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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
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DTSTART:20180325T010000
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DTSTART:20181028T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180914
DTEND;VALUE=DATE:20181016
DTSTAMP:20260829T005513
CREATED:20180914T094858Z
LAST-MODIFIED:20180914T094957Z
UID:20620-1536883200-1539647999@ces.b2sg.org
SUMMARY:Assistant Professor of Cancer Biology
DESCRIPTION:The Department of Cancer Biology at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for an Assistant Professor position in the tenure track. The successful applicant will have experience in the field of cancer biology\, including cancer genetics and proteomics\, cancer cell biology\, tumor microenvironment\, cancer stem cells\, metastasis\, tumor immunology\, chemical biology\, cancer metabolism\, oncogenic signal transduction pathways\, genome integrity\, cancer epigenetics\, and cancer-related systems biology and bioinformatics. Responsibilities include establishment and maintenance of an externally funded independent research program\, as well as teaching and mentoring of students. Applicants must have an Ph.D. and/or M.D. degree and have demonstrated excellent qualifications in education and research. \nWe seek candidates who embrace and reflect diversity in the broadest sense. \nThe University of Pennsylvania is an EOE. Minorities/Women/Individuals with disabilities/Protected Veterans are encouraged to apply. \n\nApply for this position online at:  \nhttps://www.med.upenn.edu/apps/faculty_ad/index.php/g/d5157
URL:https://ces.b2sg.org/event/ibi-14sept18/
LOCATION:University of Pennsylvania\, 3400 Civic Center Blvd\, Philadelphia\, 19104\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180916
DTEND;VALUE=DATE:20181018
DTSTAMP:20260829T005513
CREATED:20180916T161801Z
LAST-MODIFIED:20180916T161801Z
UID:20644-1537056000-1539820799@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:A Postdoctoral position in Hematopoietic Stem Cell Biology is available in the laboratory of Peter Kurre\, M.D.\, at the Comprehensive Center for Bone Marrow Failure. The Laboratory has longstanding expertise in Hematopoietic stem cell biology\, including the development of preclinical approaches to Hematopoietic Stem Cell Gene Therapy. Ongoing work is focused on the development and refinement of anchoring lentivector designs with reduced propensity for genomic integration and mutagenicity. In a rapidly growing area of science\, investigations will involve a wide range of methods in virology\, vectorology\, cell-\, molecular biology imaging and bioinformatics tools. The postdoctoral fellow will\, under the direction/guidance of a mentor Dr. Mortimer Poncz\, assume responsibility for a specific\, on-going research project. \n\nThe successful candidate will be highly motivated and creative. Excellent verbal and written communication skills are critical. Scrupulous attention to detail\, good record keeping\, the ability to work independently\, in an expanding dynamic workgroup are essential. Candidates must have a recent Ph.D.\, D.V.M\, or M.D./Ph.D. in the biological sciences. Experience with mammalian cell culture (established cell lines and primary leukemia samples)\, molecular and cell biology techniques\, flow-cytometry\, and mouse models are desirable. The position is funded by NIH funds and private grants and by the The Children’s Hospital of Philadelphia\, with an understanding that the applicant will compete for trainee funding as part of their own career development. \n\nThe successful candidate will thrive in a multi-disciplinary\, collaborative team to extend\, refine and enhance skills necessary for professional and career development\, and broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research\, and will contribute directly to the overall research goals of the project and the research group. Postdocs will participate in project planning\, recording and interpretation/evaluation of data\, and communication of results. The candidate will acquire critical technical and lab management skills for their own career\, and to be proficient at manuscript/grant writing; postdocs will participate in seminars\, lectures\, poster sessions and presentations at national meetings. Postdoctoral fellows also will participate in the supervision of junior lab members\, develop new methods and protocols for research\, and assist with the development of other research projects in the lab. \nPostdoctoral fellows at The Children’s Hospital of Philadelphia receive mentored training in a premier scientific and collaborative environment that includes the resources of the adjacent University of Pennsylvania. \n\nTo learn more about the CHOP Research Institute and the research programs visit: http://research.chop.edu. \nJob Responsibilities \n\nConduct independent scholarly research and develop new methods and protocols\nParticipate in project planning\, recording and evaluation of data\nAcquire technical\, lab management and grant writing skills\nParticipate in seminars\, lectures\, poster sessions and presentation at national meetings\nSupervise junior lab members\nAssist with other research projects\n\nRequired Education and Experience \n\nA terminal degree PhD\, MD\, DVM\, etc.\nAccording to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
URL:https://ces.b2sg.org/event/chop-16sept18/
LOCATION:Children’s Hospital of Philadelphia\, 3401 Civic Center Blvd\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180917
DTEND;VALUE=DATE:20181019
DTSTAMP:20260829T005513
CREATED:20180917T055323Z
LAST-MODIFIED:20180917T055323Z
UID:20646-1537142400-1539907199@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:A postdoctoral associate position is available in the laboratory of Dr. Jennifer Trowbridge at The Jackson Laboratory in Bar Harbor\, Maine\, to study epigenetic mechanisms governing hematopoietic stem cell lineage commitment and how deregulation of epigenetic modifications leads to myeloproliferative disorders including leukemia. The Trowbridge Lab offers a challenging but supportive environment. Past trainees have a noteworthy track record for obtaining grant funding and fellowships. For more information\, please visit: https://trowbridgelab.com.\n\n\n\nResponsibilities\n\n\n\nThe successful candidate will be able to plan\, develop\, execute\, and analyze an independent research project. \n\n\n\nQualifications\n\n\n\n\nM.D. or Ph.D. in biological or related sciences is required.\nStrong training background in molecular biology\, cell biology\, and/or epigenetics/epigenomics is preferred.\nOther areas of experience/training include stem cell biology\, immunology\, cancer biology\, or developmental biology.\nExceptional verbal and written communication skills;\nSelf-motivated and career-oriented individual preferred;\nExperience in flow cytometry and work with mouse models;\nMinimum of one 1st author paper from graduate work.\n\nTo apply\, a complete application must include a cover letter describing past research accomplishments\, research interests\, and career aspirations; a current CV; and the names of three references.
URL:https://ces.b2sg.org/event/jl-17sept18/
LOCATION:Jackson Laboratory\, 600 Main Street\, Bar Harbor\, ME\, 04609\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180918
DTEND;VALUE=DATE:20181020
DTSTAMP:20260829T005513
CREATED:20180918T171857Z
LAST-MODIFIED:20180918T172235Z
UID:20679-1537228800-1539993599@ces.b2sg.org
SUMMARY:Research Scientist - T Cell Metabolism
DESCRIPTION:Poseida Therapeutics\, Inc. is seeking an outstanding candidate to join our immuno-oncology team at La Jolla\, San Diego\, CA. The T Cell Metabolism Scientist will design and perform experiments optimizing the manufacture of chimeric antigen receptor (CAR)-T cell therapies of the T stem cell memory subset (TSCM)\, which are an ideal cell population for adoptive immunotherapy since they are long-lived\, self-renewing and multi-potent. The hypothetical attributes of a CAR-T product with a high percentage of TSCM include enhanced durability\, as well as potency against solid tumors. Investigation will focus on immunometabolism for understanding and optimizing the non-viral piggyBac™ CAR-Tscm manufacturing process via the use of in vitro human cell-based assays assessing T cell proliferation\, phenotype and function. The position will play a critical role in the evaluation and identification of manufacturing strategies for enhancing metabolic fitness and bioenergetic profile of CAR-T products.  The successful candidate will demonstrate excellent oral and written communication skills\, work well both independently and as part of a team\, and be able to work on multiple projects/product candidates simultaneously.  Broad expertise in cellular metabolism\, key regulatory pathways\, T cell culture\, and flow cytometry is required for this role.  The position is a hands-on\, laboratory-based role with the possibility of direct reports. \nPoseida Therapeutics is translating best-in-class gene engineering technologies into lifesaving cell therapies. The company is developing CAR T-cell immunotherapies for multiple myeloma\, prostate and other cancer types\, as well as gene therapies for orphan diseases. P-BCMA-101 is Poseida’s lead CAR-T therapy currently in Phase 1 clinical development for the treatment of multiple myeloma. Poseida has assembled a suite of industry-leading gene engineering technologies\, including the piggyBac™ DNA Modification System\, TAL-CLOVER™ and Cas-CLOVER™ site-specific nucleases\, and Footprint-Free™ Gene Editing (FFGE). For more information\, visit www.poseida.com. \nQualifications\nRequired Experience and Skills: \n\nPhD or equivalent in cell biology\, immunology\, or related field\nExpertise in metabolic pathways supporting T cell proliferation and differentiation (glycolysis\, fatty acid\, mitochondrial metabolism\, etc.)\nA detailed knowledge of lipid metabolism and salvage pathways used in nutrient-limiting\, solid tumor microenvironments\nUnderstanding of key T cell regulatory and differentiation pathways (PI3K-Akt-mTOR pathway in differentiation and memory formation\, etc.)\nExperience in the characterization\, culture\, expansion\, and manipulation of T cells\nAssessment of mitochondrial mass\, activity\, and spare respiratory capacity (Seahorse XF\, etc.)\nKnowledge of cellular and/or tumor immunology principles\, technologies\, and experimental techniques (cell culture\, in vitro cellular assays\, flow cytometry\, etc.)\nMulti-parameter flow cytometry and proficiency in FACS data analysis programs\nExperience designing\, executing\, and interpreting genomics and transcriptome assays (NGS\, RNA-Seq\, Single Cell RNA-Seq\, AmpliSeq\, etc.)\nCell separation technologies (e.g.\, Miltenyi AutoMACS) and FACS sorting\nAbility to organize\, communicate\, and present complex data sets to key stakeholders from diverse backgrounds\nExcellent oral and communication skills\n\nPreferred Experience and Skills: \n\nUnderstanding of epigenetic control of T cell differentiation\nExperience developing\, testing\, and/or utilizing CAR-T products\nFunctional assays measuring cellular activation\, cytokine release\, proliferation\, and killing\nWork with external academic\, biotechnology\, and contract research organizations
URL:https://ces.b2sg.org/event/poseida-18sept18/
LOCATION:Poseida Therapeutics\, 4242 Campus Point Court\, Suite 700\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180919
DTEND;VALUE=DATE:20181021
DTSTAMP:20260829T005513
CREATED:20180919T070406Z
LAST-MODIFIED:20180919T070406Z
UID:20684-1537315200-1540079999@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:A post-doctoral position is available in Dr. Carol J. Thiele’s laboratory in the Cell & Molecular Biology Section in the Pediatric Oncology Branch at the NCI to study mechanisms of epigenetic dysregulation in pediatric neuroectodermal tumors. The broad goal of the laboratory is to study mechanisms of differentiation and how they are dysregulated in embryonal cancers with an eye towards developing novel therapeutic strategies based on an understanding of tumor biology. We use state-of-the-art screening strategies to identify key regulators of growth and differentiation. Current projects are mechanisms of regulation of EZH2 in neuroblastoma\, mESC reprogramming by tumor suppressors\, mechanisms of retinoid regulation of superenhancers\, regulation of tumor cell plasticity and mechanisms of epigenetic dysregulation in pediatric tumors. \n\n\n\n\nNumber of Positions:\n\n1\n\n\n\nC.V. Required:\n\nYes\n\n\n\nNumber of References Required:\n\n3\n\n\n\nBibliography Required:\n\nYes\n\n\n\nExperience Required:\n\n\nThe successful candidate should have a PhD in genetics/molecular biology/biochemistry/cell biology with less than 2 years of post-doctoral experience. Individuals with a strong background in molecular biology and experience in chromatin biology are encouraged to apply. Experience in genome-wide assays\, bioinformatics or deep sequencing is an additional asset. Qualified candidates should have strong communication skills\, and a demonstrated record of scientific achievement through peer-reviewed publications. Successful\, well-motivated candidates will join a multi-disciplinary team of researchers working in a basic/clinical translation environment. \n\n\n\n\nHow To Apply:\n\n\nInterested individuals should send a statement of research interests\, a curriculum vitae and bibliography and 3 letters of recommendation to Carol Thiele. \n\n\n\n\nContact Name:\n\nCarol Thiele\n\n\n\nContact E-mail:\n\nct47a@nih.gov\n\n\n\nContact Phone:\n\n240-858-3849
URL:https://ces.b2sg.org/event/nih-19sept18/
LOCATION:National Institutes of Health (NIH) campus\, Bethesda\, MD\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180920
DTEND;VALUE=DATE:20181022
DTSTAMP:20260829T005513
CREATED:20180920T051242Z
LAST-MODIFIED:20180920T051242Z
UID:20686-1537401600-1540166399@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:The Zhao lab is seeking a highly motivated postdoctoral associate to study the role of RNA modification in stem cells and cancer development.  In analogous to DNA modification\, post-transcriptional modification is also identified on RNA.  Recently\, messenger RNA modification\, particularly methylation at the N6 position of adenosine or m6A\, has emerged as an exciting research area in epigenetics and RNA biology. The Zhao lab identified a protein complex that governs m6A formation. Using loss-of-function studies\, they discovered that m6A mRNA modification is essential for the proliferation and self-renewal of embryonic and neural stem cells. Mechanistically\, they reported that m6A regulates gene expression via shortening of the half-line of mRNAs or interacting with histone modifiers.  Please refer to their publications for further information (Nature Cell Biology 16 (2): 191-8\, Feb. 2014; Nature Neuroscience 21 (2): 195-206\, Feb. 2018). Currently\, we are digging deeper into the biological function and molecular mechanism of m6A in stem cells and cancer cells\, using a combination of biochemistry\, cell biology\, and high throughout sequencing technologies. \n\nRequired Experience \nEducation and/or Experience: \n\nA highly motivated Ph.D graduate with background in RNA biology\, cancer biology\, and/or molecular biology is encouraged to apply. 
URL:https://ces.b2sg.org/event/sbp-20sept18/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20180923
DTEND;VALUE=DATE:20181025
DTSTAMP:20260829T005513
CREATED:20180923T152228Z
LAST-MODIFIED:20180923T152228Z
UID:20689-1537660800-1540425599@ces.b2sg.org
SUMMARY:Postdoctoral Associate - Cancer Research
DESCRIPTION:The Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine has an exciting opportunity for a Postdoctoral Associate working in the laboratory of Dr. Feng-Chun Yang in the Department of Biochemistry and Molecular Biology. This position will focus on Cancer Epigenetics. The Postdoctoral Associate will perform cutting-edge research to understand the cellular/molecular mechanisms mediating pathogenesis of hematopoietic malignancies with a specific focus of ASXL1\, ASXL2 and NF1gene mutations.\n\nThe minimum qualifications for this position are as follows: Ph.D.\, M.D.\, or other doctoral level degree. Possess a strong background in cancer biology\, molecular and cellular biology\, biochemistry or a closely related field of study. Candidates must have successfully defended their thesis to be eligible for consideration. Prefer experience working with mammalian cells and mouse models of cancer. Applicants with experience in stem cell biology or who are familiar with bioinformatic tools (particularly next generation sequencing data analysis) are encouraged to apply. Must be goal-oriented\, proactive and hardworking with excellent organizational skills and passionate about making a difference in cancer research. Applicants should upload a CV when applying that contains a cover letter and complete list of publications.
URL:https://ces.b2sg.org/event/um-23sept18/
LOCATION:University of Miami\, 1320 S Dixie Hwy\, Coral Gables\, FL\, 33146\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180925
DTEND;VALUE=DATE:20181027
DTSTAMP:20260829T005513
CREATED:20180925T075652Z
LAST-MODIFIED:20180925T080342Z
UID:20691-1537833600-1540598399@ces.b2sg.org
SUMMARY:Clinical Geneticist
DESCRIPTION:HJF is seeking a Clinical Geneticist to support the MCC Cancer Genetics Program at the John P. Murtha Cancer Center (MCC) located at the Walter Reed National Military Medical Center (WRNMMC)\, Bethesda\, Maryland.  The MCC Cancer Genetics Program includes the Clinical Breast Care Project and the Clinical Genetics Service in WRNMMC.  HJF provides scientific\, technical and programmatic support services to MCC. \nThe John P. Murtha Cancer Center at Walter Reed Bethesda is a modern\, patient-centric\, tri-service military healthcare facility. Its comprehensive core of military and civilian oncologists and other cancer-trained clinicians and researchers provide multidisciplinary cancer-care delivery and patient-family support services. Our Cancer Center\, the only DoD Cancer Center of Excellence within the Military Health System\, offers its patients access to cutting-edge cancer diagnostic and treatment technologies. \nThe incumbent will serve as a Clinical Geneticist for the MCC Cancer Genetics Program in Walter Reed National Military Medical Center.  They will provide comprehensive genetic evaluation for clients and families with genetic\, genomic\, epigenetic\, pharmacogenetic conditions – suspected\, at risk\, proven or with a family history of such under the direction of the Principal Investigator. \nResponsibilities: \n\nServe as the Clinical Geneticist for the MCC Cancer Genetics Program in Walter Reed National Military Medical Center.\nProvides consultation to assigned staff of Walter Reed National Military Medical Center and partner Military Treatment Facilities.\nCoordinates with the other genetics professionals at Walter Reed National Military Medical Center in the planning\, development and evaluation of programs and services related to genetic counseling.\nProvides genetic services to individual patients and their family members in MCC Cancer Genetics Program and the Clinical Breast Care Project in Walter Reed National Military Medical Center.\nProvides both public and professional/academic education and participates in clinical research.\nPerforms other duties as needed.\n\nRequired Knowledge\, Skills\, and Abilities: Knowledge of procedures and techniques necessary for performing research tasks; ability to learn and become proficient in data acquisition and clinical responsibilities related to research protocols; excellent interpersonal skills. \nMinimum Education/Training Requirements: M.D. or D.O \nMinimum Experience: 6+ years experience in Clinical Genetics preferred.
URL:https://ces.b2sg.org/event/hjf-25sept18/
LOCATION:Henry M. Jackson Foundation\, 1200 5th Ave.\, Suite 1450\, Seattle\, WA\, 98101\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180926
DTEND;VALUE=DATE:20181028
DTSTAMP:20260829T005513
CREATED:20180926T161313Z
LAST-MODIFIED:20180926T161313Z
UID:20698-1537920000-1540684799@ces.b2sg.org
SUMMARY:Postdoctoral Scholar
DESCRIPTION:The Buisson Lab in the Department of Biological Chemistry at the University of California\, Irvine is seeking applicants for a Postdoctoral Scholar position. \nApplications are being sought from independent and motivated postdoctoral candidates interested in a multi-disciplinary approach to address important questions around genomic instability including: DNA damage\, DNA repair\, transcription and epigenetic control. Applicants must possess a Ph.D. degree to apply and must have one excellent first author publication in biochemistry\, molecular and cellular biology or a related field from their Ph.D. training period. In addition\, expertise in DNA damage/repair\, epigenetics and genomics is preferred but not required. \nThe Buisson lab focuses on understanding the mechanisms that cause DNA damage and genomic instability in cancer as well as the roles of tumor suppressor genes and oncogenes in DNA repair processes. These include investigating the mechanisms of DNA double-strand break repair and DNA replication through cellular\, biochemical\, genetic and structural biology approaches (Nature Structural & Molecular Biology\, 2010; Cell Reports\, 2014; Molecular Cell\, 2015; Molecular Cell\, 2017; Cancer Research\, 2017; Science\, 2018). \nFurther details about the Buisson Lab research can be found at: https://buissonlab.com. \nThe Buisson Lab is part of the Department of Biological Chemistry\, Chao Family Comprehensive Cancer Center\, and the Center for Epigenetics and Metabolism at UC Irvine. We are located in Southern California\, between Los Angeles and San Diego. For further details about UC Irvine and Southern California\, please visit https://uci.edu/. \nAdditional information regarding the position can be obtained by contacting: \nProfessor Rémi Buisson\nBuissonlab@gmail.com \nTo Apply: Interested candidates should apply through UC Irvine’s RECRUIT system located at: https://recruit.ap.uci.edu/apply/JPF04961. \nEach application must contain the following items: \n\nBrief statement of research interests and future goals\nCV detailing research experience\, publications\, any fellowships obtained during the training period\, and other relevant information\nList of any manuscripts in preparation or currently under review\nNames of 3 references that are familiar with the research experience of the candidate and who can provide letters of recommendation upon request
URL:https://ces.b2sg.org/event/irvine-26sept18/
LOCATION:UC Irvine\, Irvine\, CA\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180927
DTEND;VALUE=DATE:20181029
DTSTAMP:20260829T005513
CREATED:20180927T080301Z
LAST-MODIFIED:20180927T080356Z
UID:20700-1538006400-1540771199@ces.b2sg.org
SUMMARY:Research Fellow
DESCRIPTION:A Research Fellow position is available in the program of Dr. Keith Robertson. For more information about Dr. Robertson’s program\, please see: http://www.mayo.edu/research/faculty/robertson-keith-d-ph-d/bio-20035097 \nThe successful candidate will join the Epigenetic Etiology of Human Disease Laboratory to study the role of DNA epigenetic modifications in human disease. More specifically\, he/she will examine how DNA methylating and hydroxymethylating enzymes regulate their respective DNA epigenetic modifications and how these marks modulate expression and genome stability\, and interface with other epigenetic modifications. Disease focus areas of the laboratory include cancer (hepatocellular and renal)\, obesity\, and diabetes. Specific research areas include application of genome-wide epigenomics methods to decipher DNA methylation/hydroxymethylation defects in cancer and biochemical/cell culture-based techniques to study the regulation and interactions between chromatin remodeling factors (e.g. DNMTs\, TETs\, HMTases) and the roles of their target loci in driving disease. Techniques commonly used in the laboratory include: quantitative RT-PCR\, western blotting\, cell culture\, transfections\, bisulfite sequencing\, DNA immunoprecipitation\, pyrosequencing\, ChIP-qPCR\, ChIP-seq\, next-gen library preparation and sequencing\, Infinium 850k arrays\, bioinformatics analysis\, microscopy\, and biochemical analysis of protein function. Experience in one or more of these areas is a plus. The candidate will play a major role in the preparation of manuscripts that arise from this work and devote 100% effort to these tasks (no patient contact or other responsibilities). \nA Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars\, Research Scholars\, Professors\, Specialists\, and Student Interns sponsored by Mayo Clinic. 800146; J2WRTP \nMust have a Ph.D.\, M.D.\, or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship\, at Mayo Clinic or elsewhere. Please attach the following required documents at the time of application: \n\nCurrent curriculum vitae and bibliography\nThree letters of recommendation\, signed\, on letterhead\, describing:\n\nRelationship to the applicant.\nPast work/academic performance.\nWork qualities/personal conduct.\nOverall assessment of potential for success in research environment.\n\n\nDoctoral degree certification\, if applicable:\n\nOriginal or notarized copy of diploma or final transcript issued by school (English translation required).
URL:https://ces.b2sg.org/event/mayo-27sept18/
LOCATION:Mayo Clinic\, 200 1st St SW\, Rochester\, MN\, 55905\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180927
DTEND;VALUE=DATE:20181029
DTSTAMP:20260829T005513
CREATED:20180927T082233Z
LAST-MODIFIED:20180927T082233Z
UID:20703-1538006400-1540771199@ces.b2sg.org
SUMMARY:Postdoctoral Fellow - Cancer Immunology
DESCRIPTION:We are seeking a driven and accomplished postdoctoral fellow to join the Cancer Immunology Discovery (CID) group within the Oncology R&D (WRD) unit of Pfizer in South San Francisco\, California. \nThe successful candidate with lead a research project to understand how epigenetic mechanisms control the anti-tumor immune response\, and to translate the findings into better therapies with curative potential for cancer patients. \nThe project builds on promising preliminary data and applies cutting-edge technologies to address what is to date a major scientific question with great clinical implications. Guided by experienced mentors with strong academic track records\, the successful candidate will study fundamental questions in cancer immunology with the goal of publishing in high-impact journals. The postdoc will also interact extensively with leading scientists in small and large molecule drug discovery\, collaborate with computational\, early clinical\, and translational oncology colleagues across Pfizer\, present in internal and external conferences\, and receive mentorship to become a prolific independent scientific investigator. \nROLE RESPONSIBILITIES                                 \nThe successful candidate will work independently\, but with guidance by experienced mentors\, to: \n\nDiscover the novel mechanisms through which epigenetic enzymes regulate T cell activation\, differentiation\, trafficking and exhaustion\, in combination with I-O agents.\nDesign and perform studies to evaluate the anatomical distribution\, persistence and function of antigen-specific T cells in preclinical models of cancer.\nCollaborate with teams in tumor biology\, protein engineering\, computational biology\, clinical development to discover novel biology and as a result identify better treatments for cancer patients.\nPresent at group meetings\, internal and external conferences\, and publish in high impact journals.\nContribute to building a culture that embraces scientific excellence\, integrity\, effectiveness\, humility\, continuous learning and team work.\n\nBASIC QUALIFICATIONS  \n\nPh.D. in Immuno-oncology\, Immunology\, Cancer Biology or a comparable biological science\, with a strong track record of scientific publications.\n0-4 years of postdoctoral experience.\nSolid hands-on experience with conventional immunological techniques: immune cell isolation\, multi-color flow cytometry\, in vitro immune cell functional assays and in vivo tumor models.\nExperience in assessing T cell function\, differentiation\, exhaustion and memory development.\nMust have excellent organization and planning skills\, the ability to work in a fast-paced environment independently and as part of a team. Excellent verbal and written communication\, and strong motivation with a dedicated work ethic.\nAble to master new concepts and techniques quickly.\n\nPREFERRED QUALIFICATIONS \n\n2+ years research experience in T cell biology and/or epigenetics.\nStrong understanding of innate and adoptive immune systems.\nPrior experience or a strong interest in developing novel immunotherapies for cancer.\nHands-on experience in qRT-PCR\, ELISA\, Western blotting\, ChIP-seq\, RNA-seq\, ATAC-seq and CyTOF is desirable.\nHands-on experience in CRISPR\, RNAi\, lentiviral transduction and exogenous gene expression is a plus.\nHands-on experience in syngeneic and spontaneous tumor models\, adoptive cell transfer is desirable.
URL:https://ces.b2sg.org/event/pfizer-27sept18/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20180930
DTEND;VALUE=DATE:20181031
DTSTAMP:20260829T005513
CREATED:20180930T073203Z
LAST-MODIFIED:20180930T073203Z
UID:20706-1538265600-1540943999@ces.b2sg.org
SUMMARY:Senior Scientist - Cancer Epigenetics
DESCRIPTION:Pfizer’s Oncology Research Unit (ORU) in La Jolla\, California\, is seeking a Senior Scientist (PhD level) focused on translating basic discoveries in the field of cancer epigenetics into novel therapeutics. \nThe Senior Scientist will work within a collaborative team of motivated and scientifically rigorous scientists to conduct preclinical research and advance drug programs in the field of cancer epigenetics. Our ideal candidate will have a strong background employing state-of-the art approaches to gain a broader understanding of epigenetic regulation in cancer biology. The candidate will translate basic research findings into therapeutic strategies\, utilizing genetic and pharmacological approaches to understand target mechanism of action and generate patient stratification strategies. The successful candidate will demonstrate a proven track record of scientific productivity as evidenced by first author publications in scientific journals. Experience in the integration of molecular profiling data including epigenomic (ATAC-seq\, ChIP-seq)\, transcriptomic\, proteomic\, and genomic datasets will be a plus. \nRole Responsibilities \n\nUtilize expertise in epigenetic biology to develop innovative strategies for understanding the role of epigenetic mechanisms in cancer progression\, drug resistance and immune modulation\nDesign\, execute and analyze/interpret experiments to advance mechanism of action studies\, develop patient responder hypotheses\, elucidate mechanisms of resistance  and identify rational drug combinations that can be translated to the clinic\nWork collaboratively with computational biology group to integrate complex data sets including epigenomic and other ‘omic’ data in pre-clinical settings for target validation and increased understanding of target biology\nInterface with discovery biology\, systems biology and computational biology groups to design\, develop\, and interpret datasets developed from genetic and pharmacological screens\nProactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program\nPresent research results and methodologies at weekly meetings with immediate supervisor and/or project leader\, project team meetings and other research forums\nContribute to building a culture that embraces scientific excellence\, urgency\, partnerships with key stakeholders\, continuous learning and improvement\, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.\n\nBasic Qualifications  \n\nPhD in Molecular or Cellular Biology\, Genetics\, Pharmacology (or a comparable biological science) with a minimum of 3-5 years of relevant postdoctoral experience in an academic or pharmaceutical/biotech environment.\nExpertise in chromatin biology\, epigenetics and mechanism of transcriptional regulation as evidenced by publication in peer-reviewed journals. \nPreference for candidates with a strong track record in cancer drug discovery/translational research and the targeting of epigenetic pathways by small-molecule inhibitors.\nExpertise in techniques used for epigenetic/ transcriptional profiling including ChIP-seq\, ATAC-seq\, and RNA-seq\nAble to work in a team environment\, good communication skills and excellent leaderships skills.\n\nPreferred Qualifications \n\nProficiency in the use of bioinformatic software tools to support epigenomic data analysis including ATAC-seq\, ChIP-seq\, and RNA-seq.\nExtensive knowledge and understanding of other areas of tumor biology including but not limited to immuno-oncology\, oncogenic signaling\, cancer metabolism\, apoptosis and/or DNA damage and repair\nExperience in use of CRISPR-based techniques for gene knockout\, gene editing and as well as working knowledge of pooled CRISPR -based screening approaches
URL:https://ces.b2sg.org/event/pfizer-30sept18/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181002
DTEND;VALUE=DATE:20181104
DTSTAMP:20260829T005513
CREATED:20181002T101047Z
LAST-MODIFIED:20181002T101047Z
UID:20708-1538438400-1541289599@ces.b2sg.org
SUMMARY:Senior Research Assistant
DESCRIPTION:The primary purpose of the Senior Research Assistant position is to provide supervision\, special training to technical personnel\, and /or highly technical work in research projects. Performs a series of experiments designed to supply specific information as a part of a larger project; an answer to questions in a limited field; or\, in development of improved techniques\, production methods or procedures in the Department of Epigenetics and Molecular Carcinogenesis. \nJOB SPECIFIC COMPETENCIES\n\nResearch Support Perform research or experimental tasks to supply information as part of a research project or laboratory. Responsible for planning and executing details of an experiment\, including set up\, timing (scheduled\, staffed\, planned)\, coordination of supplies and equipment at hand\, functionality of equipment\, trained personnel. Evaluate and interpret experimental results. Assemble\, operate and troubleshoot equipment. Compile/prepare tables and charts. Assist with preparation of grant applications and progress reports.\n\nExpertise and Specialization Apply background/experience in science\, using independent evaluation\, judgment and analysis. Perform research or experimental tasks in a limited field (niche) or specialty area. Master difficult\, advanced\, skills or technology. Develop and revise protocols\, procedures\, and techniques. Introduce/implement new technology. Participate in troubleshooting and resolving problems.\n\nLaboratory Organization Supervise technicians and oversee their training. May oversee educational appointees in their work and assist them as assigned or delegated. Assess availability of supplies and advise/recommend purchasing as needed. Contribute to the laboratory; assess need for back-up and cover as necessary; cross-train. May have delegated signing authority on routine purchases. Perform other duties as assigned.\n\nOther duties as assigned.\n\n\nREQUIREMENTS\n\nEducation: Bachelor’s degree in one of the natural sciences or related field.\n\nPreferred Education:Master’s Level Degree\n\nCertification: None\n\nPreferred Certification: None\n\nExperience: Three years of experience in scientific or experimental research work. With preferred degree\, one year of required experience.\n\nPreferred Experience: Extensive experience in cell culture studies including mammalian cell culture; transfections of cell lines; post-culture analysis (cell viability\, cell counting\, cytoxicity and proliferation assays). Experience with RNA interference\, shRNA and/or siRNA; Familiarity with CRISPR/Cas 9 and next-generation sequencing preparation. Past experience with lenti virus and retro virus mediated transduction of mammalian cell lines.
URL:https://ces.b2sg.org/event/mda-2oct18/
LOCATION:MD Anderson Cancer Center Smithville\, 1808 Park Rd 1C\, Smithville\, TX\, 78957\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181006
DTEND;VALUE=DATE:20181108
DTSTAMP:20260829T005513
CREATED:20181006T103346Z
LAST-MODIFIED:20181006T104414Z
UID:20721-1538784000-1541635199@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:NIH funded postdoctoral position available immediately at Northwestern University in the Feinberg School of Medicine in the Department of Urology. The postdoctoral fellow will work closely with Joshua Meeks\, MD\, PhD in the Department of Urology and Stephen Miller\, PhD in the department of Microbiology and Immunology. Research projects associated with this fellowship include: 1) mechanisms of T-cell biology and immune activation in genitourinary disorders (including cancer)\, 2) mechanisms resistance to therapy\, 3) mechanisms of T cell tolerance 4) epigenetic regulation of T cell activity 5) novel checkpoint and immune regulatory therapies. \nCandidates are required to have US citizenship or permanent residence and a PhD or MD in Molecular biology\, or Immunology and/or comparable experience in these subjects. Preferred qualifications include experience with bioinformatics and next generation sequencing. Prior research in model systems (e.g.\, mouse models) is also considered an important criteria. \nProspective candidates will have the opportunity to submit publications\, as well as gain access to human trial specimens that will contribute to the next generation of therapies in immuno-oncology and benign urologic conditions that apply immunotherapy. In addition\, Northwestern University offers an extremely stimulating and nourishing academic environment\, with rich resources to facilitate career development for young scientists. \nFor consideration\, please send your cover letter\, CV\, and names of three references to: Dr. Joshua Meeks at\, joshua.meeks@northwestern.edu and jmeeks@nm.org. \nSpecific Responsibilities: \n\nTo oversee the molecular genetics lab including the maintain the supplies\, equipment and ordering of necessary materials;\nTo conduct laboratory experiments including mutation analysis and in situ hybridization as well as others to study melanoma cancer;\nTo help write grants and compete for funding;\nTo supervise students and other techs working in the genetics lab;\nTo help write and contribute to publications resulting from research done in the lab;\nPerforms other duties as assigned.\n\nMinimum Qualifications: \n\nPh.D. training in genetics or molecular biology competent in PCR\, mutational analysis\, and DNA sequencing.
URL:https://ces.b2sg.org/event/nwu-6oct18/
LOCATION:Northwestern University\, 633 Clark St\, Evanston\, IL\, 60208\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181007
DTEND;VALUE=DATE:20181109
DTSTAMP:20260829T005513
CREATED:20181007T065154Z
LAST-MODIFIED:20181007T065300Z
UID:20725-1538870400-1541721599@ces.b2sg.org
SUMMARY:Research/Lab Assistant
DESCRIPTION:A part time\, temporary position is available in the laboratory of Dr. Aparna Sertil in the Department of Basic Medical Sciences at the University of Arizona College of Medicine-Phoenix\, investigating the role of tumor microenvironment and stress signaling in tumor dormancy\, therapy resistance and cancer stem cell plasticity. The successful candidate will be a well-rounded\, enthusiastic individual with training in Cell Biology\, Molecular Biology\, Biochemistry or related field and experience performing research in a laboratory setting. This individual should be detailed oriented\, conscientious\, and able to follow instructions and have the ability to communicate in a clear\, concise manner orally and in writing. \nDuties & Responsibilities \n\nPerforms standard laboratory procedures such as maintaining cell cultures requiring the use of sterile technique\, processing tissue samples and preparing slides using staining techniques.\n\n\nPerforms routine experiments and analyses\, as requested.\n\n\nMaintains animal colonies which includes feeding\, watering\, sexing and breeding the subjects.\n\n\nCompiles data and assists in routine preliminary analyses; maintains research data in laboratory notebook\, writes summary reports and reports findings to investigator.\n\n\nAssists in performing surgeries and dissections on animals which includes setting up equipment and supplies\, preparing animals for surgery\, anesthetizing and monitoring heart rate of animal and harvesting tissue samples and readily accessible organs.\n\n\nCollects samples or data and performs lab analysis and/or quantifies and tabulates results.\n\n\nOperates laboratory and experimental equipment such as microtomes\, microscopes\, electron microscopes\, spectrophotometers\, centrifuges\, analytical balances\, photometers and spectrometers; makes minor repairs and makes arrangements for major repairs to be performed.\n\n\nOrganizes supplies\, materials or equipment and sets-up equipment for laboratory experiments or demonstrations; may perform minor equipment maintenance.\n\n\nMaintains detailed records of controlled substances in the laboratory; packages waste material and arranges for disposal according to established procedures.\n\n\nAssists with basic mathematical and statistical analyses.\n\n\nFollows established procedures to prepare solutions\, media and reagents using arithmetical calculations for measuring; performs library research to find appropriate procedures\, as required.\n\n\nCleans glassware and other laboratory equipment or materials using appropriate standards; keeps laboratory area clean.\n\n\nPerforms clerical tasks such as filing\, typing\, labeling and billing; inventories and requisitions supplies and materials.\n\n\nAssists in training volunteers working in the laboratory.\n\nKnowledge\, Skills\, & Abilities \n\nKnowledge of the methods\, materials and techniques used in laboratory and research work.\n\n\nKnowledge of research and laboratory equipment appropriate to the area of the assignment.\n\n\nAbility to effectively communicate.\n\n\nSkill in recording research data.
URL:https://ces.b2sg.org/event/ua-7oct18/
LOCATION:University of Arizona\, Tuscon\, AZ\, 85721\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181008
DTEND;VALUE=DATE:20181110
DTSTAMP:20260829T005513
CREATED:20181008T070634Z
LAST-MODIFIED:20181008T070634Z
UID:20728-1538956800-1541807999@ces.b2sg.org
SUMMARY:Faculty Position
DESCRIPTION:The Department of Biochemistry and Molecular Biology at Mayo Clinic is seeking an exceptional biomedical scientist studying molecular mechanisms of disease to run an independent and nationally/internationally-recognized research program. \nPosition description \nThis person will hold academic rank at Mayo Clinic commensurate with experience and qualifications. Research expertise may be in any biomedical field\, including but not limited to biochemistry\, biophysics\, cell biology\, developmental/ regenerative biology\, epigenetics\, metabolism\, and molecular biology. The successful candidate will be expected to work collaboratively with colleagues and may align with one or more institutional centers (e.g.\, biomedical discovery\, cancer\, individualized medicine\, pediatrics\, regenerative medicine). \nCredentials of a successful candidate will include a doctoral degree in a biomedical science field (PhD\, MD/PhD\, MD or equivalent) and rigorous postdoctoral training. Junior investigators should have a strong publication record; evidence of successful competition for external funding is preferred. Mid-career and senior investigators must have a strong publication record and history of NIH- or equivalent extramural funding. \nLicense or certification \nCredentials of a successful candidate will include a doctoral degree in a biomedical science field (PhD\, MD/PhD\, MD or equivalent) and rigorous postdoctoral training. Junior investigators should have a strong publication record; evidence of successful competition for external funding is preferred. Mid-career and senior investigators must have a strong publication record and history of NIH- or equivalent extramural funding. \nApplications should include a cover letter\, CV\, statement of research interests\, and contact information for at least three potential references.
URL:https://ces.b2sg.org/event/mayo-8oct18/
LOCATION:Mayo Clinic\, 200 1st St SW\, Rochester\, MN\, 55905\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20181009
DTEND;VALUE=DATE:20181111
DTSTAMP:20260829T005513
CREATED:20181009T061755Z
LAST-MODIFIED:20181009T061755Z
UID:20730-1539043200-1541894399@ces.b2sg.org
SUMMARY:Postdoctoral Research Fellow
DESCRIPTION:We seek a motivated post-doctoral research fellow to join our ongoing studies on the cancer-causing potential of new and emerging tobacco products\, including electronic cigarettes and heat-not-burn devices. Candidates are expected to have working knowledge of routine molecular biology techniques used for cancer epigenetic studies. Hands-on experience with assays to detect aberrant DNA methylation and/or histone modifications is a plus. Priority will be given to those who have prior work experience with microarray- or next generation sequencing-based platforms. Candidates with successful publication record in scholarly journals are preferred. \nTo submit an application\, please\, visit: \nhttps://usccareers.usc.edu/job/los-angeles/postdoctoral-scholar-research-associate/1209/6248579
URL:https://ces.b2sg.org/event/usc-9oct18/
LOCATION:University of Southern California\, Los Angeles\, CA\, 90007\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181011
DTEND;VALUE=DATE:20181113
DTSTAMP:20260829T005513
CREATED:20181011T071507Z
LAST-MODIFIED:20181011T071507Z
UID:20742-1539216000-1542067199@ces.b2sg.org
SUMMARY:Senior Scientist - Cell Biology (Epigenetics)
DESCRIPTION:We are seeking a highly motivated scientist to join our Epigenetics Center of Excellence. Reporting to the Director / Epigenetic Drug Discovery Head\, the candidate will be based in San Diego\, CA. He/she will be expected to design\, plan and execute biological studies for identifying new targets and to support drug discovery projects from target identification to nomination of development candidates. This role will work closely with other functions such as Bioinformatics\, Biochemistry\, Chemistry and Pharmacology to coordinate the progress of projects. With an emphasis in Oncology\, the scope of work will cover also Immuno-Oncology\, Inflammation and Neurodegenerative diseases. It will involve collaborative work with academic centers and business partners as well.  \nThe successful candidate will have a strong foundation in transcription regulation in cancer with previous experience in Drug Discovery.  \nSkills/Knowledge Required :\nPh.D. in Biology or related scientific discipline with at least 6 years of relevant cancer research experience\, preferably in Industry \nProficient in cell biology including shRNA and CRISPR technologies \nExperience in target validation\, functional and biomarker cell-based assay development. \nExperience in performing and/or interpreting epigenetic profiling studies is highly desired (DNA methylation\, RNA-sequencing\, ChIP-sequencing and ATAC-sequencing). \nSolid experience in Drug Discovery. \nHighly motivated\, innovative and strong team player. Experience to work in a cross-functional team \nExcellent time management and organizational skill. \nStrong communication skills\, both written and oral. \nStrong ability to work in a fast-paced environment is essential. \nStrong interpersonal and communication skills with a demonstrated ability for creative thinking and problem solving. 
URL:https://ces.b2sg.org/event/celgene1-11oct18/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181011
DTEND;VALUE=DATE:20181113
DTSTAMP:20260829T005513
CREATED:20181011T071738Z
LAST-MODIFIED:20181011T071738Z
UID:20743-1539216000-1542067199@ces.b2sg.org
SUMMARY:Senior Scientist
DESCRIPTION:We are seeking a talented highly motivated research scientist to join our new Sequencing Research capability in San Diego. The successful candidate will work on novel NGS profiling approaches to elucidate disease state from patient biospecimens\, PDX and organoid models\, and multi-cellular pre-clinical disease models. Work performed will contribute to therapeutic discovery and early translational research programs in oncology\, autoimmune and neurological indications. \nThe role will involve extensive partnership with scientist colleagues from across Celgene Research & Early Development (R/ED) to drive new experimental\, data capture and sample rescue strategies\, and will include inter-disciplinary collaboration with analytical research colleagues to maximize the depth and robustness of insights derived from transcriptional\, mutational and epigenetic profiling datasets. Areas of technical research focus include the successful profiling of rare\, damaged or low-yield samples\, and collaborative pursuit and assessment of diagnostic assay hypotheses. \nKey stakeholders include researchers in our thematic centers of excellence (TCoEs)\, our Translational Development and Diagnostics (TDD) function\, and colleagues in the Research Informatics and Knowledge Utilization (RIKU) department\, engaged in work towards key objectives for Celgene Research and Early Development (R/ED). \nThis position suits an individual with demonstrated scientific talent and future leadership potential\, with excellent communication and collaboration skills. Keen interest in inter-disciplinary application of high-throughput molecular profiling methods to life sciences data is imperative. \nApplications are encouraged from those looking to impact delivery of truly innovative and life-changing therapies for complex diseases of unmet medical need. \nResponsibilities will include\, but are not limited to\, the following: \n\nCollaborative design and execution of NGS profiling experiments to elucidate disease state and therapeutic response\, with focus on successful profiling of rare\, damaged or low-yield samples\, and collaborative pursuit and assessment of diagnostic assay hypotheses.\nResearch at the leading edge of NGS sample preparation and profiling technologies\, including implementation of novel protocols drawn from the literature\, Celgene academic collaborators\, and/or in-house efforts\, aligned to Celgene scientific research objectives.\nAdvise on sample extraction\, library preparation and QC\, guide collection of supporting metadata\, liaise with computational research colleagues during analytical research\, and translational scientists involved in diagnostics research.\nDesign and perform pilot experiments to test new protocols\, and assess new profiling platforms and external vendor capabilities.\nContribute to the operation of internal next-generation sequencing resources and development of supporting infrastructures\, including documentation of protocols developed and supervision of technical support staff as required.\nPresent strategies\, approaches\, results and conclusions to Celgene colleagues and external audiences to a publishable standard.\nContribute to enable strategic collaborations with academic and commercial collaborators to benefit therapeutic programs.\n\nSkills/Knowledge Required: \n\nPh.D. in biology\, biochemistry or related discipline at a recognized higher-education establishment.\nAt least 6 years of inter-disciplinary research experience with focus on cell or molecular profiling for elucidation of human disease in university\, hospital or biotechnology research scenarios.\nExpertise in performing state of the art NGS studies with demonstrable record of innovative protocol development and peer-reviewed publication in relevant areas.\nExpertise in the generation of robust molecular profiling datasets from low-yield\, damaged or contaminated human samples for translational research objectives. \nExperience in use of NGS profiling methods to answer complex research questions in cancer biology\, autoimmune disease\, epigenetics and/or immune biology.\nHands-on experience of sample and library preparation\, operation and maintenance of high- and low-throughput NGS apparatus (Illumina preferable).\nIn-depth knowledge of contemporary NGS technologies and experimental design considerations\, and familiarity with downstream bioinformatics approaches applied to process\, analyze\, visualize and interpret NGS datasets.\nAwareness of contemporary LIMS schema\, open-source bioinformatics tools and database structures.\nExperience in performing functional assays to validate experimental findings.\nExcellent time management and organizational skills\, proven problem-solving skills\, collaborative nature and adaptability across disciplines
URL:https://ces.b2sg.org/event/celgene2-110ct18/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20181014
DTEND;VALUE=DATE:20181018
DTSTAMP:20260829T005513
CREATED:20180512T183157Z
LAST-MODIFIED:20180513T090011Z
UID:20060-1539475200-1539820799@ces.b2sg.org
SUMMARY:From epigenome towards epitranscriptome in cell fate choice
DESCRIPTION:About the Workshop\n\nIn the central dogma of molecular biology\, RNA was thought only to pass genetic information from DNA to protein. Most recent findings strongly indicate that RNA modifications\, like mRNA methylation\, play dynamic regulatory roles that are analogous to the reversible epigenetic modifications of DNA and histone proteins. Understanding the function and mechanisms of the dynamic RNA modifications\, which are termed ‘RNA epigenetics’\, represents a new challenge at the frontier between different disciplines\, such as biochemistry\, epigenetics and cutting-edge technology. \nReversible RNA modifications add a new dimension to the developing picture of post-transcriptional regulation of gene expression. This new dimension awaits integration with transcriptional regulation\, i.e. DNA modifications\, to decipher the multi-layered information that controls a plethora of biological functions. Thus\, in the era of advanced technologies\, the exciting next step is to move from mapping nucleotide modifications to understanding how they contribute to biological processes. \nThis EMBO Workshop involves sessions dedicated to recent advances in the epigenomic and epitranscriptomic regulation of stem cell pluripotency and differentiation\, organismal development\, and how their alteration brings about human diseases. Particular emphasis on approaches enabling targeted manipulation of epigenetic marks\, which are revolutionising the field\, will be addressed. \nTopics to be covered include: \n1. Dynamic DNA and RNA modifications: Writers\, erasers\, and readers. This session will be dedicated to the discovery and functional elucidation of the enzymes dynamically modifying and demodifying DNA and RNA molecules. Also\, progress made on identification and characterization of proteins mediating the effects of these modifications into biological function will be discussed. \n2. Decoding the function of DNA and RNA modifications: Insights from epigenome editing and other approaches. The second session will provide new insights on the emerging approaches useful for an enhanced and more accurate interpretation of DNA and RNA dynamics. For instance\, the targeted deposition or removal of chromatin modifications promises to be a powerful tool in basic research\, to study gene function and chromatin biology\, and also in molecular medicine. \n3. DNA and RNA Epigenetics in Stem Cell and Development. This session will discuss the latest advances on the epi-control of the mechanisms underlying the cell fate decision and early developmental processes\, with a special focus on the embryonic and adult stem cells. Moreover\, DNA and RNA methylation will be discussed in the context of reprogramming events in the developing mouse germ line and zygote. \n4. Epigenomes and Epitranscriptomes: A gateway to understanding diseases. In this session\, the discussion will be focused on how understanding the regulation of DNA and RNA modifications paves the way towards identifying causes and cures for human diseases\, with particular emphasis on cancer\, muscle diseases and autoimmune disorders. \n\nRegistration\n\nABSTRACT SUBMISSION: 01 April 2018 – 15 June 2018 \nCHOSEN PARTICIPANTS WILL BE NOTIFIED BY 30 June 2018 \nTRAVEL GRANT APPLICATION: 01 April – 15 June 2018 \nREGISTRATION DEADLINE: 31 July 2018
URL:https://ces.b2sg.org/event/embo-14oct18/
LOCATION:Hotel La Palma\, Capri\, Italy
CATEGORIES:Meetings
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181014
DTEND;VALUE=DATE:20181116
DTSTAMP:20260829T005513
CREATED:20181014T192526Z
LAST-MODIFIED:20181014T192526Z
UID:20746-1539475200-1542326399@ces.b2sg.org
SUMMARY:Institute Research Scientist
DESCRIPTION:ECLIPSE (Evolution of Cancer\, Leukemia and Immunity Project) is a novel organization within the MD Anderson Cancer Center\, Houston\, Texas\, with the mission of making MDACC and its partners recognized leaders in the identification and development of innovative immunooncology therapies that will cure all hematologic malignancies. \nThe primary requirement for an individual in this position is an experienced and highly motivated individual with hands-on experience in identification and validation of potential therapeutic targets for patients with advanced hematological malignancies. Such data generated from the team is expected to influence a broad array of decisions around target prioritization and generation of therapeutic modalities against those particular targets. The successful candidate will participate in cross-functional research to design and develop novel assays that will support an understanding of target biology. The selected candidate will be expected to work at the bench and contribute to development and implementation of potential biomarker strategies to support clinical development. Previous experience in biotech/pharma is highly preferred. \n\nKey Functions \n· Design and develop key experiments contributing to the conception\, execution\, and championing of novel targets\, technology platforms\, and strategies related to the development of biologics-based clinical candidate programs. \n· Provide expert technical guidance to others on project/task groups. Determine priorities and communicate to the team. Redirect operations as necessary to achieve objectives. \n· Collaborate with team members on a discovery platform using high throughput multi-omic technologies and apply scientific expertise in immunology and cancer biology to drive these programs in a multidisciplinary and exciting research team environment. \n· Interface with scientific staff both within the institution and outside\, including industry collaborators\, external consultants and stakeholders. \n· Commitment to keep abreast of current and emerging technological and scientific advancements in the field. \nEducation \nRequired: Bachelor’s degree in Biology\, Biochemistry\, molecular biology\, cell biology\, enzymology\, pharmacology\, chemistry or related field.\n\nPreferred: PhD in Biochemistry\, Molecular Biology or a related discipline.\n\nExperience\nRequired: Ten years of relevant research laboratory experience. With Master’s degree\, eight years of required experience and with PhD\, two years of required experience.\n\n· Experience with genetic (ie RNAi and CRISPR) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study target biology utilizing state of the art molecular biology and biochemistry methods and assays.\n\n· Hands-on experience in standard in vitro and in vivo cell biology and immunology assays including\, but not limited to\, expansion of CTLs\, tetramer assays\, cytotoxicity assay\, functional assays like ADCC\, ADCP etc. is highly desirable. \n· Broad knowledge of cell culture techniques is required and knowledge of in vivo oncology models is desirable. \n· Extensive knowledge and experience in key areas of tumor biology such as oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or anti-apoptosis as evidenced by publication in peer-reviewed journals. \n· Strong data analysis skills\, ability to interpret results and contribute to the design of follow-up experiments\, troubleshoot issues with assay performance. \n· Ability to effectively present results and conclusions to co-workers\, collaborators and senior leadership. \n· Ability to approach problems with curiosity and open mindedness; offer new ideas\, solutions and/or options. Notice current processes/products needing improvement and generate new options using own technical expertise and by utilizing multiple resources. \n· Ability to effectively challenge others in a group to identify creative approaches. \n· Ability to ensure scientific excellence\, quality and completeness of programs. \n· Strong knowledge of translational immunology such as identification of targets for immunotherapy in solid tumors and/or leukemia. \n· Excellent computer skills with working knowledge of commonly used research software programs.
URL:https://ces.b2sg.org/event/mdacc-14oct18/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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END:VEVENT
END:VCALENDAR