the user groups\nPerform other related duties as assigned (to include wet protocols if suited to the candidate)\n\n\nThis list will likely change as projects evolve and you must be open-minded to learn new things. \nExpectations: \nThe following expectations should be met within the first 3 months. \n\n1 month – Develop solid understanding of at least one major collaborative project\, adapt to VAI computing resources\, and demonstrate analytical reproducibility\, supervised by a senior collaborator\n3 months – Acquire significant data\, prepare informative summaries of interim analyses\, and take over both maintenance and development of analytical pipelines from our senior collaborators.\n\n\nQualifications: \nYou will possess a Master’s degree in computational biology\, bioinformatics\, mathematics\, statistics\, computer science\, or other relevant discipline (a BS with experience will be considered). \nThe ideal candidate \n\nHas working knowledge of at least one scripting language (e.g. R) and systems language (e.g. C)\nHas substantial experience with the analysis of next generation sequencing data (e.g. RNAseq)\nHas experience\, or interest in gaining experience\, with data integration (e.g. ATAC\, WGBS\, Hi-C)\nHas an understanding of cancer biology or genetics; this is helpful but not absolutely required.\nMay see this position as an ideal launching point for further graduate or clinical studies.\nHas a commitment to open\, collegial\, reproducible science\, and the betterment of society.\n\n\nIf you possess these attributes and desire to help us drive science from the bench to the clinic\, while benefiting from a highly generous compensation package; we would welcome speaking with you and encourage you to apply today.
URL:https://ces.b2sg.org/event/vari-21may18/
LOCATION:Van Adel Research Institute\, Grand Rapids\, MI\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180522
DTEND;VALUE=DATE:20180624
DTSTAMP:20260823T013357
CREATED:20180522T110717Z
LAST-MODIFIED:20180522T110717Z
UID:20209-1526947200-1529798399@ces.b2sg.org
SUMMARY:Research Fellow
DESCRIPTION:A Research Fellow position is available in the program of Dr. Keith Robertson. For more information about Dr. Robertson’s program\, please see: http://www.mayo.edu/research/faculty/robertson-keith-d-ph-d/bio-20035097 \nThe successful candidate will join the Epigenetic Etiology of Human Disease Laboratory to study the role of DNA epigenetic modifications in human disease. More specifically\, he/she will examine how DNA methylating and hydroxymethylating enzymes regulate their respective DNA epigenetic modifications and how these marks modulate expression and genome stability\, and interface with other epigenetic modifications. Disease focus areas of the laboratory include cancer (hepatocellular and renal)\, obesity\, and diabetes. Specific research areas include application of genome-wide epigenomics methods to decipher DNA methylation/hydroxymethylation defects in cancer and biochemical/cell culture-based techniques to study the regulation and interactions between chromatin remodeling factors (e.g. DNMTs\, TETs\, HMTases) and the roles of their target loci in driving disease. Techniques commonly used in the laboratory include: quantitative RT-PCR\, western blotting\, cell culture\, transfections\, bisulfite sequencing\, DNA immunoprecipitation\, pyrosequencing\, ChIP-qPCR\, ChIP-seq\, next-gen library preparation and sequencing\, Infinium 850k arrays\, bioinformatics analysis\, microscopy\, and biochemical analysis of protein function. Experience in one or more of these areas is a plus. The candidate will play a major role in the preparation of manuscripts that arise from this work and devote 100% effort to these tasks (no patient contact or other responsibilities). \nPosition description \nA Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars\, Research Scholars\, Professors\, Specialists\, and Student Interns sponsored by Mayo Clinic. 800146; J2WRTP \nQualifications \nMust have a Ph.D.\, M.D.\, or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship\, at Mayo Clinic or elsewhere.
URL:https://ces.b2sg.org/event/mayo-22may18/
LOCATION:Mayo Clinic\, 200 1st St SW\, Rochester\, MN\, 55905\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180522
DTEND;VALUE=DATE:20180624
DTSTAMP:20260823T013357
CREATED:20180522T111743Z
LAST-MODIFIED:20180522T112043Z
UID:20211-1526947200-1529798399@ces.b2sg.org
SUMMARY:ASSOCIATE SCIENTIST - CANCER IMMUNOLOGY
DESCRIPTION:Neon Therapeutics is an immuno-oncology company focused on developing novel therapeutics leveraging neoantigen biology to treat cancer. Neon utilizes its expertise in bioinformatics\, neoepitope prediction and immune monitoring to identify tumor specific mutations and monitor clinical response to their personalized vaccines. Neon Therapeutics’ lead program is NEO-PV-01\, a bespoke neoantigen vaccine that builds upon years of research and development at the Broad Institute and Dana-Farber Cancer Institute. NEO-PV-01 is now being studied in a Phase 1b clinical trial combining the vaccine with Opdivo®\, a PD-1 immune checkpoint inhibitor from Bristol-Myers Squibb\, in patients with measurable metastatic melanoma\, non-small cell lung cancer and bladder cancer. Three additional clinical trials are planned for 2018. Also in development are NEO-PTC-01\, a bespoke autologous T cell therapy\, and NEON / SELECT\, a Shared Neoantigen Program leveraging neoepitopes that are common across patients and tumor types.\nIn addition\, Neon has established strategic partners in BMS\, Merck\, and Apexigen to harness opportunities for combination therapies. Neon leverages foundational intellectual property from the Broad Institute and the Dana-Farber Cancer Institute.Neon Therapeutics was incubated and launched by Third Rock Ventures and raised a $55M Series A in 2015 and\, more recently\, a $106M Series B in 2017. \n\nPosition Summary \nThe successful candidate will work in the Neon SELECT program that aims to develop therapies against neoantigen targets shared across patients. S/he will focus on generating and studying T cell responses to shared neoantigens\, with particular focus on peptide design and T cell receptor characterization. The candidate will need to work on a team but also independently test many different technologies. S/he will need to work effectively on a team while also independently perform cell and molecular biology assays. The candidate will work closely with the departments of T cell immunology\, molecular immunology\, peptide chemistry\, and bioinformatics. \nJob Responsibilities: \n\nCulture and manipulation of human T cells\nAssessment and analysis of specificity of human T cells by multicolor flow cytometry\nPerform scRNA and TCR sequencing as well as data analysis\nDesign and analysis of immunogenic peptide sequences\nProduction of stable cell lines using transfection or transduction\nAnalysis and presentation of results to larger scientific groups\nAssist with the training of lab personnel\nWork productively in a team environment and independently and deliver against timelines.\n\nExperience and essential skills: \n\nM.S. with 5-8 years of experience\, or Ph.D. with 0-2 years of experience in industry with a strong background in immunology.\nA strong background in adaptive immunity in the context of cancer is preferred\nDemonstrated mastery of flow cytometry and related data analysis\nExperience with functional immune assays\, such as cytokine analysis\nGeneral molecular biology techniques\, including plasmid cloning and preparation\nExperience with lentivirus preparation and infection\nAbility to organize and tabulate data.\nStrong evidence of leadership background and experience working in cross-functional teams\nExcellent and record-keeping skills.\nStrong written and oral communication skills.\nIndependent\, flexible\, self-motivated.\n\n\nTo apply\, please send your resume to careers@neontherapeutics.com
URL:https://ces.b2sg.org/event/neon-22may18/
LOCATION:Neon Therapeutics\, 40 Erie St\, Cambridge\, MA\, 02139\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180523
DTEND;VALUE=DATE:20180625
DTSTAMP:20260823T013357
CREATED:20180523T160122Z
LAST-MODIFIED:20180523T160122Z
UID:20231-1527033600-1529884799@ces.b2sg.org
SUMMARY:Postdoctoral Research Fellow
DESCRIPTION:Receive training in specific area(s) of research with the aim of progressing towards an independent career. The appointment is for one year up to a usual maximum of three to four years\, each year contingent upon satisfactory progress\, as evaluated by the supervisor/mentor. \nKey Responsibilities: \n– Receive training in specific area(s) to continue the development of personal technical knowledge and research expertise.\n– Under guidance\, design\, plan and execute original research projects or major parts thereof.\n– Develop ability to critically evaluate and analyze data.\n– Keep a careful record of experiments in laboratory notebooks.\n– Publish and present data internally and externally.\n– Assist other institute researchers in areas of personal expertise.\n– Attend and participate in institutional programs\, seminars and lectures.\n– Progress towards an independent career.\n– Encouraged to seek outside training support.\n– Provide other related duties as required \nEducation: \n      PhD in relevant field of study \nPlease complete application and submit CV to be considered for this position.
URL:https://ces.b2sg.org/event/buck-23may18/
LOCATION:Buck Institute\, 8001 Redwood Boulevard\, Novato\, CA\, 94945\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180523
DTEND;VALUE=DATE:20180625
DTSTAMP:20260823T013357
CREATED:20180523T161745Z
LAST-MODIFIED:20180523T161759Z
UID:20234-1527033600-1529884799@ces.b2sg.org
SUMMARY:
DESCRIPTION:Education: Ph.D. in molecular biology\, biochemistry\, or related field with preferred dissertation research on human or mammalian epigenetics; alternately\, M.S. plus at least five years of experience in a related field \nYears of experience: Ph.D. – At least one year of postdoctoral research in a demonstrably relevant area; M.S. – at least five years of experience \nRequired Skills: \n\nExtensive experience identifying epigenetic signatures resulting from pathology (such as viral infection or cancer)\nExperience with high-throughput assays for identifying epigenetic modifications (e.g.\, next-gen sequencing\, microarrays\, pyrosequencing\, etc.)\nDemonstrated experience analyzing genome-wide methylation profiling or chromatin remodeling\nKnowledge of virology or other infectious disease models strongly preferred\nStrong oral\, written\, and interpersonal communication skills and abilities;\nDemonstrated time management and completion of tasks to a definite deadline\nBioinformatics experience (e.g.\, experience working in a Linux environment and common scripting languages) is desirable\nCandidates must be willing to submit and be eligible for a DoD secret clearance (i.e.\, must be subject to and pass a background investigation and must be a U.S. citizen).\nMust be able to do extended deskwork at a computer\nMust be able to stand for several hours at a time to perform lab work\nMust be able to wear standard PPE (e.g.\, mask\, gloves\, lab coat) for extended periods of time\n\n\nPrimary Responsibilities: \n\nLead efforts based on the identification of epigenetic biomarkers of exposure to biological and chemical pathogens. Support experimental design\, development and optimization of biomarker identification methods and workflows\, and data analysis to validate prospective markers.\nLead and/or support technical tasks or projects within a collaborative teaming environment. The Epigenetics Specialist will work within a team of molecular biologists\, forensic scientists\, biochemists\, bioinformaticians\, database managers\, statisticians\, and project managers to provide solutions to maximize the utility\, confidence\, and rapid reporting of results for large epigenetic datasets.\nSupport projects through employing efficient and accurate data evaluation techniques\, placing levels of statistical confidence on data output\, and clearly reporting results.\nInteract with clients (on and off-site) and present technical data through presentations and report writing.\nSupport end user trainings and client interactions.\nHelp grow the biological sciences business area through the successful and timely execution of projects\, positive interactions with clients\, recognition of opportunities for follow-on work with existing clients\, establishment of new opportunities with alternate clients\, proposal development and writing support\, and maintaining a presence at marketing and business development meetings/conferences.\nTravel to project and business development meetings as needed.\nReport directly to the biology Business Area Manager under the advisement of the Director of Biological Sciences.
URL:https://ces.b2sg.org/event/signature-23may18/
LOCATION:Signature Science LLC
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180524
DTEND;VALUE=DATE:20180626
DTSTAMP:20260823T013357
CREATED:20180524T145813Z
LAST-MODIFIED:20180524T145927Z
UID:20250-1527120000-1529971199@ces.b2sg.org
SUMMARY:Research Associate
DESCRIPTION:To enable Guardant Health to lead the disruption of cancer treatments through non-invasive cancer screening\, the Technology Development Team is seeking a highly motivated Research Associate to help develop\, test\, and improve sample preparation technologies for rare variant and epigenetic studies with next-generation sequencing. At Guardant\, we leverage the most advanced technologies and work with leaders in many different fields to create the most impactful and meaningful technologies for cancer management. \nAs a Research Associate supporting product and technology development\, you will work with members within the team and interface with multiple teams including process engineering\, clinical operations\, research operations\, and bioinformatics. You will be hands on in the lab and be required to design\, implement\, and validate new technologies related to liquid biopsy sequencing assays for the early detection\, treatment\, and monitoring of all cancer types. \n\nOperate next generation sequencing instruments\nRun sequencing sample preparation assays in medium to high throughput environment\nTest and improve new sequencing sample preparation assays\nLog and track research samples throughout sequencing workflow\nMaintain appropriate inventory of lab supplies\nBring a can-do attitude to solve new and challenging problems in a high pace environment\nAnalyze data and troubleshoot issues within the tech dev team and among other teams\nCollaborate with all functions within project teams\nEngage in early design of products and perform experiments both independently and under the supervision of Senior team members within Tech Dev and Bioinformatics groups\nCan present updates\, write reports and SOPs\, and contribute to technical discussions\n\n\n\nQualifications \n\nThe ability to handle biological samples (i.e. tissue\, bio-fluid\, etc.) is a must\nExcellent written and oral communication skills is a must\nProfessional hands-on experience in industrial setting in genomics field is a plus (operational experience is preferred)\nHands-on experience in running sequencing platforms and assays is a plus
URL:https://ces.b2sg.org/event/guardant-24may18/
LOCATION:Guardant Health\, 505 Penobscot Dr.\, Redwood City\, CA\, 94063\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180524
DTEND;VALUE=DATE:20180626
DTSTAMP:20260823T013357
CREATED:20180524T150953Z
LAST-MODIFIED:20180524T150953Z
UID:20253-1527120000-1529971199@ces.b2sg.org
SUMMARY:Principal Research Scientist
DESCRIPTION:The Principal Research Scientist applies extensive biology and drug development expertise to oversee cross- functional research teams that are tasked with identifying and validating novel oncology targets\, and then apply deep biology insights to then translate these finding to position novel oncology therapeutic agents in contexts that maximally benefit patients.  \nThe mission of The Center for Co-Clinical Trials (CCCT) is to integrate biological insights with drug discovery expertise to accelerate the development of innovative targeted cancer therapeutics. The CCCT is a ground-breaking translational research team that partners with world-class drug discovery scientists at the Institute for Applied Cancer Science (IACS) along with their industry-modelled in vivo pharmacology unit and state-of-the-art computational biology infrastructure. CCCT’s cross- functional teams aim to deliver biological insights regarding genetic and functional contributions that influence tumor response to novel therapeutic agents or regimens. As part of the MD Anderson Cancer Center Moon Shots initiative\, the capabilities of the CCCT\, in concert with IACS\, support the institution’s academic and clinical research programs to help us reach our goal of delivering safer\, more effective treatments to our patients.  \nSalary Range Min $129\,000- Mid $161\,000 – Max $193\,000  \nKEY FUNCTIONS:\n1.Principal Research Scientist applies expert knowledge of tumor biology in areas such as immune oncology\, oncogenic signaling\, metabolism\, epigenetics and/or DNA damage to enable target discovery\, validation and drug development.  \n2.Oversee and/or lead multiple cross- functional research drug discovery and development programs.  \n3.Lead collaborations with computational biologists utilizing patient-centric –omic databases to identify deregulated contexts that inform on target discovery\, target validation and translational biology efforts in defined tumor contexts.  \n4.Oversee the design\, execution\, analysis and interpretation of in vitro\, ex-vivo and in vivo experiments to validate targets\, optimize compound selection and explore therapeutic potential of drug targets.  \n5.Apply knowledge of pharmacology to enable in vivo assessment of chemical matter and establishment of pharmacodynamics\, pharmacokinetic and efficacy relationships.  \n6.Lead drug discovery biology efforts to enable selection of lead candidate molecules.  \n7.Apply expertise to lead the discovery\, validation and development of cell and molecular assays to define mechanism of action\, measure pharmacodynamic changes and select patient responder populations.  \n8.Lead program biology efforts to enable clinical positioning of developmental candidates.  \n9.Develop and lead strong collaborative relationships with internal and external groups.  \n10.Manage activity of direct reports and project teams.  \n11.Interpret\, present and report research findings at internal meetings and external scientific conferences.  \n12.Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential  \nEducation  \nRequired: PhD in one of the natural sciences or related field or Medical degree.  \nExperience  \nRequired: Seven years experience of relevant research experience in lab.  \nIdeal Candidate will possess the following:\n1.MD or PhD with over 7 years of relevant post-degree experience in a pharmaceutical/biotech environment.  \n2.Evidence of utilization of cancer genomics to inform on target discovery\, validation and/or clinical positioning of development drug candidates.  \n3.Experience with genetic (ie RNAi and cDNAs) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study target biology utilizing biochemistry\, cellular and molecular biology methods and assays to drive program biology.  \n4.Experience utilizing mouse models of cancer to enable target discovery\, validation\, drug development and/or translational biology.  \n5.Experience working with chemists\, in vitro and in vivo pharmacologists to develop and utilize assays in support of the development of small molecules for target validation and as part of lead optimization.  \n6.Extensive knowledge and experience in areas of tumor biology including\, but not limited to immune oncology\, oncogenic signaling\, cancer metabolism\, epigenetic deregulation\, apoptosis and/or DNA damage and repair as evidenced by publication in peer-reviewed journals.  \n7.Strong data analysis skills\, ability to interpret results\, design of follow-up experiments\, troubleshoot issues with assay performance\, and effectively present results and conclusions to co-workers\, collaborators and senior leadership.  \n8.Evidence of leading multi-functional teams of scientists to deliver on program objectives.  \n9.Evidence of independent thinking and leadership skills. 
URL:https://ces.b2sg.org/event/mda-24may18/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180525
DTEND;VALUE=DATE:20180627
DTSTAMP:20260823T013357
CREATED:20180525T084047Z
LAST-MODIFIED:20180525T084059Z
UID:20256-1527206400-1530057599@ces.b2sg.org
SUMMARY:Labratory Technican
DESCRIPTION:The Department of Medicine\, Division of Hematology/Oncology is looking to fill two OPS Lab Tech positions. The selected candidates will need to be highly motivated individuals to study epigenetic mechanisms in cancer. \nExperimental duties will include but not be limited to\, using molecular biology techniques such as cell culture\, western blotting\, Chromatin immunoprecipitation\, CRISPR/Cas9 gene editing and next generation sequencing (RNA-seq\, ChIP-seq) to test how structural and functional mutations in proteins that regulate chromatin structure may alter gene expression and promote the tumor phenotype. Additional duties associated with the position may include performing experiments in mice and assisting in the maintenance of the lab’s animal colony and occasional lab maintenance/housekeeping/ordering. Excellent written and oral English language skills are required. Prior experience with mouse models\, flow cytometry\, western blotting and PCR is preferred but not required. In addition\, it is essential that the candidate can work independently in the lab\, maintain an electronic lab notebook describing their research activity\, participate in lab meetings and display good interpersonal skills.
URL:https://ces.b2sg.org/event/uf-25may18/
LOCATION:University of Florida\, Gainesville\, FL\, 32611\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180525
DTEND;VALUE=DATE:20180627
DTSTAMP:20260823T013357
CREATED:20180525T093115Z
LAST-MODIFIED:20180525T093219Z
UID:20259-1527206400-1530057599@ces.b2sg.org
SUMMARY:Postdoctoral Associate - Functional Genetics of Cancer
DESCRIPTION:Our group is interested in the functional genetics of cancer. We use state of the art technology in genomics\, proteomics and epigenetics to understand the molecular mechanisms that drive cancer progression\, metastasis and chemoresistance. We are recruiting a postdoctoral fellow to work on understanding the functional consequences of combinations of mutations that contribute to tumorigenesis. Highly self-driven\, ambitious candidates with a knack for solving challenging problems in cancer biology and outstanding publication track record are encouraged to apply. The candidate is expected to work as a part of multi-disciplinary\, dynamic and vibrant team\, and will have the opportunity to work and develop his/her research program with the best in the field. \n  \nEducation and/or Experience: \nYou hold a PhD degree or equivalent in bioinformatics\, statistics\, computational biology\, or related discipline of biomedical research. Experience in computational and statistical genetics\, genomics and knowledge of R and PERL and their application in cancer research is mandatory. Programming experience is required as is having worked with big data. It is desired that you are familiar with standard molecular biology\, tissue culture practices and mouse genetics protocol. The successful candidate will have strong qualifications or experience within several of the following areas: \n\nBioinformatics and systems biology at the molecular level\nCancer pathophysiology and RNA biology of Cancer.\nProject management of interdisciplinary research projects within genomics and bioinformatics (Genomics\, Non-coding RNAs\, Proteomics and Chromatin Biology)\nExperience with data structures\, databases\, and data architectures (TCGA\, SU2C etc)\nKnowledge of biomedical resources and infrastructures
URL:https://ces.b2sg.org/event/sbp-25may18/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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