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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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METHOD:PUBLISH
X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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DTSTART:20180325T010000
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TZNAME:CET
DTSTART:20181028T010000
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TZNAME:CEST
DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;VALUE=DATE:20181222
DTEND;VALUE=DATE:20190124
DTSTAMP:20260902T000009
CREATED:20181222T212941Z
LAST-MODIFIED:20181222T212941Z
UID:20953-1545436800-1548287999@ces.b2sg.org
SUMMARY:Research Assistant Scientist
DESCRIPTION:The Division of Genetic Epidemiology in the Department of Epidemiology (http://epidemiology.phhp.ufl.edu/) in the College of Public Health and Health Professions and College of Medicine invites applications for a Research Assistant Scientist to work in genetic epidemiology\, bioinformatics\, and computational biology. Candidates have opportunities to work on high-dimensional multi-omics datasets including genetics (e.g.\, GWAS\, WGS\, NGS)\, epigenetics (methylation\, microRNA\, ChIP-seq)\, transcriptomics (RNA-seq)\, metabolomics\, and proteomics for human complex disorders such as Alzheimer’s disease\, major depression\, obesity\, diabetes\, and cardiovascular disease. The Department provides an outstanding environment for interdisciplinary\, cutting-edge scientific research\, career development and interactions with other units that perform basic\, translational and clinical research. Senior faculty members in the department are committed to provide strong mentorship for junior investigators to advance their careers. Minorities are strongly encouraged to apply. \n\n\n\n\n\n\nQualifications\n\n\nMinimum required:  An appropriate doctoral level degree in epidemiology\, quantitative genetics\, bioinformatics or a related field. \nPreferred qualifications:  Strong computational skills or experience working with high-dimensional omics datasets needed. Prefer candidate who has publications in genetic epidemiology arena. \n\n\n\n\n\n\nApplication Instructions\n\n\nApplicants must submit a cover letter\, CV\, and contact information for three references. Review of materials will begin immediately and continue until appointment is made. \nThis requisition has been reposted from a previous UF faculty application system. Applicants who applied to Job# 503243 are still under consideration and need not apply.
URL:https://ces.b2sg.org/event/uf-22dec18/
LOCATION:University of Florida\, Gainesville\, FL\, 32611\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181226
DTEND;VALUE=DATE:20190128
DTSTAMP:20260902T000009
CREATED:20181226T224834Z
LAST-MODIFIED:20181226T225322Z
UID:20959-1545782400-1548633599@ces.b2sg.org
SUMMARY:Postdoc Position
DESCRIPTION:A postdoctoral position is available in the Department of Genetics\, UAB Comprehensive Cancer Center and Center for Free Radical Biology at University of Alabama\, Birmingham. Our group has a longstanding interest in understanding role of oxidative stress\, mitochondria-to-nucleus retrograde cross talk\, mitochondria-induced nuclear genomic instability and mitochondrial genetics in tumorigenesis and other human diseases. \nWe have excellent academic environment and research facilities at the Department of Genetics\, UAB Comprehensive Cancer Center and Center for Free Radical Biology. UAB is a major research university and academic health center that offers a highly interactive scientific environment with state-of-the-art research and core facilities and multidisciplinary work environment. The Department of Genetics fosters collaboration with other basic science as well as clinical departments and the UAB Comprehensive Cancer Center. \nThe candidate is expected to be self-motivated\, resourceful and should have a recently obtained Ph. D. degree. Those with interest and experience in mitochondrial biology\, biogenesis\, oxidative phosphorylation and genetics\, epigenetics such as DNA methylation and transgenic mouse and cell culture models of cancer and/or human diseases are strongly encouraged to apply. \nThe candidate must have experience in mitochondrial techniques\, OXPHOS enzymatic assays\, cell culture\, and standard molecular and epigenetic techniques including cloning\, real time PCR\, transfection\, Southern\, Northern and Western analysis and immunoprecipitation. The candidate with experience in tumorigenesis assay such as soft agar\, matrigel invasion and mouse xenograft are also preferred. The successful candidate is expected to design and perform experiments and interpret data independently. \nInterested applicants should email (in pdf format) a cover letter with the description of research interests and experience\, curriculum vitae\, and contact information of three references to mito@uab.edu. The cover letter should be addressed to: \nKeshav K. Singh\, Ph.D.\nJoy and Bill Harbert Endowed Chair\nProfessor of Genetics\, Pathology and Environmental Health\nDepartment of Genetics\, School of Medicine\nUniversity of Alabama at Birmingham\nKAUL 620\, 1530 3rd Avenue South\nBirmingham\, AL 35294-0024
URL:https://ces.b2sg.org/event/uab-26dec18-2/
LOCATION:FL
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/06/uab-University-of-Alabama-at-Birmingham.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181228
DTEND;VALUE=DATE:20190130
DTSTAMP:20260902T000009
CREATED:20181228T021949Z
LAST-MODIFIED:20181228T022639Z
UID:20962-1545955200-1548806399@ces.b2sg.org
SUMMARY:Trainee: Oncological Sciences
DESCRIPTION:Roles & Responsibilities:\nAmaia Lujambio’ research group studies mechanisms of liver cancer initiation and liver cancer maintenance.\n\nIn particular\, we are interested in how genetic alterations in cancer cells contribute to tumorigenesis\, alter treatment response\, and create vulnerabilities that may be targeted therapeutically\nIn particular\, we are interested in understanding how genetic alteration in liver cancer cells affect mechanisms of immune escape and response to immunotherapies\nOur research interests involve the establishment of in vitro and in vivo systems for the study of liver cancer\, as well as the rational use of shRNA and CRISPR libraries to identify drug targets for the disease\nWe utilize sophisticated mouse models of cancer\, RNAi and CRISPR technologies\, valuable human cancer samples\, and genetic and epigenetic profiling as key tools\nThe ultimate goal is to improve our understanding of liver cancer and to identify novel strategies that can be exploited therapeutically to improve health span and longevity\n\n\nRequirements:\n\nBachelor of Science in life sciences\nMinimum 1 year experience in a wetlab
URL:https://ces.b2sg.org/event/sinai-27dec18/
LOCATION:Mount Sinai – Icahn School of Medicine\, 1468 Madison Ave\, New York\, NY\, 10029\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181228
DTEND;VALUE=DATE:20190130
DTSTAMP:20260902T000009
CREATED:20181228T155651Z
LAST-MODIFIED:20181228T160742Z
UID:20967-1545955200-1548806399@ces.b2sg.org
SUMMARY:Post Doctoral Fellow
DESCRIPTION:NIH funded postdoctoral positions are immediately available in the laboratory of Dr. Zhao at the Hospital for Special Surgery affiliated to Weill Medical College of Cornell University in the New York City. \n\nOngoing studies include identification of novel players and regulatory mechanisms of osteoclast differentiation\, osteoblast differentiation and bone remodeling in the physiological and pathological settings in osteoimmunology field\, an exciting interdisciplinary research field linking bone biology and immune system. We apply cutting edge cellular and molecular techniques including RNAseq and ChIPseq and use various genetic and disease mouse models to accomplish the study. Relevant publications: Nature Medicine\, 15 (9):1066-71\, 2009; Journal of Experimental Medicine\, 209(2):319-34\, 2012; Journal of Clinical Investigation\, 124 (11):5057-73\, 2014. \n\nWe are recruiting postdoctoral candidates who have a recent Ph.D. and strong research interest and expertise in cell biology/signaling\, cell differentiation and development\, immunology\, metabolisms or epigenetics.  Candidates with experience in osteoclast\, osteoblast\, chondrocyte or adipocyte differentiation are preferred. Qualified candidate must have a record of peer reviewed publications and experience working with genetic mutant mice and disease models.  Familiarity with microarray or sequence analysis is highly preferred. High level of motivation\, critical thinking and strong troubleshooting ability are expected. Effective communication in English is required. PhD candidates expected graduations are highly encouraged to apply. \nCompetitive salary and an excellent benefits package (Medical\, Dental and Life insurances) are available and will commensurate with experience and accomplishments. \n\nFull applications including curriculum vitae\, a brief summary of past\, current and future research interests and accomplishments (1-2 paragraphs)\, selected reprints of publications\, three references and expected availability date should be submitted via email to: \n\nBaohong Zhao\, DMD\, PhD\nAssistant Professor \nDepartment of Medicine\nWeill Medical College of Cornell University \nAssistant Scientist\nArthritis and Tissue Degeneration Program
URL:https://ces.b2sg.org/event/hss-28dec18/
LOCATION:Hospital for Special Surgery\, New York City\, NY\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20181231
DTEND;VALUE=DATE:20190202
DTSTAMP:20260902T000009
CREATED:20181231T024641Z
LAST-MODIFIED:20181231T025644Z
UID:20971-1546214400-1549065599@ces.b2sg.org
SUMMARY:Clinical Scientist
DESCRIPTION:This position reports to the Head of Translational Medicine and will work in a collaborative\, cross-functional project team environment. The successful candidate will bring proven leadership skills and a strong background in clinical research in cancer therapeutics. This person will be involved in the translational clinical activities across a growing\, early-stage portfolio of small molecule therapeutics\, including the implementation of strategic development plans and actively participating in the conduct of clinical studies for multiple development-stage programs at FORMA Therapeutics Inc.  \nResponsibilities \n\nImplement clinical development strategies/plans for novel drug candidates in oncology and non- oncology indications as part of a cross-functional project team.\nWork closely with the Head of Translational Medicine\, project teams and the Translational Biology group to incorporate the therapeutic directions and patient selection strategies into clinical protocols\nSupport the medical monitor for clinical protocols\nPartner with Clinical Operations on clinical trial conduct and monitoring\, including GCP\, patient eligibility\, safety monitoring\, AE and SAE tracking and reporting and protocol deviations\nSupport timely and high quality cleaning\, analysis\, interpretation and communication of data in ongoing and completed studies\nReview regulatory documentation and other communications\, including IND\, IB\, annual reports\, CSR\, abstracts\, manuscripts and presentations\nCoordinate relationships with external key opinion leaders and investigators and lead/participate in investigator meetings\, advisory boards and site visits.\nWork and partner with internal and external (CRO\, investigator) stakeholders\nAdhere to and implement quality standards and SOPs in clinical development\n\nPosition Requirements: \n\nThe successful candidate’s position and title will be commensurate with experience\nBachelor’s degree with at least 5 years’ industry experience in oncology drug development\nExperience with small molecule therapeutics preferred\nExperience in Phase I protocol development and clinical strategy development is required\nKnowledge of the regulatory environment and experience with working with regulatory authorities is required\nStrong understanding of cancer biology and ability to integrate biological knowledge into clinical development strategy\nAdditional experience in non-oncology therapeutic areas (Immunology) is a plus\nA creative problem solver with the proven ability to work independently and collaboratively in a fast-paced\, results-oriented and dynamic environment\nExcellent interpersonal skills and a demonstrated ability to work well within team structure is essential\nStrong written and verbal communication skills.\nAbility to travel up to 20%
URL:https://ces.b2sg.org/event/forma-30dec18/
LOCATION:FORMA Therapeutics\, Watertown\, MA\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/12/forma1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190103
DTEND;VALUE=DATE:20190205
DTSTAMP:20260902T000009
CREATED:20190103T042201Z
LAST-MODIFIED:20190103T042614Z
UID:20976-1546473600-1549324799@ces.b2sg.org
SUMMARY:Post-Doc Fellow
DESCRIPTION:Under the direction of Principal Investigator\, perform research consisting of a variety of complex analytical and technical laboratory techniques and/or direct a research technician in the performance of research activity. Projects involve whole genome screening using cutting edge technology for new cancer drivers\, evaluation of new cancer therapy targets\, epigenetics\, patient-derived cancer cell lines\, PDXs. Work may include experiments in mouse models. Requires the application of complex methods and procedures where independent judgment is normally required. \nPerform research in the laboratory of a principal investigator. \nDevelop and implement a variety of complex\, analytical and technical laboratory procedures. \nPresent findings of ongoing research at lab meetings\, professional meetings\, and conferences. \nApply to various sponsoring agencies for fellowships that are related to the research project. \nPublish the results of their research.  \nPh.D. degree in cancer biology\, cell biology\, biochemistry\, pharmacology\, or a closely related field. Must have first author publication(s) in reputable journals from their terminal degree. Proficiency in English scientific writing. Excellent communication skills. Proven ability to work independently as well as in a team. Prior expertise with in vitro and/or in vivo cancer models\, flow cytometry\, immunofluorescence\, qPCR\,cell culture\, immunoblotting\, and molecular cloning. 
URL:https://ces.b2sg.org/event/tj-2jan19/
LOCATION:Thomas Jefferson University\, 130 S 9th St\, Philadelphia\, PA\, 19107\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190105
DTEND;VALUE=DATE:20190207
DTSTAMP:20260902T000009
CREATED:20190105T171002Z
LAST-MODIFIED:20190105T172238Z
UID:20983-1546646400-1549497599@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:We are seeking a highly motivated individual to join the Guo Laboratory at Albert Einstein College of Medicine in New York City. Our research focuses on elucidating the role of stem cell pathways in breast cancer pathogenesis. These studies are built on our recent findings in normal and malignant breast stem cells (Cell Reports 18: 2825-2835\, 2017; Cell Reports 16: 3146-3156\, 2016; Cell 148: 1015-1028\, 2012; Cell 133: 704-715\, 2008). The research focus of this position will be on stem cell plasticity and epigenetic regulation of mammary stem cells and cancer stem cells. The project will use a wide range of genomics/epigenomics methods\, CRISPR genome editing\, organoid culture\, and in vivo mouse models.\nOur laboratory is part of Gottesman Institute for Stem Cell and Regenerative Medicine Research\,\n\nDepartment of Cell Biology and Einstein Cancer Center. We are located in a state-of-the-art research building. The research will be conducted in a highly collaborative and productive environment. A successful candidate should have a strong training background in cancer biology\, stem cell biology\, and/or epigenetics. For more information\, please see the lab website – http://www.einstein.yu.edu/faculty/13006/wenjun-guo/. \nThe Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race\, color\, religion\, sex\, sexual orientation\, gender identity\, national origin\, age\, protected veteran or disabled status\, or genetic information. \n\nTO APPLY: \nInterested candidates should send the following documents to the PI\, Dr. Guo\, via email: wenjun.guo@einstein.yu.edu \n\nCV/Biosketch\nAn overview of research experience and career goal.\nContact information of three references
URL:https://ces.b2sg.org/event/aecm-5jan19/
LOCATION:Albert Einstein College of Medicine\, 1300 Morris Park Ave\, Bronx\, NY\, 10461\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190108
DTEND;VALUE=DATE:20190210
DTSTAMP:20260902T000009
CREATED:20190108T123246Z
LAST-MODIFIED:20190108T123735Z
UID:20988-1546905600-1549756799@ces.b2sg.org
SUMMARY:Postdoc Scientist
DESCRIPTION:The Research Fellow will perform routine and complex laboratory procedures throughout training period.  The successful applicant will have strong expertise in one or more of the following: cancer biology\, epigenetic regulation of chromatin\, genomics\, in vivo modeling of cancer\, analysis of drug effects on cancer cells\, high-throughput methods\, bioinformatics and computational biology. The projects are derived from two recent studies related to aggressive prostate and breast cancer\, and cancer metastasis: Rotinen\, You et al. Nature Medicine (2018 in press) and Reis-Sobreiro et al. Cancer Research 78:6086-6097 (2018). May develop\, adapt\, and implement new research techniques and protocols.  Analyzes and interprets data.  May assist in preparation of grant proposals.  Participates in publications and presentations as author or co-author.  Not responsible for generating grant funds. \nEducational Requirements: \nDoctorate (MD\, PhD\, VMD\, or DDS) in area directly related to field of research specialization required. \n\nExperience: \nWorks independently on research projects designed by a mentor (typically the PI) within area of specialization.    Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.  Demonstrated aptitude to perform experimental protocols and procedures\, including detailed data collection\, and analysis and operation and maintenance of specialized equipment. Knowledge of safety standards and maintenance of specialized equipment.
URL:https://ces.b2sg.org/event/cedars-8jan19/
LOCATION:Cedars-Sinai Medical Center\, Los Angeles\, 8700 Beverly Blvd\, Los Angeles\, CA\, 90048\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190110
DTEND;VALUE=DATE:20190212
DTSTAMP:20260902T000009
CREATED:20190110T025712Z
LAST-MODIFIED:20190110T030251Z
UID:20992-1547078400-1549929599@ces.b2sg.org
SUMMARY:Research Associate
DESCRIPTION:We are currently looking for a highly motivated\, team orientated individual to join our Carlsbad facility. \nThe Research Associate will work in our Manufacturing Department\, mostly within the Antibody Production group. The successful candidate will be a highly motivated and detailed oriented researcher with extensive background in cell culture. \nJob Description: \n\nMaintenance and expansion of existing and new hybridomas\, and manufacturing of monoclonal and recombinant antibodies under manager supervision.\nMaintain cell culture facilities and culture cell lines as required for experiments.\nFollow current protocols and methods and propose new ideas to improve in-house protocols\, processes and equipment.\nMake detailed observations\, analyze data\, and interpret results. Maintain complete and thorough lab notebook.\nMaintain accurate\, detailed records\, and present updates to managers and project teams.\nEnsure availability of materials and equipment to carry out experiments.\nAbility to multi-task and work on several projects simultaneously.\n\nRequirements: \n\nBS\, MS in biological sciences with 1-3 years working experience.\nImpeccable cell culture and sterile technique with demonstrated experience in maintenance and expansion\, cryopreservation and cell banking of cancer cell lines a must.\nExperience performing SDS-PAGE required; experience with antibody purification techniques\, Western Blotting\, ELISA.\nExperience in maintenance and expansion of mouse and rat hybridomas a plus.\nGeneral knowledge of hybridoma methodologies\, including immunizations\, fusions\, selection and screening techniques a plus.\nExperience with medium to large scale production\, including bioreactor systems\, and recombinant antibody manufacture a plus.\nMay be required to work some hours on the weekend for cell maintenance\n\nIf you are interested in a career at one of America’s fastest growing biotechnology firms\, please submit your cover letter and resume outlining your qualifications and experience. In your cover letter please indicate your experience working with antibodies. We thank all applicants\, however\, only those selected for interviews will be contacted. \nJob Type: Full-time \nExperience: \n\nSds Page: 1 year (Preferred)\nCell Culture: 1 year (Preferred)\nMaintenance: 1 year (Preferred)\nWestern Blot: 1 year (Preferred)
URL:https://ces.b2sg.org/event/act-9jan18/
LOCATION:Active Motif Inc\, 1914 Palomar Oaks Way\, Suite 150\, Carlsbad\, CA\, 92008\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190112
DTEND;VALUE=DATE:20190214
DTSTAMP:20260902T000009
CREATED:20190112T170915Z
LAST-MODIFIED:20190112T171527Z
UID:20996-1547251200-1550102399@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:Dr. Adams’ lab investigates the impact of chromatin and epigenetics on cellular senescence\, aging and cancer. In particular\, the lab hypothesizes that age-associated changes in chromatin and epigenetic programming contribute to the dramatic age-associated increase in incidence of cancer. While age is the biggest single risk factor for most cancers\, the reason for this is current poorly understood. \nThe lab strives to be highly collaborative with other labs in San Diego\, the US and elsewhere\, for example collaborating with computational biologists\, immunologists\, experts in specific mouse models of cancer and aging\, and surgeons\, pathologists and clinical oncologists. \nSummary\nApplications are invited from ambitious\, independent and motivated postdoctoral associate candidates to join the lab of Professor Peter D. Adams investigating the epigenetics of aging and cancer. The specific project in the broad epigenetics-cancer-aging area can be discussed\, but we are particularly interested in investigating aspects of epigenetic dysregulation in Acute Myeloid Leukemia that can be exploited for development of novel therapies. \nThe project can employ state-of-the-art molecular and cellular biology approaches\, including ChIP-seq\, RNA-seq\, ATAC-seq\, DNA methyl-seq and other large-scale epigenomic and chromatin analyses\, including at the single-cell level; high throughput chemical and RNAi/CRISPR phenotypic screens; cell imaging; state-of-the-art gene manipulations using RNAi and CRISPR technology. In addition\, we routinely employ sophisticated mouse models and human tissues. \nSan Diego has an outstanding scientific environment and a fabulous place to live. \nTO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter\, CV\, references and list of any publications or accomplishments. \nDuties and Responsibilities\n\nPro-actively and semi-independently lead a project focused on epigenetics of aging and/or cancer\, e.g. epigenetic mechanisms underlying acute myeloid leukemia\nPerform cell and molecular biology experiments\nWork with mouse models of cancer and aging\nGenerate hypotheses\, design experiments\, interpret data\, trouble shoot and optimize experiments\nCollaborate and synergize with other members of the lab to promote lab synergies\nPresent results to lab members at weekly lab meetings\nPresent results and data within SBP\, local La Jolla meetings and national and international meetings\, as appropriate\nMaintain and initiate collaborations between Adams lab and other labs in SBP\, San Diego\, US and worldwide\n\nRequired Skills \nRequired Experience \n\nPh.D. degree or equivalent in biological science is required\nExperience and/or expertise in an aspect of cell and/or molecular biology and/or animal models is highly desired\n\nOther Knowledge\, Skills and/or Abilities\n\nKnowledge of molecular biology of chromatin and/or epigenetics is ideal\nKnowledge of statistical methods applied to biology\nFamiliarity with public bioinformatics databases and resources\nComputational expertise is an advantage\nCommunicates effectively and collaborates well with Principal Investigators and their team members\nHave strong organizational and problem-solving skills\nPossess strong attention to detail\, analytical and time management skills\nExcellent data presentation\, communication and interpersonal skills\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/sbp-12jan19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190114
DTEND;VALUE=DATE:20190216
DTSTAMP:20260902T000009
CREATED:20190114T033553Z
LAST-MODIFIED:20190114T033553Z
UID:21000-1547424000-1550275199@ces.b2sg.org
SUMMARY:Senior Associate Scientist
DESCRIPTION:Pfizer Oncology Research & Development (ORD) in La Jolla\, California\, is seeking a Senior Associate Scientist (non-PhD) focused on translating basic discoveries in the field of cancer epigenetics into novel therapeutics. \nOur ideal candidate will work within a collaborative team environment to perform laboratory-based research. The candidate will employ genetic and pharmacological methods to discover and confirm candidates for novel cancer therapeutics. As a member of the group\, this person will also be involved in mechanism-of-action studies\, the interpretation and presentation of data\, and will function as an integral member of the team to advance new targets. The successful candidate will have experience in state-of-the-art techniques in epigenomic profiling (ATAC-seq\, ChIP-seq) as well as a basic understanding of epigenetic regulation in the tumor microenvironment. \nRole Responsibilities \nWork independently and as part of project teams to design\, execute\, analyze/interpret\, and refine experiments ranging from biochemical and molecular assays\, in vitro and in vivo target modulation in model systems\, in vitro pharmacology\, biomarker assay development\, and clinical sample analysis. \nDepending upon the stage of project\, specific duties to include: \n\nApplication of genetic and pharmacologic approaches to modulate drug targets in vitro\, and assess functional impact on cancer initiation and progression. This will include functional genomics techniques\, viral vector delivery\, transfection\, antibodies\, small molecules and other pharmacologic approaches to modulate targets in vitro.\nDevelop\, optimize\, and implement assays that constitute the compound screening funnel.\nGenerate engineered cell lines for primary and secondary pharmacology.\nExecute secondary cell-based assays across various technology platforms – qPCR\, ChIP\, RNA-seq\, ATAC-seq\, FACS\, immunofluorescence\, western blotting\, ELISA\, high content screening\, etc.\nDevelop and apply complex in vitro assays for target validation and secondary pharmacology:  spheroid models\, colony forming assays\, 3D co-culture systems.\nCollaborate with in vivo pharmacology group for efficacy testing\, PK/PD and pre-clinical PoC experiments.\nIn addition to efficacy testing\, carry out supporting assays (ELISA\, western blot\, gene expression analysis of tissue lysates) to assess target modulation levels and downstream effects.\nUse electronic data capture/analysis tools such as Excel\, GraphPad\, Biobook\, Spotfire and PowerPoint for experimental documentation and data analysis/presentations.\nPresent research results and methodologies at weekly meetings with immediate supervisor\, at Epigenetic team meetings\, and with members of the oncology research unit as appropriate (example:  project team meetings).\nContribute to building a culture that embraces scientific excellence\, urgency\, continuous learning and improvement\, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.\n\nBasic Qualifications \n\nB.S./M.S. in Cell Biology\, Molecular Biology (or a comparable biological science) with minimum of 3 years relevant post-degree experience for B.S; 0-3 years for M.S.\nExtensive hands on experience with cell-based assays to monitor and analyze effects of target modulation (ELISA\, ICW\, FRET\, Luminescence based assays).\nExperience in functional genomics techniques (CRISPR\, RNAi) for target assessment and generation of cell lines.\nExperience in molecular biology techniques for analysis of chromatin structure/function (ATAC-seq\, ChIP-seq)\, gene expression\, and protein expression\nMust be able to work in a team environment\, have excellent communication skills and be able to present data at project team meetings.\nAbility to master new concepts and techniques quickly.\nStrong attention to detail and organizational skills to manage projects in parallel.
URL:https://ces.b2sg.org/event/pfizer-13jan19/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190117
DTEND;VALUE=DATE:20190219
DTSTAMP:20260902T000009
CREATED:20190117T192833Z
LAST-MODIFIED:20190117T193057Z
UID:21002-1547683200-1550534399@ces.b2sg.org
SUMMARY:Computational Biologist I
DESCRIPTION:The MGH Center for Immunology and Inflammatory Diseases (CIID) is looking for exceptional computational biologist candidates to join the Single Cell Genomics Research Program\, which is a multidisciplinary research program focused on developing and implementing systems immunology and genomics strategies to further our understanding of the human immune system. The laboratory is also affiliated to the Broad Institute of MIT & Harvard\, offering additional opportunities to collaborate and bridge with this vibrant community.\nThis position offers the opportunity to employ the cutting-edge of computational biology\, machine learning and statistical research to solve important problems in health and disease related to the human immune system\, autoimmune diseases and cancer. Single cell genomics is revolutionizing our understanding of biology – from redefining our understanding of the types of cells\, a fundamental unit in biology\, to translating this knowledge to better understand disease phenotypes and the implications of this to therapeutics. We are looking for a highly motivated and talented individual with a computational background to join our efforts. This position represents an exciting opportunity to work as a member of an interdisciplinary team of biologists\, laboratory scientists\, computational biologists\, and physicians working together on transformative translational efforts that are bridging between the clinical and research interfaces. Our research program is developing and implementing unbiased experimental and computational strategies that can directly survey the human immune system in order to define at high resolution the key processes and players underlying healthy human immune responses as a foundation for understanding how immunity is dysregulated in diseases. This includes establishing a more comprehensive roadmap of the human immune system through identifying novel immune cell subpopulations across tissues using single-cell ‘omics’ strategies along with mapping the cellular ecosystem and associated molecular circuitry driving immune diseases. Collectively\, our research program is empowering the study of the human immune system as a function of “healthy” baseline\, inflammatory state\, disease progression\, and response to treatment with emphasis on precision medicine\, ultimately paving the way for developing a comprehensive human immune lexicon that is key to promoting effective bench-to-beside translation of findings.\nAs part of this position\, you will conceive and apply algorithms as well as analytical approaches to analyze DNA\, RNA and single-cell sequencing data generated from a wide-range of human tissue and immune-related disease conditions. The candidates will also take the lead on performing a wide range single-cell genomics analysis and collaborate directly with scientists performing experimental research studies at the bench and physicians seeing the patients. You must be capable of working in an interactive team environment while conducting self-directed research within broader goals set by group.\n\nNO PRIOR BIOLOGICAL BACKGROUND REQUIRED\, just strong computational & quantitative skills and enthusiasm to learn on the job. \n\nRESPONSIBILITIES\n\n\nDesign and implement methods for single cell analysis of biological data\n\n\nContribute to single-cell analysis of biological data\n\n\nEvaluate and recommend new emerging single-cell analytical approaches\n\n\nIntegrate single-cell data with other available genetic\, sequencing\, and epigenetic datasets to help prioritize potential cell types and therapeutic targets\n\n\nCollaborate with experimentalists and associate computational biologists to develop and apply functional genomics techniques\n\n\nCollaborate with the MGH and Broad Institute single-cell analysis community\n\n\nCreate scientifically rigorous visualizations\, communications\, and presentations of results\n\n\nContribute to generation of protocols\, publications\, and intellectual property\n\n\nQualifications \nREQUIREMENTS\n\n\nBachelors or Master’s degree and 0-2 years’ experience in computer science\, computational biology\, engineering\, physics\, mathematics\, statistics\, genetics\, or related field with a strong quantitative background and programming emphasis preferred\, but talented applicants of all levels are encouraged to apply.\n\n\nSolid foundation in the fundamentals of statistics\, the use of algorithms and data analysis relevant to computational biology\, and the ability to approach problems with scientific rigor.\n\n\nMust have demonstrated proficiency with several of the following programing languages:\nPython\, R\, Java\, C/C++\, or Matlab\, with a preference towards Python\, and R.\n\n\nProficiency working in a Linux environment\, knowledge of terminal shell usage (e.g. bash).\n\n\nFamiliarity with next-generation sequence data analysis tools; ideally will have some prior experience with statistical methods\, pipelines and tools relevant to single-cell RNAseq analysis\n\n\nExcellent verbal and written communication skills\, and the ability to explain technical/mathematical reasoning to people from non-quantitative backgrounds\n\n\nIndependent\, highly motivated\, and highly collaborative with the ability to work together with multi-disciplinary teams of biologists\, laboratory scientists\, computational biologists\, and physicians.\n\n\nExperience in a top research lab or the industry working with analysis of real genomic datasets (preferred but not required)\n\n\nSome experience with bioinformatics tools or a demonstrated interest in biology (preferred but not required)\n\n\nExperience in machine learning\, working with high performance compute clusters and cloud compute\nsolutions biology (preferred but not required)\n\n\nInterest in molecular biology and genomics\n\n\nA passion for solving important translational problems and advancing our understanding of the human body\, focusing on the immune system
URL:https://ces.b2sg.org/event/mgh-17jan19/
LOCATION:Massachusetts General Hospital Cancer Cente\, 55 Fruit St\, Boston\, MA\, 02114\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190117
DTEND;VALUE=DATE:20190219
DTSTAMP:20260902T000009
CREATED:20190117T194121Z
LAST-MODIFIED:20190117T194121Z
UID:21006-1547683200-1550534399@ces.b2sg.org
SUMMARY:Research Associate/Scientist
DESCRIPTION:In this role as a Research Associate/Scientist\, you will provide exceptional scientific leadership in coordinating lab projects in metabolism/metabolomics\, cancer biology\, and immunology. You will play an integral role in project management\, experimental design and execution\, mentoring of research trainees\, and writing up research results for manuscripts and/or grant applications. \n\nYou will possess a Ph.D.\, focusing on biochemistry\, chemistry\, molecular and cell biology\, or immunology\, and have 1 – 5 years of post-doctoral experience. The ideal candidate should possess the following characteristics: \n\n\nA self-driven and hard-working individual who has a strong curiosity about basic science and its clinical application\nA highly organized multi-tasker who pays attention to detail and values research integrity\nA collegial team member with the ability to interact effectively and cordially with colleagues and collaborators\nExperience with manuscript writing\, figure design\, and grant applications.\nExperience with bioinformatics and working knowledge of at least one scripting language (e.g. R)\, and experience with the analysis of large data sets.\nHands on experience or motivation to gain experience with metabolic techniques\, including mass spectrometry.\n\n\nEXPECTATIONS \n\nThe following expectations should be met within the first 3 months. \n\n1-3 months – Develop a solid understanding of lab projects and background\, develop familiarity with lab techniques and approaches\n3-6 months – Take leadership role in lab project coordination\, experimental design and execution.\n\n\nHOW TO APPLY \n\nIf you possess these attributes and enjoy working with motivated and driven people\, we would welcome speaking with you and encourage you to apply today! \n\nA cover letter describing your research interests\, experience\, and how you might contribute to Jones Lab Research.\nAn up-to-date Curriculum Vitae.\nA list of 2-3 individuals who have agreed to act as references along with their contact details.\n\n\nPlease contact Eric Miller (eric.miller@vai.org) for further information or questions\, or if you have any difficulty with the application process.
URL:https://ces.b2sg.org/event/vari-17jan19/
LOCATION:Van Andel Research Insitute\, Grand Rapis\, MI\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190118
DTEND;VALUE=DATE:20190220
DTSTAMP:20260902T000009
CREATED:20190118T054206Z
LAST-MODIFIED:20190118T054206Z
UID:21008-1547769600-1550620799@ces.b2sg.org
SUMMARY:Senior Drug Discovery Oncologist
DESCRIPTION:We are seeking a highly motivated and experienced Senior Scientist with deep expertise in oncology to join our Drug Discovery team. The successful candidate will have a track record of innovative and collaborative research\, demonstrated through project milestone delivery and peer-reviewed publications. The successful candidate is expected to be involved in significant interaction and collaboration within the company and with external KOLs/partners/CROs to support preclinical target validation and guide projects towards clinical development. \nResponsibilities: \n\nGuide research strategy and experimentation on small molecule oncology discovery programs\nAdvance oncology research programs from pre-clinical to clinical stage\nLead new target identification and validation efforts\nParticipate in multidisciplinary team efforts to make decisions on compound and program progression\nLead interactions with KOLs and serve as a disease biology expert on cross functional discovery teams\nStay informed on trends and emerging developments regarding research and development in the fields of oncology\n\nEssential Qualifications and Experience: \n\nPh.D. in cancer biology or related field with 8+ years postgraduate oncology drug discovery experience\nIn-depth knowledge/understanding of cancer pathways\, cellular and animal models across solid tumor and hematologic malignancies\, as well as various mechanisms of therapeutic response and resistance\nDemonstrated success as a lead biologist advancing novel scientific discoveries that impacted the course of clinical development\nExperience in managing external studies at CROs and academic collaborators including monitoring study execution and ensuring finalization of study reports within set timeline\nOutstanding presentation and communication skills\nSkilled at working in a multidisciplinary environment\n\nDesirable Skills: \n\nExperience on translational research\, IND-enabling studies\, as well as early clinical development\nKnowledge of epigenetics\, DNA damage repair\, cancer genetics\, and precision medicine\nProven record of innovative thinking to propose and champion new ideas and solve problems\nComfortable working across a number of disease areas and able to shift gears quickly. Must be open to change and the unknown with a creative and resourceful nature; a self-starter\, proactive and results-oriented with high performance standards
URL:https://ces.b2sg.org/event/schr-18jan19/
LOCATION:Schrödinger\, Inc.\, New York\, NY\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190119
DTEND;VALUE=DATE:20190221
DTSTAMP:20260902T000009
CREATED:20190119T220209Z
LAST-MODIFIED:20190119T220942Z
UID:21013-1547856000-1550707199@ces.b2sg.org
SUMMARY:Hormel Fellow
DESCRIPTION:Qualifications\n\n\nPrior experiences with cell culture\, CRISPR\, immunohistochemistry\, confocal microscopy\, flow cytometry\, mouse genetics\, and basic bioinformatics skills are desired. PhD or MD/PhD in cancer biology\, immunology\, chromatin biology & epigenetics\, cell biology\, molecular biology or relevant fields. \n\n\n\n\n\n\nAbout the Job\n\n\nA Postdoctoral Research Fellow position is available immediately in the laboratory of Dr. Liang Liu at the Hormel Institute\, University of Minnesota. Our laboratory pursues both basic and translational cancer research using a combination of functional genomics/bioinformatics analysis\, cell-based studies\, clinical tumor specimens\, and mouse models. Research topics include the identification of novel molecular targets and pathways in skin tumorigenesis\, dissection of the crosstalk between genetic and epigenetic mechanisms in cancer and inflammation\, and functional validation of biomarker genes that we identified for developing targeted cancer prevention and treatment. We are recruiting a highly motivated postdoc to join the lab.  \n\n\n\n\n\n\nAbout the Department\n\n\nThe Hormel Institute\, a biomedical research center of the University of Minnesota\, was established in 1942 and has an excellent reputation and long history for producing world-class medical research.  The Institute’s research success has resulted in a second major expansion of its research facilities and includes an additional new state-of-the-art laboratory building that opened in January 2016.  The Hormel Institute offers its research scientists complete access to state-of-the- art cutting edge equipment that includes a cryo-electron microscope (Titan Krios and Tecnai G2 Spirit Biotwin); FACS cell sorter; confocal microscopy; flow cytometry; protein crystallography robotics and defraction system; nano-HPLC-AB SCIEX triple TOF 5600 mass spectrometry; Leica tissue processor\, embedder and microtome; real-time PCR instrumentation; 5 racks of Linux GPU supercomputers for computational biology and bioinformatics; spectrophotometers; and Western blot imagers.  \n*THE HORMEL INSTITUTE IS LOCATED IN AUSTIN\, MN\, APPROXIMATELY 35 MILES SOUTHWEST OF ROCHESTER\, MN\, AND APPROXIMATELY 100 MILES SOUTH OF MINNEAPOLIS/ST. PAUL.*   \n\n\n\n\n\n\nHow To Apply\n\n\nInterested candidates should apply here on UMN\, and/or send their CV\, a statement of research experience and interests to: Liang Liu\, PhD (liu00965@umn.edu). 
URL:https://ces.b2sg.org/event/m-19jan19/
LOCATION:University of Minnesota\, St Paul\, MN\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190120
DTEND;VALUE=DATE:20190222
DTSTAMP:20260902T000009
CREATED:20190120T144056Z
LAST-MODIFIED:20190120T144056Z
UID:21017-1547942400-1550793599@ces.b2sg.org
SUMMARY:Associate Director - Regulatory Affairs
DESCRIPTION:The Associate Director of Regulatory Affairs will be responsible for leading the development and delivery of global regulatory strategies for assigned programs in alignment and compliance with local and regional requirements as well as with company policies. Reporting to the VP of Regulatory Affairs\, the Associate Director will independently lead project work for assigned programs and develop high quality submissions for global clinical trials and registrations. Programs may be complex with multiple indications\, combination therapies\, companion diagnostics\, and working with external development partners (CROs and Alliance Partners). \n\nResponsibilities \n\nDevelop and implement well-informed global regulatory strategies in a project team environment\, with a focus on clinical and nonclinical drug development\nRepresent Epizyme as liaison with the FDA\, including telephone calls\, e-mail and written submissions for assigned projects; prepare Epizyme team and facilitate the meetings and teleconferences between company and FDA\nInteract with Regulatory Affairs personnel at partner companies and vendors\nParticipate in regulatory intelligence gathering activities and maintain knowledge of US\, EU and ROW regulatory requirements\nSignificant contribution to development of relevant processes and procedures to support the Regulatory Affairs function activities\nEnsure compliance with regulatory requirements; familiar with a variety of US and non-US regulatory concepts\, requirements and expectations; maintain awareness and communicate with team members regarding changing regulatory requirements\nExecute simple and complex regulatory submissions (e.g.\, INDs\, CTAs\, amendments\, safety reports\, DSUR\, annual reports\, meeting packages\, NDAs\, etc.) in accordance with applicable regulations; this includes ability to translate regulatory requirements into practical\, workable submission plans; develop & maintain timelines; coordinate internal/external authoring/review/comment adjudication and finalization (submission and archival)\nEstablish and meet bold timelines for regulatory submissions using expedited development pathways\nProvide thoughtful & accurate comments during document (e.g.\, IB\, protocols/amendments\, ICFs\, study reports\, etc.) review\, mindful of regulatory/ICH guidance/requirements pertaining to document content\n\n\nEducation & Requirements \n\nBachelor’s degree in life sciences required; advanced degree preferred\nMinimum of 8 years in Regulatory Affairs with a B.S./B.A.\, or 8 years with M.S.\, or 5 years with Ph.D./M.D.\nEstablished knowledge of drug development\, with small molecule experience preferred\nRegulatory experience in Oncology preferred\nExcellent knowledge of FDA and ICH regulations and guidelines a must\, with experience as FDA liaison\nKnowledge of EU and Health Canada regulations and guidelines desirable\nProven track record of effective collaboration with multi-faceted project teams is a must\nExcellent written and oral communication skills required\nExcellent interpersonal skills\nAbility to work independently in a highly dynamic drug development environment\nCapable of multi-tasking\, setting priorities\, and meeting timelines\nDemonstrated ability to shape\, frame\, and present to diverse audiences is an absolute must\nProven evaluative\, analytical and interpretative skills enabling review and synthesis of reports and other documents use din regulatory planning and submissions\nStrong project management skills and drive for excellence
URL:https://ces.b2sg.org/event/20jan19/
LOCATION:Epizyme\, 400 Technology Square\, Cambridge\, MA\, 02139\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190121
DTEND;VALUE=DATE:20190223
DTSTAMP:20260902T000009
CREATED:20190121T104903Z
LAST-MODIFIED:20190121T104903Z
UID:21019-1548028800-1550879999@ces.b2sg.org
SUMMARY:Postdoctoral Scholar
DESCRIPTION:Postdoctoral positions in cancer epigenetics are available in the laboratory of Dr. Rui Lu at the University of Alabama at Birmingham (UAB). \nThe lab is interested in understanding epigenetic mechanisms underlying cancer development and developing targeted treatment strategies\, with an emphasize on blood cancers such as acute myeloid leukemia. Using cellular\, molecular and genomic approaches\, our research focus on (1) understanding the molecular basis of driver mutations in cancer; (2) discovery of novel targets for cancer epigenetic therapies; (3) development of new epigenome editing tools to study gene regulation in normal and cancer cells. For reference please see recent publications: Molecular Cell 2013 49(3): 571-82; Cancer Cell 2016 30(1): 92-107; Nature 2018 554(7692): 387-391. Please visit our website www.lu-lag.orgto learn more about our research. \nWe are looking for researchers passionate in epigenetics\, genomics\, and cancer biology to join our team. Prior experience in epigenetics or cancer research is not essential. Candidates should have an MD or PhD degree or should be close to obtaining their doctoral degree. The successful candidate will have the opportunity to establish multidisciplinary collaborations and develop state-of-the-art genetic (CRISPR/Cas9\, genome-wide screening) and genomic (ChIP-seq\, ATAC-seq\, Hi-C\, and eRRBS) technologies. UAB offers a competitive salary with excellent benefits package. \nInterested applicants should apply directly to rlu.uab [AT] gmail.com by sending (1) a cover letter summarizing research interests and accomplishments\, (2) a complete CV with a publication list\, and (3) contact information for three references.
URL:https://ces.b2sg.org/event/21jan19/
LOCATION:University of Alabama at Birmingham\, 1801 University Blvd\, Birmingham\, AL\, 35233\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190122
DTEND;VALUE=DATE:20190224
DTSTAMP:20260902T000009
CREATED:20190122T094610Z
LAST-MODIFIED:20190122T094857Z
UID:21021-1548115200-1550966399@ces.b2sg.org
SUMMARY:Postdoc Fellow
DESCRIPTION:Responsibilities\n\n\n\n\n\n\n\nTo use their training in cell/molecular biology and bioinformatics to design\, execute and analyze experiments to study epigenetic mechanisms of gene regulation that control lung epithelial cell differentiation in development and disease including the function of specific long non-coding RNAs using in vitro induced pluripotent stem cells as well as in vivo mouse models. \n\nCollects and assembles data for any type of oral or written presentation.\nIndependently develops scientific hypotheses related to ongoing work in the laboratory.\nIndependently designs experiments to test hypotheses.\nIndependently carries out or delegates procedures for experiments.\nAnalyzes results of experiments independently.\nIndependently prepares oral and written reports for the P.I. on research to include\, but not limited to: coherently and effectively communicating our laboratory research by writing abstracts\, manuscripts\, grant proposals and data reports for grants and oral presentations with corresponding slide presentation for PI\, local and national meetings.\n\nPerforms routine and more difficult procedures\, analyzes data and coherently presents results in the form of presentations\, abstracts\, manuscripts and the basis for grant writing\, preparation and submission \n\n\n\n\n\n\n\nQualifications\n\n\n\n\n\n\n\nPh.D. in cell biology\, genetics\, or molecular biology \nPrevious experience in confocal microscopy\, FACS\, RNA-sequencing analysis\, CRISPR/Cas9 preferable
URL:https://ces.b2sg.org/event/22jan19/
LOCATION:Magee Rehabilitation Hospital\, 1513 Race St\, Philadelphia\, PA\, 19102\, United States
CATEGORIES:Jobs
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