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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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METHOD:PUBLISH
X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190430
DTEND;VALUE=DATE:20190602
DTSTAMP:20260908T012908
CREATED:20190430T141117Z
LAST-MODIFIED:20190430T141117Z
UID:21221-1556582400-1559433599@ces.b2sg.org
SUMMARY:Senior Scientist- Informatics & Predictive Sciences
DESCRIPTION:We seek a talented\, collaborative computational researcher to drive the effort in multi-omics data integration and target evaluation/prioritization for solid tumor indications.\nThe successful applicant is expected to play a key scientific role in leveraging innovative computational analysis strategies across a variety of biological and chemical data sources to empower data-driven decisions in development of next generation Celgene protein homeostasis therapies for solid tumor indications. \nReporting to the Informatics Lead for Protein Homeostasis research\, the successful candidate will work alongside Celgene Research colleagues in the Protein Homeostasis Thematic Center of Excellence (TCoE) and Chemistry and Structural Biology based in San Diego California\, and the global Informatics & Predictive Sciences (IPS) department.  \nScientific objectives and research scenarios include: \n\nIntegrating data across internal and public datasets for new target identification\, prioritization and indication selection\,\ndeveloping systems biology approaches for assessing disease relevance and generating therapeutic hypothesis on novel targets\,\nearly identification and predictive leverage of patient molecular subtypes most likely to benefit from a targeted intervention\,\ninference of synergistic target combinations by leveraging pharmacogenomics data and molecular networks.\n\n\nData originate from a wide range of cellular and molecular profiling platforms\, including transcriptomic\, proteomic\, genomic\, functional and immunophenotypic assays\, and from the efforts of colleagues in structural biology and cheminformatics.\nThe role offers the opportunity to directly impact the delivery of transformational therapies in key diseases of unmet medical need. Strong interest in the inter-disciplinary application of computational analysis methods to life sciences data is imperative. \nResponsibilities \nWorking in collaboration with computational\, biological and drug discovery scientists across the Celgene Research and Development organization\, responsibilities include but are not limited to:  \n\nAccelerate cutting edge predictive computational research in drug discovery utilizing new technologies\, model systems and the power of AI.\nDevelop and apply innovative computational analysis to leverage internal\, public and partner datasets and empower data-driven decisions for new target prioritization and validation.\nLead the identification and systematic ingestion of publicly available cancer genomics and relevant annotation and literature datasets\, and their integration with internal data sources.\nCollaborate as a member of cross functional teams to drive rational decision making across early drug discovery programs.\nAuthor scientific reports\, and present methods\, results and conclusions to publishable standard.\nContribute to planning and execution of collaborative projects with leading academic and commercial research groups worldwide.\n\n\nBackground experience & complementary knowledge  \n\nPh.D. in computational biology\, bioinformatics\, or related field from a recognized higher-education establishment.\n6+ years of experience in applying quantitative approaches to solve biological problems in university\, hospital\, pharma or biotech research environments\, with considerable depth of experience in cancer genomics.\nDemonstrated ability to integrate heterogeneous data sources and perform multivariate analysis of integrated datasets.\nProven expertise in the development and/or implementation of algorithms to distill\, analyze and interpret complex datasets\, with focus on evidence integration and mechanistic inference.\nExperience of computational biology research on a wide variety of molecular profiling platforms\, including mRNA profiling\, mutational profiling\, DNA copy number quantification\, epigenetic profiling and proteomics.\nFamiliar with various cancer genomics consortium efforts\, tools and databases.\nExpertise in algorithmic implementation\, statistical programming and data manipulation\, using e.g. R/Bioconductor and contemporary\, open-source bioinformatics tools and database structures.\nTrack record of peer-reviewed publications in top-tier scientific journals.\nProven problem-solving skills\, collaborative nature and adaptability across disciplines.\nExcellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite.
URL:https://ces.b2sg.org/event/30apr19/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190430
DTEND;VALUE=DATE:20190602
DTSTAMP:20260908T012908
CREATED:20190430T142219Z
LAST-MODIFIED:20190430T143108Z
UID:21223-1556582400-1559433599@ces.b2sg.org
SUMMARY:Assistant Scientist
DESCRIPTION:The Department of Medicine\, Division of Hematology and Oncology invites applications for a non-tenure-track faculty position at the assistant scientist level. Candidates should have a strong research record in areas of epigenetics mechanisms in cancer and animal models of leukemia and myeloma. Faculty hire will be supervised by Dr. Jonathan Licht; and will have many opportunities for collaborative research throughout UF\, in agreement with institutional strategies adopted by the University of Florida to foster interdisciplinary research in cancer and epigenetics. \n\n\nQualifications\n\n\nDoctorate degree in related field. \nPreferred Qualifications: \nExperience working with animal models of myeloma\, CRISPR\,/Cas9 gene editing and next generation sequencing (RNA-se\,ChIP-seq.) \n  \n\n\n\n\n\n\nApplication Instructions\n\n\nPlease attach curriculum vitae and three letters of recommendation.
URL:https://ces.b2sg.org/event/uf-30apr19/
LOCATION:University of Florida\, Gainesville\, FL\, 32611\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/06/uni-florida.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190502
DTEND;VALUE=DATE:20190604
DTSTAMP:20260908T012908
CREATED:20190502T140627Z
LAST-MODIFIED:20190502T140808Z
UID:21227-1556755200-1559606399@ces.b2sg.org
SUMMARY:Research Fellow - Cancer Biology
DESCRIPTION:A postdoctoral position is available in the Department of Cancer Biology to understand the biology of cancer stem cells\, cancer progression and metastasis. We use molecular biology\, biochemical and mouse modeling approaches to dissect the role of posttranslational modifications\, such as protein ubiquitination and methylation in signaling pathways\, metabolism\, cancer immunity\, epigenetics and DNA damage response and their potential applications for cancer drug development. \nEducation/Experience: \nCompleted doctorate (Ph.D\, MD\, or equivalent) is required in a related field of study.
URL:https://ces.b2sg.org/event/wf-2may19/
LOCATION:Wake Forest Baptist Health\, Winston-Salem\, NC\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190507
DTEND;VALUE=DATE:20190609
DTSTAMP:20260908T012908
CREATED:20190507T165553Z
LAST-MODIFIED:20190507T165646Z
UID:21230-1557187200-1560038399@ces.b2sg.org
SUMMARY:Group Leader: Drug Discovery Biology
DESCRIPTION:We are currently seeking a highly motivated and talented Group Leader of Drug Discovery Biology. This individual will be a key team member in the organization co-leading cross functional teams to advance projects from target validation through preclinical development to clinical proof-of-concept studies\, in collaboration with MD Anderson researchers. The ideal candidate should have deep knowledge of cancer biology\, strong translational science skills\, and a proven track record of successfully leading multi-disciplinary small molecule teams from target validation through early clinical development in a biotech or pharmaceutical environment. Building on our unique model of drug discovery\, the group leader will work closely with academic and clinical collaborators to integrate innovative biology with clinical research data to position IACS small molecule assets for clinical success. As a member of our R&D leadership team\, this individual will play an essential project leadership role and will be empowered to provide strategic input to guide portfolio management decisions. \nBy joining the Therapeutics Discovery Division\, you have the opportunity to use your talents to make a direct impact on the lives of our patients. Join us\, and lead our next program from concept to clinic. \nKEY FUNCTIONS: \n1. Lead target and translational biology efforts on multiple IACS drug discovery projects\, leveraging resources from cross functional areas\, to deliver compelling translational data sets to advance IACS drug discovery programs into clinical proof-of-concept trials in distinct patient populations. \n2. Serve on the R&D Leadership team\, providing strategic insight to influence IACS portfolio strategy. \n3. Plan and execute the translational research strategy for one or more targets\, inform on target mechanism of action\, and explore translational hypotheses. \n4. Apply knowledge of pharmacology and biomarker development to enable in vivo assessment of chemical matter and establish pharmacokinetic\, pharmacodynamic\, and efficacy relationships. \n5. Coordinate\, direct and lead a team of successful internal scientists\, and collaborative relationships and alliances with internal and external partners to drive innovation and influence the IACS portfolio. \n6. Contribute to project team through lab based activities. \n7. Resource projects in a flexible manner\, including efficient use of outsourcing. \n8. Secure the intellectual property rights\, including drafting of patent applications. \n9. Complete the necessary documentation for IND- and other regulatory filing\, and for any due diligence or licensing activities. \n10. Represent the Therapeutics Discovery Division externally through presentations at key National/International meetings. \n11. Proactively identify\, evaluate and implement novel technologies to support translational activities. \n12. Supervise\, mentor\, and professionally develop a team of dedicated research and associate scientists. \n\nEducation\nRequired: PhD in one of the natural sciences or related field or Medical degree.\n\nPreferred: PhD\, MD or equivalent degree in Biology\, Cell Biology\, Pharmacology or related field.\n\nExperience\nRequired: Nine years experience of relevant research experience in lab.\n\nPreferred: 7 years of relevant research and management experience beyond post-doctoral research maintaining hands-on experience.\n\n1.Demonstrated ability to lead multidisciplinary project teams\, with experience advancing small molecule assets through discovery into clinical development.\n\n2.Experienced manager of people and projects including demonstrated ability to grow new leaders and delegate key projects appropriately.\n\n3.Extensive knowledge in cancer biology including cell signaling\, metabolism\, epigenetics\, and immune-oncology.\n\n4.Deep understanding of preclinical PK/PD/efficacy relationships as they relate to small molecule drug discovery in oncology; translation of findings to the clinic.\n\n5.Knowledge of preclinical and clinical biomarker discovery and development.\n\n6.Demonstrated ability to function efficiently in a multi-disciplinary team environment\n\n7.Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential\n\n8.Outstanding written and oral communication and negotiation skills are essential\n\n9.Strong leader with focus and drive to succeed
URL:https://ces.b2sg.org/event/7may19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190508
DTEND;VALUE=DATE:20190610
DTSTAMP:20260908T012908
CREATED:20190508T124128Z
LAST-MODIFIED:20190508T124128Z
UID:21233-1557273600-1560124799@ces.b2sg.org
SUMMARY:Research Associate
DESCRIPTION:Pediatrics – Oncology is seeking highly motivated individual for a Cancer Prevention and Research Institute of Texas (CPRIT)-Funded Projects to study the role of cohesin and Separase proteins in hematopoiesis\, hematopoietic gene transcription\, hematological malignancies\, and epigenetics of lineage specification. The lab focuses on gene transcription in a cohesin and chromatin context in normal development and disease. The incumbents will study cohesin and Separase in Hematopoietic stem cells and mice models. \nThe RA is responsible for coordinating research projects with collaborators from other laboratories. The RA must have experience in laboratory research techniques and presentation of research results in scientific fora. In addition the RA assists with initial training and functions as a mentor for post-doctoral fellows and other laboratory personnel in the design and execution of experiments\, analysis and organization of results\, and suggestions for future experiments. \nRequired: Master’s degree in a Basic Science. Experience in lieu of degree will not be accepted. PhD preferred. \nRequired: Three years of directly related experience typically as a Research Assistant\, Research Technician or Postdoctoral Fellow/Associate. Preferred: Five years’ laboratory experience. \n\nSkills: Proven ability to present and publish research results. research grant applications\, implement funded research studies\, and train Pediatric Hematology-Oncology fellows in the laboratory.
URL:https://ces.b2sg.org/event/8may19/
LOCATION:Baylor College of Medicine\, 1 Baylor Plaza\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190508
DTEND;VALUE=DATE:20190610
DTSTAMP:20260908T012908
CREATED:20190508T133603Z
LAST-MODIFIED:20190508T133603Z
UID:21236-1557273600-1560124799@ces.b2sg.org
SUMMARY:Scientist
DESCRIPTION:The incumbent will be expected to conduct research at the level of a co-principal investigator and work with Dr. Vincent Cryns on project development\, experimental design\, data analysis\, presentation and publication of results\, grant writing\, mentorship of trainees\, and collaborative research. \nThe Cryns lab focuses on understanding how tumors adapt to and survive metabolic stress caused by their rapid growth. The lab is particularly interested in translating these insights into improved cancer biomarkers and therapies. Research projects include studies in cell-based cancer model systems\, cancer metabolism and nutrition\, proteomics\, epigenetics\, and the development of unique animal models of cancer metastasis. \nCandidates should have familiarity with uwm. Candidates should be able to demonstrate mentorship/leadership experience\, have the ability to work well in a collaborative team environment\, have a passion for scientific discovery and a rigorous approach to their work. There is a collaborative learning environment through interactions with other groups across campus that allows for scientific and personal growth. \nThe School of Medicine and Public Health has a deep and profound commitment to diversity both as an end in itself but\, also as a valuable means for eliminating health disparities. As such\, we strongly encourage applications from candidates who foster and promote the values of diversity and inclusion. \n\n\n\n\nAdditional Information:\n\nHire will be subject to criminal background check requirements. \n\n\n\n\nContact:\n\nJason Weitzman\njweitzman@medicine.wisc.edu\n608-262-6019
URL:https://ces.b2sg.org/event/umw-8may19/
LOCATION:University of Wisconsin-Madison\, Madison\, MN\, 53706\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190509
DTEND;VALUE=DATE:20190611
DTSTAMP:20260908T012908
CREATED:20190509T160426Z
LAST-MODIFIED:20190509T160426Z
UID:21240-1557360000-1560211199@ces.b2sg.org
SUMMARY:Research Scientist II
DESCRIPTION:The Broad is looking for exceptional candidates to join the Precision Cardiology Laboratory. The successful candidates will join an interdisciplinary team of computational biologists\, laboratory scientists\, and clinicians working together to identify and validate new molecular targets for cardiovascular disease\, with the ultimate goal of advancing novel therapeutics to the clinic in collaboration with a strategic industry partner.  We are currently looking for candidates to take a lead on performing large-scale studies using single-cell RNA sequencing in normal and disease tissue samples from humans and animal models. The candidates will take oversee the design and processing of single-cell experiments\, supervise a research associate\, collaborate with data scientists on the analyses\, and potentially lead a therapeutics project targeting cardiovascular disease. \nExample workstreams include: \n\nDesign and implement laboratory methods for single-cell analysis of biological data\nCollaborate with computational biologists to analyze single-cell data\nIntegrate single-cell data with other available genetic\, sequencing\, and epigenetic datasets to help prioritize potential therapeutic targets and cell types\nCollaborate with Broad Institute single-cell analysis community\, Human Cell Atlas group and the Data Sciences Platform\nDesign and lead independent projects\nCreate scientifically rigorous visualizations\, communications\, and presentations of results\nContribute to generation of protocols\, publications\, and intellectual property\nMaintain and organize computational infrastructure and resources\n\nREQUIREMENTS \n\nPh.D. in Biology (Developmental\, Molecular\, Cellular Biology)\, Biochemistry\, or related life science field\n2+ years of research in an industrial or academic setting with a proven record of successful interaction with external customers\, vendors\, and team members\nHands-on experience in with single cell analyses\nExperience with CRISPR targeting ES/iPS cells and imaging protocols preferred\nAbility to develop research plans for executing strategy\, operate and maintain equipment\, and perform laboratory work\, with complete independence\nTrack record of working on complex problems\, and ability to integrate data from multiple disciplines\nStrong interpersonal\, influencing\, and collaboration skills to work in a team-oriented\, matrix environment\, and the ability to work through conflicts\nOutstanding verbal and written communication abilities\nAbility to adapt to and effectively manage changes in a fast paced and dynamic environment\nA passion for science and sense of urgency to find new medicines to benefit patients
URL:https://ces.b2sg.org/event/9may19/
LOCATION:Broad Institute\, 415 Main St\, Cambridge\, MA\, 02142\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190511
DTEND;VALUE=DATE:20190614
DTSTAMP:20260908T012908
CREATED:20190511T195544Z
LAST-MODIFIED:20190511T195544Z
UID:21242-1557532800-1560470399@ces.b2sg.org
SUMMARY:Postdoctoral Scholar
DESCRIPTION:The Director of Translational Research and Developmental Therapeutics at the Four Diamond Childhood Cancer Research Center at Penn State University College of Medicine\, Hershey\, PA\, Sinisa Dovat\, MD\, PhD is currently seeking applications for a senior Postdoctoral Scholar with experience in studies of mouse and human hematopoiesis and leukemia. The objective of the position will be to integrate the candidate’s expertise in normal and malignant hematopoiesis with our leading edge research focused on epigenetic and transcriptional regulation of gene expression. The applicant should hold a doctoral degree (M.D. or Ph.D.) in a relevant field\, be looking for a collaborative and dynamic environment\, and have a track record of productivity and innovation. Postdoctoral Scholars with extensive experience in mouse and human in vitro hematopoietic differentiation assays\, methylcellulose colony forming assay\, xenotransplantation of human hematopoietic cells into NSG mice\, serial mouse transplantation\, experience in flow cytometry\, tissue culture and retro- and lentiviral transduction of hematopoietic cells are encouraged to apply. Experience with luciferase reporter assay\, cloning\, DNA and RNA isolation\, Western blot\, and protein purification is desirable. Research in the Dovat lab uses molecular and cellular biology techniques including qRT-PCR\, quantitative chromatin immunoprecipitation (qChIP)\, and ChIP-seq.
URL:https://ces.b2sg.org/event/11may19/
LOCATION:Penn State\, Old Main\, Hershey\, PA\, 16801\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2019/04/Penn-State.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190512
DTEND;VALUE=DATE:20190615
DTSTAMP:20260908T012908
CREATED:20190512T173023Z
LAST-MODIFIED:20190512T173059Z
UID:21244-1557619200-1560556799@ces.b2sg.org
SUMMARY:Computational Biologist
DESCRIPTION:he Broad is looking for exceptional candidates to join the Precision Cardiology Laboratory. The successful candidates will join an interdisciplinary team of computational biologists\, laboratory scientists\, and clinicians working together to identify and validate new molecular targets for cardiovascular disease\, with the ultimate goal of advancing novel therapeutics to the clinic in collaboration with a strategic industry partner.  \nWe are currently looking for candidates to take a lead on the analyses of large-scale studies using single-cell RNA sequencing in normal and disease tissue samples from humans and animal models. The candidate will perform analyses of single-cell studies\, prioritize potential targets\, and collaborate directly with scientists performing experimental research studies at the bench. \nExample workstreams include: \n\n\nDesign and implement methods for single-cell analysis of biological data \n\n\nCollaborate with experimentalists and associate computational biologists to develop and apply functional genomics techniques \n\n\nIntegrate single-cell data with other available genetic\, sequencing\, and epigenetic datasets to help prioritize potential therapeutic targets and cell types \n\n\nCollaborate with Broad Institute single-cell analysis community\, Human Cell Atlas group and the Data Sciences Platform \n\n\nDesign and lead independent projects \n\n\nCreate scientifically rigorous visualizations\, communications\, and presentations of results \n\n\nContribute to generation of protocols\, publications\, and intellectual property \n\n\nMaintain and organize computational infrastructure and resources \n \n\nREQUIREMENTS \n\n\nPh.D. in computational biology\, genetics\, computer science\, statistics\, mathematics\, molecular biology\, or related field preferred\, but talented applicants of all levels are encouraged to apply \n\n\nDemonstrated expertise in statistical methods in single-cell data analysis\, including working knowledge of Seurat R package is preferred \n\n\nInterest in molecular biology and genomics \n\n\nFluency in Unix\, standard bioinformatics tools (Python\, R\, or equivalent)\, and a programming language (C/C++\, Java) \n\n\nTrack record of working on complex problems\, and ability to integrate data from multiple disciplines \n\n\nStrong interpersonal\, influencing\, and collaboration skills to work in a team-oriented\, matrix environment\, and the ability to work through conflicts \n\n\nOutstanding verbal and written communication abilities \n\n\nAbility to adapt to and effectively manage changes in a fast paced and dynamic environment \n\n\nA passion for science and sense of urgency to find new medicines to benefit patients
URL:https://ces.b2sg.org/event/12may19/
LOCATION:Broad Institute\, 415 Main St\, Cambridge\, MA\, 02142\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190514
DTEND;VALUE=DATE:20190616
DTSTAMP:20260908T012908
CREATED:20190514T085402Z
LAST-MODIFIED:20190514T085402Z
UID:21247-1557792000-1560643199@ces.b2sg.org
SUMMARY:Interdisciplinary Addiction Research
DESCRIPTION:The Department of Biobehavioral Health (https://hhd.psu.edu/bbh) in the College of Health and Human Development (https://hhd.psu.edu) at The Pennsylvania State University invites applications for an open rank\, tenured/tenure track addiction research faculty member whose research encompasses reducing disparities\, including health\, education\, racial/ethnic and socioeconomic disparities\, that are tied to addiction.  \nWe seek a colleague who has an interdisciplinary research program that integrates behavioral and biological approaches to examine addiction in vulnerable populations\, research expertise with populations who are disproportionately at risk for disparities\, and research that illuminates how addiction may contribute to disparities in biobehavioral health-relevant processes and/or outcomes.  \nPrograms that include the use of brain imaging (e.g.\, fMRI) and related neuroscience techniques to facilitate the development of new treatments and preventive interventions to improve addiction outcomes are of specific interest. In addition\, given youth vulnerability to onset of substance use and abuse\, research programs that incorporate adolescent populations are of interest. This position is part of a cluster hire by Penn State’s Social Science Research Institute (SSRI; http://www.ssri.psu.edu) of up to eight new faculty members across the social and behavioral sciences\, whose research focuses on reducing disparities. The scholarship and teaching of BBH faculty focuses on how biological\, behavioral\, psychological\, sociocultural\, and environmental variables interact to influence health. Departmental research includes physiological processes; health behaviors; neuroscience; health disparities; genetics and epigenetics; chronic disease; psychological states and processes; environmental exposures; bioethics; global health; public health and prevention sciences. Department faculty are highly research active\, interdisciplinary\, and collaborative.  \nThis position will build on the growing strength of departmental expertise to promote and enhance a vibrant\, rigorous\, and interdisciplinary research environment that aims to improve health at the levels of both the person and population. The responsibilities of the position are to establish and/or continue a fundable line of interdisciplinary addiction research relevant to disparities\, teach graduate and undergraduate courses\, supervise student research\, and provide service to the Department\, College\, SSRI\, and University. Applicants should have a strong record of scholarly research in addiction and disparities commensurate with their experience\, and show excellent potential to establish external research funding.  \nA doctorate in neuroscience\, behavioral science\, psychology\, biology\, sociology\, public health\, genetics\, biostatistics or a related field is required. In addition to involvement in SSRI\, there are opportunities for affiliations with a range of research centers and institutes at Penn State\, including the Social\, Life and Engineering Sciences Imaging Center (https://www.imaging.psu.edu); Prevention Research Center (PRC; http://prevention.psu.edu/); Huck Institute of Life Sciences (https://www.huck.psu.edu/); Center for Educational Disparities Research (CEDR\, http://www.ssri.psu.edu/center-educational-disparities-research); Child Study Center (CSC\, http://csc.la.psu.edu/); Methodology Center (https://methodology.psu.edu/); Quantitative Developmental Systems Core (https://quantdev.ssri.psu.edu/); Child Maltreatment Solutions Network (http://solutionsnetwork.psu.edu/); Population Research Institute (www.pop.psu.edu); Center for Healthy Aging (http://healthyaging.psu.edu)\, Africana Research Center (http://arc.la.psu.edu/); Penn State Cancer Institute (https://cancer.psu.edu/); Institute for CyberScience (https://ics.psu.edu) and the Penn State Clinical and Translational Science Institute (http://ctsi.psu.edu/). The successful candidate will be committed to and able to work effectively with diverse populations and audiences\, as well as with diverse students\, faculty\, and staff. Salary is competitive\, commensurate with background and experience. An attractive benefits package is available. Review of applications will begin immediately and will continue until the position is filled. The expected start date is August 2019.  \nQuestions about this position may be directed to the search committee chair\, Dr. Robert Turrisi\, at bbhfacultysearch@psu.edu. To apply\, applicants must complete an online application including a cover letter describing research and teaching interests and experiences\, curriculum vitae\, and 3 reprints or preprints that convey research interests and expertise. Four professional letters of reference should be sent directly from the letter writers to Dr. Robert Turrisi at bbhfacultysearch@psu.edu or postal mail to Dr. Robert Turrisi\, The Pennsylvania State University\, Department of Biobehavioral Health\, 219 Biobehavioral Health Building\, University Park\, PA 16802. Please indicate “Addiction – BBH search” in the subject line of email correspondence.
URL:https://ces.b2sg.org/event/14may19/
LOCATION:Penn State\, Old Main\, Hershey\, PA\, 16801\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190515
DTEND;VALUE=DATE:20190617
DTSTAMP:20260908T012908
CREATED:20190515T091925Z
LAST-MODIFIED:20190515T091925Z
UID:21249-1557878400-1560729599@ces.b2sg.org
SUMMARY:Scientist - Molecular Discovery
DESCRIPTION:Pfizer Integrative Biotechnology Group (IBG) located in Pearl River\, NY is within the Oncology division of Pfizer Worldwide Research & Development. IBG is dedicated to developing the next generation oncology therapeutics and therapeutic combinations by employing a multidisciplinary approach to target cancer cell cycle and modulate tumor microenvironment. We are seeking a qualified candidate at the Scientist level to join the group to contribute to drug discovery efforts by applying functional genomics and advanced molecular biology strategies to study novel cellular mechanisms underlying synthetic lethality with Pfizer’s preclinical and clinical assets. Primary responsibility of this role includes generating data packages to support advancement of late stage projects and publications in top-tiered research journals. \nThe qualified candidate for this position will be a highly motivated and collaborative scientist with strong interest in cancer biology\, epigenetics\, cell cycle progression and/or senescence response. \nS/he will demonstrate clear and professional verbal and written communication skills\, maintain an electronic notebook\, and can present scientific results to collaborators and at team meetings. \nROLE RESPONSIBILITIES  \n\nPerform experiments to study genetic and epigenetic factors that promote tumor growth and maintenance\nDevelop cellular and molecular assays to define mechanism of action relevant to target inhibition either by genetic approaches or compound treatment\nPerform cell-based assays for drug response alone or in combination to identify drug synergy\nPerform RNAi/CRISPR-based functional genomics screens for target discovery and validate novel drug targets both in vitro and in vivo\nPresent experiment results in group meetings\nMaintain experimental records in electronic lab notebook\nShare common lab responsibilities such as lab supply order and inventory management\nContribute to a dynamic\, exciting culture that embraces teamwork and innovation.\n\nBASIC QUALIFICATIONS  \n\nB.S. degree with 6+ years of experience or M.S. degree with 5+ years of experience in molecular biology\, cell biology\, genetics or related discipline\nMinimum 5 years of hands-on laboratory research\nAbility to plan and execute in vitro and/or ex vivo experiments with minimal supervision\nExperience in cell culture\, cell-based assays and standard molecular biology techniques such as SDS-PAGE\, ELISA\, Western Blot\, DNA/RNA purification\, PCR/RT-PCR\, and lentiviral packaging &transduction\nExperience with data processing software including Excel and Prism\nExcellent organization and planning skills\, the ability to work independently or as part of a team\, good verbal & written communication and interpersonal skills\, and strong motivation with a pro-active attitude and dedicated work ethic\nAbility and desire to learn new techniques\n\nPREFERRED QUALIFICATIONS \n\nExperience in cancer biology especially in cell cycle regulation and cancer epigenetics\nKnowledge of RNAi technology and experience in pooled RNAi-based screens\nExperience in use of CRISPR-based techniques for gene knockout\, gene editing as well as working knowledge of pooled CRISPR-based screening approaches\nExperience with flow cytometry and NextGen sequencing\nExperience with tumor cell dissociation and processing
URL:https://ces.b2sg.org/event/15may19/
LOCATION:Pfizer – Pearl River\, NY\, 401 North Middletown Road\, Pearl River\, NY\, 10965\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190515
DTEND;VALUE=DATE:20190617
DTSTAMP:20260908T012908
CREATED:20190515T092730Z
LAST-MODIFIED:20190515T092730Z
UID:21251-1557878400-1560729599@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:The Terskikh laboratory has a Postdoctoral Associate opening. The Terskikh laboratory is thriving is at the intersection of neurogenesis (including neural crest and adult hippocampal neurogenesis)\, brain cancer (glioblastoma)\, and epigenetic regulation. They have established mouse models of adult neurogenesis using conditional ablation of SOX2 and primary cilia (Shh signaling) in radial glia stem cells and developed a novel platform for microscopic imaging of epigenetic landscape (MIEL) in single cells. MIEL uses advanced imaging and machine learning to investigate the change of epigenetic signatures during cell differentiation and upon exposure to the environment\, including the high throughput drug screening format. They have also established a pipeline for hair follicle regeneration using human induced pluripotent stem cells. \nThe Postdoctoral Associate will be developing their own project while supporting several ongoing projects in the laboratory through automating information and analysis pipelines\, data integration\, pattern-matching analyses and visualization of a variety of different data sets\, including single cell sequencing\, bulk NGS\, ChIP-Seq\, Nuc-Seq\, ATAC-Seq\, and proteomics. \nTO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter\, CV\, references and list of any publications or accomplishments.  \n\nPrimary Responsibilities\n\nUtilizes heterogeneous high-throughput datasets (bulk RNA-Seq\, single cell RNA-seq\, proteomics) collected from cellular and animal models to discover networks and pathways and generates functional predictions and testable hypotheses (e.g. using Cytoscape\, IPA\, WGCNA\, NextBio)\nIndependently designs and performs experiments and procedures with high degree of complexity\, demonstrating increasing expertise with a wide range of techniques\nSupports projects directed by lab investigators and contributes to the general technical knowledge of researchers\nWrites reports\, manuscripts\, and applications for funding with increasing responsibility over time\nWorks collaboratively across lab functions and train other junior lab staff as needed\n\n   \nRequired Experience \n\nPh.D. degree in bioinformatics\, or biological sciences (including Computer Science\, Bioinformatics\, Biostatistics\, Life Sciences) is required\nStudies with strong emphasis on bioinformatics related to the genetics of disease is a plus\nThe qualified candidate must have strong experience in one or more of the following areas:  Bioinformatics\, or in molecular biology and genetics or related discipline with an emphasis on bioinformatics\n1-2 years of experience after PhD degree in Computer Science\, Bioinformatics\, or Biostatistics with Biological or Life Science lab experience is preferred\n\n\nKnowledge\, Skills\, and Abilities\n\nStrong ability in bioinformatics\, systems biology\, sequence analyses\, network analyses or genetics including expertise in high-throughput data analyses\, such as RNA-Seq\, single cell RNA-seq\, differential gene expression analyses\, gene co-expression analyses\, and proteomics\nStrong programming skills (Python\, R\, Java or C++ and Unix/Linux shell)\nFamiliarity with algorithms and tools\, such as Bowtie\, cufflinks\, BWA\, STAR\, RSEM\, UCSC Genome Browser\, samtools\, bedtools\, vcf-tools etc.\nKnowledge of machine learning approaches\nDemonstrated independent and critical thinking\nExcellent communication and teamwork skills\nDemonstrated strong publication record (at least one first-author publications)\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/sbp-15may19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190517
DTEND;VALUE=DATE:20190620
DTSTAMP:20260908T012908
CREATED:20190517T193504Z
LAST-MODIFIED:20190517T193504Z
UID:21254-1558051200-1560988799@ces.b2sg.org
SUMMARY:Research Fellow
DESCRIPTION:The Polyak laboratory focuses on translational studies with potential clinical impact. Her laboratory is an integral part of the Breast Cancer Research program in Dana-Farber Cancer Institute (DFCI) and Dana-Farber/Harvard Cancer Center (DF/HCC)\, and two of the strategic centers in DFCI: the Center for Cancer Genome Discovery (CCGC) and Center for Functional Cancer Epigenetics (CFCE). Research in the laboratory is dedicated to the molecular analysis of human breast cancer. The overall goal is to dissect breast tumor evolution and use this information to improve the clinical management of breast cancer patients. The three main areas of interests are: (1) how to accurately predict breast cancer risk and prevent breast cancer initiation or progression from in situ to invasive disease\, (2) better understand drivers of tumor evolution with special emphasis on metastatic progression and therapeutic resistance\, and (3) novel therapeutic targets in breast cancer with particular focus on “bad” cancers such as triple negative breast cancer and inflammatory breast cancer. All of the studies start with analyzing samples from breast cancer patients (or normal healthy for the risk studies)\, formulate hypotheses based on our observations\, use experimental models to test these\, and then translate back our findings into clinical care. \n\n\n\n\nResponsibilities\n\n\n\n\nPerform RNA-seq and ChIP-seq analysis\n\n\nPerform cell and molecular biology research\nPerform a variety of basic assays\, and experiments in breast cancer research\nEffectively work with research technicians and cross-functional project teams\n\n\nMaintain accurate records\, write reports\, and prepare/give presentations\n\n  \n\n\n\nQualifications\n\n\n\nPosition requires a minimum of a Ph.D. in the field of study in Molecular Biology\, Biochemistry\, or Genetics.
URL:https://ces.b2sg.org/event/df-17may19/
LOCATION:Dana-Farber Cancer Institute\, 450 Brookline Avenue\, Boston\, MA\, 02215\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190517
DTEND;VALUE=DATE:20190620
DTSTAMP:20260908T012908
CREATED:20190517T194409Z
LAST-MODIFIED:20190517T194453Z
UID:21256-1558051200-1560988799@ces.b2sg.org
SUMMARY:Research Associate III
DESCRIPTION:Rutgers\, The State University of New Jersey\, is seeking a Research Associate III for the Department of Pathology and Laboratory Medicine. Under the direction of the Principal Investigator (PI)\, the Research Associate IIIperforms specialized research activities and design and executes advanced experimental procedures independently or with minimal supervision in pathology laboratory. The Research Associate III works to develop novel hepatocytes able to be infected with hepatitis B and C viruses (HBV\, HCV) for the study of underlying genetic and epigenetic events of HBV and HCV-induced hepatocellular carcinogenesis. \n\nDesigns and performs diverse experimental models including small animal model to explore novel natural compounds and specific nanozymes.\nDesigns and explores the possibility of vaccines targeting cell surface residing oncoproteins for hepatocellular carcinoma immunotherapy.\nDevelops the fourth generation of GPC4-specific chimeric antigen receptor for hepatocellular carcinoma.\nUses state of the art molecular technologies including two dimensional electrophoresis\, western blot\, recombinant DNA construction and mutagenesis\, cell culture\, DNA and RNA transfection among others.\nWorks with the lab technician for operation and maintenance of experimental equipment.\nAnalyzes data from experiments\, prepares and publishes scientific manuscripts.\nAttends and participates in seminars.\n\n\nMust have extensive experience performing experimental research relevant to the field of hepatocellular carcinogenesis.\nAbility to work in a team environment and work independently.
URL:https://ces.b2sg.org/event/research-associate-iii/
LOCATION:Rutgers Cancer Institute of New Jersey\, 195 Little Albany St\, New Brunswick\, NJ\, 08903\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190518
DTEND;VALUE=DATE:20190620
DTSTAMP:20260908T012908
CREATED:20190518T103359Z
LAST-MODIFIED:20190518T103528Z
UID:21259-1558137600-1560988799@ces.b2sg.org
SUMMARY:Research Scientist
DESCRIPTION:As part of the TRACTION team\, the Research Scientist will be part of our team of translational biologists who are responsible for leading preclinical translational activities to inform on clinical development of late-stage preclinical therapeutics. The position requires leading translational activities utilizing state-of-the-art preclinical models\, platforms and assays to discover\, validate and translate tumor biology insights into informative clinical trials. To enble these activities\, the Research Scientist will contribute to a cross-functional team\, collaborating with our corporate partners\, subject matter experts and cores across the Institution. These efforts will allow us to advance novel therapeutics currently under development by our Therapeutics Discovery teams and partners.\n\nBy joining the Therapeutics Discovery Division\, you have the opportunity to use your talents to make a direct impact on the lives of our patients. We are seeking a highly motivated and collaborative individual to become a part of our team. Ideal candidates will have a proven track record of leading translational efforts in support of advancing and positioning therapeutics in the clinical\, as well as possess excellent communication\, collaboration\, organization and leadership skills.\n\nKEY FUNCTIONS:\n\n1. Apply and develop basic science tools and methodologies to develop complex strategies and enable advancement of projects through leadership and experimental activities.\n\n2. Apply cutting edge functional genomics approaches to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.\n\n3. Independently design\, execute and interpret in vitro\, ex-vivo and in vivo experiments to validate and explore therapeutic potential of drug targets.\n\n4. Work with research\, computational biology and bioinformatics teams to utilize internal biological and oncogenomic data sets to generate and test biological hypotheses.\n\n5. Develop and implement biomarker strategies to guide early clinical development of drugs.\n\n6. Design\, develop and utilize biomarker assays to define mechanism of action for compounds and utilize pharmacodynamic markers to inform on compound activity\, response and resistance pre-clinical and clinical setting and test patient selection strategies.\n\n7. Develop extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or apoptosis.\n\n8. Adapt to new technologies and find solutions to related program studies.\n\n9. Interpret\, present and report research findings at internal meetings and external scientific conferences.\n\n\n\nEducation Required: Master’s degree in Biology\, Biochemistry\, molecular biology\, cell biology\, enzymology\, pharmacology\, chemistry or related field.\n\n\nPreferred: PhD\, MD or equivalent degree in Biology\, Cell Biology\, Molecular biology or related field\n\n\nExperience Required: Six years experience of relevant research experience in lab. With preferred degree\, two years of required experience\n\n\n\nPreferred: At least two years of post-degree experience in a biotech or pharmaceutical environment.\n\n\n1. Evidence of utilization of cancer genetics to inform on target discovery\, validation or on clinical development of drug candidates.\n\n2. Experience with genetic (ie RNAi and cDNAs) and pharmacological (i.e. small molecule inhibitors or antibodies) approaches to study target biology utilizing state of the art molecular biology and biochemistry methods and assays essential to drive projects.\n\n3. A demonstrated track record in the development and implementation of functional genomics strategies to enable systematic investigation into mechanisms of tumorigenesis and drug resistance.\n\n4. Broad knowledge of cell culture techniques is required and knowledge of how to utilize in vivo oncology models is desirable. Hands-on experience utilizing genetically engineered mouse models and orthotopic or subcutaneous primary or established tumor cell line xenograft models is desirable.\n\n5. Extensive knowledge and experience in key areas of tumor biology including\, but not limited to oncogenic signaling\, tumor microenvironment\, tumor immunology\, metabolism\, epigenetic deregulation or anti-apoptosis as evidenced by publication in peer-reviewed journals.\n\n6. Strong data analysis skills\, ability to interpret results and contribute to the design of follow-up experiments\, troubleshoot issues with assay performance\, and effectively present results and conclusions to co-workers\, collaborators and senior leadership.\n\n7. Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential.\n\n8. Flexibility to accommodate to rapidly changing priorities and deadlines is required\n\n9. Collaborative attitude and ability to work in a team-based environment is crucial for this position.\n\n10. Excellent oral and written communication skills.\n\n11. Experience mentoring junior scientists is a plus.
URL:https://ces.b2sg.org/event/18may19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190521
DTEND;VALUE=DATE:20190623
DTSTAMP:20260908T012908
CREATED:20190521T120620Z
LAST-MODIFIED:20190521T123349Z
UID:21253-1558396800-1561247999@ces.b2sg.org
SUMMARY:Senior Research Associate
DESCRIPTION:In collaboration with the Principal Investigator\, under general supervision\, the Senior Research Associate will be responsible for making independent contributions to research and experiments. Incumbent will perform a) isolation of four cell types (hepatocytes\, Hepatic Stellate Cells\, Kupffer cells\, and Endothelial cells) from livers which are rejected for transplantation; b) cell characterization and cryopreservation\, storage\, cataloging; c) in vitro studies using cell stimulation\, co-culturing; d) generation of humanized mice. Incumbent will develop an independent scientific project focused on NASH and ASH-induced cross-talk between human hepatocytes/HSCs/Kupffer cells\, characterization of their gene expression profile and epigenetic signature. Will assist in writing grant applications\, applying for NIH funds to support the Human Cell Isolation lab and research projects. Will contribute to the preparation and editing of grant review proposals for federal\, state and private funding agencies. Will draft\, edit or criticize proposal aims and research plans. \nThe Senior Research Associate will manage and coordinate research efforts with other collaborators as appropriate for multidisciplinary research. Plan\, execute and follow-up on high level regular and ad hoc meetings of investigators and management. Independently conceive\, plan\, and conduct research projects based on reviews of scientific literature and recent advances in related fields\, organizing and executing all techniques involved. Contribute novel ideas of major methodological significance to the research projects\, designing key experiments and developing new techniques. Will perform complex data analysis using various statistical tools. Will author or co-author scientific journal manuscripts and book chapters and report directly to funding agencies and journal editors. Prepare and implement research study budgets based on analysis of data. Perform other duties as needed. \nThe Senior Research Associate will contribute significant\, innovative and original ideas and recommendations concerning challenging experimental procedures\, using specialized knowledge and a high level of technical skill and competence. The Senior Research Associate will develop and adapt new techniques and modify established protocols to further experiments. Interpretation of data and results of experiments for report production\, while also recognizing and investigating misleading results. \nMINIMUM QUALIFICATIONS\n\nBachelor’s degree in biology\, molecular biology\, biochemistry\, or related field and senior level laboratory experience.\nExperience with hepatocytes\, hepatic stellate\, kupffer and endothelial cells\, biochemistry\, cellular and molecular biology\, including experience in establishing\, maintaining\, transfecting\, and selecting clones from primary liver cell preparations with expertise in sterile technique.\nExperience with characterizing and behavior of human liver cell types\, specifically hepatocytes\, hepatic stellate cells\, kupffer cells and endothelial cells.\nProven experience with primary cell culture\, including large scale cell culture. Strong proven experience performing cell culture techniques including demonstrated ability working with sterile equipment and supplies. Ability to troubleshoot problems during all aspects of cell isolation and culture.\nExperience in managing multiple projects and working under milestones driven projects\, including knowledge in writing reports and experience in communicating with funding agencies.\nExperience in technical direction and training of students\, post-docs\, and technicians.\nDemonstrated experience in DNA and RNA extraction and use of extracted products in various PCR methods.\nExperience in designing and performing next generation RNA sequencing samples preparation and analyses.\nExceptional experience and knowledge in developing hypotheses\, design experiments\, conduct experiments\, analyze data\, write manuscripts\, and publish results in peer-reviewed journals\, including all interactions with Reviewers and Editors.\nDemonstrated experience in mouse models of liver fibrosis and cancer.\nExperience performing surgical implantation of shRNA-transfected tumor cell lines and intra-hepatic injections of human primary cells.\nProven experience with primary cell isolation from whole liver\, including large scale isolations.\nDemonstrated experience with standard biochemical and molecular biological laboratory procedures such as DNA cloning\, gel electrophoresis (including knowledge of SDS-PAGE and Coomassie Blue Staining)\, PCR\, RNA purification\, reverse transcription\, real time quantitative PCR\, Western Blotting\, ELISA and Histological analysis including paraffin and frozen block making\, sectioning and staining.\nProven experience with qPCR analysis\, and immunohistochemistry.\n\nPREFERRED QUALIFICATIONS\n\nProven experience in successful preparation of research grant proposals for funding by NIH or other major funding source.\nMaster’s degree or Doctoral degree in a related field.\n\nStrong organizational skills\, including experience in laboratory record keeping\, budget analysis and managing logistics.
URL:https://ces.b2sg.org/event/21may19/
LOCATION:UC San Diego Health – Moores Cancer Center\, 3855 Health Sciences Drive\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190521
DTEND;VALUE=DATE:20190623
DTSTAMP:20260908T012908
CREATED:20190521T124310Z
LAST-MODIFIED:20190521T124310Z
UID:21264-1558396800-1561247999@ces.b2sg.org
SUMMARY:Scientist- Functional Genomics
DESCRIPTION:The successful candidate will work independently or as part of a research team that is focused on developing and running functional genomic screens and identifying new targets for the OTD department. Use of shRNA or CRISPR technology platforms to screen and identify targets regulating oncology and or immune related disease pathways is essential. He/she will also provide weekly assay development \, cell culture\, and molecular biology support for different projects and programs. \nROLE SUMMARY \nPfizer Integrative Biotechnology Group (IBG) located in Pearl River\, NY is within the Oncology division of Pfizer Worldwide Research & Development. IBG is dedicated to developing the next generation oncology therapeutics and therapeutic combinations by employing a multidisciplinary approach to target cancer cell cycle and modulate tumor microenvironment. We are seeking a qualified candidate at the Scientist level to join the group to contribute to drug discovery efforts by applying functional genomics and advanced molecular biology strategies to study novel cellular mechanisms underlying synthetic lethality with Pfizer’s preclinical and clinical assets. Primary responsibility of this role includes generating data packages to support advancement of late stage projects and publications in top-tiered research journals. \nThe qualified candidate for this position will be a highly motivated and collaborative scientist with strong interest in cancer biology\, epigenetics\, cell cycle progression and/or senescence response. \nS/he will demonstrate clear and professional verbal and written communication skills\, maintain an electronic notebook\, and can present scientific results to collaborators and at team meetings. \nROLE RESPONSIBILITIES  \n\nPerform experiments to study genetic and epigenetic factors that promote tumor growth and maintenance\nDevelop cellular and molecular assays to define mechanism of action relevant to target inhibition either by genetic approaches or compound treatment\nPerform cell-based assays for drug response alone or in combination to identify drug synergy\nPerform RNAi/CRISPR-based functional genomics screens for target discovery and validate novel drug targets both in vitro and in vivo\nPresent experiment results in group meetings\nMaintain experimental records in electronic lab notebook\nShare common lab responsibilities such as lab supply order and inventory management\nContribute to a dynamic\, exciting culture that embraces teamwork and innovation.\n\nBASIC QUALIFICATIONS  \n\nB.S. degree with 6+ years of experience or M.S. degree with 5+ years of experience in molecular biology\, cell biology\, genetics or related discipline\nMinimum 5 years of hands-on laboratory research\nAbility to plan and execute in vitro and/or ex vivo experiments with minimal supervision\nExperience in cell culture\, flow cytometry\, cell-based assays and standard molecular biology techniques such as SDS-PAGE\, ELISA\, Western Blot\, DNA/RNA purification\, PCR/RT-PCR\, and lentiviral packaging & transduction\nExperience with data processing software including Excel and Prism\nExcellent organization and planning skills\, the ability to work independently or as part of a team\, good verbal & written communication and interpersonal skills\, and strong motivation with a pro-active attitude and dedicated work ethic\nAbility and desire to learn new techniques\n\nPREFERRED QUALIFICATIONS \n\nExperience in cancer biology especially in cell cycle regulation and cancer epigenetics\nKnowledge of RNAi technology and experience in pooled RNAi-based screens\nExperience in use of CRISPR-based techniques for gene knockout\, gene editing as well as working knowledge of pooled CRISPR-based screening approaches\nExperience with NextGen sequencing\nExperience with tumor cell dissociation and processing
URL:https://ces.b2sg.org/event/p-21may19/
LOCATION:Pfizer – Pearl River\, NY\, 401 North Middletown Road\, Pearl River\, NY\, 10965\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190522
DTEND;VALUE=DATE:20190624
DTSTAMP:20260908T012908
CREATED:20190522T123208Z
LAST-MODIFIED:20190522T130329Z
UID:21266-1558483200-1561334399@ces.b2sg.org
SUMMARY:Staff Scientist
DESCRIPTION:We are seeking an outstanding and highly motivated Staff Scientist to join department of Computational Biology’s Genomics Laboratory. The Staff Scientist will have the opportunity to join our efforts dedicated to advancing the understanding of the molecular and cellular basis of pediatric cancers. The job responsibilities include performing single cell droplet experiments for both RNA end counting and DNA variant detection\, improving the workflow efficiency for NGS sequencing on the Illumina sequencing platform\, and evaluating and optimizing single cell DNA\, RNA\, and epigenetic protocols. In addition\, duties for this position include performing standard NGS protocols on the Illumina\, Pacific Biosciences\, and Oxford Nanopore sequencing platforms. \nQualified candidates will have a strong background in molecular and cellular biology\, single cell sequencing\, UMI applications\, and familiarity with the operation of the Illumina sequencing platform. Excellent written and communication skills\, the ability to effectively collaborate with peer scientists\, and execute tasks in a timely manner are highly desired. \nRecognized as a world leader in pediatric cancer genomics\, the department of Computational Biology at St. Jude Children’s Research Hospital has developed state-of-art computational algorithms\, well-established analytical pipelines\, and deep data analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature\, NEJM\, Nature Genetics\, and Nature Methods. The department provides a highly interactive environment with projects involving basic and clinical research collaborators\, access to high performance computing clusters\, cloud computing environment\, innovative visualization tools\, highly automated analytical pipelines and teamwork with scientists who have deep experience in data analysis\, data management and delivery of high-quality results for highly competitive projects. This position is located in Memphis\, TN\, and relocation assistance is available. \n\n\n\nMinimum Education\n\n\n\n\nA Ph.D. in an appropriate scientific field is required\n\n\n\n\nMinimum Experience\n\n\n\n\nA minimum of five (5) years of relevant and productive (combined) years postdoctoral research associate or five (5) years of combined academic experience at the postdoctoral level or above.\n\nStrong background in molecular and cellular biology\, single cell sequencing\, UMI applications\, and familiarity with the operation of the Illumina sequencing platform.
URL:https://ces.b2sg.org/event/stj-22may19/
LOCATION:St. Jude Children’s Hospital\, 262 Danny Thomas Pl\, Memphis\, TN\, 38105\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190526
DTEND;VALUE=DATE:20190629
DTSTAMP:20260908T012908
CREATED:20190526T185047Z
LAST-MODIFIED:20190526T185047Z
UID:21269-1558828800-1561766399@ces.b2sg.org
SUMMARY:Senior Research Scientist
DESCRIPTION:Dr. Kapil N. Bhalla is currently seeking a Senior Research Scientist who will be responsible for conducting research in his NIH-funded laboratory. The focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases\, methyltransferases and demethylases\, BET proteins\, as well as the chaperone biology of heat shock proteins and their cancer relevant client proteins regulating cell growth\, differentiation and survival of the human leukemia stem/progenitor cells. The qualified candidate must possess a Ph.D. in Biology\, Biological Sciences\, Life Sciences or related field and a keen interest and experience in cancer research. The candidate must have completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla’s laboratory. The qualified candidate must have the ability to troubleshoot in the design and conduct of the laboratory studies. Experience in molecular studies involving gene transfection\, analysis of gene expression through QPCR\, microarrays\, immunoblots and flow cytometry\, as well as experience in chromatin immunoprecipitation studies\, evaluation of protein biochemistry with 2D gels and the yeast-two-hybrid system\, and tissue culture techniques is required. Experience in the ability to utilize CRISPR technology for gene editing and to utilize confocal microscopy for molecular imaging is highly desired. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia\, and confocal microscopy is also desired. An outstanding research environment\, new laboratory and core facilities are provided. \nThe salary range is: min-$53\,200\, mid-$66\,500 and max-$79\,800. \nKEY FUNCTIONS \nResearch Design and implementation \nPlans\, organizes\, coordinates\, directs and conducts scientific research projects. Develops and maintains standard procedures and protocols to ensure the quality and integrity of the procedures performed. Coordinates with other investigators to provide appropriate support on analytical techniques. Maintains detailed experimental records\, evaluates resulting research data\, and presents findings to physicians and/or professional groups. \nData Analysis \nAnalyzes and evaluates research data and revises techniques and approaches to work problems. Works with the Principal Investigator on projects in the area of biomarker development and leukemia biology. Participates in adopting new techniques and learning new skills to enhance research efforts. \nLab Development/Publications \nSupervises\, mentors\, and counsels trainees and other laboratory personnel with respect to proper laboratory techniques\, the use of laboratory equipment and safety procedures. Publications/Manuscripts and Presentations. Contributes to manuscripts and prepares documents for publication. Compiles\, writes\, and submits reports to superior. Presents results at national meetings. \nOther duties as assigned. \n\nEDUCATION \nRequired: PhD in one of the natural sciences or related field or Medical degree. \nEXPERIENCE\nRequired: With PhD\, no experience required. With Medical degree\, two years of experience in experimental or scientific work. \nPreferred: With PhD must have completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla’s laboratory.
URL:https://ces.b2sg.org/event/26may19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190527
DTEND;VALUE=DATE:20190630
DTSTAMP:20260908T012908
CREATED:20190527T144250Z
LAST-MODIFIED:20190527T144250Z
UID:21271-1558915200-1561852799@ces.b2sg.org
SUMMARY:Vice President - Biology
DESCRIPTION:FORMA Therapeutics is seeking a VP of Biology to drive FORMA’s current and future discovery research and translational biology to\nadvance products from target selection to the clinic. This is a key leadership role reporting directly to the Head of Research and Development. The ideal candidate will be adept at working within an open\, matrixed\, multi-disciplinary team and possess a passion for exploration of novel biology\, to address unmet needs of patients with cancer and other serious diseases. In this role\, the VP of Biology will also play a critical leadership role in guiding teams through the assessment and development of molecules in discovery and clinical\ndevelopment\, such as mode of action studies\, in vitro and in vivo models\, and building pre-clinical support for IND enabling activities and beyond. \nThe successful candidate will be a dynamic and innovative scientist who will provide leadership\, guidance and management to a broad range of biology-related activities in the discovery and translational teams. It is critical that the candidate is experienced with the drug discovery and development process as evidenced by key contributions to the discovery of new therapies that have advanced to clinical proof of concept. The candidate should also be able to develop and mentor project leaders and support cross-functional and other collaborative activities. \nEssential Functions: \n\n\nBuild and lead a world class Discovery and Translational Biology team while driving an innovative culture that cultivates teamwork and optimizes performance to advance novel\, innovative compounds\nLead by example with a high level of emotional intelligence and effectively collaborate with leaders in Early Discovery\, Early Development\, Chemistry and other functional groups\nProvide scientific expertise/direction and leadership to the Discovery Biology organization. A strong level of experience and accomplishment in the oncology therapeutic area is essential\nLead the identification and prosecution of a sustainable flow of actionable biology targets for screening and discovery to achieve FORMA’s drug discovery goals with the ultimate objective to bring unprecedented new medicines to patients\nActively assist in seeking\, driving and managing product and technology alliances with academia\, government and industry partners\nWork with biology project teams to set objectives and address specific challenges and meet goals.\nEffectively apply state-of-the-art technologies and best practices to improve operational efficiency\nEnsure performance standards are maintained and that experimental work is performed to a consistently high standard\nProvide critical cancer biology expertise for FORMA’s portfolio\nProvide the necessary expertise in in vivo pharmacology and in tumor model systems (transgenic\, syngeneic and xenogeneic) to define the anti-cancer therapeutic activity of FORMA’s portfolio\nServe as subject matter expert in preparing and presenting research results at external scientific conferences\nActive member on the Research Leadership Team\, playing a critical role in the development and execution of FORMA’s research and development strategy\nOperationally responsible for the biology research team and its deliverables\n\nQualifications\, Education and Experience: \n\nPh.D. or M.D./Ph.D. in appropriate Biological Sciences Discipline; Oncology (preferred)\nAt least 15 years industry experience in the discovery of potential novel therapeutics\, preferably small molecules\nExperience in leading translational biology efforts to advance early projects through Phase I\nA record of building\, leading highly productive teams\, with a strong record of organizational experience\nDemonstrated scientific leadership in cancer biology\, an innovative aptitude\, coupled with strong practical execution\nBalances leadership strength with self-awareness\, confidence and humility\nExceptional track record of publication in high impact\, high visibility scientific journals\nExceptional verbal and written communication skills\nTrack record of establishing expertise in in vivo pharmacology across different disease areas. Expertise in cancer pharmacology is highly preferred\nExperience in managing external research collaborations with academic institutions as well as companies\nAbility to balance execution of tasks required to accomplish goals with creating an environment of scientific curiosity\, innovation and open exchange of ideas
URL:https://ces.b2sg.org/event/forma-27may19/
LOCATION:FORMA Therapeutics\, Watertown\, MA\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190527
DTEND;VALUE=DATE:20190630
DTSTAMP:20260908T012908
CREATED:20190527T144759Z
LAST-MODIFIED:20190527T144759Z
UID:21273-1558915200-1561852799@ces.b2sg.org
SUMMARY:Scientist I- Protein Homeostasis
DESCRIPTION:Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer\, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients\, quest for innovation\, spirit of independence and love of challenge. With a presence in more than 70 countries – and growing we look for talented people to grow our business\, advance our science and contribute to our unique culture. The key therapeutic platforms currently under investigation leverage a broad range of biological activities that allow for the development of novel paradigm-changing therapeutics. Our discovery research teams are organized into four Thematic Centers of Excellence (TCoE)\, including Protein Homeostasis\, Epigenetics\, Immuno-oncology and Inflammation & Immunology. Within each these areas\, discovery research\, translational research\, and early clinical development are integrated into a single team. \nSummary/Scope\nThe early drug discovery effort of our team in the Protein Homeostasis TCoE is focused on the exploration of the molecular underpinning of cancer development and progression\, and the design and characterization of novel antitumor agents. We are seeking a PhD scientist to define the underlying mechanism of response and resistance to novel cereblon modulating agents targeting protein turnover and function for the treatment of hematological cancers. More specifically\, Next Generation Sequencing tools\, proteomics and molecular/genetic approaches will be utilized to delineate the molecular\, genetic and epigenetic signatures of cancer cell specific addiction programs\, which could be manipulated by cereblon modulating agents to achieve antitumor activity. The understanding of mechanism of action of these agents will help us identify the right disease indications\, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership. \nResponsibilities will include\, but are not limited to\, the following: \n\nGenerate testable hypotheses\, design research protocols and execute experiments\nUtilize CRISPR and RNAi to determine the disease relevance of novel cereblon substrates\nPerform cellular experiments to help define the SAR of cereblon modulators\nUtilize genetic and pharmacological approaches to define the MOA of candidate agents\nDesign and develop novel assays\nDocument\, interpret and troubleshoot results\nConvey data analysis and interpretation to supervisor and colleagues\nCommunicate with peers and supervisors and foster teamwork\nContribute to collaborative efforts\nStrong commitment to quality and reproducibility\nDemonstrate adaptability\nSupervise or guide research staffs\n\n\nQualifications:\nPh.D. in molecular genetics or related scientific discipline with at least 2 years of work experience.  Bachelor’s degree in a scientific discipline with at least 10 years work experience or Master’s degree with at least 8 years work experience may be considered.\nPrefer graduate work focusing on the regulation of gene expression at the molecular level.\nStrong publication record in major scientific journals.  \nSkills/Knowledge Required: \n\nExtensive wet-lab experience with routine molecular\, cellular and genetic biology tools\nExtensive experience with Cas9-CRISPR mediated gene editing\nExtensive experience with flow cytometry analysis and FACS\nExtensive experience with next generation sequencing(NGS) methods\nExperience with analysis of NGS datasets is preferred but not required\nHighly motivated and strong team player with a high degree of independence\nInnovative and critical thinking\nExcellent time management and organizational skills\nStrong communication skills\, both written and oralFunctional/Scientific/Technical Skills:\n• Able to design complex experiments with scientific rationale.\n• Able to critically analyze and interpret data.\n• Learning the drug development process.\n• Draw appropriate conclusions.\n• Possess in-depth knowledge in area.\n• Understands fundamental scientific problems and can apply knowledge to research and development projects and problems in a positive manner.\n• Developing skills in critical interpretation of scientific data and problem solving and reporting of scientific data. \nTasks and Responsibilities:\n• Contributes individually as well as on cross functional teams.\n• Responsible for more complex assignments and for more than 1 project.\n• Able to evaluate CRO’s.\n• Well versed in fundamentals of functional area.\n• Understands the context\, impact and timely communication of data. \nDiscretion/Latitude:\n• Works as an individual contributor.\n• Viewed as a knowledgeable resource within the department.\n• Supervising/mentor role in function. \nCreativity and Problem Solving:\n• Critically assess project(s) and formulates ideas.\n• Implement solutions independently.\n• Scope of problem solving is generally within the departmental function.\n• Recommend and formulate protocols and experimental plans. \nTeamwork and Influence:\n• Communicates with cross functional team.\n• Routinely contributes to the achievement of workgroup/team goals.\n• Represents workgroup/team or department on multi-disciplinary or cross functional teams. \nOrganizational Impact:\n• Beginning to have a direct impact on departmental performance.\n• Impact is achieved primarily by contributing to team efforts. \nBehavioral Competencies:\n• Acts with integrity\n• Analysis of issues\n• Building relationships\n• Coaching and developing others\n• Delivers presentations\n• Develops systems & process\n• Fosters open communication\n• Influence others\n• Innovates\n• Manages execution\n• Planning
URL:https://ces.b2sg.org/event/cel-27may19/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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DTSTART;VALUE=DATE:20190529
DTEND;VALUE=DATE:20190701
DTSTAMP:20260908T012908
CREATED:20190529T082757Z
LAST-MODIFIED:20190529T082757Z
UID:21275-1559088000-1561939199@ces.b2sg.org
SUMMARY:Scientist (Biochemistry)
DESCRIPTION:We’re seeking a highly motivated and technically proficient laboratory Scientist with a strong enzymology background to join our dynamic biochemistry team. The successful candidate will provide biochemistry solutions across multiple projects in all therapeutic areas in a high-visibility\, highly-matrixed environment. Creativity\, enthusiasm\, organization\, and excellent communication skills a must. Excellent development and advancement potential. \nJob Responsibilities \n\nConceptual design and execution of novel biochemical assays to kinetically characterize enzyme targets\nDevelop strategies to ensure quality expression\, purification\, and biophysical characterization of enzymes produced from multiple expression systems\nInteract with exploratory cell biologists to help elucidate relevant intracellular biochemistry\, genetic and epigenetic regulation of our targets and advance them through validation\nInteract closely with medicinal chemistry to guide small molecule drug discovery through the execution of inhibitor or activator mechanism of action studies\nDual leadership from bench and in CRO management; manage external FTE resources; transfer and validate assays to external partners\n\nQualifications \n\nPhD in Enzymology\, Biochemistry or related field with 0-5+ years industry research experience or an MS or BS degree with 7-10 years of industry research experience in the context of small-molecule drug discovery\nA strong background in steady-state enzymology with emphasis on mechanism of action and kinetic studies with (UV/VIS\, TR-FRET\, FP) readouts. Past experience with coupled enzyme assay systems\, transient kinetics\, KNIME informatics environment\, and LCMS-based enzyme assays is a plus.\nIn-depth understanding of recombinant protein expression and purification from bacterial\, insect\, and yeast systems.\nA proven history of effective team work with excellent collaborative and communication skills is required
URL:https://ces.b2sg.org/event/29may19/
LOCATION:Agios Pharmaceuticals\, 88 Sidney Street\, Cambridge\, MA\, 02139\, United States
CATEGORIES:Jobs
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DTSTART;VALUE=DATE:20190529
DTEND;VALUE=DATE:20190701
DTSTAMP:20260908T012908
CREATED:20190529T094511Z
LAST-MODIFIED:20190529T094511Z
UID:21278-1559088000-1561939199@ces.b2sg.org
SUMMARY:Research Assistant
DESCRIPTION:The fundamental structure of chromatin suggests that all DNA-templated processes\, including a wide range of epigenetic phenomena\, are influenced by chromatin alterations with far-reaching implications for human biology and disease. Research in Dr. Allis’ laboratory is centered on chromatin and its regulation though post-translational modification of histone (and non-histone) proteins\, ATP-dependent remodeling of chromatin\, and the exchange of histone variants.\n\n\n\n\nDetailed Description\n\n\n\nThis position will involve contributing directly to work by a physician scientist (MD\, PhD) who specializes in medical oncology. The overall aim of the work is to understand the fundamental epigenetic mechanisms of cancer-associated mutations. Projects may also involve preclinical drug development of anticancer therapeutics. The Research Assistant will be responsible for performing cell culture\, generation of cell lines harboring tumor-derived mutations\, cell-based chromatin assays (eg. ChIP\, DNA methylation and/or produce next-generation sequencing libraries)\, measurements of small molecule activity\, and cellular differentiation assays. Will record data and analyze results\, maintain and perform experiments with cells in tissue culture\, and maintain inventory of frozen cell stocks.\n\n\n\n\nJob Requirements\n\n\n\nBachelor’s degree in science required; Master’s degree preferred. Previous experience with cell culture\, molecular biology and biochemical techniques strongly preferred. Must self-motivated\, inquisitive\, ambitious and enthusiastic about conducting research. Excellent verbal and written communication skills and the ability to thrive in a fast-paced environment necessary. Must be able to work both independently and as part of a team.
URL:https://ces.b2sg.org/event/r-29may19/
LOCATION:The Rockefeller University\, 1230 York Ave\,\, New York\, NY\, 10065\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190531
DTEND;VALUE=DATE:20190605
DTSTAMP:20260908T012908
CREATED:20181010T170232Z
LAST-MODIFIED:20181011T070215Z
UID:20736-1559260800-1559692799@ces.b2sg.org
SUMMARY:ASCO Annual Meeting
DESCRIPTION:ASCO wants to ensure that you never miss a deadline. From the opening of registration and hotel reservations to the release of abstracts\, keep these dates in mind as you prepare to attend the 2019 ASCO Annual Meeting. \n  \nEARLY FEBRUARY\, 2019\nGroup and Exhibitor Registration Open \nFEBRUARY 12\, 2019 AT 11:59 PM EST\nAbstract submission deadline \nMARCH 14\, 2019 AT 12:00 PM (NOON) EST\nLate-Breaking Data Submission Deadline (authors must submit a shell/placeholder by the February 12\, 2019 deadline to be considered for Late-Breaking Submission) \nAPRIL 24\, 2019\nEarly Registration Deadline
URL:https://ces.b2sg.org/event/asco2019/
LOCATION:McCormick Place\, 2301 S King Dr\, Chicago\, IL\, 60616\, United States
CATEGORIES:Meetings
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