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X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190226
DTEND;VALUE=DATE:20190331
DTSTAMP:20260905T165527
CREATED:20190226T184944Z
LAST-MODIFIED:20190226T184944Z
UID:21084-1551139200-1553990399@ces.b2sg.org
SUMMARY:Postdoctoral Scientist
DESCRIPTION:This position is primarily a temporary/training position in which the incumbent plays a substantive role in planning and conducting research by designing and conducting experiments in a controlled laboratory setting. In collaboration with the Principal Investigator\, this role will participate in the planning of independent research\, will analyze and interpret data\, will publish results\, will represent the university at conferences and meetings\, and may develop new theories and methodologies. This position may also help the Principal Investigator to lead and direct the work of lower level research staff. This role performs work under the supervision of experienced researchers. \nAdditionally\, the Postdoctoral Scientist utilizes several techniques including DNAmethylation and histone marks\, RNA-IP\, ChIP assay\, Molecular cloning\, mass spectrometry\, site directed mutagenesis\, in-vitro transcription. \nOther duties:\n-Interprets assay results \n-Summarizes findings\n-Assist with manuscript preparation\n-Performs other work related duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position \n\nPreferred Qualifications: \nPh.D in biochemistry\, molecular biology\, immunology or related field preferred. \nStrong experience in Immunology\, Epigenetics\, Cancer biology and animal handling\, in addition to some of the following laboratory techniques: tissue culture\, mouse models\, immunological techniques\, molecular biology\, flow cytometry and cellular biology etc. desired.
URL:https://ces.b2sg.org/event/26feb19/
LOCATION:George Washington University\, 2121 I St NW\, Washington\, DC\, 20052\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190227
DTEND;VALUE=DATE:20190401
DTSTAMP:20260905T165527
CREATED:20190227T093319Z
LAST-MODIFIED:20190227T093319Z
UID:21086-1551225600-1554076799@ces.b2sg.org
SUMMARY:Staff Scientist - DNA damage & repair
DESCRIPTION:One (1) staff scientist position is available in October 2019 in the Laboratory of Genome Integrity (Center for Cancer Research\, National Cancer Institute\, National Institutes of Health) to use computational methods in the study of mechanisms involved in DNA double-strand break repair and the roles of repair and replication proteins in a variety of cancers that include leukemias and breast cancers\, using mouse models. The ideal candidate will play a leading role in providing computational and biological insight by analyzing large data sets derived from genomics\, epigenetics and proteomics experiments. The position will emphasize efforts to understand gene regulation\, chromatin\, regulatory and coding variation and its relation to cancer. The position will support all laboratory investigators who use applications involving high-throughput DNA sequencing methods for a variety of assays\, including RNA-seq\, exon sequencing\, ATAC-seq\, DNase-seq\, ChIP-seq and newer and cutting-edge methodologies such as END-seq that have recently been developed.  Salary is commensurate with experience. \n\n\n\n\nNumber of Positions: \n\n1\n\n\n\nC.V. Required: \n\nYes\n\n\n\nNumber of References Required: \n\n3\n\n\n\nExperience Required: \n\n\nQualified candidates should have: \n\nA Ph.D. in computational biology\, bioinformatics\, mathematics\, or related field with no more than five (5) years of postdoc experience;\nResearch fellows in the NCI are encouraged to apply;\nAbility to program in Python/Perl and R/Matlab in Unix environment is required;\nKnowledge of SQL will be considered a plus;\nDemonstrated applied bioinformatics/computational proficiency as evidenced by relevant publications in peer-reviewed journals;\nStrong computational as well as a strong biological background;\nAn interdisciplinary background in bioinformatics & computational biology;\nAdvanced expertise in the analysis and interpretation of sequencing data generated in-house and its integration with other “omics” data sources such as ENCODE and TCGA;\nLaboratory bench experience\, while not essential\, will be considered an advantage.\n\n\n\n\n\nHow To Apply: \n\n\nCandidates should send CV and three (3) letters of reference via email directly to sam.john@nih.gov \n\n\n\n\nContact Name: Sam John\n\n\nContact E-mail: sam.john@nih.gov\n\n\nContact Phone: 240-760-7601
URL:https://ces.b2sg.org/event/27feb19/
LOCATION:National Institutes of Health (NIH) campus\, Bethesda\, MD\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190227
DTEND;VALUE=DATE:20190331
DTSTAMP:20260905T165527
CREATED:20190227T131517Z
LAST-MODIFIED:20190227T134029Z
UID:21088-1551225600-1553990399@ces.b2sg.org
SUMMARY:Bioinformatics Specialist
DESCRIPTION:A Bioinformatics Specialist position is available in the lab of Prof. Peter D. Adams for ambitious\, independent and motivated candidates to join the team investigating the epigenetics of aging and cancer at Sanford-Burnham-Prebys Medical Discovery Institute\, San Diego. The successful candidate will use computational and bioinformatics approaches to investigate age-associated epigenetic events\, derived from mouse tissues and cell culture models\, are related to epigenetic hallmarks of aging and disease\, most notably cancer. Datasets will include ChIP-seq\, RNA-seq\, ATAC-seq\, DNA methyl-seq and other large-scale epigenomic and chromatin analyses\, including at the single-cell level\, as well as results from high throughput chemical and RNAi/CRISPR phenotypic screens. \nPrimary Responsibilities\n\n\n\nPerforms computational analysis and integration of large transcriptomic and epigenetic datasets\nProvides access of public genetic\, epigenetic and transcriptomic large datasets\, for integration with those datasets generated in the lab\nUtilizes existing lab data analysis pipelines\nBuilds new data analysis pipelines\, e.g. for single cell RNA-seq and ATAC-seq.\nManages large dataset storage\, in databases\, lab wiki and lab UCSC browser\nPresents results to lab members at weekly lab meetings\nPresents results and data within SBP\, local La Jolla meetings and national and international meetings\, as appropriate\nMaintains and initiates collaborations between Adams lab and other labs in SBP\, San Diego\, US and worldwide\n\n\n\nRequired Skills \nRequired Experience \n\n\n\nBachelor’s Degree in Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies AND a minimum of 5 years work experience OR a Master’s degree in Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies AND 3 years of work experience in related field OR Ph.D. in Computer Science\, Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies\, is required\nPh.D. degree in Computer Science\, Bioinformatics\, or Life Sciences or equivalent studies is preferred\nExperience or background in molecular biology or biochemistry is preferred\nExperience with Illumina NGS data analysis is preferred\nPrevious Postdoc training is not required\n\n\n\nKnowledge\, Skills and/or Abilities\n\nGeneral familiarity with wet lab assays\nExcellent bioinformatics and programming skills (e.g. Perl\, Python\, C/C++\, Java\, R or Web applications)\nStrong command of Linux/UNIX operating system\nStrong knowledge and skills in bioinformatics\, statistics and next-generation sequencing data analysis\nAbility to use current bioinformatics tools and have an in depth knowledge of advanced sequencing and array-based technologies\nCommunicates effectively and collaborates well with Principal Investigators and their team members\nHave strong organizational and problem-solving skills\nPossesses strong attention to detail\, analytical and time management skills\nExcellent communication and interpersonal skills\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/sbp-27feb19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190228
DTEND;VALUE=DATE:20190401
DTSTAMP:20260905T165527
CREATED:20190228T101141Z
LAST-MODIFIED:20190228T101141Z
UID:21092-1551312000-1554076799@ces.b2sg.org
SUMMARY:Research Associate - Biology
DESCRIPTION:The Disease Biology Group in the Protein Homeostasis Thematic Center of Excellence (PH TCOE) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a highly motivated Research Associate with experience in molecular biology and state-of-the-art techniques of epigenetic profiling such as ATAC-seq and ChIP-seq. The successful candidate will work collaboratively in a multi-disciplinary environment to further our understanding of the molecular mechanism of action of our novel compounds and targets. Responsibilities will include to design and execute genetic and epigenetic studies in multiple disease models to support drug target validation\, mechanism of drug action\, biomarker discovery and potential drug combination strategies.  The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership. \nProtein Homeostasis at Celgene \nThe PH TCoE at Celgene is one of the fundamental research and early development engines delivering therapeutics to patients.  As a thematic center\, the PH TCoE is agnostic to therapeutic modality or disease area. The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system\, protein translation\, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company’s most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic\, exciting and creative environment that exploits excellent science in biology\, biochemistry\, structural biology\, computational biology and translational development. \nResponsibilities will include\, but are not limited to the following: \nWork independently to design\, execute\, analyze\, interpret and troubleshoot scientific experiments in molecular and cell biology\, cellular biochemistry and assay development Accurately maintain written reports and present results in an organized and timely manner to supervisor and colleagues Communicate with peers and supervisors\, foster teamwork and contribute to collaborative efforts Strong commitment to quality and demonstrate adaptability \nSkills/Knowledge Required: \n\nBachelor’s degree in molecular biology\, cell biology\, or related scientific discipline with at least 2 years laboratory experience.\nHands-on experience with molecular biology techniques including but not limited to\, quantitative PCR\, ATAC-seq and ChIP-seq and manipulation/editing of gene/message/protein via RNAi and/or CRISPR methods\nExperience with mammalian cell culture and cell-based assays to analyze compound effects (Western blot\, ELISA\, immunoprecipitation\, immunofluorescence and functional assays such as cell cycle and apoptosis)\nExcellent communication\, presentation and organizational skills are required as well as the ability to independently design\, execute\, and troubleshoot experiments through completion\nData analysis skills and experience with a variety of scientific software applications are required\nAbility to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.
URL:https://ces.b2sg.org/event/cel-28feb19/
LOCATION:Celgene\, 86 Morris Ave\, Summit\, NJ\, 07901\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190301
DTEND;VALUE=DATE:20190402
DTSTAMP:20260905T165527
CREATED:20190301T224956Z
LAST-MODIFIED:20190301T225457Z
UID:21095-1551398400-1554163199@ces.b2sg.org
SUMMARY:Life Science Technician I
DESCRIPTION:Stanford University is seeking a Life Science Technician to perform techniques independently involved in cancer biology\, stem cell biology and molecular medicine. \n \nAbout the Department of Pathology\nComprised of extraordinary faculty and staff\, our mission is to improve the diagnosis\, treatment and basic understanding of human disease.  We accomplish this through our clinical services\, research\, and training the future leaders in pathology and related fields.  A major focus of clinical research in the Department continues to be the correlation of patient outcome and treatment response with the surgical pathologic diagnosis of human cancers.  Everything we do is to provide the highest quality of pathology diagnostic services to the patients for whom we passionately care. \n \nFor more information about the department visit http://pathology.stanford.edu/  \n  \nDescription:\nThe Department of Pathology\, Van Rechem Lab\, seeks a Life Science Technician 1 (LST-1) to assist with research projects in epigenetics and cancer. The LST-1 will perform routine technical tasks in cellular and molecular biology\, including cell culture maintenance\, FACS\, qPCR\, protein immunoblots\, cloning\, preparation and aliquote of reagents. The LST-1 will also assist in maintaining lab organization as needed. \n\n\nQualifications:\n\nApproximately one year of previous laboratory experience in molecular and/or cellular biology is required. Basic technical writing beneficial but not required.\nMust be capable of and willing to pay strict attention to detail\, including following written and oral instruction.\n\nFamiliarity with the following experimental techniques preferred:\n\n\n\n\nplasmid cloning\ntissue culture\nimmunohistochemistry (IHC) and/or immunofluorescence (IF)\nflow cytometry (FACS)\nWestern Blot\nQPCR\n\n\n\n\nMust be detail-oriented and able to keep accurate records of experiments.\nGeneral understanding of scientific principles.\nGeneral computer skills and ability to quickly learn.\nAbility to work under deadlines with general guidance.\nExcellent organizational skills and demonstrated ability to accurately complete detailed work.\n\n\nEDUCATION & EXPERIENCE (REQUIRED):\nOne year’s employment experience in laboratory work or equivalent training. \n \nKNOWLEDGE\, SKILLS AND ABILITIES (REQUIRED):\nMust be detail-oriented and able to keep accurate records of experiments.\nGeneral understanding of scientific principles.\nGeneral computer skills\, experience with databases.\nAbility to work under deadlines with general guidance is essential.\nExcellent organizational skills and demonstrated ability to complete detailed work accurately.\n \nPHYSICAL REQUIREMENTS*:\nFrequently stand\, walk\, twist\, bend\, stoop\, squat\, grasp lightly\, use fine manipulation\, grasp forcefully\, perform desk-based computer tasks\, use telephone\, write by hand\, lift\, carry\, push and pull objects weighing over 40 pounds.\nOccasionally sit\, kneel\, crawl\, reach and work above shoulders\, sort and file paperwork or parts.\nMust have correctible vision to perform duties of the job.\nAbility to bend\, squat\, kneel\, stand\, reach above shoulder level\, and move on hard surfaces for up to eight hours.
URL:https://ces.b2sg.org/event/1mar19/
LOCATION:Stanford University\, School of Medicine\, 291 Campus Drive\, Stanford\, CA\, 94305\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190306
DTEND;VALUE=DATE:20190408
DTSTAMP:20260905T165527
CREATED:20190306T132535Z
LAST-MODIFIED:20190306T132626Z
UID:21099-1551830400-1554681599@ces.b2sg.org
SUMMARY:Postdoctoral Associate- Bioinformatics
DESCRIPTION:The Terskikh laboratory has a Postdoctoral Associate opening. The Terskikh laboratory is thriving is at the intersection of neurogenesis (including neural crest and adult hippocampal neurogenesis)\, brain cancer (glioblastoma)\, and epigenetic regulation. We have established mouse models of adult neurogenesis using conditional ablation of SOX2 and primary cilia (Shh signaling) in radial glia stem cells and developed a novel platform for microscopic imaging of epigenetic landscape (MIEL) in single cells. MIEL uses advanced imaging and machine learning to investigate the change of epigenetic signatures during cell differentiation and upon exposure to the environment\, including the high throughput drug screening format. We have also established a pipeline for hair follicle regeneration using human induced pluripotent stem cells. The Postdoctoral Associate will be developing his/her own project while supporting several ongoing projects in the laboratory through automating information and analysis pipelines\, data integration\, pattern-matching analyses and visualization of a variety of different data sets\, including single cell sequencing\, bulk NGS\, ChIP-Seq\, Nuc-Seq\, ATAC-Seq\, and proteomics. \nTO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter\, CV\, references and list of any publications or accomplishments.  \nPrimary Responsibilities\n\nUtilizes heterogeneous high-throughput datasets (bulk RNA-Seq\, single cell RNA-seq\, proteomics) collected from cellular and animal models to discover networks and pathways and to generate functional predictions and testable hypotheses (e.g. using Cytoscape\, IPA\, WGCNA\, NextBio)\nIndependently design and perform experiments and procedures with high degree of complexity\, demonstrating increasing expertise with a wide range of techniques\nSupports projects directed by lab investigators and contributes to the general technical knowledge of researchers\nWrites reports\, manuscripts\, and application for funding with increasing responsibility over time\nWorks collaboratively across lab functions and train other junior lab staff as needed\n\nRequired Experience \n\nPh.D. degree in bioinformatics or biological sciences (including Computer Science\, Bioinformatics\, Biostatistics\, Life Sciences) is required\nStrong emphasis on bioinformatics\, preferably related to genetics of disease\nThe qualified candidate should have proven experience in one or more of the following areas:  Bioinformatics or molecular biology and genetics or related discipline with an emphasis on bioinformatics\n1-2 years of experience after PhD degree is preferred\n\nKnowledge\, Skills and/or Abilities\n\nStrong ability in bioinformatics\, systems biology\, sequence analyses\, network analyses or genetics including expertise in high-throughput data analyses\, such as RNA-Seq\, single cell RNA-seq\, differential gene expression analyses\, gene co-expression analyses\, and proteomics\nStrong programming skills (Python\, R\, Java or C++ and Unix/Linux shell)\nFamiliarity with algorithms and tools\, such as Bowtie\, cufflinks\, BWA\, STAR\, RSEM\, UCSC Genome Browser\, samtools\, bedtools\, vcf-tools etc\nKnowledge of machine learning approaches is a plus\nDemonstrated ability for independent and critical thinking\, excellent communication and teamwork skills\nHas strong publication record (at least one first-author publication is preferred)\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/3mar19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190306
DTEND;VALUE=DATE:20190408
DTSTAMP:20260905T165527
CREATED:20190306T133939Z
LAST-MODIFIED:20190306T134527Z
UID:21102-1551830400-1554681599@ces.b2sg.org
SUMMARY:Research Scientist II
DESCRIPTION:We are seeking an exceptional cancer biologist to join our team of scientists engaged in an industry collaboration to leverage the therapeutic potential of cancer genomic discoveries. The successful candidate will be expected to independently design and carry out target validation\, mechanism of action\, and assay development experiments using diverse molecular\, cellular\, and biochemical techniques. Additional responsibilities include the generation and study of models of resistance to small molecule inhibitors. Applicants should have established expertise in cancer biology\, as demonstrated by a track record of high-impact publications\, and will be expected to collaborate and communicate effectively.  Knowledge of epigenetics or kinase biochemistry would be a plus. \nREQUIREMENTS \n\nPhD in the life sciences with 2+ years of relevant research experience
URL:https://ces.b2sg.org/event/bi-6mar19/
LOCATION:Broad Institute\, 415 Main St\, Cambridge\, MA\, 02142\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190308
DTEND;VALUE=DATE:20190410
DTSTAMP:20260905T165527
CREATED:20190308T205131Z
LAST-MODIFIED:20190308T210258Z
UID:21104-1552003200-1554854399@ces.b2sg.org
SUMMARY:Post Doctoral Associate
DESCRIPTION:CORE JOB FUNCTIONS \nConducts research on specific areas of study as assigned. Prepares research reports and technical papers for publishing. Investigates the feasibility of applying a wide variety of scientific principles and theories. Maintains substantial knowledge of state-of-the-art principles and theories. Develops advanced analytical models and systems and provides solutions and analyses to support strategic and tactical decisions. Adheres to University and unit-level policies and procedures and safeguards University assets. \nThis list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary. \nCORE QUALIFICATIONS \nEducation: \nPh.D. required \nCertification and Licensing: \nNot Applicable \nExperience: \nNo prior experience required \nKnowledge\, Skills and Attitudes: \n\nSkill in collecting\, organizing\, and analyzing data.\nAbility to recognize\, analyze\, and solve a variety of problems.\nAbility to exercise sound judgment in making critical decisions.
URL:https://ces.b2sg.org/event/8mar19/
LOCATION:University of Miami\, 1320 S Dixie Hwy\, Coral Gables\, FL\, 33146\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190309
DTEND;VALUE=DATE:20190411
DTSTAMP:20260905T165527
CREATED:20190309T131805Z
LAST-MODIFIED:20190309T133035Z
UID:21106-1552089600-1554940799@ces.b2sg.org
SUMMARY:In Vivo Pharmacology Scientist (non-PhD)
DESCRIPTION:We seek an accomplished Scientist level oncologist/immunologist to join the in vivo pharmacology group within the Oncology Research Unit (ORU) of Pfizer’s Worldwide Research & Development (WRD) division in La Jolla\, California. The successful candidate will join a dynamic team of scientists in the Oncology In Vivo Pharmacology Group\, playing a leading role in the characterization of models of cancer and evaluating new drug candidates. \nParticipate in pre-clinical drug discovery and development projects with a focus on targeted therapeutics\, epigenetics and the tumor microenvironment. Characterize and develop small molecules in close collaboration with partner lines as an integral member of drug discovery teams. Evaluate anti-tumor effects in combination with biologics. Employ and develop new cutting-edge in vivo mouse and human cancer models. Provide technical and scientific expertise in in vivo pharmacology to the tumor cell biology department to enable target identification\, validation\, prioritization and efficient drug discovery of small molecules. \nThe candidate must have a strong background in hands-on laboratory based experimentation.   Experience with scRNA sequencing technologies (10X Genomics) is required. Knowledge in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20\, Cytobank\, FlowJo\, FACS\, MACS) is desired. Ideal applicants will have excellent communication and organizational skills\, critical problem-solving abilities\, and a commitment to excellence. \nROLE RESPONSIBILITIES  \n\nExecute and analyze cells within the tumor microenvironment by multi-parameter flow cytometric and RNAseq studies.\nCharacterize new in vivo mouse models\, including syngeneic tumor and genetically engineered mouse (GEM) models\, to study biologic mechanisms and support exploration of novel therapies.\nConduct in vivo studies to evaluate and establish efficacy\, PK/PD relationship\, combination strategy\, biomarker identification and analysis.\nInterpretation\, presentation and documentation of experiments.\nPresentation of results within a multidisciplinary team environment.\n\nBASIC QUALIFICATIONS  \n\nBS/MS in Cancer Biology\, Immunology or equivalent experience in a related discipline.\n> 6 years of laboratory work experience in academia or industry\nHands on laboratory skills. In vivo skills (IV\, PO dosing)\, blood/tissue collection is a plus.\nAbility to follow novel scientific or technological developments\, and to implement them in the laboratory.\nExcellent written and oral communication and presentation skills in English.\nStrong ability to multi-task and work productively in a fast-paced\, highly collaborative\, and diverse team environment. Capability to contribute to a vivid and challenging intellectual environment.\n\nPREFERRED QUALIFICATIONS \n\nExpertise in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20\, Cytobank\, FlowJo\, FACS\, MACS) or scRNA sequencing technologies (10X Genomics) preferred\nExperience with animal models of human cancers preferred.
URL:https://ces.b2sg.org/event/9mar19/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190310
DTEND;VALUE=DATE:20190412
DTSTAMP:20260905T165527
CREATED:20190310T103556Z
LAST-MODIFIED:20190310T103556Z
UID:21108-1552176000-1555027199@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow in the laboratory of Dr. Sangeeta Dhawan\, at the Diabetes and Metabolism Research Institute. The lab is looking for a highly motivated postdoctoral fellow interested in studying the epigenetic regulation of pancreatic beta-cell mass in health and diabetes. In addition\, the lab is interested in the dynamics of beta-cell diversity\, islet organization and cell-cell interaction in fetal and neonatal development. The Dhawan lab utilizes genetic mouse models\, molecular biology and epigenetic techniques to study the cellular identity\, function\, remodeling\, and survival of beta-cells in physiological and pathological conditions. \nThe ideal candidate will have extensive experience in molecular biology and cell or developmental biology. Experience with epigenetic techniques and rodent models preferred.  The candidate should be self-motivated\, with a proven track record of productivity.\n \n \n  \nBasic education\, experience and skills required for consideration: \n\nPhD in Molecular\, Cellular or Developmental Biology.\nStrong interest in diabetes research.\nExtensive experience with basic molecular biology skills.\nExperience with tissue collection\, histology\, immunohistochemistry\, and cell sorting.\nExperience with cell culture\, immunofluorescence\, and flow cytometry.\nStrong work ethic\, meticulous and detail-oriented record keeping habits.\nExcellent written and verbal communication skills. Evidence of productivity reflected in first author publications in peer-reviewed journals.\nGood problem solving skills and passion to follow relevant literature.\nAbility to conduct independent research\, and work effectively in a team.\n\nPreferred education experience and skills: \n\nExperience in handling animal models.\nExperience with epigenetic techniques.
URL:https://ces.b2sg.org/event/hope-10mar19/
LOCATION:City of Hope\, 1500 East Duarte Road\, Duarte\, 91010\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190312
DTEND;VALUE=DATE:20190414
DTSTAMP:20260905T165527
CREATED:20190312T185617Z
LAST-MODIFIED:20190312T185617Z
UID:21111-1552348800-1555199999@ces.b2sg.org
SUMMARY:Associate Computational Biologist
DESCRIPTION:Focus: Chromatin and gene regulation in human disease \nKadoch Laboratory\, Dana-Farber Cancer Institute/HMS/Broad Institute \nThe Kadoch Laboratory at the Dana-Farber Cancer Institute\, Harvard Medical School\, and Broad Institute is seeking a highly qualified post-graduate student (student graduating with BA/BS this Spring/Summer 2019 or in the previous year) to join our team as a Computational Biologist focused at the intersection of cancer biology\, epigenetics\, and chromatin regulation. Our lab uses multidisciplinary approaches including genomics and epigenomics\, systems biology\, functional genetic screening\, biochemistry\, structural biology\, and chemical biology\, to explore the mechanisms of chromatin remodeling complexes\, which are frequently mutated in human cancers and other diseases. Our exciting and diverse set of projects involve collaborations across the Harvard and MIT centers in Boston and Cambridge. \nThis is a unique opportunity with significant potential for the student to work closely with the PI and carry forward independent projects resulting in presentations and publications. Computational Biologists in our laboratory participate in lab meetings and journal clubs\, participate in subgroup meetings\, work closely with graduate students and postdocs\, and have typically authored several publications prior to entering PhD or MD/PhD programs following their time in our lab. The successful applicant will have advanced experience in R and/or Python and familiarity with genomics-centered approaches such as ChIP-seq\, RNA-seq\, ATAC-seq\, Hi-C\, and others through prior lab research experience as well as undergraduate coursework. The ideal candidate will also have some familiarity with chromatin biology and in reading and dissecting literature in this area. We are looking for candidates who can dedicate at least two years in the lab and who may be considering applying to graduate and/or medical school following their time in the lab. The ideal candidate will be exceptionally motivated\, detailed\, goal-oriented and will possess excellent organizational\, communication\, and analytical skills. \nPlease see http://www.kadochlab.org; twitter: @kadochlab; @ckadoch for more information\, as well as PubMed for recent papers from our lab:https://www.ncbi.nlm.nih.gov/pubmed/?term=kadoch+c.
URL:https://ces.b2sg.org/event/12mar19/
LOCATION:DC
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190314
DTEND;VALUE=DATE:20190416
DTSTAMP:20260905T165527
CREATED:20190314T142734Z
LAST-MODIFIED:20190314T142912Z
UID:21113-1552521600-1555372799@ces.b2sg.org
SUMMARY:Research Technician
DESCRIPTION:There is an immediate opening for a research technician in Qi group at the Dana-Farber Cancer Institute to look for exceptional researcher in Chemistry and Chemical Biology field. The Qi lab studies gene regulatory pathways using the emerging discipline of chemical biology. Successful candidates will work with an interdisciplinary team of scientists including medicinal chemists\, biochemists\, computational biologists\, and cancer biologists to develop novel inhibitors of chromatin modifying enzymes\, such as methyltransferases\, demethylases as well as other epigenetic targets and transcription factors. The successful candidate will perform research that establish fundamental insights to cancer biology using novel small molecule inhibitors to gain mechanistic understanding in cancer therapy. We expect that novel therapeutics for human clinical investigation will emerge directly from these efforts through academic/industry collaborations. \nThis position will assist scientists in performing scientific research\, development and/or clinical tasks of varying complexity. In general\, this position will assist in the set up\, operation and maintenance of laboratory instruments and equipment\, monitoring experiments\, making observations and calculating and recording results.  \nWe are looking for candidates who have at least a two-year availability. \n\n\n\nResponsibilities\n\n\n\n\nSkill in organic chemistry\, compound characterization with NMR and mass spec\nUnderstanding the medicinal chemistry for small molecule inhibitor design\nPerforming laboratory experiments and conducting data analysis\nDesigning experiments and executing protocols\ndeveloping and executing design and synthesis small molecule inhibitors while investigating novel biological mechanisms of action of inhibitors in cancer with team\nMaintaining accurate records\, writing reports\, and preparing presentations\nContribute to the organization of the overall laboratory and safety\nSet up\, adjust\, calibrate\, clean\, maintain and troubleshoot equipment.\nClean\, maintain and prepare supplies and work areas and may be responsible for ordering of supplies. Collaborates with Purchasing and may be responsible for negotiating with vendors.\nConduct standardized biological\, microbiological or biochemical tests and laboratory analyses\, including the collection of information and samples from organic substances\, such as blood\, drugs\, and animals.\nIsolate\, identify and prepare specimens for examination.\nAnalyze experimental data and interpret results to write reports and summaries of findings\, including grant preparation and presentations\, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results to staff. \nParticipate in grant application process and manuscript preparation as required.\nMaintains detailed notebook of all work-related activities.\nMonitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.\nExpected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications.\nMay be responsible for the development\, modification and improvement of standard operating procedures.\nUses computers\, computer-interfaced equipment\, robotics or high-technology applications to perform work duties.\nMay be responsible for designing and executing advanced experiments and setting strategy. \nMay be responsible for the examination of animals and specimens to detect the presence of disease or other problems.\nMay be responsible for monitoring laboratory budgets.\n\n  \n\n\n\nQualifications\n\n\n\n\nBachelor’s Degree required with a major in chemistry or biochemistry preferred. \nKnowledge of information and techniques in the fields of organic chemistry\, medicinal chemistry\, or biochemistry\nMust have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.\nEnthusiastic\, team player\, and self-motivated individual\nAbility to analyze information and use logic to address work-related issues and problems.\nMust have attention to detail and be thorough in completing work tasks.\nAbility to work within a team environment.
URL:https://ces.b2sg.org/event/14mar19/
LOCATION:Dana-Farber Cancer Institute\, 450 Brookline Avenue\, Boston\, MA\, 02215\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190314
DTEND;VALUE=DATE:20190416
DTSTAMP:20260905T165527
CREATED:20190314T145033Z
LAST-MODIFIED:20190314T145123Z
UID:21116-1552521600-1555372799@ces.b2sg.org
SUMMARY:Computational Biologist / Bioinformatics Analyst
DESCRIPTION:Novartis Institutes for BioMedical Research\, Inc. (NIBR) is seeking a computational biologist / bioinformatics analyst to join the Novartis Oncology Bioinformatics Team. Oncology Bioinformatics provides computational biology expertise to the department\, from target ID through clinical development\, for both targeted and immune therapies. We work at the cutting edge of science to solve important challenges in biomedical research\, making use of both publicly available and internally generated unique and expansive preclinical and clinical datasets. The successful candidate will be highly motivated\, creative\, and an effective collaborator. \nResponsibilities will include: \n•Supporting translational biology\, model characterization\, and data mining efforts to solve unmet medical needs.\n•Implementing and developing state-of-the-art computational methods and data mining strategies to address key challenges in oncology drug discovery (e.g. drug resistance\, difficult-to-drug targets\, harnessing anti-tumor immunity).\n•Working closely with wet- and dry-lab collaborators to analyze and interpret assay data.\n•Formulating testable hypotheses and collaborating in the design of rigorous experiments. \n\n\nMinimum requirements \n•M.S. in computational biology\, statistics\, computer science\, or a related field\n•Familiar with fundamental concepts in molecular biology\, statistics\, and bioinformatics\n•Fluency in one or more programming languages with bioinformatics applications (e.g. Python or R)\n•Experience with statistical methods for mining ‘omics data (genomics\, epigenetics\, proteomics) and/or NGS data strongly preferred\n•Knowledge of cancer genomics\, immunology / immune-oncology\, clinical and translational science preferred\n•Experience with current analysis methods for processing NGS data\, high throughput pooled screening\, or other high-dimension data sets preferred
URL:https://ces.b2sg.org/event/novartis-14mar19/
LOCATION:Novartis (MA)\, 250 Massachusetts Ave\, Cambridge\, 02139\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190317
DTEND;VALUE=DATE:20190419
DTSTAMP:20260905T165527
CREATED:20190317T194959Z
LAST-MODIFIED:20190317T194959Z
UID:21119-1552780800-1555631999@ces.b2sg.org
SUMMARY:Postdoctoral Scholar
DESCRIPTION:Two Postdoctoral or Visiting Scholar positions are available to (1) study the mechanism of breast cancer metastasis and develop novel therapeutic strategies for treating metastatic breast cancer; and (2) investigate the epigenetic mechanisms of chemical carcinogenesis. These projects will use cell culture and mouse models to investigate the epigenetic mechanisms (DNA methylation\, histone posttranslational modifications and non-coding RNAs) of breast cancer metastasis and chemical carcinogenesis. Candidates should have a recent Ph.D. degree with strong background in cell/molecular biology and cancer biology. Experiences in studies on cancer epigenetics\, non-coding RNAs\, and cancer stem cells with skills in handling mice\, producing tumors in mice and treating mice with commonly-used drug administration approaches would be advantageous. The expected qualifications of candidates include: be highly self-motivated with strong interest in learning new knowledge and techniques; have excellent communication and organizational skills and attention to details\, be capable of conceptualizing\, designing experiments and conducting studies independently as well as cooperatively with other lab members as a team; and have the capability to write manuscripts for quality publications. Compensations including salary and benefits will be highly competitive depending upon candidates’ qualifications. Interested applicants\, please send a cover letter describing your research training experience\, a brief statement of your research interest\, scientific achievements and future career goal\, curriculum vitae (CV) and contact information (names\, e-mails\, and telephone numbers) of three references to: Dr. Zhishan Wang (zhishan.wang@uky.edu) or Dr. Chengfeng Yang (chengfeng.yang@uky.edu)\, Department of Toxicology and Cancer Biology\, University of Kentucky\, Lexington\, KY 40536. Only short-listed applicants will be contacted for interview. \nRequired Documents: Curriculum Vita\, Cover Letter\, Writing Sample\, Academic Transcripts\, for Specific Request 1\, please supply a copy of your PhD diploma & English translation if not in English\, and for Specific Request 2\, please submit a written document of your future career goals. \n\n\n\n\nSkills / Knowledge / Abilities\nExperiences in studies on cancer epigenetics\, non-coding RNAs\, and cancer stem cells with skills in handling mice\, producing tumors in mice and treating mice with commonly-used drug administration approaches would be advantageous. The expected qualifications of candidates include: be highly self-motivated with strong interest in learning new knowledge and techniques; have excellent communication and organizational skills and attention to details\, be capable of conceptualizing\, designing experiments and conducting studies independently as well as cooperatively with other lab members as a team; and have the capability to write manuscripts for quality publications.
URL:https://ces.b2sg.org/event/17mar19/
LOCATION:University of Kentucky\, 410 Administration Drive\, Lexington\, KY\, 40506\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190318
DTEND;VALUE=DATE:20190420
DTSTAMP:20260905T165527
CREATED:20190318T090147Z
LAST-MODIFIED:20190318T090147Z
UID:21121-1552867200-1555718399@ces.b2sg.org
SUMMARY:Research Scientist
DESCRIPTION:As part of the TRACTION team\, the Research Scientist will be part of our team of translational biologists who are responsible for leading preclinical translational activities to inform on clinical development of late-stage preclinical therapeutics. The position requires leading translational activities utilizing state-of-the-art preclinical models\, platforms and assays to discover\, validate and translate tumor biology insights into informative clinical trials. To enble these activities\, the Research Scientist will contribute to a cross-functional team\, collaborating with our corporate partners\, subject matter experts and cores across the Institution. These efforts will allow us to advance novel therapeutics currently under development by our Therapeutics Discovery teams and partners.\nBy joining the Therapeutics Discovery Division\, you have the opportunity to use your talents to make a direct impact on the lives of our patients. We are seeking a highly motivated and collaborative individual to become a part of our team. Ideal candidates will have a proven track record of leading translational efforts in support of advancing and positioning therapeutics in the clinical\, as well as possess excellent communication\, collaboration\, organization and leadership skills.\n\n\nKEY FUNCTIONS:\n\n1.Apply and develop basic science tools and methodologies to develop complex strategies and enable advancement of projects through leadership and experimental activities.\n\n2.Apply cutting edge functional genomics approaches to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.\n\n3.Independently design\, execute and interpret in vitro\, ex-vivo and in vivo experiments to validate and explore therapeutic potential of drug targets.\n\n4.Work with research\, computational biology and bioinformatics teams to utilize internal biological and oncogenomic data sets to generate and test biological hypotheses.\n\n5.Develop and implement biomarker strategies to guide early clinical development of drugs.\n\n6.Design\, develop and utilize biomarker assays to define mechanism of action for compounds and utilize pharmacodynamic markers to inform on compound activity\, response and resistance pre-clinical and clinical setting and test patient selection strategies.\n\n7.Develop extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or apoptosis.\n\n8.Adapt to new technologies and find solutions to related program studies.\n\n9.Interpret\, present and report research findings at internal meetings and external scientific conferences.\n\nEducation\nRequired: Bachelor’s degree in Biology\, Biochemistry\, molecular biology\, cell biology\, enzymology\, pharmacology\, chemistry or related field.\n\nPreferred: PhD\, MD or equivalent degree in Biology\, Cell Biology\, Molecular biology or related field\n\nExperience\nRequired: Ten years of relevant research laboratory experience. With Master’s degree\, eight years of required experience and with PhD\, two years of required experience.\n\n\nPreferred: At least two years of post-degree experience in a biotech or pharmaceutical environment.\n\n1.Evidence of utilization of cancer genetics to inform on target discovery\, validation or on clinical development of drug candidates.\n\n2.Experience with genetic (ie RNAi and cDNAs) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study target biology utilizing state of the art molecular biology and biochemistry methods and assays essential to drive projects.\n\n3.A demonstrated track record in the development and implementation of functional genomics strategies to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.\n\n4.Broad knowledge of cell culture techniques is required and knowledge of how to utilize in vivo oncology models is desirable. Hands-on experience utilizing genetically engineered mouse models and orthotopic or subcutaneous primary or established tumor cell line xenograft models is desirable.\n\n5.Extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or anti-apoptosis as evidenced by publication in peer-reviewed journals.\n\n6.Strong data analysis skills\, ability to interpret results and contribute to the design of follow-up experiments\, troubleshoot issues with assay performance\, and effectively present results and conclusions to co-workers\, collaborators and senior leadership.\n\n7.Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential.\n\n8.Flexibility to accommodate to rapidly changing priorities and deadlines is required\n\n9.Collaborative attitude and ability to work in a team-based environment is crucial for this position.\n\n10.Excellent oral and written communication skills.\n\n11.Experience mentoring junior scientists is a plus.
URL:https://ces.b2sg.org/event/18mar19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190320
DTEND;VALUE=DATE:20190422
DTSTAMP:20260905T165527
CREATED:20190320T094811Z
LAST-MODIFIED:20190320T094811Z
UID:21123-1553040000-1555891199@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:Postdoctoral Research Scientist in Mammalian Tissue & Organ Regeneration\nSeattle Children’s Research Institute & University of Washington\, Seattle\, WA\n\nPostdoctoral Scientist Position Available: An exceptional opportunity is available for a postdoctoral scientist to work on a newly funded NIH-RO1 grant at the Seattle Children’s Research Institute & University of Washington. We are studying organ regeneration & scarless wound healing in adult mammals using the African spiny mouse model (pmid: 23108966; BioRxiv-315069). Our current focus is on a comparative analysis of wound healing in human\, mouse\, and spiny mouse kidney and vascular system. We are seeking motivated individuals with a strong publication record\, an interest in translational research\, and experience in one or more of the following areas: mouse models\, RNA seq analysis\, single cell transcriptomics\, epigenetics\, enhancer characterization\, bioinformatics\, kidney or vascular development/disease\, and/or fibrosis. Screening of applicants will begin immediately and continue until the position is filled.\n\nWe are a multi-investigator group of basic and clinical investigators in Seattle\, WA. Seattle Children’s Research Institute is located in close proximity to Fred Hutchinson Cancer Research Center\, the Allen Institute\, the Institute for Systems Biology\, and the UW-South Lake Union campus. Please send a CV\, statement of research interests\, and names/contact information for three reference letters by email to:\n\nMark W. Majesky\, Ph.D.\, email: mwm84@uw.edu\, using the subject line “Postdoctoral position”.\n\n\n\nRequirements\n\n\n\nRequired education:\n\nRecent or expected Ph.D. degree in a biological discipline related to the project.\n\n\nPreferred experience in one or more of the following:\n\nSignificant experience in epigenetics-related techniques (ATAC-seq; ChIP-seq; Cut&Run assays)\nSome experience in RNA seq analysis\, validation of gene targets\, and related bioinformatics.\nSome experience in confocal or lightsheet imaging and related image analysis.
URL:https://ces.b2sg.org/event/sch-20mar19/
LOCATION:Seattle Children’s Hospital\, 4800 Sand Point Way NE\, Seattle\, WA\, 98105\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190322
DTEND;VALUE=DATE:20190424
DTSTAMP:20260905T165527
CREATED:20190322T212029Z
LAST-MODIFIED:20190322T212029Z
UID:21128-1553212800-1556063999@ces.b2sg.org
SUMMARY:Research Scientist Engineer 1
DESCRIPTION:The Dog Aging Project at the University of Washington currently has an outstanding opportunity for a RESEARCH SCIENTIST ENGINEER 1 to assist with our exploration of the epigenetic basis for aging in companion dogs.  \nOur goal is to understand how chromatin accessibility changes in dogs during the aging process\, to define epigenetic loci that are altered during the aging process\, and to establish an “epigenetic clock” for aging in companion dogs. To this end\, we seek a member of our team to refine and implement a pipeline for collection of PBMCs from donated blood samples\, quality control and flow cytometric analysis and sorting of these samples\, isolation and transposition of chromatin\, and preparation of ATAC-Seq libraries.  \nWe are seeking someone with a strong background in biology\, strong lab skills in molecular and cell biology\, and experience with chromatin biology\, next-generation sequencing library preparation\, and flow cytometry. Strong organizational skills are a must\, as this project comprises potentially hundreds to thousands of samples.  \nResponsibilities:  \nThe Research Scientist/Engineer 1 will:  \n\nIsolate PBMCs from donated blood samples. \nPerform quality control analysis on white blood cells\, including cell density and viability assessments. \nPerform flow cytometric analysis and possible sorting. \nPerform chromatin transposition (ATAC) on thawed whole or sorted cell samples. \nPrepare ATAC-SEQ libraries for next-gen sequencing analysis. \nEstablish a robust and standardized pipeline for the above steps\, including an efficient and well-organized workflow for numerous samples. \nContribute to regular meetings and one-on-one discussions about project design and progress. \nMinimum Requirements: \nBachelor’s degree in cell and molecular biology or a related discipline and at least one year of research experience of cell biology in a lab setting. \nEquivalent education/experience will substitute for all minimum qualifications except when there are legal requirements\, such as a license/certification/registration.  \nOther required qualifications include: \nPractical understanding of the principles of epigenetics and genetic regulation \nVery strong organizational skills. \nAbility to learn and integrate new analysis methods. \nExcellent oral and written communication skills. \nAbility and enthusiasm for working independently\, and also collaboratively as part of a team \nDesired: \nFlow cytometry experience \nNext-gen sequencing library preparation experience on the Illumina platform. \nPractical understanding of the cell biology of aging. \nBroad experience with next-generation sequence analysis\, including bwa\, bowtie/tophat/cufflinks\, DeSeq\, MACS2\, Galaxy\, HOMER\, or other standard next-gen software analysis software.
URL:https://ces.b2sg.org/event/22mar19/
LOCATION:University of Washington\, Seattle\, WA\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190323
DTEND;VALUE=DATE:20190425
DTSTAMP:20260905T165527
CREATED:20190323T151159Z
LAST-MODIFIED:20190323T151159Z
UID:21130-1553299200-1556150399@ces.b2sg.org
SUMMARY:Research Fellow
DESCRIPTION:Dr. Oser is seeking a highly motivated and qualified postdoctoral candidate interested in pursuing several projects aimed at identifying new therapeutic targets for SCLC.\n\nThe position will require a core foundation of molecular and cellular biology\, tissue culture\, and some basic training in mouse modeling and epigenetics.\n\nThe successful candidate will be expected to lead and develop several independent projects.\n\n\n\nQualifications\n\n\n\nThe candidate must have a MD\, PhD or MD/PhD with several years of relevant experience in molecular biology with some research experience in cancer biology.
URL:https://ces.b2sg.org/event/23mar19/
LOCATION:Dana-Farber Cancer Institute\, 450 Brookline Avenue\, Boston\, MA\, 02215\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190324
DTEND;VALUE=DATE:20190426
DTSTAMP:20260905T165527
CREATED:20190324T194116Z
LAST-MODIFIED:20190324T194116Z
UID:21132-1553385600-1556236799@ces.b2sg.org
SUMMARY:Senior Scientist\, Molecular Discovery
DESCRIPTION:This senior scientist will join the Integrative Biotechnology Group of the Pfizer Oncology Research Department where s/he will apply functional genomics to study cellular mechanisms that impact tumor response to late stage oncology pipeline assets. \nThe qualified candidate should be a highly motivated\, creative\, and collaborative individual with strong interest and publication record relevant to tumor intrinsic / extrinsic signaling regulating cell cycle progression\, epigenetics\, and/or senescence response. The candidate must be flexible to study novel mechanisms underlying tumor vulnerabilities discovered from functional genomics screening efforts. This role includes developing and applying flow cytometry based biological endpoint assays to enable prioritization of screen hits that elicit desired outcome. \nThe successful candidate must have strong communication skills and will be expected to present their research to multidisciplinary teams\, senior management\, and at external scientific meetings. \nROLE RESPONSIBILITIES  \n\nDevelop and execute assays for in vitro / in vivo synthetic lethal functional genomics screens in relevant cancer models to discover genes that impact sensitivity or resistance to late stage oncology compounds.\nPrioritize drug discovery opportunities by integrating screen results with knowledge gained from publicly available datasets and multi-omics profiling of tumor response to small molecule inhibitors.\nCollaborate with a diverse team of cancer and molecular biologists to validate and determine the mechanism of action of prioritized targets.\nIncorporate advances in CRISPR/RNAi technologies to maintain cutting edge functional genomics platform.\nPresent key findings that highlight research progress and opportunities to senior management and at internal meetings.\nContinue excellent publication and presentation record by publishing research discoveries in high impact journals and presenting at external scientific conferences.\n\nBASIC QUALIFICATIONS  \n\nPh.D. in Cell Biology or related discipline and 3+ years of academic experience at the postdoctoral level or 2+ years of industry experience in cancer research.\nBroad understanding of and advanced technical expertise in research of signaling pathways that underlie cell cycle progression\, epigenetics\, and/or mechanisms that govern senescence.\n\nPREFERRED QUALIFICATIONS \n\nExperience executing pooled CRISPR/RNAi screens in cancer models in vitro and / or in vivo.\nStrong technical expertise in flow cytometry / sorting.\nDeveloped/applied biological endpoint assays to gain mechanistic insights into the consequences of gene knockdown or inhibition.\nExperience working with 2D and 3D mammalian cell culture systems.\nExpert molecular biology skills as well as expertise in immunofluorescence\, immunoprecipitation\, transgene mutagenesis / expression\, western blot\, and Q-PCR.\nSignificant impact in field of study as demonstrated by publications in top tier peer-reviewed research journals.
URL:https://ces.b2sg.org/event/24mar19/
LOCATION:Pfizer – Pearl River\, NY\, 401 North Middletown Road\, Pearl River\, NY\, 10965\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190325
DTEND;VALUE=DATE:20190427
DTSTAMP:20260905T165527
CREATED:20190325T131859Z
LAST-MODIFIED:20190325T131859Z
UID:21134-1553472000-1556323199@ces.b2sg.org
SUMMARY:Postdoctoral Research Associate
DESCRIPTION:Multiple postdoctoral research associate positions available for highly motivated candidates with a fresh PhD training in molecular biology\, biochemistry and cell biology to join the Lineberger Comprehensive Cancer Center and Department of Biochemistry\, University of North Carolina at Chapel Hill (UNC) School of Medicine\, USA. Our lab (http://www.gregwanglab.com) emphasizes on mechanistic understandings of gene regulation\, chromatin\, stem cells\, and human disease notably cancer. We have recently published our findings at various gene regulatory mechanisms\, including those related to DNA methyltransferase and histone modifying enzymes\, at Molecular Cell (2013); Blood (2015); Cell Reports (2015); Cancer Cell 2016; Nature (2018); Stem Cell Reports (2018) and Molecular Cell (2018). With recent acquisition of funds from NIH and NCI\, we have multiple positions available for 1) Bioinformatics associate focused on computation analysis of genomics dataset 2) Postdoctoral associates focused on experimental biology The on-going projects include (1) biochemical characterization of epigenetic factors/complexes that regulate gene expression in stem cells or cancer cells; (2) CRISPR/dCas9-based editing and screening of pathways crucial for cancer development; (3) knockout and knock-in mouse models with deficiency in histone /DNA methylation regulation in context of development and tumorigenesis\, with a special focus on hematopoietic disease; (4) epigenomic and transcriptome analyses (ChIP-Seq and RNA-Seq) of normal versus cancer cells to understand 3D chromatin structure and to delineate pathways essential for tumor growth. \n\n\n\n\nMinimum Qualifications: \nApplicants should be self-motivated with a track record of publication in the above area\, have laboratory and analytical skills\, and be a critical thinker. Application shall include CV\, a cover letter (with summary of research experiences and future interests\, and expected availability date)\, reprints of publications\, and contact information of three references.   Ph.D. training in molecular biology\, cell biology or biochemistry related field.
URL:https://ces.b2sg.org/event/25mar19/
LOCATION:University of North Carolina – UNC-Chapel Hill\, Chapel Hill\, NC\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190327
DTEND;VALUE=DATE:20190429
DTSTAMP:20260905T165527
CREATED:20190327T171057Z
LAST-MODIFIED:20190327T213323Z
UID:21137-1553644800-1556495999@ces.b2sg.org
SUMMARY:Research Professional 2
DESCRIPTION:The research professional will conduct research in aspects of chemical carcinogenesis\, epigenetics\, and chemical biology relevant to our ongoing studies of DNA adducts and epigenetic deregulation in lung cancer. This position is expected to provide daily support to the research activities in the laboratory by conducting cell culture and animal experiments in support of many ongoing projects\, lab organization\, documentation\, and supply orders. \nPrincipal Duties and Responsibilities:\n40 % Cell culture experiments\nMaintain mammalian cell culture\, Conduct cell culture treatments\, extract proteins\, RNA\, DNA \n30 % Management of the research laboratory\nTake care of supply orders\, lab organization\, support smooth operation of the lab. \n15% Animal experiments\nOperate animal exposures\, collect tissues\, extract proteins\, RNA\, DNA \n10 % Record-keeping and Preparation of Manuscripts\nMaintaining detailed laboratory records; preparing data for manuscripts and presentations. \n5% Training Graduate and Undergraduate Students\nTraining of students in proper cell culture techniques \nSupervision:\nResearch professional will be trained by\, and work in conjunction with a faculty mentor (Natalia Tretyakova) who determines the training agenda. They report to Natalia Tretyakova. \nThe Department of Medicinal Chemistry consists of a diverse group of faculty members\, graduate students and postdoctoral fellows\, and research scientists working at the interface of chemistry and biology and is home to the editorial offices of the Journal of Medicinal Chemistry and ACS Infectious Diseases. \nThe department is part of the College of Pharmacy and Academic Health Center\, which house nationally and internationally acclaimed programs in the areas of biochemistry\, neuroscience\, pharmacology\, virology\, immunology\, cancer biology\, structural biology\, and drug delivery. \nApplications must be submitted online. To be considered for this position\, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume. \nAdditional documents may be attached after application by accessing your “My Job Applications” page and uploading documents in the “My Cover Letters and Attachments” section. \nTo request an accommodation during the application process\, please e-mail employ@umn.edu or call (612) 624-UOHR (8647).
URL:https://ces.b2sg.org/event/27mar19/
LOCATION:DC
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190328
DTEND;VALUE=DATE:20190430
DTSTAMP:20260905T165527
CREATED:20190328T194943Z
LAST-MODIFIED:20190328T194943Z
UID:21145-1553731200-1556582399@ces.b2sg.org
SUMMARY:Scientist (non-PhD)
DESCRIPTION:Pfizer is seeking applications for an exceptional non-PhD scientist with chemical biology\, cell biology and mass spectrometry-based proteomics experience. Such a candidate will be a highly motivated and creative scientist with the desire to join and support chemical biology and proteomics capabilities for our oncology pipeline. This person will align across Pfizer’s tumor cell biology groups enabling impact across the small molecule oncology portfolio from early exploratory target identification through the drug discovery pipeline and into early clinical development.  \nThe individual will support and aid in the development and application of chemical biology and innovative mass spectrometry platforms. Their work will drive a deeper understanding of our molecules and cellular targets. Relevant methodologies include but are not limited to: identification of novel oncology targets\, small molecule target deconvolution\, small molecule target occupancy studies using chemical probes\, direct substrate identification and characterization\, protein turnover studies\, protein post-translation modification studies and small molecule–protein interactome analyses. \nROLE RESPONSIBILITIES  \n\nApply quantitative protein mass spectrometry technologies for chemo-proteomics and general proteomics across the oncology portfolio.\nParticipate in all aspects of laboratory operations including sample preparation\, running samples on the MS\, data analysis and interpretation.\nDevelopment of methods for direct identification of kinase substrates.\nPresenting and reporting data with follow up discussions for project teams including data impact and interpretation.\nComplete and effectively manage multiple projects within timelines ensuring that all tasks and responsibilities are carried out according to high scientific and ethical standards.\nEngage in collaborative and strategic partnerships with internal research teams to apply proteomics for oncology discovery\, impacting all oncology research focuses including: Systems Therapeutics\, Tumor Intrinsic Biology\, Immuno-oncology and Epigenetics.\n\nBASIC QUALIFICATIONS \n\nA qualified applicant holds a M.S/B.S. in biological sciences\, chemical biology\, analytical chemistry\, or a related field.\n6+ years of research experience with applied cell biology\, chemical biology and mass spectrometry-based proteomics desired.\nExpertise in growing\, maintaining and harvesting cancer cells lines.\nGeneral understanding of chemical proteomics methodologies including small-molecule affinity enrichment\, target occupancy and Chem-Seq. \nGeneral understanding of target deconvolution methods including CETSA\, DARTS\, FUSION and chemical probes/proteomics.\nExcellent verbal and written communication skills.\nKnowledge and application of complex sample preparation methodologies as applied to protein mass spectrometry workflows.\nAbility and understanding of methods to characterize protein post-translational modifications including phosphorylation\, methylation\, acetylation\, PARylation and ubiquitination.\nExperience and knowledge in the operation of different types of mass spectrometers including Q Exactive Hybrid Quadrupole and Orbitrap Fusion Lumos Tribrid.
URL:https://ces.b2sg.org/event/28mar19/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190329
DTEND;VALUE=DATE:20190404
DTSTAMP:20260905T165527
CREATED:20181010T135414Z
LAST-MODIFIED:20181011T070426Z
UID:20732-1553817600-1554335999@ces.b2sg.org
SUMMARY:AACR Annual Meeting 2019
DESCRIPTION:Integrative Cancer Science • Global Impact • Individualized Patient Care \nFriday\, March 29-Wednesday\, April 3\, 2019\nGeorgia World Congress Center\nAtlanta\, Georgia \n  \nProgram Committee Chair\nJohn D. Carpten\, USC Keck School of Medicine\, Los Angeles\, California \n\nDownload the Call for Abstracts\nAbstract Submission Deadline: Thursday\, Nov. 15\, 2018\, 11:59 p.m. ET\nLate-Breaking and Clinical Trials Abstract Submission Deadline: Thursday\, Jan. 10\, 2019\, 11:59 p.m. ET\nHousing Deadline: Wednesday\, Feb. 13\, 2019\nEarly Registration Deadline: Friday\, Dec. 7\, 2018\, 11:59 p.m. ET\n\nThe AACR Annual Meeting program covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology\, translational\, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world.  More information about the AACR Annual Meeting 2019 will be available online and in the Call for Abstracts in late August 2018.  \nProgram Committee Vice Chairs\nKenneth C. Anderson\, Dana-Farber Cancer Institute\, Boston\, Massachusetts\nMarcia R. Cruz-Correa\, University of Puerto Rico Comprehensive Cancer Center\, San Juan\, Puerto Rico\nTodd R. Golub\, Broad Institute of MIT and Harvard\, Cambridge\, Massachusetts\nStephen D. Hursting\, University of North Carolina at Chapel Hill\, Chapel Hill\, North Carolina\nPatricia M. LoRusso\, Yale Cancer Center\, New Haven\, Connecticut\nRichard M. Marais\, Cancer Research UK Manchester Institute\, Manchester\, United Kingdom\nAviv Regev\, Massachusetts Institute of Technology and Broad Institute of MIT and Harvard\, Cambridge\, Massachusetts\nAntoni Ribas\, UCLA Medical Center\, Los Angeles\, California\nBrian M. Rivers\, Morehouse School of Medicine\, Atlanta\, Georgia\nDavid A. Tuveson\, Cold Spring Harbor Laboratory Cancer Center\, Cold Spring Harbor\, New York \nProgram Committee Cochairs\nNilofer S. Azad\, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center\, Baltimore\, Maryland\nAnna D. Barker\, Arizona State University\, Scottsdale\, Arizona\nJulian Blagg\, Institute of Cancer Research\, Sutton\, Surrey\, United Kingdom\nJohn M. Carethers\, University of Michigan\, Ann Arbor\, Michigan\nLouis Chesler\, Institute of Cancer Research\, Sutton\, United Kingdom\nDavid C. Christiani\, Harvard Medical School\, Boston\, Massachusetts\nMario P. Colombo\, Fondazione IRCCS Istituto Nazionale Tumori\, Milan\, Italy\nJoseph N. Contessa\, Yale University\, New Haven\, Connecticut\nLisa M. Coussens\, OHSU Knight Cancer Institute\, Portland\, Oregon\nDavid W. Craig\, USC Keck School of Medicine\, Los Angeles\, California\nChristina Curtis\, Stanford University\, Stanford\, California\nRiccardo Dalla-Favera\, Columbia University Institute for Cancer Genetics\, New York\, New York\nCaroline Dive\, Cancer Research UK Manchester Institute\, Manchester\, United Kingdom\nLaura Fejerman\, University of California\, San Francisco\, San Francisco\, California\nKevin L. Gardner\, Columbia University\, New York\, New York\nDavid R. Gius\, Northwestern University\, Chicago\, Illinois\nMithat Gönen\, Memorial Sloan Kettering Cancer Center\, New York\, New York\nJennifer Rubin Grandis\, University of California\, San Francisco\, San Francisco\, California\nJohn D. Groopman\, Johns Hopkins University School of Public Health\, Baltimore\, Maryland\nSusan E. Hankinson\, University of Massachusetts Amherst\, Amherst\, Massachusetts\nJamie N. Holloway\, Georgetown University\, Washington\, District of Columbia\nCatriona H.M. Jamieson\, UCSD Moores Cancer Center\, La Jolla\, California\nPeter Kuhn\, University of Southern California\, Los Angeles\, California\nSherene Loi\, Peter MacCallum Cancer Centre\, Camberwell\, Victoria\, Australia\nThomas J. Lynch\, Jr.\, Bristol-Myers Squibb Co.\, New York\, New York\nCrystal L. Mackall\, Stanford University School of Medicine\, Stanford\, California\nTak W. Mak\, Campbell Family Institute for Breast Cancer Research\, Toronto\, Ontario\, Canada\nHiroyuki Mano\, National Cancer Center Research Institute\, Tokyo\, Japan\nGordon B. Mills\, OHSU Knight Cancer Institute\, Portland\, Oregon\nLisa A. Newman\, Henry Ford Health System\, Detroit\, Michigan\nKunle Odunsi\, Roswell Park Cancer Institute\, Buffalo\, New York\nMoshe Oren\, Weizmann Institute of Science\, Rehovot\, Israel\nKlaus Pantel\, University Medical Center Hamburg\, Hamburg\, Germany\nWilliam Pao\, Roche Pharma Research and Early Development\, Basel\, Switzerland\nLuis F. Parada\, Memorial Sloan Kettering Cancer Center\, New York\, New York\nElectra D. Paskett\, Ohio State University Comprehensive Cancer Center\, Columbus\, Ohio\nEdith A. Perez\, Genentech\, Inc.\, South San Francisco\, California\nEric H. Rubin\, Merck Research Laboratories\, North Wales\, Pennsylvania\nAnil K. Rustgi\, University of Pennsylvania School of Medicine\, Philadelphia\, Pennsylvania\nPatty Spears\, UNC Lineberger Comprehensive Cancer Center\, Chapel Hill\, North Carolina\nVictor E. Velculescu\, Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine\, Baltimore\, Maryland\nJennifer A. Wargo\, The University of Texas MD Anderson Cancer Center\, Houston\, Texas\nE. John Wherry III\, University of Pennsylvania\, Philadelphia\, Pennsylvania\nLouis M. Weiner\, Georgetown Lombardi Comprehensive Cancer Center\, Washington\, District of Columbia \n  \nAbout the Location\nAtlanta\, the capital of and the most populous city in Georgia\, is a cultural and economic center of the state and the ninth largest metropolitan area in the United States. The city is the primary transportation hub of the Southeastern United States\, via highway\, railroad\, and air\, with Hartsfield–Jackson Atlanta International Airport being the world’s busiest airport since 1998. Atlanta is home to nationally renowned private colleges and universities\, most notably Emory University\, a leading liberal arts and research institution that ranks among the top 20 schools in the United States. Emory University – home to Winship Cancer Institute – also operates Emory Healthcare\, the largest health care system in Georgia.
URL:https://ces.b2sg.org/event/aacr-29mar19/
LOCATION:Georgia World Congress Center\, 285 Andrew Young International Blvd NW\, Atlanta\, GA\, 30313\, United States
CATEGORIES:Meetings
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190329
DTEND;VALUE=DATE:20190501
DTSTAMP:20260905T165527
CREATED:20190329T075153Z
LAST-MODIFIED:20190329T075153Z
UID:21147-1553817600-1556668799@ces.b2sg.org
SUMMARY:Research Specialist
DESCRIPTION:A Research Specialist position is available in the Benevolenskaya lab with Department of Biochemistry and Molecular Genetics at the University of Illinois at Chicago /College of Medicine. The laboratory is broadly interested in tumor suppressor genes and epigenetic mechanisms. Research in the lab focuses on the histone demethylase KDM5A and is aimed at better understanding of the roles played by pRB and KDM5A in cell metabolism and differentiation.  \nIdeal candidate is expected to contribute to research done in the laboratory\, including the design\, execution and data analysis of experiments. Job duties include using cellular and animal models\, cellular and molecular biology techniques such CRISPR/Cas gene editing\, SDS-PAGE\, Western blotting\, PCR\, gene cloning\, and lab management.  \nBachelor’s degree in basic science and 3 years of experience in biochemistry\, molecular genetics or cancer biology. Master’s degree in science is preferred. \nRecent graduates are highly encouraged to apply. Interested candidates should send their curriculum vitae\, the names of 3 references via the University electronic application process at https://jobs.uic.edu/job-board/job-details?jobID=111435 by April 12\, 2019.  UIC is an Equal Opportunity\, Affirmative Action employer.  Minorities\, women\, veterans and individuals with disabilities are encouraged to apply. 
URL:https://ces.b2sg.org/event/29mar19/
LOCATION:University of Illinois at Chicago\, Chicago\, IL\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190330
DTEND;VALUE=DATE:20190502
DTSTAMP:20260905T165527
CREATED:20190330T162853Z
LAST-MODIFIED:20190330T162853Z
UID:21149-1553904000-1556755199@ces.b2sg.org
SUMMARY:Research Scientist
DESCRIPTION:Multiple Myeloma is a cancer of the blood system. Clinically there has been much progress in improving outcomes but 30% of cases have aggressive clinical disease that does not respond well to therapy and new-targeted therapies are required to address this. The Multiple Myeloma Program at NYU is a new initiative to understand the biology and develop new therapies for this devastating illness. Major aims of the program are to utilize biological knowledge to treat high-risk disease and to prevent the development of the disease by manipulating the evolutionary trajectory of its premalignant precursor phases\, which are common in the general population. To achieve these aims we will focus on three main areas studying the epigenetic basis of disease progression\, the role of complex genetic structural rearrangements and the impact these have on the bone marrow microenvironment. We will use advanced genetic technologies to study the biology of these different areas. The person in this position will play an important role in the program being responsible for establishing a robust research environment\, coordinating activities in the laboratory\, inputting into the coordination\, receipt and processing of clinical samples and establishing new technologies to meet the needs of the program. The position will require a sound knowledge and expertise in molecular genetic techniques and cell culture. The laboratory benefits from the vibrant scientific environment\, collaboration with leading researchers and an outstanding medical school infrastructure that supports the most advanced technologies. Responsible for collaborating with Principal Investigators (PI) and working independently within the scientific framework of the PIs Laboratory. \n\n\nJob Responsibilities: \n\nDemonstrates knowledge of the organizations Core Values and incorporates them into the performance of duties.\nInitiates\, interprets\, organizes\, executes\, and coordinates research assignments critical to departments mission.\nFormulates and conducts research on problems of considerable scope and complexity.\nExplores subject area and defines scope and selection of problems for investigation through conceptually related studies or series of projects of lesser scope.\nMakes decisions and recommendations that have a major impact on extensive scientific research activities.\nDevelops new ideas that promote current research. Exercises a high degree of creativity\, foresight\, and mature judgment in planning\, organizing\, and guiding extensive scientific research programs and activities of outstanding novelty and/or importance.\nMay manage the operations of a lab for the Principal Investigator by supervising Post Docs and technicians. Oversees the maintenance and upkeep of all instruments and laboratory facilities.\nEnsures timely and accurate completion of research projects.\nMay provide students with technical guidance and direction in the operation of various sample preparation techniques\, extraction of cell lines\, and equipment as well as general laboratory practices and safety protocols.\nMay seek grant funding from external sources in support of their independent research projects with consent of the PI and the Department Chair. May participate in writing grant proposals.\nMay be responsible for research/lab quality control and compliance.\nMay develop protocols for the collection and quality of research data.\nDevelops research techniques and methodologies.\nMay determine and establish laboratory policies\, procedures and practices.\nMaintains a thorough knowledge of the advances in specialized fields through attendance of scientific conferences.\nMay make significant contributions to scientific paper writing and act as a resource/ author/ co-author for reports and presentations.\nMay provide recommendations for equipment purchases and for the redesign of lab space.\nMay coordinate the activity and experimental design between various labs\, scientific staff\, and collaborators. Identifies and resolves technical problems.\nMay serve on internal committees to help further goals of research projects and bring new expertise to the research program.\nPerforms other related duties as assigned.\n\n\n\nMinimum Qualifications:\nTo qualify you must have a MS degree and 2-4 years of experience. \n\n\nPreferred Qualifications:\nSubstantial experience from having completed Post Doc training. Established a record of publications. PhD Degree\nExperience:\nMolecular genetic skills\nExperience with PDX models\nCell culture \n\n\nQualified candidates must be able to effectively communicate with all levels of the organization.
URL:https://ces.b2sg.org/event/30mar19/
LOCATION:NYU School of Medicine\, 550 1st Avenue\, New York\, NY\, 10016\, United States
CATEGORIES:Jobs
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