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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;VALUE=DATE:20190217
DTEND;VALUE=DATE:20190321
DTSTAMP:20260905T075624
CREATED:20190217T210917Z
LAST-MODIFIED:20190217T210917Z
UID:21067-1550361600-1553126399@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:A Postdoctoral Associate position is available in the lab of Dr. Tao Wu in the Department of Molecular & Human Genetics at Baylor College of Medicine (https://www.bcm.edu/research/labs/tao-wu). The Wu lab focuses on the epigenetic mechanisms of cancer therapeutic resistance; in particular\, the functional mechanisms of novel DNA methylation (6mA). We seek to decipher the epigenetic driver mechanisms underlying cancer treatment resistance\, to define new biomarkers\, and to develop new approaches to overcome the therapeutic resistance of cancer. We apply multiple wet lab techniques\, as well as dry lab genomic profiling and bioinformatics approaches in cancer models. \nWe are seeking a Postdoctoral Associate whose research will focus on bioinformatics.  This position will require developing analytical approaches to solve computational scripts and analytical code\, genomic data analysis of sequencing data sets\, and generating statistical figures.  Experience in genomic profiling data analysis\, cancer epigenetics\, and/or bioinformatics analysis preferred.  Please apply at https://chk.tbe.taleo.net/chk01/ats/careers/requisition.jsp?org=BCM&cws=42&rid=18295 \nIdeal candidates should be able to creatively conceive the study\, critically design experiments and insightfully analyze genomic data. Applicants should be self-motivated\, open-minded\, detail-oriented and collaborative. Expertise in one (or more) of the following research areas is required: molecular and cell biology\, genetics\, genomics\, bioinformatics\, and systems biology studies. \nAll applicants are encouraged to apply at www.bcm.edu/careers.  Work visa sponsorship available for qualified candidates. \nApplication process: \nFor more information and to apply please visit www.bcm.edu/careers \nIn addition to submitting an application\, applicants should send a cover letter describing past research experience and potential research projects\, a curriculum vitae\, and the contact information of three references to Dr. Tao Wu (Tao.Wu@bcm.edu) with the subject line “2019__Postdoc Application _ (Your Name)”.
URL:https://ces.b2sg.org/event/b17feb19/
LOCATION:Baylor College of Medicine\, 1 Baylor Plaza\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190219
DTEND;VALUE=DATE:20190323
DTSTAMP:20260905T075624
CREATED:20190219T121239Z
LAST-MODIFIED:20190219T121239Z
UID:21075-1550534400-1553299199@ces.b2sg.org
SUMMARY:Postdoctoral Training- Molecular Epidemiology
DESCRIPTION:The Cancer Epidemiology Program of the H. Lee Moffitt Cancer Center & Research Institute\, Inc. invites applications to its T32 Post-Doctoral Training Program in Molecular Epidemiology of Cancer. This NCI-supported interdisciplinary training program is designed to prepare fellows for careers as independent investigators engaged in cancer epidemiological research that incorporates biomarkers identified at the molecular\, biochemical\, or -omic level. The two year program combines a specialized curriculum (formal didactic training and one-on-one interactions with mentors) with research experience (participation in funded studies under the guidance of an experienced investigator). \nMentoring will be provided by teams of experienced faculty from a variety of epidemiology-related disciplines\, including cancer epidemiology\, statistical genetics\, cancer genetics\, bioinformatics and clinical specialties spanning diverse areas of research interests and cancer sites. Selected research interests of faculty in Cancer Epidemiology include: \n\nDevelopment of quantitative imaging models to improve risk prediction and reduce over-diagnosis of lung cancer\nEnvironmental and genetic risk factors of melanoma and familial melanoma\nEpidemiologic\, molecular biomarker\, and radiologic approaches to impact pancreatic cancer and its precursor lesions\nGenetic\, viral\, and nutritional risk factors of primary brain tumor glioma\nGenetic and epigenetic biomarkers associated with risk and progression of prostate cancer\nIntegrative molecular epidemiology approaches to dissect the function of cancer susceptibility loci identified by GWAS\nInterplay of cutaneous malignancies with cutaneous viral infections\, UV radiation exposure and immune function\nLife course approaches to evaluate epidemiologic exposures affecting ovarian cancer development and progression\nHPV natural history and clinical trials for the prevention of HPV-related cancers\n\nApplicants must have a terminal degree in epidemiology\, nursing\, public health\, medicine or related discipline. We expect that most candidates will have some previous training in epidemiology and/or biostatistics. Stipends and benefits are highly competitive. Review of applications will begin immediately and continue until our open positions for the 2018-19 academic year is filled. Applicants must be U.S. citizens or legal permanent residents. Individuals on temporary visas are not eligible. \nVisit our website www.moffitt.org/CancerEpidemio… for information on \napplying and application materials. Email a completed application packet to \nMeredith.Brenner@Moffitt.org.
URL:https://ces.b2sg.org/event/19feb19/
LOCATION:Moffitt Cancer Center Magnolia Campus\, 12902 USF Magnolia Drive\, Tampa\, FL\, 33612\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190220
DTEND;VALUE=DATE:20190324
DTSTAMP:20260905T075624
CREATED:20190220T190151Z
LAST-MODIFIED:20190220T190151Z
UID:21077-1550620800-1553385599@ces.b2sg.org
SUMMARY:Postdoctoral Research Associate
DESCRIPTION:A postdoctoral position is available to teach gross anatomy under the supervision of Dr. Rebecca Fisher in the Department of Basic Medical Sciences at the University of Arizona College of Medicine – Phoenix. Current faculty research areas in the department include: phylogenetics and mammalian paleontology; human and primate skeletal anatomy; paleoanthropology; bioarchaeology and paleopathology; and vertebrate and invertebrate functional anatomy. \nThe Department of Basic Medical Sciences is a multidisciplinary unit composed of faculty with research interests in cardiac and vascular biology; developmental\, cell and molecular biology; evolution of vertebrate morphology; gene environment interactions and epigenetics; host-microbe interactions and immunology; medical education; platform development\, medical devices and procedures; and signaling and steroid biology. In addition\, the Center for Applied NanoBioscience and Medicine and affiliate institutions such as the Translational Genomics Research Institute\, Phoenix Children’s Hospital\, St. Joseph’s Hospital/Barrow Neurological Institute and the Arizona Alzheimer’s Consortium offer abundant opportunities for collaborative research efforts. \nThe University of Arizona College of Medicine – Phoenix anchors the 28-acre Phoenix Biomedical Campus in the heart of the Valley of the Sun. The College inspires and trains individuals to become exemplary physicians\, scientists and leaders who are life-long learners and inquisitive scholars. We embrace professionalism\, innovation and collaboration to optimize health and health care for all. The Phoenix Biomedical Campus embodies the University’s priorities of engagement\, partnership\, innovation\, and synergy in its world-class academic and research initiatives\, with clinical facilities throughout Greater Phoenix. The campus also houses the UA Colleges of Public Health\, Pharmacy\, and Nursing\, as well as Northern Arizona University’s College of Health and Human Services\, the Translational Genomics Research Institute (TGen) and the International Genomics Consortium. The University of Arizona Cancer Center in association with Dignity Health recently opened a new clinical facility and a new research building is under construction. \nOutstanding UA benefits include health\, dental\, vision\, and life insurance; paid vacation\, sick leave\, and holidays; UA/ASU/NAU tuition reduction for the employee and qualified family members; access to UA recreation and cultural activities; and more! \nThe University of Arizona has been listed by Forbes as one of America’s Best Employers in the United States and WorldatWork and the Arizona Department of Health Services have recognized us for our innovative work-life programs. For more information about working at the University of Arizona and relocation services\, please click here. \nDuties & Responsibilities \n\nTeach gross anatomy to medical\, physician assistant\, physical therapy\, and graduate students\, including lab instruction\, selected lectures\, office hours\, and review sessions.\n\n\nAssist the anatomy faculty in writing and revising exam questions and setting up and proctoring exams.\n\n\nTeach in the summer remediation course for medical students and community outreach programs for high school students.\n\n\nConduct research in the anatomical sciences or medical education\, submit research for publication in peer reviewed journals\, and present findings at departmental seminars and professional meetings.\n\nKnowledge\, Skills\, & Abilities Minimum Qualifications \n\nPhD degree.\n\n\nPrior human anatomy teaching experience in a dissection-based course.\n\nPreferred Qualifications \n\nResearch interests in phylogenetics and mammalian paleontology; human and primate skeletal anatomy; paleoanthropology; bioarchaeology and paleopathology; or vertebrate/invertebrate functional anatomy.
URL:https://ces.b2sg.org/event/20feb19/
LOCATION:University of Arizona\, Tuscon\, AZ\, 85721\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190221
DTEND;VALUE=DATE:20190325
DTSTAMP:20260905T075624
CREATED:20190221T180326Z
LAST-MODIFIED:20190221T180326Z
UID:21079-1550707200-1553471999@ces.b2sg.org
SUMMARY:Sr. Scientist - Sequencing Research
DESCRIPTION:We are seeking a talented highly motivated research scientist to join our new Sequencing Research capability in San Diego. The successful candidate will work on novel NGS profiling approaches to elucidate disease state from patient biospecimens\, PDX and organoid models\, and multi-cellular pre-clinical disease models. Work performed will contribute to therapeutic discovery and early translational research programs in oncology\, autoimmune and neurological indications. \nThe role will involve extensive partnership with scientist colleagues from across Celgene Research & Early Development (R/ED) to drive new experimental\, data capture and sample rescue strategies\, and will include inter-disciplinary collaboration with analytical research colleagues to maximize the depth and robustness of insights derived from transcriptional\, mutational and epigenetic profiling datasets. Areas of technical research focus include the successful profiling of rare\, damaged or low-yield samples\, and collaborative pursuit and assessment of diagnostic assay hypotheses. \nKey stakeholders include researchers in our thematic centers of excellence (TCoEs)\, our Translational Development and Diagnostics (TDD) function\, and colleagues in the Research Informatics and Knowledge Utilization (RIKU) department\, engaged in work towards key objectives for Celgene Research and Early Development (R/ED). \nThis position suits an individual with demonstrated scientific talent and future leadership potential\, with excellent communication and collaboration skills. Keen interest in inter-disciplinary application of high-throughput molecular profiling methods to life sciences data is imperative.\nApplications are encouraged from those looking to impact delivery of truly innovative and life-changing therapies for complex diseases of unmet medical need. \nResponsibilities will include\, but are not limited to\, the following: \n\nCollaborative design and execution of NGS profiling experiments to elucidate disease state and therapeutic response\, with focus on successful profiling of rare\, damaged or low-yield samples\, and collaborative pursuit and assessment of diagnostic assay hypotheses.\nResearch at the leading edge of NGS sample preparation and profiling technologies\, including implementation of novel protocols drawn from the literature\, Celgene academic collaborators\, and/or in-house efforts\, aligned to Celgene scientific research objectives.\nAdvise on sample extraction\, library preparation and QC\, guide collection of supporting metadata\, liaise with computational research colleagues during analytical research\, and translational scientists involved in diagnostics research.\nDesign and perform pilot experiments to test new protocols\, and assess new profiling platforms and external vendor capabilities.\nContribute to the operation of internal next-generation sequencing resources and development of supporting infrastructures\, including documentation of protocols developed and supervision of technical support staff as required.\nPresent strategies\, approaches\, results and conclusions to Celgene colleagues and external audiences to a publishable standard.\nContribute to enable strategic collaborations with academic and commercial collaborators to benefit therapeutic programs.\n\n\nSkills/Knowledge Required: \n\nPh.D. in biology\, biochemistry or related discipline at a recognized higher-education establishment.\nAt least 6 years of inter-disciplinary research experience with focus on cell or molecular profiling for elucidation of human disease in university\, hospital or biotechnology research scenarios.\nExpertise in performing state of the art NGS studies with demonstrable record of innovative protocol development and peer-reviewed publication in relevant areas.\nExpertise in the generation of robust molecular profiling datasets from low-yield\, damaged or contaminated human samples for translational research objectives. \nExperience in use of NGS profiling methods to answer complex research questions in cancer biology\, autoimmune disease\, epigenetics and/or immune biology.\nHands-on experience of sample and library preparation\, operation and maintenance of high- and low-throughput NGS apparatus (Illumina preferable).\nIn-depth knowledge of contemporary NGS technologies and experimental design considerations\, and familiarity with downstream bioinformatics approaches applied to process\, analyze\, visualize and interpret NGS datasets.\nAwareness of contemporary LIMS schema\, open-source bioinformatics tools and database structures.\nExperience in performing functional assays to validate experimental findings.\nExcellent time management and organizational skills\, proven problem-solving skills\, collaborative nature and adaptability across disciplines\nExcellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.
URL:https://ces.b2sg.org/event/cel-21feb19/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190225
DTEND;VALUE=DATE:20190329
DTSTAMP:20260905T075624
CREATED:20190225T153243Z
LAST-MODIFIED:20190225T153448Z
UID:21081-1551052800-1553817599@ces.b2sg.org
SUMMARY:Faculty Position
DESCRIPTION:The Department of Urology and the Robert H. Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine are leading the search for a full-time tenure track Investigator at the rank Assistant Professor in the area of prostate cancer biology and cancer epigenetics. \nQualified candidates will have a PhD or MD or dual degree and an outstanding record of research in prostate cancer biology and cancer genetics. The successful applicant will have experience in the field of cancer biology\, including cancer genetics and proteomics\, cancer cell biology\, tumor microenvironment\, cancer stem cells\, metastasis\, tumor immunology\, chemical biology\, cancer metabolism\, oncogenic signal transduction pathways\, genome integrity\, and cancer epigenetics.  We are seeking an individual with an established program in prostate cancer who is drawn to the broad opportunities at Northwestern with its collaborative clinical programs at Northwestern Memorial Hospital. The Center for Genetic Medicine houses the NUgene biobank and the Robert H. Lurie Comprehensive Cancer Center offers a robust research infrastructure for translation. \nThe start date is negotiable and the position will remain open until filled. When applying\, please upload this completed list of references form to suggest the names of individuals who could write letters of reference on your behalf. \nPlease read ALL instructions and make preparations before proceeding to the application page: \n\nApplications will only be accepted via online submission (see link below).\nPlease prepare all documents in advance as Adobe PDF files\, and please be sure all information is entered correctly and accurately (especially names and email addresses)\, as there will be no opportunity for online revision after your application has been submitted.\nAll required fields in the application form are marked with an asterisk and must be filled before clicking the “Submit” button.\nBe aware that incomplete applications cannot be saved.
URL:https://ces.b2sg.org/event/nwu-25feb19/
LOCATION:Northwestern University\, 633 Clark St\, Evanston\, IL\, 60208\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190226
DTEND;VALUE=DATE:20190331
DTSTAMP:20260905T075624
CREATED:20190226T184944Z
LAST-MODIFIED:20190226T184944Z
UID:21084-1551139200-1553990399@ces.b2sg.org
SUMMARY:Postdoctoral Scientist
DESCRIPTION:This position is primarily a temporary/training position in which the incumbent plays a substantive role in planning and conducting research by designing and conducting experiments in a controlled laboratory setting. In collaboration with the Principal Investigator\, this role will participate in the planning of independent research\, will analyze and interpret data\, will publish results\, will represent the university at conferences and meetings\, and may develop new theories and methodologies. This position may also help the Principal Investigator to lead and direct the work of lower level research staff. This role performs work under the supervision of experienced researchers. \nAdditionally\, the Postdoctoral Scientist utilizes several techniques including DNAmethylation and histone marks\, RNA-IP\, ChIP assay\, Molecular cloning\, mass spectrometry\, site directed mutagenesis\, in-vitro transcription. \nOther duties:\n-Interprets assay results \n-Summarizes findings\n-Assist with manuscript preparation\n-Performs other work related duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position \n\nPreferred Qualifications: \nPh.D in biochemistry\, molecular biology\, immunology or related field preferred. \nStrong experience in Immunology\, Epigenetics\, Cancer biology and animal handling\, in addition to some of the following laboratory techniques: tissue culture\, mouse models\, immunological techniques\, molecular biology\, flow cytometry and cellular biology etc. desired.
URL:https://ces.b2sg.org/event/26feb19/
LOCATION:George Washington University\, 2121 I St NW\, Washington\, DC\, 20052\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190227
DTEND;VALUE=DATE:20190401
DTSTAMP:20260905T075624
CREATED:20190227T093319Z
LAST-MODIFIED:20190227T093319Z
UID:21086-1551225600-1554076799@ces.b2sg.org
SUMMARY:Staff Scientist - DNA damage & repair
DESCRIPTION:One (1) staff scientist position is available in October 2019 in the Laboratory of Genome Integrity (Center for Cancer Research\, National Cancer Institute\, National Institutes of Health) to use computational methods in the study of mechanisms involved in DNA double-strand break repair and the roles of repair and replication proteins in a variety of cancers that include leukemias and breast cancers\, using mouse models. The ideal candidate will play a leading role in providing computational and biological insight by analyzing large data sets derived from genomics\, epigenetics and proteomics experiments. The position will emphasize efforts to understand gene regulation\, chromatin\, regulatory and coding variation and its relation to cancer. The position will support all laboratory investigators who use applications involving high-throughput DNA sequencing methods for a variety of assays\, including RNA-seq\, exon sequencing\, ATAC-seq\, DNase-seq\, ChIP-seq and newer and cutting-edge methodologies such as END-seq that have recently been developed.  Salary is commensurate with experience. \n\n\n\n\nNumber of Positions: \n\n1\n\n\n\nC.V. Required: \n\nYes\n\n\n\nNumber of References Required: \n\n3\n\n\n\nExperience Required: \n\n\nQualified candidates should have: \n\nA Ph.D. in computational biology\, bioinformatics\, mathematics\, or related field with no more than five (5) years of postdoc experience;\nResearch fellows in the NCI are encouraged to apply;\nAbility to program in Python/Perl and R/Matlab in Unix environment is required;\nKnowledge of SQL will be considered a plus;\nDemonstrated applied bioinformatics/computational proficiency as evidenced by relevant publications in peer-reviewed journals;\nStrong computational as well as a strong biological background;\nAn interdisciplinary background in bioinformatics & computational biology;\nAdvanced expertise in the analysis and interpretation of sequencing data generated in-house and its integration with other “omics” data sources such as ENCODE and TCGA;\nLaboratory bench experience\, while not essential\, will be considered an advantage.\n\n\n\n\n\nHow To Apply: \n\n\nCandidates should send CV and three (3) letters of reference via email directly to sam.john@nih.gov \n\n\n\n\nContact Name: Sam John\n\n\nContact E-mail: sam.john@nih.gov\n\n\nContact Phone: 240-760-7601
URL:https://ces.b2sg.org/event/27feb19/
LOCATION:National Institutes of Health (NIH) campus\, Bethesda\, MD\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190227
DTEND;VALUE=DATE:20190331
DTSTAMP:20260905T075624
CREATED:20190227T131517Z
LAST-MODIFIED:20190227T134029Z
UID:21088-1551225600-1553990399@ces.b2sg.org
SUMMARY:Bioinformatics Specialist
DESCRIPTION:A Bioinformatics Specialist position is available in the lab of Prof. Peter D. Adams for ambitious\, independent and motivated candidates to join the team investigating the epigenetics of aging and cancer at Sanford-Burnham-Prebys Medical Discovery Institute\, San Diego. The successful candidate will use computational and bioinformatics approaches to investigate age-associated epigenetic events\, derived from mouse tissues and cell culture models\, are related to epigenetic hallmarks of aging and disease\, most notably cancer. Datasets will include ChIP-seq\, RNA-seq\, ATAC-seq\, DNA methyl-seq and other large-scale epigenomic and chromatin analyses\, including at the single-cell level\, as well as results from high throughput chemical and RNAi/CRISPR phenotypic screens. \nPrimary Responsibilities\n\n\n\nPerforms computational analysis and integration of large transcriptomic and epigenetic datasets\nProvides access of public genetic\, epigenetic and transcriptomic large datasets\, for integration with those datasets generated in the lab\nUtilizes existing lab data analysis pipelines\nBuilds new data analysis pipelines\, e.g. for single cell RNA-seq and ATAC-seq.\nManages large dataset storage\, in databases\, lab wiki and lab UCSC browser\nPresents results to lab members at weekly lab meetings\nPresents results and data within SBP\, local La Jolla meetings and national and international meetings\, as appropriate\nMaintains and initiates collaborations between Adams lab and other labs in SBP\, San Diego\, US and worldwide\n\n\n\nRequired Skills \nRequired Experience \n\n\n\nBachelor’s Degree in Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies AND a minimum of 5 years work experience OR a Master’s degree in Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies AND 3 years of work experience in related field OR Ph.D. in Computer Science\, Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies\, is required\nPh.D. degree in Computer Science\, Bioinformatics\, or Life Sciences or equivalent studies is preferred\nExperience or background in molecular biology or biochemistry is preferred\nExperience with Illumina NGS data analysis is preferred\nPrevious Postdoc training is not required\n\n\n\nKnowledge\, Skills and/or Abilities\n\nGeneral familiarity with wet lab assays\nExcellent bioinformatics and programming skills (e.g. Perl\, Python\, C/C++\, Java\, R or Web applications)\nStrong command of Linux/UNIX operating system\nStrong knowledge and skills in bioinformatics\, statistics and next-generation sequencing data analysis\nAbility to use current bioinformatics tools and have an in depth knowledge of advanced sequencing and array-based technologies\nCommunicates effectively and collaborates well with Principal Investigators and their team members\nHave strong organizational and problem-solving skills\nPossesses strong attention to detail\, analytical and time management skills\nExcellent communication and interpersonal skills\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/sbp-27feb19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190228
DTEND;VALUE=DATE:20190401
DTSTAMP:20260905T075624
CREATED:20190228T101141Z
LAST-MODIFIED:20190228T101141Z
UID:21092-1551312000-1554076799@ces.b2sg.org
SUMMARY:Research Associate - Biology
DESCRIPTION:The Disease Biology Group in the Protein Homeostasis Thematic Center of Excellence (PH TCOE) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a highly motivated Research Associate with experience in molecular biology and state-of-the-art techniques of epigenetic profiling such as ATAC-seq and ChIP-seq. The successful candidate will work collaboratively in a multi-disciplinary environment to further our understanding of the molecular mechanism of action of our novel compounds and targets. Responsibilities will include to design and execute genetic and epigenetic studies in multiple disease models to support drug target validation\, mechanism of drug action\, biomarker discovery and potential drug combination strategies.  The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership. \nProtein Homeostasis at Celgene \nThe PH TCoE at Celgene is one of the fundamental research and early development engines delivering therapeutics to patients.  As a thematic center\, the PH TCoE is agnostic to therapeutic modality or disease area. The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system\, protein translation\, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company’s most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic\, exciting and creative environment that exploits excellent science in biology\, biochemistry\, structural biology\, computational biology and translational development. \nResponsibilities will include\, but are not limited to the following: \nWork independently to design\, execute\, analyze\, interpret and troubleshoot scientific experiments in molecular and cell biology\, cellular biochemistry and assay development Accurately maintain written reports and present results in an organized and timely manner to supervisor and colleagues Communicate with peers and supervisors\, foster teamwork and contribute to collaborative efforts Strong commitment to quality and demonstrate adaptability \nSkills/Knowledge Required: \n\nBachelor’s degree in molecular biology\, cell biology\, or related scientific discipline with at least 2 years laboratory experience.\nHands-on experience with molecular biology techniques including but not limited to\, quantitative PCR\, ATAC-seq and ChIP-seq and manipulation/editing of gene/message/protein via RNAi and/or CRISPR methods\nExperience with mammalian cell culture and cell-based assays to analyze compound effects (Western blot\, ELISA\, immunoprecipitation\, immunofluorescence and functional assays such as cell cycle and apoptosis)\nExcellent communication\, presentation and organizational skills are required as well as the ability to independently design\, execute\, and troubleshoot experiments through completion\nData analysis skills and experience with a variety of scientific software applications are required\nAbility to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.
URL:https://ces.b2sg.org/event/cel-28feb19/
LOCATION:Celgene\, 86 Morris Ave\, Summit\, NJ\, 07901\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190301
DTEND;VALUE=DATE:20190402
DTSTAMP:20260905T075624
CREATED:20190301T224956Z
LAST-MODIFIED:20190301T225457Z
UID:21095-1551398400-1554163199@ces.b2sg.org
SUMMARY:Life Science Technician I
DESCRIPTION:Stanford University is seeking a Life Science Technician to perform techniques independently involved in cancer biology\, stem cell biology and molecular medicine. \n \nAbout the Department of Pathology\nComprised of extraordinary faculty and staff\, our mission is to improve the diagnosis\, treatment and basic understanding of human disease.  We accomplish this through our clinical services\, research\, and training the future leaders in pathology and related fields.  A major focus of clinical research in the Department continues to be the correlation of patient outcome and treatment response with the surgical pathologic diagnosis of human cancers.  Everything we do is to provide the highest quality of pathology diagnostic services to the patients for whom we passionately care. \n \nFor more information about the department visit http://pathology.stanford.edu/  \n  \nDescription:\nThe Department of Pathology\, Van Rechem Lab\, seeks a Life Science Technician 1 (LST-1) to assist with research projects in epigenetics and cancer. The LST-1 will perform routine technical tasks in cellular and molecular biology\, including cell culture maintenance\, FACS\, qPCR\, protein immunoblots\, cloning\, preparation and aliquote of reagents. The LST-1 will also assist in maintaining lab organization as needed. \n\n\nQualifications:\n\nApproximately one year of previous laboratory experience in molecular and/or cellular biology is required. Basic technical writing beneficial but not required.\nMust be capable of and willing to pay strict attention to detail\, including following written and oral instruction.\n\nFamiliarity with the following experimental techniques preferred:\n\n\n\n\nplasmid cloning\ntissue culture\nimmunohistochemistry (IHC) and/or immunofluorescence (IF)\nflow cytometry (FACS)\nWestern Blot\nQPCR\n\n\n\n\nMust be detail-oriented and able to keep accurate records of experiments.\nGeneral understanding of scientific principles.\nGeneral computer skills and ability to quickly learn.\nAbility to work under deadlines with general guidance.\nExcellent organizational skills and demonstrated ability to accurately complete detailed work.\n\n\nEDUCATION & EXPERIENCE (REQUIRED):\nOne year’s employment experience in laboratory work or equivalent training. \n \nKNOWLEDGE\, SKILLS AND ABILITIES (REQUIRED):\nMust be detail-oriented and able to keep accurate records of experiments.\nGeneral understanding of scientific principles.\nGeneral computer skills\, experience with databases.\nAbility to work under deadlines with general guidance is essential.\nExcellent organizational skills and demonstrated ability to complete detailed work accurately.\n \nPHYSICAL REQUIREMENTS*:\nFrequently stand\, walk\, twist\, bend\, stoop\, squat\, grasp lightly\, use fine manipulation\, grasp forcefully\, perform desk-based computer tasks\, use telephone\, write by hand\, lift\, carry\, push and pull objects weighing over 40 pounds.\nOccasionally sit\, kneel\, crawl\, reach and work above shoulders\, sort and file paperwork or parts.\nMust have correctible vision to perform duties of the job.\nAbility to bend\, squat\, kneel\, stand\, reach above shoulder level\, and move on hard surfaces for up to eight hours.
URL:https://ces.b2sg.org/event/1mar19/
LOCATION:Stanford University\, School of Medicine\, 291 Campus Drive\, Stanford\, CA\, 94305\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190306
DTEND;VALUE=DATE:20190408
DTSTAMP:20260905T075624
CREATED:20190306T132535Z
LAST-MODIFIED:20190306T132626Z
UID:21099-1551830400-1554681599@ces.b2sg.org
SUMMARY:Postdoctoral Associate- Bioinformatics
DESCRIPTION:The Terskikh laboratory has a Postdoctoral Associate opening. The Terskikh laboratory is thriving is at the intersection of neurogenesis (including neural crest and adult hippocampal neurogenesis)\, brain cancer (glioblastoma)\, and epigenetic regulation. We have established mouse models of adult neurogenesis using conditional ablation of SOX2 and primary cilia (Shh signaling) in radial glia stem cells and developed a novel platform for microscopic imaging of epigenetic landscape (MIEL) in single cells. MIEL uses advanced imaging and machine learning to investigate the change of epigenetic signatures during cell differentiation and upon exposure to the environment\, including the high throughput drug screening format. We have also established a pipeline for hair follicle regeneration using human induced pluripotent stem cells. The Postdoctoral Associate will be developing his/her own project while supporting several ongoing projects in the laboratory through automating information and analysis pipelines\, data integration\, pattern-matching analyses and visualization of a variety of different data sets\, including single cell sequencing\, bulk NGS\, ChIP-Seq\, Nuc-Seq\, ATAC-Seq\, and proteomics. \nTO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter\, CV\, references and list of any publications or accomplishments.  \nPrimary Responsibilities\n\nUtilizes heterogeneous high-throughput datasets (bulk RNA-Seq\, single cell RNA-seq\, proteomics) collected from cellular and animal models to discover networks and pathways and to generate functional predictions and testable hypotheses (e.g. using Cytoscape\, IPA\, WGCNA\, NextBio)\nIndependently design and perform experiments and procedures with high degree of complexity\, demonstrating increasing expertise with a wide range of techniques\nSupports projects directed by lab investigators and contributes to the general technical knowledge of researchers\nWrites reports\, manuscripts\, and application for funding with increasing responsibility over time\nWorks collaboratively across lab functions and train other junior lab staff as needed\n\nRequired Experience \n\nPh.D. degree in bioinformatics or biological sciences (including Computer Science\, Bioinformatics\, Biostatistics\, Life Sciences) is required\nStrong emphasis on bioinformatics\, preferably related to genetics of disease\nThe qualified candidate should have proven experience in one or more of the following areas:  Bioinformatics or molecular biology and genetics or related discipline with an emphasis on bioinformatics\n1-2 years of experience after PhD degree is preferred\n\nKnowledge\, Skills and/or Abilities\n\nStrong ability in bioinformatics\, systems biology\, sequence analyses\, network analyses or genetics including expertise in high-throughput data analyses\, such as RNA-Seq\, single cell RNA-seq\, differential gene expression analyses\, gene co-expression analyses\, and proteomics\nStrong programming skills (Python\, R\, Java or C++ and Unix/Linux shell)\nFamiliarity with algorithms and tools\, such as Bowtie\, cufflinks\, BWA\, STAR\, RSEM\, UCSC Genome Browser\, samtools\, bedtools\, vcf-tools etc\nKnowledge of machine learning approaches is a plus\nDemonstrated ability for independent and critical thinking\, excellent communication and teamwork skills\nHas strong publication record (at least one first-author publication is preferred)\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/3mar19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190306
DTEND;VALUE=DATE:20190408
DTSTAMP:20260905T075624
CREATED:20190306T133939Z
LAST-MODIFIED:20190306T134527Z
UID:21102-1551830400-1554681599@ces.b2sg.org
SUMMARY:Research Scientist II
DESCRIPTION:We are seeking an exceptional cancer biologist to join our team of scientists engaged in an industry collaboration to leverage the therapeutic potential of cancer genomic discoveries. The successful candidate will be expected to independently design and carry out target validation\, mechanism of action\, and assay development experiments using diverse molecular\, cellular\, and biochemical techniques. Additional responsibilities include the generation and study of models of resistance to small molecule inhibitors. Applicants should have established expertise in cancer biology\, as demonstrated by a track record of high-impact publications\, and will be expected to collaborate and communicate effectively.  Knowledge of epigenetics or kinase biochemistry would be a plus. \nREQUIREMENTS \n\nPhD in the life sciences with 2+ years of relevant research experience
URL:https://ces.b2sg.org/event/bi-6mar19/
LOCATION:Broad Institute\, 415 Main St\, Cambridge\, MA\, 02142\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190308
DTEND;VALUE=DATE:20190410
DTSTAMP:20260905T075624
CREATED:20190308T205131Z
LAST-MODIFIED:20190308T210258Z
UID:21104-1552003200-1554854399@ces.b2sg.org
SUMMARY:Post Doctoral Associate
DESCRIPTION:CORE JOB FUNCTIONS \nConducts research on specific areas of study as assigned. Prepares research reports and technical papers for publishing. Investigates the feasibility of applying a wide variety of scientific principles and theories. Maintains substantial knowledge of state-of-the-art principles and theories. Develops advanced analytical models and systems and provides solutions and analyses to support strategic and tactical decisions. Adheres to University and unit-level policies and procedures and safeguards University assets. \nThis list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary. \nCORE QUALIFICATIONS \nEducation: \nPh.D. required \nCertification and Licensing: \nNot Applicable \nExperience: \nNo prior experience required \nKnowledge\, Skills and Attitudes: \n\nSkill in collecting\, organizing\, and analyzing data.\nAbility to recognize\, analyze\, and solve a variety of problems.\nAbility to exercise sound judgment in making critical decisions.
URL:https://ces.b2sg.org/event/8mar19/
LOCATION:University of Miami\, 1320 S Dixie Hwy\, Coral Gables\, FL\, 33146\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190309
DTEND;VALUE=DATE:20190411
DTSTAMP:20260905T075624
CREATED:20190309T131805Z
LAST-MODIFIED:20190309T133035Z
UID:21106-1552089600-1554940799@ces.b2sg.org
SUMMARY:In Vivo Pharmacology Scientist (non-PhD)
DESCRIPTION:We seek an accomplished Scientist level oncologist/immunologist to join the in vivo pharmacology group within the Oncology Research Unit (ORU) of Pfizer’s Worldwide Research & Development (WRD) division in La Jolla\, California. The successful candidate will join a dynamic team of scientists in the Oncology In Vivo Pharmacology Group\, playing a leading role in the characterization of models of cancer and evaluating new drug candidates. \nParticipate in pre-clinical drug discovery and development projects with a focus on targeted therapeutics\, epigenetics and the tumor microenvironment. Characterize and develop small molecules in close collaboration with partner lines as an integral member of drug discovery teams. Evaluate anti-tumor effects in combination with biologics. Employ and develop new cutting-edge in vivo mouse and human cancer models. Provide technical and scientific expertise in in vivo pharmacology to the tumor cell biology department to enable target identification\, validation\, prioritization and efficient drug discovery of small molecules. \nThe candidate must have a strong background in hands-on laboratory based experimentation.   Experience with scRNA sequencing technologies (10X Genomics) is required. Knowledge in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20\, Cytobank\, FlowJo\, FACS\, MACS) is desired. Ideal applicants will have excellent communication and organizational skills\, critical problem-solving abilities\, and a commitment to excellence. \nROLE RESPONSIBILITIES  \n\nExecute and analyze cells within the tumor microenvironment by multi-parameter flow cytometric and RNAseq studies.\nCharacterize new in vivo mouse models\, including syngeneic tumor and genetically engineered mouse (GEM) models\, to study biologic mechanisms and support exploration of novel therapies.\nConduct in vivo studies to evaluate and establish efficacy\, PK/PD relationship\, combination strategy\, biomarker identification and analysis.\nInterpretation\, presentation and documentation of experiments.\nPresentation of results within a multidisciplinary team environment.\n\nBASIC QUALIFICATIONS  \n\nBS/MS in Cancer Biology\, Immunology or equivalent experience in a related discipline.\n> 6 years of laboratory work experience in academia or industry\nHands on laboratory skills. In vivo skills (IV\, PO dosing)\, blood/tissue collection is a plus.\nAbility to follow novel scientific or technological developments\, and to implement them in the laboratory.\nExcellent written and oral communication and presentation skills in English.\nStrong ability to multi-task and work productively in a fast-paced\, highly collaborative\, and diverse team environment. Capability to contribute to a vivid and challenging intellectual environment.\n\nPREFERRED QUALIFICATIONS \n\nExpertise in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20\, Cytobank\, FlowJo\, FACS\, MACS) or scRNA sequencing technologies (10X Genomics) preferred\nExperience with animal models of human cancers preferred.
URL:https://ces.b2sg.org/event/9mar19/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/05/pfizer_new_logo.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190310
DTEND;VALUE=DATE:20190412
DTSTAMP:20260905T075624
CREATED:20190310T103556Z
LAST-MODIFIED:20190310T103556Z
UID:21108-1552176000-1555027199@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow in the laboratory of Dr. Sangeeta Dhawan\, at the Diabetes and Metabolism Research Institute. The lab is looking for a highly motivated postdoctoral fellow interested in studying the epigenetic regulation of pancreatic beta-cell mass in health and diabetes. In addition\, the lab is interested in the dynamics of beta-cell diversity\, islet organization and cell-cell interaction in fetal and neonatal development. The Dhawan lab utilizes genetic mouse models\, molecular biology and epigenetic techniques to study the cellular identity\, function\, remodeling\, and survival of beta-cells in physiological and pathological conditions. \nThe ideal candidate will have extensive experience in molecular biology and cell or developmental biology. Experience with epigenetic techniques and rodent models preferred.  The candidate should be self-motivated\, with a proven track record of productivity.\n \n \n  \nBasic education\, experience and skills required for consideration: \n\nPhD in Molecular\, Cellular or Developmental Biology.\nStrong interest in diabetes research.\nExtensive experience with basic molecular biology skills.\nExperience with tissue collection\, histology\, immunohistochemistry\, and cell sorting.\nExperience with cell culture\, immunofluorescence\, and flow cytometry.\nStrong work ethic\, meticulous and detail-oriented record keeping habits.\nExcellent written and verbal communication skills. Evidence of productivity reflected in first author publications in peer-reviewed journals.\nGood problem solving skills and passion to follow relevant literature.\nAbility to conduct independent research\, and work effectively in a team.\n\nPreferred education experience and skills: \n\nExperience in handling animal models.\nExperience with epigenetic techniques.
URL:https://ces.b2sg.org/event/hope-10mar19/
LOCATION:City of Hope\, 1500 East Duarte Road\, Duarte\, 91010\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/png:https://ces.b2sg.org/wp-content/uploads/2017/02/City-of-hope.png
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190312
DTEND;VALUE=DATE:20190414
DTSTAMP:20260905T075624
CREATED:20190312T185617Z
LAST-MODIFIED:20190312T185617Z
UID:21111-1552348800-1555199999@ces.b2sg.org
SUMMARY:Associate Computational Biologist
DESCRIPTION:Focus: Chromatin and gene regulation in human disease \nKadoch Laboratory\, Dana-Farber Cancer Institute/HMS/Broad Institute \nThe Kadoch Laboratory at the Dana-Farber Cancer Institute\, Harvard Medical School\, and Broad Institute is seeking a highly qualified post-graduate student (student graduating with BA/BS this Spring/Summer 2019 or in the previous year) to join our team as a Computational Biologist focused at the intersection of cancer biology\, epigenetics\, and chromatin regulation. Our lab uses multidisciplinary approaches including genomics and epigenomics\, systems biology\, functional genetic screening\, biochemistry\, structural biology\, and chemical biology\, to explore the mechanisms of chromatin remodeling complexes\, which are frequently mutated in human cancers and other diseases. Our exciting and diverse set of projects involve collaborations across the Harvard and MIT centers in Boston and Cambridge. \nThis is a unique opportunity with significant potential for the student to work closely with the PI and carry forward independent projects resulting in presentations and publications. Computational Biologists in our laboratory participate in lab meetings and journal clubs\, participate in subgroup meetings\, work closely with graduate students and postdocs\, and have typically authored several publications prior to entering PhD or MD/PhD programs following their time in our lab. The successful applicant will have advanced experience in R and/or Python and familiarity with genomics-centered approaches such as ChIP-seq\, RNA-seq\, ATAC-seq\, Hi-C\, and others through prior lab research experience as well as undergraduate coursework. The ideal candidate will also have some familiarity with chromatin biology and in reading and dissecting literature in this area. We are looking for candidates who can dedicate at least two years in the lab and who may be considering applying to graduate and/or medical school following their time in the lab. The ideal candidate will be exceptionally motivated\, detailed\, goal-oriented and will possess excellent organizational\, communication\, and analytical skills. \nPlease see http://www.kadochlab.org; twitter: @kadochlab; @ckadoch for more information\, as well as PubMed for recent papers from our lab:https://www.ncbi.nlm.nih.gov/pubmed/?term=kadoch+c.
URL:https://ces.b2sg.org/event/12mar19/
LOCATION:TX
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190314
DTEND;VALUE=DATE:20190416
DTSTAMP:20260905T075624
CREATED:20190314T142734Z
LAST-MODIFIED:20190314T142912Z
UID:21113-1552521600-1555372799@ces.b2sg.org
SUMMARY:Research Technician
DESCRIPTION:There is an immediate opening for a research technician in Qi group at the Dana-Farber Cancer Institute to look for exceptional researcher in Chemistry and Chemical Biology field. The Qi lab studies gene regulatory pathways using the emerging discipline of chemical biology. Successful candidates will work with an interdisciplinary team of scientists including medicinal chemists\, biochemists\, computational biologists\, and cancer biologists to develop novel inhibitors of chromatin modifying enzymes\, such as methyltransferases\, demethylases as well as other epigenetic targets and transcription factors. The successful candidate will perform research that establish fundamental insights to cancer biology using novel small molecule inhibitors to gain mechanistic understanding in cancer therapy. We expect that novel therapeutics for human clinical investigation will emerge directly from these efforts through academic/industry collaborations. \nThis position will assist scientists in performing scientific research\, development and/or clinical tasks of varying complexity. In general\, this position will assist in the set up\, operation and maintenance of laboratory instruments and equipment\, monitoring experiments\, making observations and calculating and recording results.  \nWe are looking for candidates who have at least a two-year availability. \n\n\n\nResponsibilities\n\n\n\n\nSkill in organic chemistry\, compound characterization with NMR and mass spec\nUnderstanding the medicinal chemistry for small molecule inhibitor design\nPerforming laboratory experiments and conducting data analysis\nDesigning experiments and executing protocols\ndeveloping and executing design and synthesis small molecule inhibitors while investigating novel biological mechanisms of action of inhibitors in cancer with team\nMaintaining accurate records\, writing reports\, and preparing presentations\nContribute to the organization of the overall laboratory and safety\nSet up\, adjust\, calibrate\, clean\, maintain and troubleshoot equipment.\nClean\, maintain and prepare supplies and work areas and may be responsible for ordering of supplies. Collaborates with Purchasing and may be responsible for negotiating with vendors.\nConduct standardized biological\, microbiological or biochemical tests and laboratory analyses\, including the collection of information and samples from organic substances\, such as blood\, drugs\, and animals.\nIsolate\, identify and prepare specimens for examination.\nAnalyze experimental data and interpret results to write reports and summaries of findings\, including grant preparation and presentations\, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results to staff. \nParticipate in grant application process and manuscript preparation as required.\nMaintains detailed notebook of all work-related activities.\nMonitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.\nExpected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications.\nMay be responsible for the development\, modification and improvement of standard operating procedures.\nUses computers\, computer-interfaced equipment\, robotics or high-technology applications to perform work duties.\nMay be responsible for designing and executing advanced experiments and setting strategy. \nMay be responsible for the examination of animals and specimens to detect the presence of disease or other problems.\nMay be responsible for monitoring laboratory budgets.\n\n  \n\n\n\nQualifications\n\n\n\n\nBachelor’s Degree required with a major in chemistry or biochemistry preferred. \nKnowledge of information and techniques in the fields of organic chemistry\, medicinal chemistry\, or biochemistry\nMust have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.\nEnthusiastic\, team player\, and self-motivated individual\nAbility to analyze information and use logic to address work-related issues and problems.\nMust have attention to detail and be thorough in completing work tasks.\nAbility to work within a team environment.
URL:https://ces.b2sg.org/event/14mar19/
LOCATION:Dana-Farber Cancer Institute\, 450 Brookline Avenue\, Boston\, MA\, 02215\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/11/Dana-Farber.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190314
DTEND;VALUE=DATE:20190416
DTSTAMP:20260905T075624
CREATED:20190314T145033Z
LAST-MODIFIED:20190314T145123Z
UID:21116-1552521600-1555372799@ces.b2sg.org
SUMMARY:Computational Biologist / Bioinformatics Analyst
DESCRIPTION:Novartis Institutes for BioMedical Research\, Inc. (NIBR) is seeking a computational biologist / bioinformatics analyst to join the Novartis Oncology Bioinformatics Team. Oncology Bioinformatics provides computational biology expertise to the department\, from target ID through clinical development\, for both targeted and immune therapies. We work at the cutting edge of science to solve important challenges in biomedical research\, making use of both publicly available and internally generated unique and expansive preclinical and clinical datasets. The successful candidate will be highly motivated\, creative\, and an effective collaborator. \nResponsibilities will include: \n•Supporting translational biology\, model characterization\, and data mining efforts to solve unmet medical needs.\n•Implementing and developing state-of-the-art computational methods and data mining strategies to address key challenges in oncology drug discovery (e.g. drug resistance\, difficult-to-drug targets\, harnessing anti-tumor immunity).\n•Working closely with wet- and dry-lab collaborators to analyze and interpret assay data.\n•Formulating testable hypotheses and collaborating in the design of rigorous experiments. \n\n\nMinimum requirements \n•M.S. in computational biology\, statistics\, computer science\, or a related field\n•Familiar with fundamental concepts in molecular biology\, statistics\, and bioinformatics\n•Fluency in one or more programming languages with bioinformatics applications (e.g. Python or R)\n•Experience with statistical methods for mining ‘omics data (genomics\, epigenetics\, proteomics) and/or NGS data strongly preferred\n•Knowledge of cancer genomics\, immunology / immune-oncology\, clinical and translational science preferred\n•Experience with current analysis methods for processing NGS data\, high throughput pooled screening\, or other high-dimension data sets preferred
URL:https://ces.b2sg.org/event/novartis-14mar19/
LOCATION:Novartis (MA)\, 250 Massachusetts Ave\, Cambridge\, 02139\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190316
DTEND;VALUE=DATE:20190322
DTSTAMP:20260905T075624
CREATED:20181103T104012Z
LAST-MODIFIED:20200520T113106Z
UID:20805-1552694400-1553212799@ces.b2sg.org
SUMMARY:USCAP 108th Annual Meeting: ASCP & ASIP Joint Meeting
DESCRIPTION:Current and Future Revolution in Pathology Practice: (Focus on) Immuno-oncology and Cancer Epigenetics \nASIP/ASCP will bring together 4 speakers from across two unique disciplines of pathology to discuss the practice\, science\, and challenges of immuno-oncology and cancer epigenetics intended to inform and education residents\, fellows\, and practicing pathologists.  The course will begin with a practical discussion of IO in current practice (Mamatha Chivukula\, Sutter Health\, CA) from the perspective of a community-based pathologist. This segment will review the current landscape of “companion diagnostics” in the immuno-oncology space including but not limited to treatment-specific biomarker assessment (PD-1)\, tumor mutational burden\, sequencing\, etc.\, with specific emphasis on treatment selection challenges\, quality across the testing/reporting spectrum\, pitfalls\, and practical solutions. This will be followed up by a discussion of cutting-edge science in the IO space (Mike Milone\, UPenn) with emphasis on those technologies and tools that are likely to move into clinical space soon. This same approach to cancer epigenetics (David Williams\, UNC) will be revealed and discussed in the third presentation. Both of these cutting-edge talks will identify current and forthcoming basic and translational science in immuno-oncology and cancer epigenetics likely to generate immediate or future diagnostics.  To finish off\, a “future talk” focused on how cancer epigenetics will affect patient care and everyday diagnostics will be presented (I.M. Bennani-Baiti\, President & CEO\, Cancer Epigenetics Society). This portion will assess the implications for the practicing pathologist of current and future science in cancer epigenetics to daily practice and best patient care. \nCourse Learning Objectives\nUpon completion of this educational activity\, the learner will be able to: \n\nReview the current landscape of “companion diagnostics” in the immuno-oncology space including but not limited to treatment-specific biomarker assessment (PD-1)\, tumor mutational burden\, sequencing\, etc. with specific emphasis on treatment selection challenges\, quality across the testing/reporting spectrum\, pitfalls\, and practical solutions\nIdentify current and forthcoming basic and translational science in immuno-oncology and cancer epigenetics likely to generate immediate or future diagnostics\nAssess the implications for the practicing pathologist of current and future science in cancer epigenetics to daily practice and best patient care\n\n\nSESSION CHAIRS\n\nModerator \nDanny Milner\, MD\, MSc\, ASCP\n\n\n\n\n\nPRESENTATIONS\n\n\n1:30 PM\n1:35 PM\n\n\nIntroduction to the Session and Outline of the Symposium Objectives\n\n\nDanny Milner\, MD\, MSc\nASCP\n\n\n\n\n\n\n\n1:35 PM\n2:10 PM\n\n\n“Immunotherapy” From Bench to Community Practice- Are Pathologists Ready for the #gamechanger?\n\n\nMamatha Chivukula\, MD\, FASCP\nMills-Peninsula Hospital\, Sutter Health Affiliate\n\n\n\n\n\n\n\n2:10 PM\n2:45 PM\n\n\nCutting Edge Science in Immuno-Oncology: Where to next?\n\n\nMichael Milone\, MD\, PhD\nUniversity of Pennsylvania Perelman School of Medicine\n\n\n\n\n\n\n\n2:45 PM\n3:20 PM\n\n\nBreak\n\n\n\n\n\n\n3:20 PM\n3:55 PM\n\n\nFrom DNA Methylation to Chromatin Remodeling\, the Expanding Role of Epigenetic Changes in Cancer Biology\n\n\nDavid Williams\, MD\, PhD\nUniversity of North Carolina at Chapel Hill\n\n\n\n\n\n\n\n3:55 PM\n4:30 PM\n\n\nPractical Epigenetics: How Today’s Cancer Epigenetics Research Will Change the Field of Pathology Tomorrow\n\n\nI.M. Bennani-Baiti\, PhD\, MSc\, FRSM\, CRSM\nCancer Epigenetics Society\n\n\n\n\n\n\n\n4:30 PM\n5:00 PM\n\n\nPanel Discussion\n\n\nDanny Milner\, MD\, MSc
URL:https://ces.b2sg.org/event/events-uscap108/
LOCATION:Gaylord National Harbor Convention Center\, 201 Waterfront Street\, National Harbor\, MD\, 20745\, United States
CATEGORIES:Meetings
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190317
DTEND;VALUE=DATE:20190322
DTSTAMP:20260905T075624
CREATED:20180519T165918Z
LAST-MODIFIED:20180519T170059Z
UID:20110-1552780800-1553212799@ces.b2sg.org
SUMMARY:Epigenetics and Human Disease
DESCRIPTION:Epigenetics is a major mechanism in human health and disease. Data from a range of diseases (cancer\, neurological and immunological disorders) have uncovered altered epigenomes arising from mutations\, altered expression and/or copy number alterations of numerous epigenetic factors (histones\, DNA and chromatin modifying enzymes\, reader proteins\, chromatin modulators and noncoding RNAs). Genome-wide analyses have illustrated the relationship between altered epigenetic states (e.g.\, modified DNA\, histones and chromatin packaging) and disease onset and progression. Furthermore\, both local and long-range nuclear chromatin architecture are increasingly recognized as major contributors to normal and pathologic epigenetic states.  \nThis meeting\, held jointly with “3D genome”\, will cover the most current knowledge of epigenetic events modulating nuclear function (gene expression regulation\, enhancer modulation\, domains and structural organization as well as cell division and differentiation)\, while relating this to normal and disease models. In addition\, this meeting will highlight the impact that preclinical and clinical epigenetic therapeutics have on multiple diseases including cancer\, immunology\, and neurological disorders. An interdisciplinary panel of speakers including both thought leaders in the field as well as young investigators will survey the latest research results and conceptual understanding of fundamental mechanisms of epigenetic signaling\, especially as relates to regulation of gene expression programs. Presentations and workshops will highlight the latest technologies and methodologies for studying epigenetic states and 3D chromatin architecture in cells\, tissues and organisms. \n  \nThe meeting will begin on Sunday\, March 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday\, March 21 with a closing plenary session from 17:00 to 19:00\, followed by a social hour and entertainment. We recommend return travel on Friday\, March 22 in order to fully experience the meeting.  \n  \nProgram: \n– 3D Epigenome/Epigenetics and Disease \n-Workshop: 4DN Nucleome Consortium Resources \n-Epigenetic Dysregulation in Neurobiology  \n-Single Cell Analysis of Genome Architecture  \n-Understanding and Targeting Epigenetic Dysregulation \n-Analysis of 3D Genome with Advanced Microscopy  \n– Workshop: ENCODE Consortium Resources \n-Infectious Diseases and Autoimmunity  \n-Chromatin and Epigenetics  \n-Chromatin Signaling and Epigenetic Mechanisms \n-3D Genome and Gene Regulation \n-Workshop: International Human Epigenome Consortium  \n-Metabolic Diseases and Aging \n-Genome Architecture and Development \n-Epigenetic Regulation in Immunoncology and Cancer Therapeutics  \n-Computational Analysis of 3D Genome \n-3D Genome and Disease \n  \nDeadlines: \nScholarship Deadline: Nov 15\, 2018 \n Discounted Abstract Deadline: Nov 15\, 2018\n Abstract Deadline: Dec 12\, 2018\n Discounted Registration Deadline: Jan 22\, 2019 \n 
URL:https://ces.b2sg.org/event/keystone-17mar19/
LOCATION:Fairmont Banff Springs\, 405 Spray Avenue\, Banff\, Alberta\, T1L 1J4\, Canada
CATEGORIES:Meetings
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/keystone-e1494159273833.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190317
DTEND;VALUE=DATE:20190419
DTSTAMP:20260905T075624
CREATED:20190317T194959Z
LAST-MODIFIED:20190317T194959Z
UID:21119-1552780800-1555631999@ces.b2sg.org
SUMMARY:Postdoctoral Scholar
DESCRIPTION:Two Postdoctoral or Visiting Scholar positions are available to (1) study the mechanism of breast cancer metastasis and develop novel therapeutic strategies for treating metastatic breast cancer; and (2) investigate the epigenetic mechanisms of chemical carcinogenesis. These projects will use cell culture and mouse models to investigate the epigenetic mechanisms (DNA methylation\, histone posttranslational modifications and non-coding RNAs) of breast cancer metastasis and chemical carcinogenesis. Candidates should have a recent Ph.D. degree with strong background in cell/molecular biology and cancer biology. Experiences in studies on cancer epigenetics\, non-coding RNAs\, and cancer stem cells with skills in handling mice\, producing tumors in mice and treating mice with commonly-used drug administration approaches would be advantageous. The expected qualifications of candidates include: be highly self-motivated with strong interest in learning new knowledge and techniques; have excellent communication and organizational skills and attention to details\, be capable of conceptualizing\, designing experiments and conducting studies independently as well as cooperatively with other lab members as a team; and have the capability to write manuscripts for quality publications. Compensations including salary and benefits will be highly competitive depending upon candidates’ qualifications. Interested applicants\, please send a cover letter describing your research training experience\, a brief statement of your research interest\, scientific achievements and future career goal\, curriculum vitae (CV) and contact information (names\, e-mails\, and telephone numbers) of three references to: Dr. Zhishan Wang (zhishan.wang@uky.edu) or Dr. Chengfeng Yang (chengfeng.yang@uky.edu)\, Department of Toxicology and Cancer Biology\, University of Kentucky\, Lexington\, KY 40536. Only short-listed applicants will be contacted for interview. \nRequired Documents: Curriculum Vita\, Cover Letter\, Writing Sample\, Academic Transcripts\, for Specific Request 1\, please supply a copy of your PhD diploma & English translation if not in English\, and for Specific Request 2\, please submit a written document of your future career goals. \n\n\n\n\nSkills / Knowledge / Abilities\nExperiences in studies on cancer epigenetics\, non-coding RNAs\, and cancer stem cells with skills in handling mice\, producing tumors in mice and treating mice with commonly-used drug administration approaches would be advantageous. The expected qualifications of candidates include: be highly self-motivated with strong interest in learning new knowledge and techniques; have excellent communication and organizational skills and attention to details\, be capable of conceptualizing\, designing experiments and conducting studies independently as well as cooperatively with other lab members as a team; and have the capability to write manuscripts for quality publications.
URL:https://ces.b2sg.org/event/17mar19/
LOCATION:University of Kentucky\, 410 Administration Drive\, Lexington\, KY\, 40506\, United States
CATEGORIES:Jobs
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DTSTART;VALUE=DATE:20190318
DTEND;VALUE=DATE:20190420
DTSTAMP:20260905T075624
CREATED:20190318T090147Z
LAST-MODIFIED:20190318T090147Z
UID:21121-1552867200-1555718399@ces.b2sg.org
SUMMARY:Research Scientist
DESCRIPTION:As part of the TRACTION team\, the Research Scientist will be part of our team of translational biologists who are responsible for leading preclinical translational activities to inform on clinical development of late-stage preclinical therapeutics. The position requires leading translational activities utilizing state-of-the-art preclinical models\, platforms and assays to discover\, validate and translate tumor biology insights into informative clinical trials. To enble these activities\, the Research Scientist will contribute to a cross-functional team\, collaborating with our corporate partners\, subject matter experts and cores across the Institution. These efforts will allow us to advance novel therapeutics currently under development by our Therapeutics Discovery teams and partners.\nBy joining the Therapeutics Discovery Division\, you have the opportunity to use your talents to make a direct impact on the lives of our patients. We are seeking a highly motivated and collaborative individual to become a part of our team. Ideal candidates will have a proven track record of leading translational efforts in support of advancing and positioning therapeutics in the clinical\, as well as possess excellent communication\, collaboration\, organization and leadership skills.\n\n\nKEY FUNCTIONS:\n\n1.Apply and develop basic science tools and methodologies to develop complex strategies and enable advancement of projects through leadership and experimental activities.\n\n2.Apply cutting edge functional genomics approaches to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.\n\n3.Independently design\, execute and interpret in vitro\, ex-vivo and in vivo experiments to validate and explore therapeutic potential of drug targets.\n\n4.Work with research\, computational biology and bioinformatics teams to utilize internal biological and oncogenomic data sets to generate and test biological hypotheses.\n\n5.Develop and implement biomarker strategies to guide early clinical development of drugs.\n\n6.Design\, develop and utilize biomarker assays to define mechanism of action for compounds and utilize pharmacodynamic markers to inform on compound activity\, response and resistance pre-clinical and clinical setting and test patient selection strategies.\n\n7.Develop extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or apoptosis.\n\n8.Adapt to new technologies and find solutions to related program studies.\n\n9.Interpret\, present and report research findings at internal meetings and external scientific conferences.\n\nEducation\nRequired: Bachelor’s degree in Biology\, Biochemistry\, molecular biology\, cell biology\, enzymology\, pharmacology\, chemistry or related field.\n\nPreferred: PhD\, MD or equivalent degree in Biology\, Cell Biology\, Molecular biology or related field\n\nExperience\nRequired: Ten years of relevant research laboratory experience. With Master’s degree\, eight years of required experience and with PhD\, two years of required experience.\n\n\nPreferred: At least two years of post-degree experience in a biotech or pharmaceutical environment.\n\n1.Evidence of utilization of cancer genetics to inform on target discovery\, validation or on clinical development of drug candidates.\n\n2.Experience with genetic (ie RNAi and cDNAs) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study target biology utilizing state of the art molecular biology and biochemistry methods and assays essential to drive projects.\n\n3.A demonstrated track record in the development and implementation of functional genomics strategies to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.\n\n4.Broad knowledge of cell culture techniques is required and knowledge of how to utilize in vivo oncology models is desirable. Hands-on experience utilizing genetically engineered mouse models and orthotopic or subcutaneous primary or established tumor cell line xenograft models is desirable.\n\n5.Extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or anti-apoptosis as evidenced by publication in peer-reviewed journals.\n\n6.Strong data analysis skills\, ability to interpret results and contribute to the design of follow-up experiments\, troubleshoot issues with assay performance\, and effectively present results and conclusions to co-workers\, collaborators and senior leadership.\n\n7.Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential.\n\n8.Flexibility to accommodate to rapidly changing priorities and deadlines is required\n\n9.Collaborative attitude and ability to work in a team-based environment is crucial for this position.\n\n10.Excellent oral and written communication skills.\n\n11.Experience mentoring junior scientists is a plus.
URL:https://ces.b2sg.org/event/18mar19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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DTSTART;VALUE=DATE:20190320
DTEND;VALUE=DATE:20190422
DTSTAMP:20260905T075624
CREATED:20190320T094811Z
LAST-MODIFIED:20190320T094811Z
UID:21123-1553040000-1555891199@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:Postdoctoral Research Scientist in Mammalian Tissue & Organ Regeneration\nSeattle Children’s Research Institute & University of Washington\, Seattle\, WA\n\nPostdoctoral Scientist Position Available: An exceptional opportunity is available for a postdoctoral scientist to work on a newly funded NIH-RO1 grant at the Seattle Children’s Research Institute & University of Washington. We are studying organ regeneration & scarless wound healing in adult mammals using the African spiny mouse model (pmid: 23108966; BioRxiv-315069). Our current focus is on a comparative analysis of wound healing in human\, mouse\, and spiny mouse kidney and vascular system. We are seeking motivated individuals with a strong publication record\, an interest in translational research\, and experience in one or more of the following areas: mouse models\, RNA seq analysis\, single cell transcriptomics\, epigenetics\, enhancer characterization\, bioinformatics\, kidney or vascular development/disease\, and/or fibrosis. Screening of applicants will begin immediately and continue until the position is filled.\n\nWe are a multi-investigator group of basic and clinical investigators in Seattle\, WA. Seattle Children’s Research Institute is located in close proximity to Fred Hutchinson Cancer Research Center\, the Allen Institute\, the Institute for Systems Biology\, and the UW-South Lake Union campus. Please send a CV\, statement of research interests\, and names/contact information for three reference letters by email to:\n\nMark W. Majesky\, Ph.D.\, email: mwm84@uw.edu\, using the subject line “Postdoctoral position”.\n\n\n\nRequirements\n\n\n\nRequired education:\n\nRecent or expected Ph.D. degree in a biological discipline related to the project.\n\n\nPreferred experience in one or more of the following:\n\nSignificant experience in epigenetics-related techniques (ATAC-seq; ChIP-seq; Cut&Run assays)\nSome experience in RNA seq analysis\, validation of gene targets\, and related bioinformatics.\nSome experience in confocal or lightsheet imaging and related image analysis.
URL:https://ces.b2sg.org/event/sch-20mar19/
LOCATION:Seattle Children’s Hospital\, 4800 Sand Point Way NE\, Seattle\, WA\, 98105\, United States
CATEGORIES:Jobs
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