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PRODID:-//Cancer Epigenetics Society - ECPv5.3.2.1//NONSGML v1.0//EN
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METHOD:PUBLISH
X-WR-CALNAME:Cancer Epigenetics Society
X-ORIGINAL-URL:https://ces.b2sg.org
X-WR-CALDESC:Events for Cancer Epigenetics Society
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
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TZNAME:CEST
DTSTART:20190331T010000
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TZNAME:CET
DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190521
DTEND;VALUE=DATE:20190623
DTSTAMP:20260908T182233
CREATED:20190521T120620Z
LAST-MODIFIED:20190521T123349Z
UID:21253-1558396800-1561247999@ces.b2sg.org
SUMMARY:Senior Research Associate
DESCRIPTION:In collaboration with the Principal Investigator\, under general supervision\, the Senior Research Associate will be responsible for making independent contributions to research and experiments. Incumbent will perform a) isolation of four cell types (hepatocytes\, Hepatic Stellate Cells\, Kupffer cells\, and Endothelial cells) from livers which are rejected for transplantation; b) cell characterization and cryopreservation\, storage\, cataloging; c) in vitro studies using cell stimulation\, co-culturing; d) generation of humanized mice. Incumbent will develop an independent scientific project focused on NASH and ASH-induced cross-talk between human hepatocytes/HSCs/Kupffer cells\, characterization of their gene expression profile and epigenetic signature. Will assist in writing grant applications\, applying for NIH funds to support the Human Cell Isolation lab and research projects. Will contribute to the preparation and editing of grant review proposals for federal\, state and private funding agencies. Will draft\, edit or criticize proposal aims and research plans. \nThe Senior Research Associate will manage and coordinate research efforts with other collaborators as appropriate for multidisciplinary research. Plan\, execute and follow-up on high level regular and ad hoc meetings of investigators and management. Independently conceive\, plan\, and conduct research projects based on reviews of scientific literature and recent advances in related fields\, organizing and executing all techniques involved. Contribute novel ideas of major methodological significance to the research projects\, designing key experiments and developing new techniques. Will perform complex data analysis using various statistical tools. Will author or co-author scientific journal manuscripts and book chapters and report directly to funding agencies and journal editors. Prepare and implement research study budgets based on analysis of data. Perform other duties as needed. \nThe Senior Research Associate will contribute significant\, innovative and original ideas and recommendations concerning challenging experimental procedures\, using specialized knowledge and a high level of technical skill and competence. The Senior Research Associate will develop and adapt new techniques and modify established protocols to further experiments. Interpretation of data and results of experiments for report production\, while also recognizing and investigating misleading results. \nMINIMUM QUALIFICATIONS\n\nBachelor’s degree in biology\, molecular biology\, biochemistry\, or related field and senior level laboratory experience.\nExperience with hepatocytes\, hepatic stellate\, kupffer and endothelial cells\, biochemistry\, cellular and molecular biology\, including experience in establishing\, maintaining\, transfecting\, and selecting clones from primary liver cell preparations with expertise in sterile technique.\nExperience with characterizing and behavior of human liver cell types\, specifically hepatocytes\, hepatic stellate cells\, kupffer cells and endothelial cells.\nProven experience with primary cell culture\, including large scale cell culture. Strong proven experience performing cell culture techniques including demonstrated ability working with sterile equipment and supplies. Ability to troubleshoot problems during all aspects of cell isolation and culture.\nExperience in managing multiple projects and working under milestones driven projects\, including knowledge in writing reports and experience in communicating with funding agencies.\nExperience in technical direction and training of students\, post-docs\, and technicians.\nDemonstrated experience in DNA and RNA extraction and use of extracted products in various PCR methods.\nExperience in designing and performing next generation RNA sequencing samples preparation and analyses.\nExceptional experience and knowledge in developing hypotheses\, design experiments\, conduct experiments\, analyze data\, write manuscripts\, and publish results in peer-reviewed journals\, including all interactions with Reviewers and Editors.\nDemonstrated experience in mouse models of liver fibrosis and cancer.\nExperience performing surgical implantation of shRNA-transfected tumor cell lines and intra-hepatic injections of human primary cells.\nProven experience with primary cell isolation from whole liver\, including large scale isolations.\nDemonstrated experience with standard biochemical and molecular biological laboratory procedures such as DNA cloning\, gel electrophoresis (including knowledge of SDS-PAGE and Coomassie Blue Staining)\, PCR\, RNA purification\, reverse transcription\, real time quantitative PCR\, Western Blotting\, ELISA and Histological analysis including paraffin and frozen block making\, sectioning and staining.\nProven experience with qPCR analysis\, and immunohistochemistry.\n\nPREFERRED QUALIFICATIONS\n\nProven experience in successful preparation of research grant proposals for funding by NIH or other major funding source.\nMaster’s degree or Doctoral degree in a related field.\n\nStrong organizational skills\, including experience in laboratory record keeping\, budget analysis and managing logistics.
URL:https://ces.b2sg.org/event/21may19/
LOCATION:UC San Diego Health – Moores Cancer Center\, 3855 Health Sciences Drive\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190521
DTEND;VALUE=DATE:20190623
DTSTAMP:20260908T182233
CREATED:20190521T124310Z
LAST-MODIFIED:20190521T124310Z
UID:21264-1558396800-1561247999@ces.b2sg.org
SUMMARY:Scientist- Functional Genomics
DESCRIPTION:The successful candidate will work independently or as part of a research team that is focused on developing and running functional genomic screens and identifying new targets for the OTD department. Use of shRNA or CRISPR technology platforms to screen and identify targets regulating oncology and or immune related disease pathways is essential. He/she will also provide weekly assay development \, cell culture\, and molecular biology support for different projects and programs. \nROLE SUMMARY \nPfizer Integrative Biotechnology Group (IBG) located in Pearl River\, NY is within the Oncology division of Pfizer Worldwide Research & Development. IBG is dedicated to developing the next generation oncology therapeutics and therapeutic combinations by employing a multidisciplinary approach to target cancer cell cycle and modulate tumor microenvironment. We are seeking a qualified candidate at the Scientist level to join the group to contribute to drug discovery efforts by applying functional genomics and advanced molecular biology strategies to study novel cellular mechanisms underlying synthetic lethality with Pfizer’s preclinical and clinical assets. Primary responsibility of this role includes generating data packages to support advancement of late stage projects and publications in top-tiered research journals. \nThe qualified candidate for this position will be a highly motivated and collaborative scientist with strong interest in cancer biology\, epigenetics\, cell cycle progression and/or senescence response. \nS/he will demonstrate clear and professional verbal and written communication skills\, maintain an electronic notebook\, and can present scientific results to collaborators and at team meetings. \nROLE RESPONSIBILITIES  \n\nPerform experiments to study genetic and epigenetic factors that promote tumor growth and maintenance\nDevelop cellular and molecular assays to define mechanism of action relevant to target inhibition either by genetic approaches or compound treatment\nPerform cell-based assays for drug response alone or in combination to identify drug synergy\nPerform RNAi/CRISPR-based functional genomics screens for target discovery and validate novel drug targets both in vitro and in vivo\nPresent experiment results in group meetings\nMaintain experimental records in electronic lab notebook\nShare common lab responsibilities such as lab supply order and inventory management\nContribute to a dynamic\, exciting culture that embraces teamwork and innovation.\n\nBASIC QUALIFICATIONS  \n\nB.S. degree with 6+ years of experience or M.S. degree with 5+ years of experience in molecular biology\, cell biology\, genetics or related discipline\nMinimum 5 years of hands-on laboratory research\nAbility to plan and execute in vitro and/or ex vivo experiments with minimal supervision\nExperience in cell culture\, flow cytometry\, cell-based assays and standard molecular biology techniques such as SDS-PAGE\, ELISA\, Western Blot\, DNA/RNA purification\, PCR/RT-PCR\, and lentiviral packaging & transduction\nExperience with data processing software including Excel and Prism\nExcellent organization and planning skills\, the ability to work independently or as part of a team\, good verbal & written communication and interpersonal skills\, and strong motivation with a pro-active attitude and dedicated work ethic\nAbility and desire to learn new techniques\n\nPREFERRED QUALIFICATIONS \n\nExperience in cancer biology especially in cell cycle regulation and cancer epigenetics\nKnowledge of RNAi technology and experience in pooled RNAi-based screens\nExperience in use of CRISPR-based techniques for gene knockout\, gene editing as well as working knowledge of pooled CRISPR-based screening approaches\nExperience with NextGen sequencing\nExperience with tumor cell dissociation and processing
URL:https://ces.b2sg.org/event/p-21may19/
LOCATION:Pfizer – Pearl River\, NY\, 401 North Middletown Road\, Pearl River\, NY\, 10965\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190522
DTEND;VALUE=DATE:20190624
DTSTAMP:20260908T182233
CREATED:20190522T123208Z
LAST-MODIFIED:20190522T130329Z
UID:21266-1558483200-1561334399@ces.b2sg.org
SUMMARY:Staff Scientist
DESCRIPTION:We are seeking an outstanding and highly motivated Staff Scientist to join department of Computational Biology’s Genomics Laboratory. The Staff Scientist will have the opportunity to join our efforts dedicated to advancing the understanding of the molecular and cellular basis of pediatric cancers. The job responsibilities include performing single cell droplet experiments for both RNA end counting and DNA variant detection\, improving the workflow efficiency for NGS sequencing on the Illumina sequencing platform\, and evaluating and optimizing single cell DNA\, RNA\, and epigenetic protocols. In addition\, duties for this position include performing standard NGS protocols on the Illumina\, Pacific Biosciences\, and Oxford Nanopore sequencing platforms. \nQualified candidates will have a strong background in molecular and cellular biology\, single cell sequencing\, UMI applications\, and familiarity with the operation of the Illumina sequencing platform. Excellent written and communication skills\, the ability to effectively collaborate with peer scientists\, and execute tasks in a timely manner are highly desired. \nRecognized as a world leader in pediatric cancer genomics\, the department of Computational Biology at St. Jude Children’s Research Hospital has developed state-of-art computational algorithms\, well-established analytical pipelines\, and deep data analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature\, NEJM\, Nature Genetics\, and Nature Methods. The department provides a highly interactive environment with projects involving basic and clinical research collaborators\, access to high performance computing clusters\, cloud computing environment\, innovative visualization tools\, highly automated analytical pipelines and teamwork with scientists who have deep experience in data analysis\, data management and delivery of high-quality results for highly competitive projects. This position is located in Memphis\, TN\, and relocation assistance is available. \n\n\n\nMinimum Education\n\n\n\n\nA Ph.D. in an appropriate scientific field is required\n\n\n\n\nMinimum Experience\n\n\n\n\nA minimum of five (5) years of relevant and productive (combined) years postdoctoral research associate or five (5) years of combined academic experience at the postdoctoral level or above.\n\nStrong background in molecular and cellular biology\, single cell sequencing\, UMI applications\, and familiarity with the operation of the Illumina sequencing platform.
URL:https://ces.b2sg.org/event/stj-22may19/
LOCATION:St. Jude Children’s Hospital\, 262 Danny Thomas Pl\, Memphis\, TN\, 38105\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190526
DTEND;VALUE=DATE:20190629
DTSTAMP:20260908T182233
CREATED:20190526T185047Z
LAST-MODIFIED:20190526T185047Z
UID:21269-1558828800-1561766399@ces.b2sg.org
SUMMARY:Senior Research Scientist
DESCRIPTION:Dr. Kapil N. Bhalla is currently seeking a Senior Research Scientist who will be responsible for conducting research in his NIH-funded laboratory. The focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases\, methyltransferases and demethylases\, BET proteins\, as well as the chaperone biology of heat shock proteins and their cancer relevant client proteins regulating cell growth\, differentiation and survival of the human leukemia stem/progenitor cells. The qualified candidate must possess a Ph.D. in Biology\, Biological Sciences\, Life Sciences or related field and a keen interest and experience in cancer research. The candidate must have completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla’s laboratory. The qualified candidate must have the ability to troubleshoot in the design and conduct of the laboratory studies. Experience in molecular studies involving gene transfection\, analysis of gene expression through QPCR\, microarrays\, immunoblots and flow cytometry\, as well as experience in chromatin immunoprecipitation studies\, evaluation of protein biochemistry with 2D gels and the yeast-two-hybrid system\, and tissue culture techniques is required. Experience in the ability to utilize CRISPR technology for gene editing and to utilize confocal microscopy for molecular imaging is highly desired. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia\, and confocal microscopy is also desired. An outstanding research environment\, new laboratory and core facilities are provided. \nThe salary range is: min-$53\,200\, mid-$66\,500 and max-$79\,800. \nKEY FUNCTIONS \nResearch Design and implementation \nPlans\, organizes\, coordinates\, directs and conducts scientific research projects. Develops and maintains standard procedures and protocols to ensure the quality and integrity of the procedures performed. Coordinates with other investigators to provide appropriate support on analytical techniques. Maintains detailed experimental records\, evaluates resulting research data\, and presents findings to physicians and/or professional groups. \nData Analysis \nAnalyzes and evaluates research data and revises techniques and approaches to work problems. Works with the Principal Investigator on projects in the area of biomarker development and leukemia biology. Participates in adopting new techniques and learning new skills to enhance research efforts. \nLab Development/Publications \nSupervises\, mentors\, and counsels trainees and other laboratory personnel with respect to proper laboratory techniques\, the use of laboratory equipment and safety procedures. Publications/Manuscripts and Presentations. Contributes to manuscripts and prepares documents for publication. Compiles\, writes\, and submits reports to superior. Presents results at national meetings. \nOther duties as assigned. \n\nEDUCATION \nRequired: PhD in one of the natural sciences or related field or Medical degree. \nEXPERIENCE\nRequired: With PhD\, no experience required. With Medical degree\, two years of experience in experimental or scientific work. \nPreferred: With PhD must have completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla’s laboratory.
URL:https://ces.b2sg.org/event/26may19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190527
DTEND;VALUE=DATE:20190630
DTSTAMP:20260908T182233
CREATED:20190527T144250Z
LAST-MODIFIED:20190527T144250Z
UID:21271-1558915200-1561852799@ces.b2sg.org
SUMMARY:Vice President - Biology
DESCRIPTION:FORMA Therapeutics is seeking a VP of Biology to drive FORMA’s current and future discovery research and translational biology to\nadvance products from target selection to the clinic. This is a key leadership role reporting directly to the Head of Research and Development. The ideal candidate will be adept at working within an open\, matrixed\, multi-disciplinary team and possess a passion for exploration of novel biology\, to address unmet needs of patients with cancer and other serious diseases. In this role\, the VP of Biology will also play a critical leadership role in guiding teams through the assessment and development of molecules in discovery and clinical\ndevelopment\, such as mode of action studies\, in vitro and in vivo models\, and building pre-clinical support for IND enabling activities and beyond. \nThe successful candidate will be a dynamic and innovative scientist who will provide leadership\, guidance and management to a broad range of biology-related activities in the discovery and translational teams. It is critical that the candidate is experienced with the drug discovery and development process as evidenced by key contributions to the discovery of new therapies that have advanced to clinical proof of concept. The candidate should also be able to develop and mentor project leaders and support cross-functional and other collaborative activities. \nEssential Functions: \n\n\nBuild and lead a world class Discovery and Translational Biology team while driving an innovative culture that cultivates teamwork and optimizes performance to advance novel\, innovative compounds\nLead by example with a high level of emotional intelligence and effectively collaborate with leaders in Early Discovery\, Early Development\, Chemistry and other functional groups\nProvide scientific expertise/direction and leadership to the Discovery Biology organization. A strong level of experience and accomplishment in the oncology therapeutic area is essential\nLead the identification and prosecution of a sustainable flow of actionable biology targets for screening and discovery to achieve FORMA’s drug discovery goals with the ultimate objective to bring unprecedented new medicines to patients\nActively assist in seeking\, driving and managing product and technology alliances with academia\, government and industry partners\nWork with biology project teams to set objectives and address specific challenges and meet goals.\nEffectively apply state-of-the-art technologies and best practices to improve operational efficiency\nEnsure performance standards are maintained and that experimental work is performed to a consistently high standard\nProvide critical cancer biology expertise for FORMA’s portfolio\nProvide the necessary expertise in in vivo pharmacology and in tumor model systems (transgenic\, syngeneic and xenogeneic) to define the anti-cancer therapeutic activity of FORMA’s portfolio\nServe as subject matter expert in preparing and presenting research results at external scientific conferences\nActive member on the Research Leadership Team\, playing a critical role in the development and execution of FORMA’s research and development strategy\nOperationally responsible for the biology research team and its deliverables\n\nQualifications\, Education and Experience: \n\nPh.D. or M.D./Ph.D. in appropriate Biological Sciences Discipline; Oncology (preferred)\nAt least 15 years industry experience in the discovery of potential novel therapeutics\, preferably small molecules\nExperience in leading translational biology efforts to advance early projects through Phase I\nA record of building\, leading highly productive teams\, with a strong record of organizational experience\nDemonstrated scientific leadership in cancer biology\, an innovative aptitude\, coupled with strong practical execution\nBalances leadership strength with self-awareness\, confidence and humility\nExceptional track record of publication in high impact\, high visibility scientific journals\nExceptional verbal and written communication skills\nTrack record of establishing expertise in in vivo pharmacology across different disease areas. Expertise in cancer pharmacology is highly preferred\nExperience in managing external research collaborations with academic institutions as well as companies\nAbility to balance execution of tasks required to accomplish goals with creating an environment of scientific curiosity\, innovation and open exchange of ideas
URL:https://ces.b2sg.org/event/forma-27may19/
LOCATION:FORMA Therapeutics\, Watertown\, MA\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190527
DTEND;VALUE=DATE:20190630
DTSTAMP:20260908T182233
CREATED:20190527T144759Z
LAST-MODIFIED:20190527T144759Z
UID:21273-1558915200-1561852799@ces.b2sg.org
SUMMARY:Scientist I- Protein Homeostasis
DESCRIPTION:Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer\, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients\, quest for innovation\, spirit of independence and love of challenge. With a presence in more than 70 countries – and growing we look for talented people to grow our business\, advance our science and contribute to our unique culture. The key therapeutic platforms currently under investigation leverage a broad range of biological activities that allow for the development of novel paradigm-changing therapeutics. Our discovery research teams are organized into four Thematic Centers of Excellence (TCoE)\, including Protein Homeostasis\, Epigenetics\, Immuno-oncology and Inflammation & Immunology. Within each these areas\, discovery research\, translational research\, and early clinical development are integrated into a single team. \nSummary/Scope\nThe early drug discovery effort of our team in the Protein Homeostasis TCoE is focused on the exploration of the molecular underpinning of cancer development and progression\, and the design and characterization of novel antitumor agents. We are seeking a PhD scientist to define the underlying mechanism of response and resistance to novel cereblon modulating agents targeting protein turnover and function for the treatment of hematological cancers. More specifically\, Next Generation Sequencing tools\, proteomics and molecular/genetic approaches will be utilized to delineate the molecular\, genetic and epigenetic signatures of cancer cell specific addiction programs\, which could be manipulated by cereblon modulating agents to achieve antitumor activity. The understanding of mechanism of action of these agents will help us identify the right disease indications\, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership. \nResponsibilities will include\, but are not limited to\, the following: \n\nGenerate testable hypotheses\, design research protocols and execute experiments\nUtilize CRISPR and RNAi to determine the disease relevance of novel cereblon substrates\nPerform cellular experiments to help define the SAR of cereblon modulators\nUtilize genetic and pharmacological approaches to define the MOA of candidate agents\nDesign and develop novel assays\nDocument\, interpret and troubleshoot results\nConvey data analysis and interpretation to supervisor and colleagues\nCommunicate with peers and supervisors and foster teamwork\nContribute to collaborative efforts\nStrong commitment to quality and reproducibility\nDemonstrate adaptability\nSupervise or guide research staffs\n\n\nQualifications:\nPh.D. in molecular genetics or related scientific discipline with at least 2 years of work experience.  Bachelor’s degree in a scientific discipline with at least 10 years work experience or Master’s degree with at least 8 years work experience may be considered.\nPrefer graduate work focusing on the regulation of gene expression at the molecular level.\nStrong publication record in major scientific journals.  \nSkills/Knowledge Required: \n\nExtensive wet-lab experience with routine molecular\, cellular and genetic biology tools\nExtensive experience with Cas9-CRISPR mediated gene editing\nExtensive experience with flow cytometry analysis and FACS\nExtensive experience with next generation sequencing(NGS) methods\nExperience with analysis of NGS datasets is preferred but not required\nHighly motivated and strong team player with a high degree of independence\nInnovative and critical thinking\nExcellent time management and organizational skills\nStrong communication skills\, both written and oralFunctional/Scientific/Technical Skills:\n• Able to design complex experiments with scientific rationale.\n• Able to critically analyze and interpret data.\n• Learning the drug development process.\n• Draw appropriate conclusions.\n• Possess in-depth knowledge in area.\n• Understands fundamental scientific problems and can apply knowledge to research and development projects and problems in a positive manner.\n• Developing skills in critical interpretation of scientific data and problem solving and reporting of scientific data. \nTasks and Responsibilities:\n• Contributes individually as well as on cross functional teams.\n• Responsible for more complex assignments and for more than 1 project.\n• Able to evaluate CRO’s.\n• Well versed in fundamentals of functional area.\n• Understands the context\, impact and timely communication of data. \nDiscretion/Latitude:\n• Works as an individual contributor.\n• Viewed as a knowledgeable resource within the department.\n• Supervising/mentor role in function. \nCreativity and Problem Solving:\n• Critically assess project(s) and formulates ideas.\n• Implement solutions independently.\n• Scope of problem solving is generally within the departmental function.\n• Recommend and formulate protocols and experimental plans. \nTeamwork and Influence:\n• Communicates with cross functional team.\n• Routinely contributes to the achievement of workgroup/team goals.\n• Represents workgroup/team or department on multi-disciplinary or cross functional teams. \nOrganizational Impact:\n• Beginning to have a direct impact on departmental performance.\n• Impact is achieved primarily by contributing to team efforts. \nBehavioral Competencies:\n• Acts with integrity\n• Analysis of issues\n• Building relationships\n• Coaching and developing others\n• Delivers presentations\n• Develops systems & process\n• Fosters open communication\n• Influence others\n• Innovates\n• Manages execution\n• Planning
URL:https://ces.b2sg.org/event/cel-27may19/
LOCATION:Celgene San Diego\, 10300 Campus Point Dr\, San Diego\, CA\, 92121\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190529
DTEND;VALUE=DATE:20190701
DTSTAMP:20260908T182233
CREATED:20190529T082757Z
LAST-MODIFIED:20190529T082757Z
UID:21275-1559088000-1561939199@ces.b2sg.org
SUMMARY:Scientist (Biochemistry)
DESCRIPTION:We’re seeking a highly motivated and technically proficient laboratory Scientist with a strong enzymology background to join our dynamic biochemistry team. The successful candidate will provide biochemistry solutions across multiple projects in all therapeutic areas in a high-visibility\, highly-matrixed environment. Creativity\, enthusiasm\, organization\, and excellent communication skills a must. Excellent development and advancement potential. \nJob Responsibilities \n\nConceptual design and execution of novel biochemical assays to kinetically characterize enzyme targets\nDevelop strategies to ensure quality expression\, purification\, and biophysical characterization of enzymes produced from multiple expression systems\nInteract with exploratory cell biologists to help elucidate relevant intracellular biochemistry\, genetic and epigenetic regulation of our targets and advance them through validation\nInteract closely with medicinal chemistry to guide small molecule drug discovery through the execution of inhibitor or activator mechanism of action studies\nDual leadership from bench and in CRO management; manage external FTE resources; transfer and validate assays to external partners\n\nQualifications \n\nPhD in Enzymology\, Biochemistry or related field with 0-5+ years industry research experience or an MS or BS degree with 7-10 years of industry research experience in the context of small-molecule drug discovery\nA strong background in steady-state enzymology with emphasis on mechanism of action and kinetic studies with (UV/VIS\, TR-FRET\, FP) readouts. Past experience with coupled enzyme assay systems\, transient kinetics\, KNIME informatics environment\, and LCMS-based enzyme assays is a plus.\nIn-depth understanding of recombinant protein expression and purification from bacterial\, insect\, and yeast systems.\nA proven history of effective team work with excellent collaborative and communication skills is required
URL:https://ces.b2sg.org/event/29may19/
LOCATION:Agios Pharmaceuticals\, 88 Sidney Street\, Cambridge\, MA\, 02139\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190529
DTEND;VALUE=DATE:20190701
DTSTAMP:20260908T182233
CREATED:20190529T094511Z
LAST-MODIFIED:20190529T094511Z
UID:21278-1559088000-1561939199@ces.b2sg.org
SUMMARY:Research Assistant
DESCRIPTION:The fundamental structure of chromatin suggests that all DNA-templated processes\, including a wide range of epigenetic phenomena\, are influenced by chromatin alterations with far-reaching implications for human biology and disease. Research in Dr. Allis’ laboratory is centered on chromatin and its regulation though post-translational modification of histone (and non-histone) proteins\, ATP-dependent remodeling of chromatin\, and the exchange of histone variants.\n\n\n\n\nDetailed Description\n\n\n\nThis position will involve contributing directly to work by a physician scientist (MD\, PhD) who specializes in medical oncology. The overall aim of the work is to understand the fundamental epigenetic mechanisms of cancer-associated mutations. Projects may also involve preclinical drug development of anticancer therapeutics. The Research Assistant will be responsible for performing cell culture\, generation of cell lines harboring tumor-derived mutations\, cell-based chromatin assays (eg. ChIP\, DNA methylation and/or produce next-generation sequencing libraries)\, measurements of small molecule activity\, and cellular differentiation assays. Will record data and analyze results\, maintain and perform experiments with cells in tissue culture\, and maintain inventory of frozen cell stocks.\n\n\n\n\nJob Requirements\n\n\n\nBachelor’s degree in science required; Master’s degree preferred. Previous experience with cell culture\, molecular biology and biochemical techniques strongly preferred. Must self-motivated\, inquisitive\, ambitious and enthusiastic about conducting research. Excellent verbal and written communication skills and the ability to thrive in a fast-paced environment necessary. Must be able to work both independently and as part of a team.
URL:https://ces.b2sg.org/event/r-29may19/
LOCATION:The Rockefeller University\, 1230 York Ave\,\, New York\, NY\, 10065\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190602
DTEND;VALUE=DATE:20190704
DTSTAMP:20260908T182233
CREATED:20190602T105004Z
LAST-MODIFIED:20190602T105004Z
UID:21282-1559433600-1562198399@ces.b2sg.org
SUMMARY:Research Asst. Professor
DESCRIPTION:The Research Assistant Professor of the Department of Medicine\, Division of Hematology  will have as his or her main duty\, the conduct of reliable and independent laboratory research on transcription factors as they relate to epigenetics of breast cancer and other Runx1 related diseases (e.g. MDs and AML). The successful candidate should hold a PhD and/or MD degree and have research expertise in epigenetics of breast cancer. \nThe individual’s research must have been published in peer-reviewed scientific journals. The person in this position will also write and submit grant proposals\, select and recommend equipment\, define duties of laboratory personnel\, supervise laboratory personnel and/or graduate students\, collect and analyze data\, and write scientific papers and abstracts. This candidate will be expected to become a member of the Sylvester Comprehensive Cancer Center (SCCC). Reappointments are reviewed annually and are contingent upon performance and availability of funding. \nAll Applicants Must Apply Online
URL:https://ces.b2sg.org/event/2jun19/
LOCATION:University of Miami\, 1320 S Dixie Hwy\, Coral Gables\, FL\, 33146\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190602
DTEND;VALUE=DATE:20190810
DTSTAMP:20260908T182233
CREATED:20190602T105658Z
LAST-MODIFIED:20190602T105841Z
UID:21284-1559433600-1565395199@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:The new R&D Oncology organisation brings together early and late oncology teams\, from discovery through to late-stage development\, with oncology specific Regulatory and Biometrics groups. \nYou’ll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example\, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What’s more\, you’ll have the support of a leading academic advisor\, who’ll provide you with the guidance and knowledge you need to develop your career. \nYou’ll be associated with a project aligned with our scientific platform of Tumour Driver and Resistance\, aiming to elucidate the mechanism of an epigenetic protein that functions as a resistance mechanism for cancer and define the combination strategy to overcome the drug resistance. \nEducation and Experience required: \nEssential: \n\nPhD in oncology\, cell biology\, or related field\nStrong desire to learn and perform cancer research in an industry setting\nExpertise in epigenetic oncology and/or RTK signalling pathways\nStrong scientific background in mechanisms of disease and drug resistance.\nExperience with a variety of laboratory\, molecular\, and cellular biology techniques  \n\nDesirable: \n\nRelevant bioinformatic experience\n\nSkills and Capabilities required: \n\nHighly motivated\, innovative and reliable with the ability to effectively problem solve\nFlexible\, collaborative and team-oriented mind set\nStrong publication track record\nExcellent communication skills (oral and written)\n\nThis is a 3-year programme.  2 years will be a Fixed Term Contract\, with a 1-year extension which will be merit based.  The role will be based in Waltham\, MA\, USA\, with a competitive salary on offer. To apply for this position\, please click the apply link below.
URL:https://ces.b2sg.org/event/az-2jun19/
LOCATION:AstraZeneca\, Gaithersburg\, MD\, 20878\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190604
DTEND;VALUE=DATE:20190706
DTSTAMP:20260908T182233
CREATED:20190604T124026Z
LAST-MODIFIED:20190604T124026Z
UID:21287-1559606400-1562371199@ces.b2sg.org
SUMMARY:Biological Scientist III
DESCRIPTION:The Department of Medicine\, Division of Hematology – Oncology is looking to fill a Biological Scientist III position.This position is created to work in a research laboratory with special emphasis on epigenetic mechanisms in cancer; perform research laboratory assays on patient specimens as part of core laboratory function for clinical trial networks; laboratory management to include maintaining sufficient inventory of materials\, supplies and equipment for efficient laboratory performance; and assist in developing operating budgets. \nDuties include: \n\nPerforming scientific experiments with a focus on uveal melanoma and a CRISPR based screen to determine susceptibilities of these tumors to gene ablation in cell system with or without key mutations relevant to uveal melanoma.\nDuties will also focus on genome wide patterns of chromatin accessibility and looping in response to GNAQ\, Ras and other oncogenes in the contacts of loss of chromatin regulators such as Bap1\, KMT2D and KMT2C.\n\n\nExperimental duties will include but not be limited to\, using molecular biology techniques such as cell culture\, western blotting\, Chromatin immunoprecipitation\, CRISPR/Cas9 gene editing and next generation sequencing (RNA-seq\, ChIP-seq) to test how structural and functional mutations in proteins that regulate chromatin structure may alter gene expression and promote the tumor phenotype.\nAssist with training of junior lab technician staff and oversee laboratory processes.\n\n\nAdditional duties associated with the position include performing experiments in mice and assisting in the maintenance of the lab’s animal colony and occasional lab maintenance/housekeeping/ordering.\nCommunicate with the principal investigator and laboratory technicians regarding ongoing processes of the laboratory and the progress being made on such processes.\nPerform research experiments to advance research in the laboratory.\nMaintain an adequate research supply and reagent inventory\, reordering such supplies as needed\, and justifying laboratory equipment requests\n\n\nPerform statistical analysis on results and prepare data for publication. Prepare reports on research findings.\n\n\nIndividual will be responsible for the preventative maintenance on laboratory as required and other duties as assigned.\n\n\n\n\n\nExpected Salary:\n\n$48\,000 – $52\,000 \n\n\n\n\nMinimum Requirements:\n\nDoctoral degree in biology or a closely related field and two years of relevant experience; or a master’s degree in biology or a closely related field and five years of relevant experience; or a bachelor’s degree in biology or a closely related field and seven years of relevant experience. \nThis position is available for current UF employees only. \n\n\n\n\nPreferred Qualifications:\n\nDoctoral degree in biology or a closely related field and two years of experience in the field or in a related area; or master’s degree in biology or a closely related field and five years of experience in the field or in a related area; or bachelor’s degree in biology or a closely related field and seven years of experience in the field or in a related area. \nThe incumbent must have good communication skills and be able to work well with colleagues\, representatives of pharmaceutical and biotechnology companies\, and be able to seek information as needed when future experiments require special abilities or experience found only outside of the university.
URL:https://ces.b2sg.org/event/4jun19/
LOCATION:University of Florida\, Gainesville\, FL\, 32611\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190605
DTEND;VALUE=DATE:20190707
DTSTAMP:20260908T182233
CREATED:20190605T124445Z
LAST-MODIFIED:20190605T124557Z
UID:21289-1559692800-1562457599@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:A postdoctoral position is available in the Cancer Molecular Pathology section headed by Frederic G. Barr\, MD PhD\, in the Laboratory of Pathology\, Center for Cancer Research\, National Cancer Institute\, Bethesda\, MD. This research laboratory uses a multidisciplinary approach involving genomics and bioinformatics along with cell culture and animal models to study recurrent genetic and epigenetic alterations in cancer. By focusing on specific cancer types\, such as the rhabdomyosarcoma family of myogenic soft tissue cancers\, this research laboratory is investigating the molecular basis and biological consequences of chromosomal translocations\, amplification events\, and methylation changes in these cancers. In addition\, the section works closely with clinicians to investigate the utility of these recurrent changes as biomarkers for diagnosis and management.
URL:https://ces.b2sg.org/event/5jun19/
LOCATION:National Institutes of Health (NIH) campus\, Bethesda\, MD\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190606
DTEND;VALUE=DATE:20190709
DTSTAMP:20260908T182233
CREATED:20190606T163252Z
LAST-MODIFIED:20190606T163252Z
UID:21291-1559779200-1562630399@ces.b2sg.org
SUMMARY:Life Science Research Professor I
DESCRIPTION:An LSRP position is available in the laboratory of Dr. Matt van de Rijn in the Department of Pathology at Stanford University. \n\nOur lab applies cutting-edge high-throughput methods to study soft tissue sarcomas. We seek to understand the molecular underpinnings of these cancers\, with the goal of developing new diagnostic\, prognostic\, and/or predictive biomarkers and therapeutic targets that can be applied in clinical practice.  Our research interests include the genetic\, epigenetic\, and transcriptomic characteristics of various types of soft tissue tumors including leiomyosarcoma and leiomyoma. The LSRP will be involved in a research project that aims to perform molecular analyses of these tumors on a single cell level\, in order to better understand the biology\, evolution and clinical behavior of these tumors\, and to identify novel therapeutic strategies. Specifically\, LSRP will be making single cell and single nuclei preparations from different types of soft tissue tumors\, doing molecular profiling (DNA sequencing\, RNA sequencing\, and methylome profiling) and apply computational biology methods to analyze and interpret the next generation sequencing data.  The position also includes lab management tasks such as ordering supplies\, maintaining our slide/block/tissue inventory\, keeping detailed lab records\, and adhering to safety regulations. \n\nWe welcome candidates with a growth mindset\, interest in a variety of cancer research questions related to molecular underpinnings of disease\, and a willingness to take on challenging learning opportunities. \n\nIn addition to comparable research compensation\, candidates will have the opportunity to learn and to develop their C.V. or resume through research publications and presentations. \n\nDuties include: \n\n Plan and perform experiments in support of research projects in the laboratory based on knowledge of scientific theory. Interpret and perform basic analyses of the results.\nApply protocols for preparation of single cell and/or single nuclei suspension from fresh\, frozen\, and/or formalin fixed paraffin embedded tissue and subsequent library construction for next generation sequencing (sequencing performed at a core laboratory).  Sequencing data generated can be analyzed using existing software programs.  Downstream experiments may include designing a targeted sequencing test\, in situ hybridization\, and/or immunohistochemical biomarker testing.\nReview literature on an ongoing basis to remain current with new procedures and related research.\nApply the theories and methods of molecular and/or computational biology to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols under supervision of a senior researcher.\nMaintain detailed records of experiments and outcomes.\nContribute to publication of findings as needed. Participate in the preparation of written documents\, including procedures\, presentations\, and proposals.\nHelp with general lab maintenance as needed; maintain lab stocks\, manage chemical inventory and safety records\, and provide general lab support as needed.\nAssist with orientation and training of new staff or students on lab procedures or techniques.\n\nDESIRED QUALIFICATIONS: \n\nA bachelor’s degree in biological sciences or a related field.\nPrevious experience or established knowledge of basic laboratory techniques in molecular biology.\nStrong analytical skills and excellent judgment.\nAbility to work under deadlines with general guidance is essential.\nMust be accurate\, efficient\, organized and have excellent record keeping abilities.\nAbility to work with team members in a cooperative fashion.\nExcellent communication skills.\n\n  \nEDUCATION & EXPERIENCE (REQUIRED): \n  \nBachelor’s degree in related scientific field. \n\nKNOWLEDGE\, SKILLS AND ABILITIES (REQUIRED): \n\nGeneral understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.\nDemonstrated ability to apply theoretical knowledge of science principals to problem solve work.\nAbility to maintain detailed records of experiments and outcomes.\nGeneral computer skills and ability to quickly learn and master computer programs\, databases\, and scientific applications.\nAbility to work under deadlines with general guidance.\nExcellent organizational skills and demonstrated ability to accurately complete detailed work.
URL:https://ces.b2sg.org/event/6jun19/
LOCATION:Stanford University\, School of Medicine\, 291 Campus Drive\, Stanford\, CA\, 94305\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190612
DTEND;VALUE=DATE:20190714
DTSTAMP:20260908T182233
CREATED:20190612T121959Z
LAST-MODIFIED:20190612T122112Z
UID:21294-1560297600-1563062399@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:A Postdoctoral Associate position is available in the laboratory of Dr. Maria Diaz-Meco. The overall goal of Dr. Diaz-Meco’s laboratory is to study metabolism and inflammation in the context of prostate cancer (Pca)\, with the aim of understanding the biology of this disease and to identify potentially novel therapeutic targets. \nThe Postdoctoral Associate will study the role of epigenetic and metabolic reprogramming in lineage plasticity and therapy resistance in prostate cancer.  The project is based on our recent publication on this topic: Reina-Campos et al.\, 2019\, Cancer Cell [https://doi.org/10.1016/j.ccell.2019.01.018]. \nTO APPLY: Interested candidates should apply online to the SBP career site by submitting a single PDF document with a cover letter\, CV\, three references and list of any publications or accomplishments. Please include a brief description of research accomplishments\, research interests and career goals. \nPrimary Responsibilities\n\nIndependently design and perform experiments and procedures with high degree of complexity\nDemonstrate flexibility in adapting methods and skills according to evolving project priorities\nProvide independent experimental design and planning\nBe able to analyze and interpret data from different sources and draw relevant conclusions\nDemonstrate knowledge in relevant specialized disciplines\nBe able to present results at internal and external meetings\nAccurately document experiments\nContribute to writing of reports and manuscripts with increasing responsibility over time\nWork collaboratively across lab functions and train other junior lab staff as needed \n\nRequired Experience \n\nPh.D. degree in biological science is required\nThe qualified candidate should have expertise in this area and experience in mouse models\n\nKnowledge\, Skills\, and/or Abilities\n\nHighly motivated and enthusiastic interest in this very competitive topic\nThe ability to work independently and to handle multiple projects and deadlines\nDemonstrated ability to work in an interactive and collaborative team\nExcellent presentation\, verbal\, and written communication skills\nPossess strong attention to detail\, analytical\, time management\, organizational\, and interpersonal skills\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/sbp-12jun19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190613
DTEND;VALUE=DATE:20190716
DTSTAMP:20260908T182233
CREATED:20190613T171334Z
LAST-MODIFIED:20190613T171422Z
UID:21298-1560384000-1563235199@ces.b2sg.org
SUMMARY:Research Assistant 1
DESCRIPTION:Research Assistant 1-B/H (Job Opening 450454) – Research Assistant 1-B/H to assist and provide support of research studies in investigating the epigenetic regulation of T cell function during infections and cancer as directed in the Department of Microbial Infection and Immunity; conducts planned research activities using observation\, measurement and analytical techniques; prepares solutions and live culture media for scientific experiments; performs a variety of assays and experimental tests; collects\, sorts and processes tissue and blood samples; records and consolidates research data; performs routine experimental procedures on laboratory animals including surgical procedures and/or administration of drugs; assists with care of laboratory animals; assists with preparation of data and materials for inclusion in research reports\, publications and grant applications written by principal investigator; researches current scientific literature on specified topics; assists with instructing research aides\, undergraduate and graduate students in laboratory procedures and operation of equipment; calibrates various laboratory equipment and operates microscopes\, centrifuges and other laboratory equipment; assists with ordering\, stocking and maintenance of research supplies.\n\n\n\n\n\n\nEducation and Experience:\n\n\n\n\n\n\nA Bachelor’s degree in a biological/health science or an equivalent combination of education and experience is required. Requires successful completion of a background check. Qualified candidates may be requested to complete a pre-employment physical including a drug screen.
URL:https://ces.b2sg.org/event/13jun19/
LOCATION:Ohio State University\, Columbus\, OH\, 43210\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190617
DTEND;VALUE=DATE:20190719
DTSTAMP:20260908T182233
CREATED:20190617T121326Z
LAST-MODIFIED:20190617T121547Z
UID:21301-1560729600-1563494399@ces.b2sg.org
SUMMARY:Post Doctoral Scientist - Bioinformatics and Functional Genomics
DESCRIPTION:Principle Investigator\, Dr. Megan Hitchins is a member of the faculty of Biomedical Sciences at Cedars-Sinai Medical Center and is situated with the Center for Bioinformatics and Functional Genomics (BFG). The BFG brings together teams specializing in bioinformatics and computational biology\, functional analysis of the genome and epigenome coupled with next generation sequencing\, epigenetic profiling\, and genome editing\, to provide a complete pipeline for identifying the functional consequences of genetic and epigenetic variation in cancer risk\, subtypes\, and outcomes. Dr. Hitchins’ group focuses in particular on the role of genetic and epigenetic variants in high-risk cancers\, and on DNA methylation markers of cancer\, as applied to the detection of circulating tumor DNAs.\n\nDr. Hitchins\, is looking for a Postdoctoral scientist to join the Center for Bioinformatics and Functional Genomics to investigate methylation markers specific to cancer that may be exploited as biomarkers for cancer risk stratification\, detection\, diagnosis\, prediction of treatment outcomes\, and monitoring of treatment outcomes. The ideal candidate we are searching for will have wet-lab training in genetic\, transcriptional and/or methylation analysis methods that include next generation sequencing based assays\, methylation analysis techniques\, and solid statistical analysis skills. The position requires a solid understanding of the molecular biology (genetics\, epigenetics and gene regulation) underlying cancer.\n\nAs an appointed post-doctoral fellow\, you will work with Dr. Hitchins (Molecular Geneticist and Epigeneticist) on germline genetic variation\, RNA expression\, and DNA methylation associated with cancer phenotypes. S/he will be supported by a Research Associate/Laboratory Manager and work within a highly integrated and multi-disciplinary group comprising senior and junior post-doctoral scientists\, research technicians\, clinical fellows and graduate students in the Center for Bioinformatics and Functional Genomics.\n\nAs the successful candidate\, you will be expected to conduct wet-lab research and statistical analyses of data (both directed and independent) under the mentorship of Dr. Megan Hitchins\, submit and publish papers and posters\, and make oral presentations. This post-holder must be well organized and be able to demonstrate written and oral presentation skills.\n\nEssential job duties and responsibilities:\n\n\n\nLead research project(s) in the genomics and epigenomics of cancer that form part of the research program under the mentorship of the Principal Investigator. This will include the undertaking of intellectual\, technical (wet-lab)\, and analytical aspects of the project(s)\n\n\nDraft manuscripts for publication and author or co-author\n\n\nContribute to the drafting of grant proposals\n\n\nAttend\, contribute to\, and present at laboratory group meetings and departmental meetings\n\n\nPresent research findings at national and international conferences\n\n\nProvide miscellaneous research support (ad hoc data analysis\, hypothesis development\, programming\, troubleshooting\, etc.)\n\n\nLead and train incoming Graduates Students\, Research Fellows\, lower level Research Associates\, and other related support staff and may be requested by Pl to take on specific day-to-day supervisory activities\n\n\nComply with all safety standards and procedures\n\n\nAssist with the establishment and maintenance of IRB proposals and protocols relating to projects in the laboratory\n\n\nAssist with the maintenance of database and accompanying biorepository\n\n\n\n\n\n\nEducational requirements: \n\n\nPh.D in a relevant area (Human Genetics/Epigenetics/Cancer Biology/Molecular or Cellular Biology)\n\n\nExperience:\n\n\n\nAt least 4 years of wet-lab experience\, which may include the Ph.D training period\nPh.D. in a relevant area (Human Genetics/Epigenetics/Cancer Biology/Molecular or Cellular Biology)\nAt least 4 years of wet-lab experience\, which may include the Ph.D training period\n\nTechnical expertise in some of the following: \n\n\n\nSafe handling and processing of clinical samples (such as human blood\, saliva\, or formalin fixed paraffin embedded (FFPE) tissue blocks); Sterile cell culture; DNA and RNA extractions from fresh\, frozen\, and FFPE tissues\nExpertise in an array of genetic\, epigenetic\, or other molecular biology techniques (such as PCR and real-time PCR\, cDNA synthesis and reverse transcriptase PCR\, generation of libraries for next generation sequencing\, exome sequencing\, whole genome sequencing\, whole genome bisulfite sequencing\, gel electrophoresis\, western blotting\, pyrosequencing\, sodium bisulfite conversion of genomic DNA for methylation analyses\, various techniques for DNA methylation analysis\, ChIP). On-site training will be provided for essential techniques\nFamiliarity with online genomics interrogation tools such as primer design\, BLAST\, human genome browser\, ENCODE\, functional prediction/interpretation of genetic variants\nBasic bioinformatics data analysis skills for the analysis of next generation sequencing data\, such as R\, LINUX and programming languages (Python)\, pedigree analysis tools\nBasic statistical analysis skills and familiarity with programs/software (such as R package or SPSS)\nSolid understanding of the biology and genetics underlying gene regulation and genetic variation is strongly preferred
URL:https://ces.b2sg.org/event/cs-17jun19/
LOCATION:Cedars-Sinai Medical Center\, Los Angeles\, 8700 Beverly Blvd\, Los Angeles\, CA\, 90048\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190617
DTEND;VALUE=DATE:20190719
DTSTAMP:20260908T182233
CREATED:20190617T122115Z
LAST-MODIFIED:20190617T122115Z
UID:21304-1560729600-1563494399@ces.b2sg.org
SUMMARY:Associate Scientist- In Vivo Pharmacology
DESCRIPTION:ROLE SUMMARY \nWe are seeking an Associate Scientist level to join the In Vivo Pharmacology Group within the Oncology Research Unit (ORU) of Pfizer’s Worldwide Research & Development (WRD) division in La Jolla\, California. The successful candidate will join a dynamic team of scientists\, playing a leading role in the characterization of models of cancer and evaluating new drug candidates. Participate in pre-clinical drug discovery and development projects with a focus on targeted therapeutics\, epigenetics and the tumor microenvironment. Characterize and develop small molecules in close collaboration with partner lines as an integral member of drug discovery teams. Evaluate anti-tumor effects in combination with biologics\, employ and develop new cutting-edge in vivo cancer models and provide technical and scientific expertise in in vivo pharmacology to the tumor cell biology department to enable target identification\, validation\, prioritization and efficient drug discovery of small molecules.  \nIdeal applicants will have excellent communication and organizational skills\, critical problem-solving abilities\, and a commitment to excellence. \nROLE RESPONSIBILITIES:  \n\nAssist/Conduct in vivo studies to evaluate and establish efficacy\, PK/PD relationship\, combination strategy\, biomarker identification and analysis.\nInterpretation\, presentation and documentation of experiments.\nPresentation of results within a multidisciplinary team environment.\nRegularly read scientific papers and implement learnings in the study designs or project strategies.\n\nBASIC QUALIFICATIONS: \n\nBachelor of Science degree in Cancer Biology\, Immunology or related discipline.\n0-3 years of laboratory work experience in academia or industry.\nAbility to follow novel scientific or technological developments\, and to implement them in the laboratory. \nExcellent written and oral communication and presentation skills.\nStrong ability to multi-task and work productively in a fast-paced\, highly collaborative\, and diverse team environment.\nCapability to contribute to a vivid and challenging intellectual environment.\n\nPREFERRED QUALIFICATIONS: \n\nIn vivo skills (IV\, PO dosing)\, blood/tissue collections\nExperience with in vivo models\nSome ex vivo skills such as FACS or Western blot are a plus
URL:https://ces.b2sg.org/event/pf-17jun19/
LOCATION:Pfizer – La Jolla\, CA\, 10350 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190617
DTEND;VALUE=DATE:20190719
DTSTAMP:20260908T182233
CREATED:20190617T122718Z
LAST-MODIFIED:20190617T122718Z
UID:21306-1560729600-1563494399@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:The Puri laboratory has a Postdoctoral Associate position available.  Dr. Puri’s laboratory investigates the molecular mechanism underpinning genome reprogramming during cell lineage commitment and terminal differentiation of embryonic and adult stem cells\, and during induced pluripotency. The Puri lab studies how extrinsic and intrinsic cues are converted into epigenetic information that controls gene expression in embryonic and adult stem cells. The lab is especially interested in skeletal muscle progenitors\, and one area of focus is how deregulated gene expression in these cells leads to development of rhabdomyosarcoma (RMS). \nTO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter\, CV\, references and list of any publications or accomplishments.  \n\nPrimary Responsibilities\n\nIndependently design and perform experiments and procedures with high degree of complexity\, demonstrating increasing expertise with a wide range of techniques\nDemonstrate flexibility in adapting methods and skills according to evolving project priorities\nProvide independent experimental design and planning\nBe able to analyze and interpret data from different sources and draw relevant conclusions\nDemonstrate knowledge in relevant specialized disciplines\nBe able to present results at internal and external meetings\nAccurately document experiments\nContribute to writing of reports and manuscripts with increasing responsibility over time\nWork collaboratively across lab functions and train other junior lab staff as needed \n\nRequired Experience \n\nPh.D. degree in Science is required\nPrevious Postdoc training is not required.\n\n\nKnowledge\, Skills and/or Abilities\n\nThe ability to work independently and to handle multiple projects and deadlines\nDemonstrated ability to work in an interactive and collaborative team\nExcellent presentation\, verbal\, and written communication skills\nPossess strong attention to detail\, analytical\, time management\, organizational\, and interpersonal skills\nEmbody the Institute’s core values of Commitment\, Collaboration\, Communication\, Community and Compassion
URL:https://ces.b2sg.org/event/sbp-17jun19/
LOCATION:Sanford Burnham Prebys Medical Discovery Institute\, 10901 N Torrey Pines Rd\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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