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METHOD:PUBLISH
X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
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TZNAME:CEST
DTSTART:20190331T010000
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DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190406
DTEND;VALUE=DATE:20190509
DTSTAMP:20260907T043215
CREATED:20190406T173130Z
LAST-MODIFIED:20190406T173130Z
UID:21185-1554508800-1557359999@ces.b2sg.org
SUMMARY:Postdoctoral Research Associate
DESCRIPTION:Postdoctoral positions in bone biology and epigenetics are available immediately at the University of Southern California/Norris Comprehensive Cancer.  Specifically\, our projects are aimed at understanding how histone modifications and chromatin factors influence epigenetic pathways in osteoclast differentiation.  Successful applicants will be self-driven and highly motivated individuals with established track records of success\, including first-author publications. \nMinimum education and experience \nPh.D. or equivalent doctorate within previous three years \nAnalysis\nAssessment/evaluation\nCommunication—written and oral skills\nOrganization\nPlanning\nProblem identification and resolution\nProject management\nResearch
URL:https://ces.b2sg.org/event/6apr19/
LOCATION:University of Southern California\, Los Angeles\, CA\, 90007\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190407
DTEND;VALUE=DATE:20190510
DTSTAMP:20260907T043215
CREATED:20190407T201951Z
LAST-MODIFIED:20190407T201951Z
UID:21188-1554595200-1557446399@ces.b2sg.org
SUMMARY:Postdoctoral Research Associate- Obstetrics & Gynecology
DESCRIPTION:The laboratory of Dr. Melissa Herbst-Kralovetz\, as a part of a translational research program in the Department of Obstetrics and Gynecology at the University of Arizona College of Medicine-Phoenix\, invites applicants to apply for a challenging and rewarding opportunity to contribute as a Postdoctoral Research Associate. The successful candidate will study the microbiota composition\, and inflammatory profile as it relates to mucosal homeostasis of the female reproductive tract. The research couples clinical and translational research to advance women’s health. This position allows for the opportunity to work closely within an interdisciplinary and translational research team on a variety of diseases. For more information on the Herbst-Kralovetz laboratory\, see http://herbstkralovetzlab.weebly.com/. \nThe Department of Obstetrics and Gynecology is composed of employed and private practice physicians creating a unique hybrid model. The faculty supports the OB/GYN residency program\, and is actively engaged in research and mentoring with interests ranging from general gynecology and obstetrics to subspecialties. Areas of interest include maternal-fetal medicine\, vaginal dysbiosis\, gynecologic oncology\, reproductive endocrinology and infertility\, sexual health\, urogynecology and pelvic pain. Additional departments include the Department of Basic Medical Sciences\, which is a multidisciplinary unit composed of faculty with research interests in cardiac and vascular biology; developmental\, cell and molecular biology; evolution of vertebrate morphology; gene environment interactions and epigenetics; host-microbe interactions and immunology; medical education; platform development\, medical devices and procedures; and signaling and steroid biology. In addition\, the Center for Applied NanoBioscience and Medicine and affiliate institutions such as the Translational Genomics Research Institute\, Phoenix Children’s Hospital\, St. Joseph’s Hospital/Barrow Neurological Institute and the Arizona Alzheimer’s Consortium offer abundant opportunities for collaborative research efforts. \n\nDuties & Responsibilities: \n\nStudy host-microbe interactions as it relates to the female reproductive tract.\n\n\nProcessing and analyzing clinical specimens for multi-omics analyses.\n\n\nAnalyze\, organize and report data for presentation and publications.\n\n\nProvide status reports in the form of laboratory meetings.\n\n\nBioinformatics/biostatistical knowledge and application.\n\n\nParticipate in grant applications and submit fellowship applications.\n\n\nKnowledge\, Skills\, & Abilities: \n\nSkill utilizing protein assays (Western blot and ELISA) and nucleic acid-based assays (extraction\, RT-PCR assays\, quantification\, etc.) and standard molecular biology techniques.\n\n\nExcellent writing and verbal skills as evidenced by prior publications and presentations in the area of Microbiology/Virology and/or Immunology.\n\n\nResourceful\, self-motivated and possess a proven record of scientific advances in the form of publications.\n\n\nKnowledge of microbiology/virology\, cell biology and immunology and related techniques.\n\n\nAbility to work in an interdisciplinary team environment.\n\n\nBiostatistical analysis of data sets.\n\n\nMinimum Qualifications: \nMD\, PhD or MD/PhD degree in Microbiology\, Virology\, Immunology\, Bioinformatics\, Computational Biology or Genetics.
URL:https://ces.b2sg.org/event/7apr19/
LOCATION:University of Arizona\, Tuscon\, AZ\, 85721\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190408
DTEND;VALUE=DATE:20190511
DTSTAMP:20260907T043215
CREATED:20190408T174835Z
LAST-MODIFIED:20190408T174835Z
UID:21190-1554681600-1557532799@ces.b2sg.org
SUMMARY:Bioinformatics Specialist
DESCRIPTION:A Bioinformatics Specialist position is available in the lab of Prof. Peter D. Adams for ambitious\, independent and motivated candidates to join the team investigating the epigenetics of aging and cancer at Sanford-Burnham-Prebys Medical Discovery Institute\, San Diego. The successful candidate will use computational and bioinformatics approaches to investigate age-associated epigenetic events\, derived from mouse tissues and cell culture models\, are related to epigenetic hallmarks of aging and disease\, most notably cancer. Datasets will include ChIP-seq\, RNA-seq\, ATAC-seq\, DNA methyl-seq and other large-scale epigenomic and chromatin analyses\, including at the single-cell level\, as well as results from high throughput chemical and RNAi/CRISPR phenotypic screens. The work schedule will be between 35-40 hours per week. \n\nPrimary Responsibilities\n\n\n\nPerforms computational analysis and integration of large transcriptomic and epigenetic datasets\nProvides access of public genetic\, epigenetic and transcriptomic large datasets\, for integration with those datasets generated in the lab\nUtilizes existing lab data analysis pipelines\nBuilds new data analysis pipelines\, e.g. for single cell RNA-seq and ATAC-seq.\nManages large dataset storage\, in databases\, lab wiki and lab UCSC browser\nPresents results to lab members at weekly lab meetings\nPresents results and data within SBP\, local La Jolla meetings and national and international meetings\, as appropriate\nMaintains and initiates collaborations between Adams lab and other labs in SBP\, San Diego\, US and worldwide\n\n\n\n\n\nRequired Skills \nRequired Experience \n\n\n\nBachelor’s Degree in Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies AND a minimum of 5 years work experience OR a Master’s degree in Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies AND 3 years of work experience in related field OR Ph.D. in Computer Science\, Bioinformatics\, Biostatistics\, or Life Sciences or equivalent studies\, is required\nPh.D. degree in Computer Science\, Bioinformatics\, or Life Sciences or equivalent studies is preferred\nExperience or background in molecular biology or biochemistry is preferred\nExperience with Illumina NGS data analysis is preferred\nPrevious Postdoc training is not required\n\n\n\n\nKnowledge\, Skills\, and Abilities\n\nGeneral familiarity with wet lab assays\nExcellent bioinformatics and programming skills (e.g. Perl\, Python\, C/C++\, Java\, R or Web applications)\nStrong command of Linux/UNIX operating system\nStrong knowledge and skills in bioinformatics\, statistics and next-generation sequencing data analysis\nAbility to use current bioinformatics tools and have an in depth knowledge of advanced sequencing and array-based technologies\nCommunicates effectively and collaborates well with Principal Investigators and their team members\nHave strong organizational and problem-solving skills\nPossesses strong attention to detail\, analytical and time management skills\nExcellent communication and interpersonal skills\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/8apr19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190409
DTEND;VALUE=DATE:20190512
DTSTAMP:20260907T043215
CREATED:20190409T075042Z
LAST-MODIFIED:20190415T121233Z
UID:21192-1554768000-1557619199@ces.b2sg.org
SUMMARY:Associate Scientific Director- Translational Science
DESCRIPTION:As an Associate Scientific Director\, Translational Science working on the Translational Science team\, you will be empowered to establish a collaborative and influential role within Immuno-Oncology Drug Discovery project teams and provides scientific contributions which have significant impact on portfolio progress \, and a typical day will include: \nOBJECTIVES: \nProvides scientific insight from large and diverse biological datasets. Works with a dedicated team of scientists to form data driven decisions\, propose actionable solutions to be tested in the lab or clinic\, and to identify and progress novel cancer therapeutics. Contributes to our mission to provide innovative immuno-oncology therapies to patients across our pipeline of novel therapeutics including small molecule\, large molecule and cell-based therapies. Drives change across the entire drug discovery spectrum from target identification and validation through early clinical proof of concept\, formulating translational hypotheses that inform pharmacodynamic and predictive biomarkers. \nScientific leader with deep subject-matter expertise\, driving project team progression and development of technical capabilities and supporting development of junior team members. \nACCOUNTABILITIES: \n\nApplies computational methods to integrate\, visualize and interpret data resulting from whole genome\, epigenome\, transcriptome\, proteome\, single cell and efficacy studies from preclinical mouse in-vitro\, ex-vivo or in-vivo studies and preclinical human in-vitro and ex-vivo studies.\nEstablishes a collaborative and influential role within Immuno-Oncology Drug Discovery project teams comprised of cell biologists\, biochemists\, pharmacologists and translational scientists. Is responsible for analysis to deduce\, summarize and communicate results directly contributing to the understanding of drug indication\, mechanism of action\, identification of response predictors and translational biomarkers. Works collaboratively with biologists and clinicians to realize clinical benefit from their work.\nWorks collaboratively with data scientists and the information technology group to build knowledgebase solutions within our AWS computational infrastructure capable of performing and communicating genome scale data analysis on abundant proprietary and comprehensive public data\, especially focused on forward and reverse translation challenges.\nPlays a leading scientific role on project team(s)\, setting high standards for rigor of thought\nProvides scientific contributions which have significant impact on portfolio progress or development of technical capabilities\, based on benchmarking to industry best-in-class\nActs as internal key opinion leader for his/her area of technical expertise and serving in a development capacity for junior team members\nSupports or identifies BD opportunities to enhance project progression\, or functional capability expansion\, with clear application to specific portfolio needs\nContinual development of scientific expertise\, particularly through external interactions\, linked to specific deliverables\nContributes to development and implementation of scientific strategy\, through tangible deliverables; challenges dogmas and internal ‘blind spots’; actively pressure-tests ideas cross-functionally and via external network\nEstablishes a strong external reputation\, through scientific publication and presentation\nNote: Job responsibilities are progressive and cumulative\n\nEDUCATION\, EXPERIENCE\, KNOWLEDGE AND SKILLS: \n\nPhD degree in a scientific discipline with 10+ years of experience in computational biology\, or MS with 14+ years of experience in computational biology\, or BS with 16+ years of experience in computational biology\nOutstanding expertise and depth of knowledge within a scientific area\nKeeps up with the up-to-date scientific advancement (e.g. competitive landscape\, new technology\, new research portfolio\, and new partnership)\nDemonstrates well-developed knowledge of other disciplines\, and departments and how they function together. In particular\, the candidate should have extensive experience working closely with biologists or clinicians to influence experimental design.\nThe ideal candidate would have:\n\nExperience with genome scale or big data analysis derived from Next Generation Sequencing including; Exome\, RNA\, miRNA\, Copy Number\, Epigenetics\, Single Cell and synthetic lethal screens\, as well as a track record of using preclinically derived translational hypotheses to influence clinical trial practice.\nData mining\, text mining\, systems biology and visualization solutions including: RStudio\, Shiny\, Omicsoft Array Studio\, Spotfire\, MetaCore\, Ingenuity and MSigDB.\nProgramming\, AWS cloud computing and command line expertise; R\, SQL\, Perl\, Python.
URL:https://ces.b2sg.org/event/9apr19/
LOCATION:Takeda Pharmaceuticals\, 35 Landsdowne St\, Cambridge\, MA\, 02139\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190415
DTEND;VALUE=DATE:20190518
DTSTAMP:20260907T043215
CREATED:20190415T121010Z
LAST-MODIFIED:20190415T121010Z
UID:21204-1555286400-1558137599@ces.b2sg.org
SUMMARY:Research Technologist
DESCRIPTION:A Research Technologist position is available immediately in Dr. Sinisa Dovat’s lab in the Department of Pediatrics. The focus of our lab research is to study the epigenetic regulation of gene expression in high-risk leukemia and to develop the novel\, targeted therapy for childhood cancer. We are searching for a highly organized and self-motivated individual\, ideally with previous experience in lab management and assisting lab members in individual projects. Conduct experiments including observations\, collect\, compile and process data. Organize data and findings. Analyze data collected. Provide support to the PI\, researchers and technicians both within the lab and collaborating researchers. Order supplies and maintain and organize the inventory. Assist with IACUC and IRB protocols. Train students and others in the lab.  \nSuccessful applicants should have a degree in Biology or related fields. Please upload your CV along with contact information for three references. This job will be filled as a level 1\, or level 2\, depending upon the successful candidate’s competencies\, education\, and experience 
URL:https://ces.b2sg.org/event/penn15apr19/
LOCATION:Penn State\, Old Main\, Hershey\, PA\, 16801\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190425
DTEND;VALUE=DATE:20190527
DTSTAMP:20260907T043215
CREATED:20190425T132257Z
LAST-MODIFIED:20190425T132257Z
UID:21208-1556150400-1558915199@ces.b2sg.org
SUMMARY:Associate Director - Cancer Biology
DESCRIPTION:Associate Director\, Cancer Biology \nAgios (agios.com) is a biopharmaceutical company driven to discover and develop transformative therapies for cancer and rare genetic disease. Agios is growing rapidly\, having recently secured approval of a first-in-class oncology precision medicine\, with multiple additional novel investigational therapies in development and a robust drug discovery pipeline. We continue to build upon our scientific leadership in dysregulated metabolism as we seek precision medicines in metabolism and adjacent biology areas. In oncology\, Agios strives to uncover\, characterize and drug novel targets with robust patient selection strategies and potential for rapid\, biomarker-driven clinical development. \nIn this role\, you will bring your project and people leadership to our dynamic company. We are looking for a highly motivated and skilled leader with a strong background in oncology and drug discovery to join our team. \nKey Responsibilities \n\nDevises and oversees the cell biology efforts for novel oncology therapeutic program(s)\nEnsures timely delivery of incisive and actionable biology data that defines/refines drug discovery strategy\nServes as a target champion and internal expert in disease biology for one or more oncology drug discovery programs\nDevises and executes cancer biology experiments to support projects from validation to clinical candidate selection\nLeads cross-functional team efforts for hit-to-lead and lead-op stage drug discovery program(s)\nManages the work of multiple internal biologists and leverages CROs and academic collaborators effectively to drive program science forward\nPropagates a development-oriented culture & champions the growth of a talented and aspirational team of cancer biologists\nMaintains high-functioning and synergistic cross-functional relationships across the Agios discovery organization\nCommunicates science and strategy effectively in a variety of internal and external settings\n\nQualifications \n\nPh.D. in cancer biology or related field with 8+ years of industry experience\nDemonstrated success as a lead biologist advancing novel\, first-in-class therapeutics through hit-finding and lead optimization. Experience with IND-enabling studies is desired\nExpertise in cancer epigenetics is highly preferable\nPrior experience managing and mentoring direct reports and working with international CROs\nExcellent verbal and written communication and interpersonal skills to work across functions and within external collaborations\, and a demonstrated ability to organize and communicate complex data sets in a clear and concise manner to cross-functional audiences\nStrong organizational and time-management skills and demonstrated ability to lead cross-functional collaborations including managing relationships with academic collaborators and CROs\nDesire and capacity to participate in a dynamic and fast-paced research setting\nRecognized scientific innovation and accomplishment evidenced by strong record of publication and conference presentations in cancer biology
URL:https://ces.b2sg.org/event/agios-25apr19/
LOCATION:Agios Pharmaceuticals\, 88 Sidney Street\, Cambridge\, MA\, 02139\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190425
DTEND;VALUE=DATE:20190527
DTSTAMP:20260907T043215
CREATED:20190425T133846Z
LAST-MODIFIED:20190425T134140Z
UID:21210-1556150400-1558915199@ces.b2sg.org
SUMMARY:Senior Fellow - Gerontology
DESCRIPTION:The Plymate laboratory in the Department of Medicine at the University of Washington is looking for a highly motivated postdoctoral fellow\, who is interested in research involving novel small molecules affecting androgen receptor function in prostate cancer. \nThe Plymate laboratory is specifically interested in the epigenetic modulation of androgen receptor signaling by kinases and phosphatases. The postdoctoral fellow will work in a highly interactive laboratory environment and collaborate with clinical experts\, molecular biologists\, and chemists. \nFaculty at the University of Washington engage in teaching and research. This is a 12-month full-time position with the title of Senior Fellow with the possibility for renewal.  Anticipated start date is April 2019. \nQualifications\nApplicants should have a PhD degree or equivalent in the field of the molecular and cell biology\, a strong publication record\, and good spoken/written communication skills. \nCompetitive candidates will have expertise in: 1) Molecular and cell biology 2) RNA and DNA analysis including RNA -seq and CHiP -seq and 3) proficiency in scientific writing. \nInstructions\nSubmit CV and Cover Letter outlining specific experience via the Interfolio link provided.  \nApplication review will continue until the position is filled.  \nQuestions about this position may be directed to Cynthia Sprenger\, PhD \, CTS2501@uw.edu.
URL:https://ces.b2sg.org/event/wu-25apr19/
LOCATION:University of Washington\, Seattle\, WA\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190425
DTEND;VALUE=DATE:20190527
DTSTAMP:20260907T043215
CREATED:20190425T144542Z
LAST-MODIFIED:20190425T144542Z
UID:21213-1556150400-1558915199@ces.b2sg.org
SUMMARY:Postdoctoral Scientist
DESCRIPTION:Dr. Wu’s lab in the Department of Medicine focuses on two epigenetic modulators and members of the AT-rich interaction domain family\, ARID4A and ARID4B. Epigenetics plays an important role in human health and disease. Disruption of epigenetic modifications leads to dysregulation of gene function without altering the DNA sequence per se. A major challenge in understanding the importance of epigenetics in human health and diseases is to identify the specific epigenetic factors and the signaling involved. \nCurrently\, we are investigating the role of ARID4A and ARID4B in development and cancer disease using state-of-the-art conditional knockout mouse models and genomic and proteomic approach. We also study the role of ARID4B in cancer stem cells that have been suggested as the major cause for therapy resistance and the driving force behind cancer metastasis and relapse. To investigate whether and how ARID4B drive cancer development\, we evalute the underlying molecular mechanisms by which ARID4B promotes therapy resistance and aggressive cancer. \nDr. Wu’s lab in the Department of Medicine has an opening for a Postdoctoral Scientist. \nDuties include: \n\nculture and transfection of mammial cells\ncollection of samples for reporter gene assays\nwestern blooting to analyze protein expression\n\n-cancer cell migration and invasion assays -human cancer xenogrant experiments using SCID/NOD mice. \n\nother duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position.\n\n\nThis post-doc scientist is also required to work with genetically modified mice and in a BSL2 laboratory setting. \nMinimum Qualifications: \nQualified candidates will hold a PhD in a related discipline. Degree must be conferred by the start date of the position \nAdditional Required Licenses/Certifications/Posting Specific Minimum Qualifications: Preferred Qualifications: \nPh.D. degree\, with experience in molecular and cellular biology.
URL:https://ces.b2sg.org/event/gwu-25apr19/
LOCATION:George Washington University\, 2121 I St NW\, Washington\, DC\, 20052\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190426
DTEND;VALUE=DATE:20190528
DTSTAMP:20260907T043215
CREATED:20190426T122600Z
LAST-MODIFIED:20190426T122739Z
UID:21215-1556236800-1559001599@ces.b2sg.org
SUMMARY:Research Technician
DESCRIPTION:Located in Boston and the surrounding communities\, Dana-Farber Cancer Institute brings together world renowned clinicians\, innovative researchers and dedicated professionals\, allies in the common mission of conquering cancer\, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment\, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners\, including other Harvard Medical School-affiliated hospitals. \nWe are looking for a self-motivated researcher to join a team of scientists and physician scientists in the laboratory of Dr. Zuzana Tothova with a joint appointment at the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard. In this critical role\, the research associate will function as a member of a multi-disciplinary team of physician scientists\, scientists and computational biologists working at the Broad Institute and the Dana-Farber Cancer Institute in a fast-paced\, cutting-edge project focused on cancer epigenetics\, with a specific goal to understand the role of chromatin architecture and find novel therapeutic opportunities in myeloid malignancies\, including myelodysplastic syndromes and acute myeloid leukemia. \n\n\n\n\nResponsibilities\n\n\n\n  \nOVERALL RESPONSIBILITY \nThe candidate will be involved in a series of research activities\, including experimental design\, testing model systems in cellular and molecular assays\, including in a high-throughput manner\, building in vitro and in vivo human disease relevant models\, use of next generation sequencing as well as molecular and cellular biology experiments with a special emphasis on understanding the biology of human myeloid malignancies. \n  \nThe candidate is expected to work largely independently on a daily basis after training\, and will be closely mentored by a physician scientist. She/he will interact and collaborate closely with other scientists\, biologists\, chemists and computational biologists. \n  \nCHARACTERISTIC DUTIES \n  \n\nDesigns and carries out small independent projects and joins in team efforts for larger scale experiments.\nDocuments\, compiles\, and analyzes experimental data. Reports data in oral and written reports.\nAttends team meetings to share results\, plan projects and experiments.\nMaintains and improves technical knowledge base.\nHelps with maintenance of mouse colony\, tissue processing and analysis.\nOperates and maintains laboratory equipment to complete investigations.\nPrepares\, orders\, and maintains stocks of necessary reagents\, solutions and supplies.\nOther related tasks as required.\n\n  \nSKILLS AND ABILITIES \n  \n\nStrong interpersonal\, communication and organizational skills\, including the ability to handle a variety of tasks in a fast-paced environment\, positive attitude and attention to detail\, as well as ability to think on one’s feet are a required.\nMust possess a high level of initiative\, curiosity and dedication\, proactivity in identifying problems and solutions to address them.\nMust be a strong team player.\nComputational skills are a plus.\n\nThis position will be located at both the Broad Institute in Cambridge and Dana-Farber Cancer Institute in the Boston Longwood medical area. \n\n\n\nQualifications\n\n\n\n\nBachelor degree in the life sciences or related field required.\nFamiliarity with basic laboratory techniques and principles of molecular biology required; some experience working in a medical or scientific research setting or comparable technology-oriented business environment a plus.\nExcellent written\, documentation and oral communication skills required.\nStrong organizational skills\, including the ability to handle a variety of tasks in a fast-paced environment required.\nA minimum of 6 months of lab research experience required (undergraduate experience will be considered).\n\nWe are looking for candidates with at least 2 years of availability.
URL:https://ces.b2sg.org/event/df-26apr19/
LOCATION:Dana-Farber Cancer Institute\, 450 Brookline Avenue\, Boston\, MA\, 02215\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190426
DTEND;VALUE=DATE:20190528
DTSTAMP:20260907T043215
CREATED:20190426T131444Z
LAST-MODIFIED:20190426T131444Z
UID:21218-1556236800-1559001599@ces.b2sg.org
SUMMARY:Institute Research Scientist
DESCRIPTION:Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted\, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery\, with a multidisciplinary team of dedicated researchers\, doctors\, drug developers and scientific experts working together to develop small-molecule drugs\, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility\, bringing novel medicines from concept to clinic quickly and efficiently – all under the same roof.\n\n  \nThe Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS)\, ORBIT (Oncology Research for Biologics and Immunotherapy Translation)\, TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium.\n\n  \nTRACTION is the translational biology team within the Therapeutics Discovery Division. We employ disruptive technologies\, innovative biomarker approaches\, cutting-edge pre-clinical modeling and unparalleled access to patient data to accelerate drug development and inform innovative clinical trials. Through integration with basic and clinical research faculty across MD Anderson Cancer Center\, we leverage a team science approach with unmatched focus on patient-centric research. In partnership with the drug discovery engines of Therapeutics Discovery\, TRACTION scientists execute ground-breaking translational science in support of our mission to advance our portfolio of novel therapeutic concepts into transformative treatments.\n\n  \nAs part of the TRACTION team\, the Research Scientist will be part of our team of translational biologists who are responsible for leading preclinical translational activities to inform on clinical development of late-stage preclinical therapeutics. The position requires leading translational activities utilizing state-of-the-art preclinical models\, platforms and assays to discover\, validate and translate tumor biology insights into informative clinical trials. To enble these activities\, the Research Scientist will contribute to a cross-functional team\, collaborating with our corporate partners\, subject matter experts and cores across the Institution. These efforts will allow us to advance novel therapeutics currently under development by our Therapeutics Discovery teams and partners.\nBy joining the Therapeutics Discovery Division\, you have the opportunity to use your talents to make a direct impact on the lives of our patients. We are seeking a highly motivated and collaborative individual to become a part of our team. Ideal candidates will have a proven track record of leading translational efforts in support of advancing and positioning therapeutics in the clinical\, as well as possess excellent communication\, collaboration\, organization and leadership skills.\n\n  \nKEY FUNCTIONS:\n\n  \n1. Apply and develop basic science tools and methodologies to develop complex strategies and enable advancement of projects through leadership and experimental activities.\n\n2. Apply cutting edge functional genomics approaches to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.\n\n  \n3. Independently design\, execute and interpret in vitro\, ex-vivo and in vivo experiments to validate and explore therapeutic potential of drug targets.\n\n  \n4. Work with research\, computational biology and bioinformatics teams to utilize internal biological and oncogenomic data sets to generate and test biological hypotheses.\n\n  \n5. Develop and implement biomarker strategies to guide early clinical development of drugs.\n\n  \n6. Design\, develop and utilize biomarker assays to define mechanism of action for compounds and utilize pharmacodynamic markers to inform on compound activity\, response and resistance pre-clinical and clinical setting and test patient selection strategies.\n\n  \n7. Develop extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or apoptosis.\n\n  \n8. Adapt to new technologies and find solutions to related program studies.\n\n  \n9. Interpret\, present and report research findings at internal meetings and external scientific conferences.\n\nEducation\nRequired: Bachelor’s degree in Biology\, Biochemistry\, molecular biology\, cell biology\, enzymology\, pharmacology\, chemistry or related field.\n\nPreferred: PhD\, MD or equivalent degree in Biology\, Cell Biology\, Molecular biology or related field\n\nExperience\nRequired: Ten years of relevant research laboratory experience. With Master’s degree\, eight years of required experience and with PhD\, two years of required experience.\n\n\nPreferred: At least two years of post-degree experience in a biotech or pharmaceutical environment.\n\n1. Evidence of utilization of cancer genetics to inform on target discovery\, validation or on clinical development of drug candidates.\n\n2. Experience with genetic (ie RNAi and cDNAs) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study target biology utilizing state of the art molecular biology and biochemistry methods and assays essential to drive projects.\n\n3. A demonstrated track record in the development and implementation of functional genomics strategies to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.\n\n4. Broad knowledge of cell culture techniques is required and knowledge of how to utilize in vivo oncology models is desirable. Hands-on experience utilizing genetically engineered mouse models and orthotopic or subcutaneous primary or established tumor cell line xenograft models is desirable.\n\n5. Extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or anti-apoptosis as evidenced by publication in peer-reviewed journals.\n\n6. Strong data analysis skills\, ability to interpret results and contribute to the design of follow-up experiments\, troubleshoot issues with assay performance\, and effectively present results and conclusions to co-workers\, collaborators and senior leadership.\n\n7. Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential.\n\n8. Flexibility to accommodate to rapidly changing priorities and deadlines is required\n\n9. Collaborative attitude and ability to work in a team-based environment is crucial for this position.\n\n10. Excellent oral and written communication skills.\n\n11. Experience mentoring junior scientists is a plus.
URL:https://ces.b2sg.org/event/mda-26apr19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190430
DTEND;VALUE=DATE:20190602
DTSTAMP:20260907T043215
CREATED:20190430T141117Z
LAST-MODIFIED:20190430T141117Z
UID:21221-1556582400-1559433599@ces.b2sg.org
SUMMARY:Senior Scientist- Informatics & Predictive Sciences
DESCRIPTION:We seek a talented\, collaborative computational researcher to drive the effort in multi-omics data integration and target evaluation/prioritization for solid tumor indications.\nThe successful applicant is expected to play a key scientific role in leveraging innovative computational analysis strategies across a variety of biological and chemical data sources to empower data-driven decisions in development of next generation Celgene protein homeostasis therapies for solid tumor indications. \nReporting to the Informatics Lead for Protein Homeostasis research\, the successful candidate will work alongside Celgene Research colleagues in the Protein Homeostasis Thematic Center of Excellence (TCoE) and Chemistry and Structural Biology based in San Diego California\, and the global Informatics & Predictive Sciences (IPS) department.  \nScientific objectives and research scenarios include: \n\nIntegrating data across internal and public datasets for new target identification\, prioritization and indication selection\,\ndeveloping systems biology approaches for assessing disease relevance and generating therapeutic hypothesis on novel targets\,\nearly identification and predictive leverage of patient molecular subtypes most likely to benefit from a targeted intervention\,\ninference of synergistic target combinations by leveraging pharmacogenomics data and molecular networks.\n\n\nData originate from a wide range of cellular and molecular profiling platforms\, including transcriptomic\, proteomic\, genomic\, functional and immunophenotypic assays\, and from the efforts of colleagues in structural biology and cheminformatics.\nThe role offers the opportunity to directly impact the delivery of transformational therapies in key diseases of unmet medical need. Strong interest in the inter-disciplinary application of computational analysis methods to life sciences data is imperative. \nResponsibilities \nWorking in collaboration with computational\, biological and drug discovery scientists across the Celgene Research and Development organization\, responsibilities include but are not limited to:  \n\nAccelerate cutting edge predictive computational research in drug discovery utilizing new technologies\, model systems and the power of AI.\nDevelop and apply innovative computational analysis to leverage internal\, public and partner datasets and empower data-driven decisions for new target prioritization and validation.\nLead the identification and systematic ingestion of publicly available cancer genomics and relevant annotation and literature datasets\, and their integration with internal data sources.\nCollaborate as a member of cross functional teams to drive rational decision making across early drug discovery programs.\nAuthor scientific reports\, and present methods\, results and conclusions to publishable standard.\nContribute to planning and execution of collaborative projects with leading academic and commercial research groups worldwide.\n\n\nBackground experience & complementary knowledge  \n\nPh.D. in computational biology\, bioinformatics\, or related field from a recognized higher-education establishment.\n6+ years of experience in applying quantitative approaches to solve biological problems in university\, hospital\, pharma or biotech research environments\, with considerable depth of experience in cancer genomics.\nDemonstrated ability to integrate heterogeneous data sources and perform multivariate analysis of integrated datasets.\nProven expertise in the development and/or implementation of algorithms to distill\, analyze and interpret complex datasets\, with focus on evidence integration and mechanistic inference.\nExperience of computational biology research on a wide variety of molecular profiling platforms\, including mRNA profiling\, mutational profiling\, DNA copy number quantification\, epigenetic profiling and proteomics.\nFamiliar with various cancer genomics consortium efforts\, tools and databases.\nExpertise in algorithmic implementation\, statistical programming and data manipulation\, using e.g. R/Bioconductor and contemporary\, open-source bioinformatics tools and database structures.\nTrack record of peer-reviewed publications in top-tier scientific journals.\nProven problem-solving skills\, collaborative nature and adaptability across disciplines.\nExcellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.
URL:https://ces.b2sg.org/event/30apr19/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190430
DTEND;VALUE=DATE:20190602
DTSTAMP:20260907T043215
CREATED:20190430T142219Z
LAST-MODIFIED:20190430T143108Z
UID:21223-1556582400-1559433599@ces.b2sg.org
SUMMARY:Assistant Scientist
DESCRIPTION:The Department of Medicine\, Division of Hematology and Oncology invites applications for a non-tenure-track faculty position at the assistant scientist level. Candidates should have a strong research record in areas of epigenetics mechanisms in cancer and animal models of leukemia and myeloma. Faculty hire will be supervised by Dr. Jonathan Licht; and will have many opportunities for collaborative research throughout UF\, in agreement with institutional strategies adopted by the University of Florida to foster interdisciplinary research in cancer and epigenetics. \n\n\nQualifications\n\n\nDoctorate degree in related field. \nPreferred Qualifications: \nExperience working with animal models of myeloma\, CRISPR\,/Cas9 gene editing and next generation sequencing (RNA-se\,ChIP-seq.) \n  \n\n\n\n\n\n\nApplication Instructions\n\n\nPlease attach curriculum vitae and three letters of recommendation.
URL:https://ces.b2sg.org/event/uf-30apr19/
LOCATION:University of Florida\, Gainesville\, FL\, 32611\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190502
DTEND;VALUE=DATE:20190604
DTSTAMP:20260907T043215
CREATED:20190502T140627Z
LAST-MODIFIED:20190502T140808Z
UID:21227-1556755200-1559606399@ces.b2sg.org
SUMMARY:Research Fellow - Cancer Biology
DESCRIPTION:A postdoctoral position is available in the Department of Cancer Biology to understand the biology of cancer stem cells\, cancer progression and metastasis. We use molecular biology\, biochemical and mouse modeling approaches to dissect the role of posttranslational modifications\, such as protein ubiquitination and methylation in signaling pathways\, metabolism\, cancer immunity\, epigenetics and DNA damage response and their potential applications for cancer drug development. \nEducation/Experience: \nCompleted doctorate (Ph.D\, MD\, or equivalent) is required in a related field of study.
URL:https://ces.b2sg.org/event/wf-2may19/
LOCATION:Wake Forest Baptist Health\, Winston-Salem\, NC\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190507
DTEND;VALUE=DATE:20190609
DTSTAMP:20260907T043215
CREATED:20190507T165553Z
LAST-MODIFIED:20190507T165646Z
UID:21230-1557187200-1560038399@ces.b2sg.org
SUMMARY:Group Leader: Drug Discovery Biology
DESCRIPTION:We are currently seeking a highly motivated and talented Group Leader of Drug Discovery Biology. This individual will be a key team member in the organization co-leading cross functional teams to advance projects from target validation through preclinical development to clinical proof-of-concept studies\, in collaboration with MD Anderson researchers. The ideal candidate should have deep knowledge of cancer biology\, strong translational science skills\, and a proven track record of successfully leading multi-disciplinary small molecule teams from target validation through early clinical development in a biotech or pharmaceutical environment. Building on our unique model of drug discovery\, the group leader will work closely with academic and clinical collaborators to integrate innovative biology with clinical research data to position IACS small molecule assets for clinical success. As a member of our R&D leadership team\, this individual will play an essential project leadership role and will be empowered to provide strategic input to guide portfolio management decisions. \nBy joining the Therapeutics Discovery Division\, you have the opportunity to use your talents to make a direct impact on the lives of our patients. Join us\, and lead our next program from concept to clinic. \nKEY FUNCTIONS: \n1. Lead target and translational biology efforts on multiple IACS drug discovery projects\, leveraging resources from cross functional areas\, to deliver compelling translational data sets to advance IACS drug discovery programs into clinical proof-of-concept trials in distinct patient populations. \n2. Serve on the R&D Leadership team\, providing strategic insight to influence IACS portfolio strategy. \n3. Plan and execute the translational research strategy for one or more targets\, inform on target mechanism of action\, and explore translational hypotheses. \n4. Apply knowledge of pharmacology and biomarker development to enable in vivo assessment of chemical matter and establish pharmacokinetic\, pharmacodynamic\, and efficacy relationships. \n5. Coordinate\, direct and lead a team of successful internal scientists\, and collaborative relationships and alliances with internal and external partners to drive innovation and influence the IACS portfolio. \n6. Contribute to project team through lab based activities. \n7. Resource projects in a flexible manner\, including efficient use of outsourcing. \n8. Secure the intellectual property rights\, including drafting of patent applications. \n9. Complete the necessary documentation for IND- and other regulatory filing\, and for any due diligence or licensing activities. \n10. Represent the Therapeutics Discovery Division externally through presentations at key National/International meetings. \n11. Proactively identify\, evaluate and implement novel technologies to support translational activities. \n12. Supervise\, mentor\, and professionally develop a team of dedicated research and associate scientists. \n\nEducation\nRequired: PhD in one of the natural sciences or related field or Medical degree.\n\nPreferred: PhD\, MD or equivalent degree in Biology\, Cell Biology\, Pharmacology or related field.\n\nExperience\nRequired: Nine years experience of relevant research experience in lab.\n\nPreferred: 7 years of relevant research and management experience beyond post-doctoral research maintaining hands-on experience.\n\n1.Demonstrated ability to lead multidisciplinary project teams\, with experience advancing small molecule assets through discovery into clinical development.\n\n2.Experienced manager of people and projects including demonstrated ability to grow new leaders and delegate key projects appropriately.\n\n3.Extensive knowledge in cancer biology including cell signaling\, metabolism\, epigenetics\, and immune-oncology.\n\n4.Deep understanding of preclinical PK/PD/efficacy relationships as they relate to small molecule drug discovery in oncology; translation of findings to the clinic.\n\n5.Knowledge of preclinical and clinical biomarker discovery and development.\n\n6.Demonstrated ability to function efficiently in a multi-disciplinary team environment\n\n7.Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential\n\n8.Outstanding written and oral communication and negotiation skills are essential\n\n9.Strong leader with focus and drive to succeed
URL:https://ces.b2sg.org/event/7may19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190508
DTEND;VALUE=DATE:20190610
DTSTAMP:20260907T043215
CREATED:20190508T124128Z
LAST-MODIFIED:20190508T124128Z
UID:21233-1557273600-1560124799@ces.b2sg.org
SUMMARY:Research Associate
DESCRIPTION:Pediatrics – Oncology is seeking highly motivated individual for a Cancer Prevention and Research Institute of Texas (CPRIT)-Funded Projects to study the role of cohesin and Separase proteins in hematopoiesis\, hematopoietic gene transcription\, hematological malignancies\, and epigenetics of lineage specification. The lab focuses on gene transcription in a cohesin and chromatin context in normal development and disease. The incumbents will study cohesin and Separase in Hematopoietic stem cells and mice models. \nThe RA is responsible for coordinating research projects with collaborators from other laboratories. The RA must have experience in laboratory research techniques and presentation of research results in scientific fora. In addition the RA assists with initial training and functions as a mentor for post-doctoral fellows and other laboratory personnel in the design and execution of experiments\, analysis and organization of results\, and suggestions for future experiments. \nRequired: Master’s degree in a Basic Science. Experience in lieu of degree will not be accepted. PhD preferred. \nRequired: Three years of directly related experience typically as a Research Assistant\, Research Technician or Postdoctoral Fellow/Associate. Preferred: Five years’ laboratory experience. \n\nSkills: Proven ability to present and publish research results. research grant applications\, implement funded research studies\, and train Pediatric Hematology-Oncology fellows in the laboratory.
URL:https://ces.b2sg.org/event/8may19/
LOCATION:Baylor College of Medicine\, 1 Baylor Plaza\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190508
DTEND;VALUE=DATE:20190610
DTSTAMP:20260907T043215
CREATED:20190508T133603Z
LAST-MODIFIED:20190508T133603Z
UID:21236-1557273600-1560124799@ces.b2sg.org
SUMMARY:Scientist
DESCRIPTION:The incumbent will be expected to conduct research at the level of a co-principal investigator and work with Dr. Vincent Cryns on project development\, experimental design\, data analysis\, presentation and publication of results\, grant writing\, mentorship of trainees\, and collaborative research. \nThe Cryns lab focuses on understanding how tumors adapt to and survive metabolic stress caused by their rapid growth. The lab is particularly interested in translating these insights into improved cancer biomarkers and therapies. Research projects include studies in cell-based cancer model systems\, cancer metabolism and nutrition\, proteomics\, epigenetics\, and the development of unique animal models of cancer metastasis. \nCandidates should have familiarity with uwm. Candidates should be able to demonstrate mentorship/leadership experience\, have the ability to work well in a collaborative team environment\, have a passion for scientific discovery and a rigorous approach to their work. There is a collaborative learning environment through interactions with other groups across campus that allows for scientific and personal growth. \nThe School of Medicine and Public Health has a deep and profound commitment to diversity both as an end in itself but\, also as a valuable means for eliminating health disparities. As such\, we strongly encourage applications from candidates who foster and promote the values of diversity and inclusion. \n\n\n\n\nAdditional Information:\n\nHire will be subject to criminal background check requirements. \n\n\n\n\nContact:\n\nJason Weitzman\njweitzman@medicine.wisc.edu\n608-262-6019
URL:https://ces.b2sg.org/event/umw-8may19/
LOCATION:University of Wisconsin-Madison\, Madison\, MN\, 53706\, United States
CATEGORIES:Jobs
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