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DTSTART;VALUE=DATE:20200728
DTEND;VALUE=DATE:20200729
DTSTAMP:20200723T185535Z
CREATED:20200711T191810Z
LAST-MODIFIED:20200723T185535Z
UID:21522-1595894400-1595980799@ces.b2sg.org
SUMMARY:Epigenetic Therapeutic Targets
DESCRIPTION:The Epigenetic Therapeutic Targets meeting brings together academic and industry leaders in the field of epigenetics. These include:\n\n  \nSTORM therapeutics / AstraZeneca / GSK / Oryzon Genomics / Incyte / EpiZyme / 4SC / Bluebird Bio / Bristol Myers Squibb / Prelude Therapeutics / Corvidia Therapeutics / Foghorn Therapeutics / Epigeneron / Abcam / Salarius Pharmaceuticals / Twentyeight-Seven Therapeutics / aTyr Pharma / Epitoire / Epic Therapeutics / Constellation Pharmaceuticals / Vertex / Volition / Novartis / Imago Biosciences / Omega Therapeutics / Genentech / Resverlogix Corp / Accent Therapeutics / Johns Hopkins Medicine / Zenith Epigenetics / Imperial College London / Ohio State University / University of Rome La Sapienza / Viracta Therapeutics / Cancer Epigenetics Society / Dovetail Genomics / University of California San Diego \n\nMeeting program:\n\n7:30 am Online speed networking\n\nSynopsis\nGrab a quick cup of tea or coffee from the comfort of your own kitchen and jump straight into your opportunity to connect with new contacts from active companies in the field and exchange digital business cards. Network and form lasting connections through this exclusive virtual speed networking! \n\n\n\n8:00 am Opening Keynote Address: Chromatin-modifying and RNA-modifying Enzyme Inhibitors as Precision Cancer Therapeutics\n\nRobert Copeland\, President\, Chief Scientific Officer and Co-Founder \, Accent Therapeutics\n\n\n\nSynopsis\n\nThe history of epigenetics – from first wave to present day \nBenefits of RNA modifying enzymes as a target \nPrecise combination therapeutics in cancer (including epigenetics) for patients in the future \n\n\n\n\n8:30 am Targeting cancer with first-in-class inhibitors of the RNA m6A methyltransferase METTL3\n\nMark Albertella\, Vice President\, Translational Oncology\, Storm Therapeutics\n\n\n\nSynopsis\n\nIntroduction to RNA modifications\, the role of METTL3 and the m6A modification on selected mRNA species\nOverview of our drug discovery efforts to identify potent and selective inhibitors of METTL3\nCharacterisation of potent\, selective\, bioavailable inhibitors of METTL3 in biochemical\, biophysical and cellular assays\nExploration of utility of METTL3 inhibitors in hematological and solid tumour cell lines\nDemonstration of in vivo activity of METTL3 inhibitors in hematological and solid tumour models\n\n\n\n\n9:00 am From Somatic Mutations to Chromatin Topology – Emerging Tools For Epigenetic Biomarker Discovery\n\nTodd Dickinson\, CEO\, Dovetail Genomics\n\n\n\nSynopsis\n\nIntroduction to Omni-C\, a single assay for SNP detection\, SV mapping and\nchromatin 3-D landscape characterization\nInsights into drug response by capturing the 3-D gene regulatory landscape\nChromatin topology improves cancer genome characterization\nEnhancing bio-marker discoveries with genome topology\n\n\n\n\n9:15 am Overcoming Therapy Resistance to Cancer Immune Therapy – The role of epigenetic modulators\n\nSvetlana Hamm\, Head of Research and Translational Medicine\, 4SC\n\n\n\nSynopsis\n\nCancer immunophenotypes and immune escape mechanisms – how to address resistance to immune checkpoint therapy\nImmunomodulatory features of epigenetic drugs – rationale selection of combinations\, dose\, and schedule\nCase studies: i) Broad-spectrum HDAC inhibitor resminostat in combination with opsonizing antibodies in haematological cancer; ii) Class I HDAC inhibitor domatinostat in combination with checkpoint blockade – translation of preclinical findings into the clinic\n\n\n\n\n9:45 am Modulation of the Lysine Specific Demethylase 1 with iadademstat and vafidemstat: Cancer\, Cognition and Behavior\n\nRobert Soliva\, Drug Discovery Director\, Oryzon Genomics\n\n\n\nSynopsis\n\nInhibition of LSD1 by irreversible binding to the FAD cofactor\nIadademstat for treatment of AML and SCLC\nIncreased of neuronal plasticity and improvement of cognitive and behavioral functions by treatment with vafidemstat\nModulation of LSD1 activity as a personalized medicine strategy in CNS disease.\n\n\n\n\n10:15 am Online speed networking\n\n\nSynopsis\nGrab a quick cup of tea or coffee from the comfort of your own kitchen and jump straight into your opportunity to connect with new contacts from active companies in the field and exchange digital business cards. Network and form lasting connections through this exclusive virtual speed networking! \n\n\n\n10:45 am Epigenetic Dual Targeting Compounds: Together is Better\n\nAntonello Mai\, Professor\, Spienza University of Rome\n\n\n\nSynopsis\n\nThe design and biological validation of compounds able to simultaneously hit two epigenetic targets will be discussed with their effects in cancer diseases\, in comparison with the single-target inhibitors.\n\n\n\n\n11:15 am Automated High-throughput ChIP-seq Workflow using Covaris Adaptive Focused Acoustics® System for Accelerated Epigenetic Drug Screening\n\nAlon Goren\, Assistant Professor\, Department of Medicine\, University of California San Diego\n\n\n\nSynopsis\n\nStreamlining and reduce workflow time using automated ChIP-seq with the Covaris Adaptive Focused Acoustics (AFA)\nEvaluation of the AFA technology in a range of epitopes\, including H3K4me3\, H3K27me3\, H3K27ac\, RNA Pol-II\, CTCF\, and HNF4A in different cell lines.\nHow to utilize AFA-based ChIP-seq processes for rapid epigenetic drug screening and clinical diagnostics\n\n\n\n\n11:30 am Targeting epigenetic adaptation in ovarian cancer\n\nRobert Brown\, Professor\, Imperial College London\n\n\n\nSynopsis\n\nImproving treatment of ovarian cancer is a major clinical unmet need.\nEpigenetic adaptation is a driver of drug resistance in ovarian cancer.\nPotential of histone methyltransferases to overcome drug resistance.\nModulation of the immune microenvironment by histone methyltransferases.\n\n\n\n\n11:50 am The use of epigenetic therapy to improve the efficacy of immune checkpoint therapy for multiple common cancer types\n\nStephen Baylin\, Professor of Oncology\, John Hopkins University\n\n\n\n\n\n12:10 pm Panel: Combination Therapies vs Monotherapies – Approaches with epigenetic therapies\n\nRobert Brown\, Professor\, Imperial College London\nStephen Baylin\, Professor of Oncology\, John Hopkins University\nIM Bennani-Baiti\, President & CEO\, Cancer Epigenetics Society\n\n\n\nSynopsis\n\nCan HDAC inhibitors really work as a monotherapy?\nClinical trial implications of combination therapies\n\n\n\n\n12:40 pm Panel: Our Social Media Feeds Are Personalized – Why Isn’t Our Medical Treatment?\n\nElisabetta Chiarparin\, Director of Oncology Chemistry and Programme Leader\, AstraZeneca\nPeter Atadja\, Director & Head\, Drug Discovery \, Novartis\nRobert Copeland\, President\, Chief Scientific Officer and Co-Founder \, Accent Therapeutics\nRajarshi Choudhury\, Genome Editing Investigator\, GSK\n\n\n\nSynopsis\n\nThe journey to personalized medicine and the role epigenetics will play \nHow to design a drug development pipeline for precision medicine \nThe future of personalised medicine – a pipe dream or legitimate goal? \n\n\n\n\n1:20 pm Online speed networking\n\n\nSynopsis\nAutomated online speed networking – randomized matches made automatically based on profile – 5 rounds of 3 mins – to help people “accidentally meet”. \n\n\n\n1:50 pm Panel: Toxicity and Off-Target Effects\n\nNeil Michaud\, Senior Director\, Translational Medicine\, Epizyme\nPaul Kayne\, Head\, Discovery Genomics & Proteomics\, Bristol-Myers Squibb\nKai He\, Assistant Professor of Medicine The Ohio State\, University College of Medicine\nTamara Maes\, CSO\, VP and founder\, Oryzon Genomics\n\n\n\nSynopsis\n\nOvercoming the obstacles of toxicity regardless of target \nTechniques for monitoring toxicity and balancing this with efficacy \nDebating the dangers of off-target effects versus on-target effects \n\n\n\n\n2:30 pm Case Study: The Tazemetostat Story\n\nNeil Michaud\, Senior Director\, Translational Medicine\, Epizyme\n\n\n\nSynopsis\n\nDesigning a successful clinical trial – balancing efficacy and safety\nPatient cohorts based on a diagnostic tool that identifies patients with specific EZH2 mutations\nFuture implications\, plans and the move towards precision medicine in oncology\n\n\n\n\n3:00 pm Selective Bromodomain Inhibition with the Bromodomain and Extraterminal Domain Inhibitor Apabetalone: Discovery to Phase 3 Cardiovascular Outcomes Study\n\nNorman Wong\, Co-Founder and CSO\, Resverlogix Corp\n\n\n\nSynopsis\n\nEpigenetic regulation and BET system in CVD/T2DM\nMechanism of Apabetalone\nHighlights of Pre-clinical and Clinical Data\n\n\n\n\n3:30 pm Targeting SMARCA4-mutant lung cancers through selective\, chemically-induced degradation of SMARCA2\n\nRobert Yauch\, Director & Principal Scientist\, Discovery Oncology\, Genentech\n\n\n\nSynopsis\n\nSMARCA4 is mutationally-inactivated in subsets of lung cancer leading to a dependency on the paralog helicase\, SMARCA2\nThe discovery and development of selective SMARCA2 inhibitors would be essential for therapeutically targeting SMARCA4-mutant lung cancers\nIn vitro characterization and demonstration of in vivo activity of potent and selective degraders of SMARCA2\n\n\n\n\n4:00 pm Targeting cancer therapy with an epigenetic drug: Pre-clinical and clinical experience\n\nRichard Trauger\, Senior Director Translational Medicine\, Viracta Therapeutics\n\n\n\nSynopsis\n\nSpecificity and properties of a compound in relation to clinical application\nCreating an oral drug and a dosing schedule that works\nVirus activation vs HDAC inhibitors\n\n\n\n\n4:30 pm Online Networking break\n\n\nSynopsis\nGrab a quick cup of tea or coffee from the comfort of your own kitchen and jump straight into your opportunity to connect with new contacts from active companies in the field and exchange digital business cards. Network and form lasting connections through this exclusive virtual speed networking! \n\n\n\n5:00 pm Design of combination strategies and identification of biomarkers associated with clinical response to the BET bromodomain inhibitor ZEN-3694 in combination with enzalutamide in metastatic castration-resistant prostate cancer (mCRPC) patients\n\nEric Campeau\, Senior Director\, Translational Medicine\, Zenith Epigenetics\n\n\n\nSynopsis\n\nOptimal combination agents to use with BET bromodomain inhibitors in the clinic\nPatient populations that can benefit from combinatorial therapies with ZEN-3694\nBiomarkers of response of ZEN-3694 + enzalutamide in mCRPC patients\n\n\n\n\n5:20 pm The antileukemic effect exerted by LSD1 inhibition\n\nHugh Young\, Reinhoff\, CEO\, Imago BioSciences\n\n\n\n\n\n5:40 pm Panel: The Role of Epigenetics in an Oncology Portfolio\n\nMahesh Karande\, President and CEO\, Omega Therapeutics\nSusan Wee\, Senior Director\, Oncology Drug Discovery\, Incyte\nEric Campeau\, Senior Director\, Translational Medicine\, Zenith Epigenetics\nHugh Young\, Reinhoff\, CEO\, Imago BioSciences\n\n\n\nSynopsis\n\nUtilizing epigenetics in combination with immunotherapies to further bolster the immune response\nBuilding a differentiated oncology portfolio based on standalone epigenetic (mono)therapies\nImagining the future of epigenetic therapies in oncology and beyond\n\n\n\n\n6:30 pm Close of virtual conference
URL:https://ces.b2sg.org/event/epigenetic-therapeutic-targets/
CATEGORIES:Meetings
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2020/07/Epigenetics-Meeting-July-28_2020.jpg
ORGANIZER;CN="Hanson Wade":MAILTO:info@hansonwade.com
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191209
DTEND;VALUE=DATE:20200112
DTSTAMP:20191209T235453Z
CREATED:20191209T235453Z
LAST-MODIFIED:20191209T235453Z
UID:21488-1575849600-1578787199@ces.b2sg.org
SUMMARY:Assistant/Associate Professor
DESCRIPTION:The Department of Molecular and Structural Biochemistry at North Carolina State University invites applications for a tenure-track faculty position\, at the rank of either Assistant or Associate Professor\, in the broad area of structure\, function\, and mechanism\, with an emphasis on molecular systems in complex disease states. \nThe position will be 80% Research and 20% Teaching\, which is a typical split for research programs in the department.\nThe successful candidate will be expected to develop a rigorous\, independently funded research program in systems level examination of biological mechanisms using modern structural\, chemical biology\, imaging\, and/or quantitative analytical methods. We are especially interested in candidates who use one or more macromolecular structural determination and characterization methods including but not limited to NMR spectroscopy\, cryo-electron microscopy\, sophisticated biophysical analysis\, or x-ray crystallography\, and apply molecular insights to understand systems with translational application in medicine or agriculture. \nThis position will have opportunities to collaborate with biochemistry faculty who have expertise in nutrient/hormone metabolism and disease\, protein structure determination\, and quantitative metabolomics\, and will bridge collaborative efforts between the departments of Chemistry\, Chemical and Biomolecular Engineering\, and Molecular Biomedical Sciences. In particular\, this position is expected to benefit from interfaces with research programs that are focused on signal transduction pathways\, epigenetic mechanisms\, metabolic flux\, cancer metabolomics\, lipid metabolism\, biosensors and signaling\, drug development and regenerative medicine. This faculty member will further benefit from a rich environment for protein structure and metabolomics research at the basic/translational interface\, as well as access to state-of-the-art macromolecular structure determination instruments through university-supported facilities. \nNC State’s location in the Research Triangle offers collaborative opportunities with the University of North Carolina at Chapel Hill\, Duke University\, and the National Institute of Environmental Health Science\, as well as numerous industry partners. The proposed faculty member may be considered for an affiliative appointment in relevant departments and assist in team teaching at the graduate level with other departments as appropriate. Inclusiveness and diversity are critical to the success of the College and University as a whole. Therefore\, the successful candidate will be expected to foster an environment that is respectful and welcoming of all groups. \nThe department will begin reviewing applications October 21\, 2019\, and continue until the position is filled. Applicants for positions at a rank higher than assistant professor will be expected to demonstrate a strong track record of extramural funding and international prominence commensurate with expectations for achievement of that rank.
URL:https://ces.b2sg.org/event/ncsu-9dec19/
LOCATION:North Carolina State University\, Raleigh\, NC\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191206
DTEND;VALUE=DATE:20200108
DTSTAMP:20191206T192214Z
CREATED:20191206T192214Z
LAST-MODIFIED:20191206T192214Z
UID:21486-1575590400-1578441599@ces.b2sg.org
SUMMARY:Postdoctoral Associate
DESCRIPTION:Focus: Pediatric liver cancer research with an emphasis on mechanisms of invasive disease and development of novel models \n\n\nJob Duties\n\nA position is available for a full time postdoctoral fellow to pursue studies on the molecular pathogenesis of liver cancer\, including primarily hepatocellular carcinoma. In particular\, this position will focus on the generation of novel cell line and animal models\, the study of invasive disease and circulating tumor cells\, and the study of novel pre-clinical therapeutics in the regulation of cancer pathogenesis\, invasion\, and metastasis. \n\n\n\nMinimum Qualifications\n\nEducation: Ph.D in Basic Science\, Health Science\, or a related field. \nExperience: None required. \n\n\n\nSkills:\n\n\nExperience in in vivo tumor models\, tissue culture\, molecular cloning\, quantitative RT-PCR (qPCR)\, immunoblotting\, immunohistochemistry/immunofluorescence\, kinase and phosphatase assays\, chromatin immunoprecipitation\, cell cycle analysis\, flow cytometry\, apoptosis assays\, microscopy\, and knowledge/experience with genomic\, transcriptomic\, and epigenetic profiling of tumors.\nExperience with flow cytometry and bioinformatics and sequencing analyses is a plus.\nMust be a motivated team player in our cooperative/collaborative laboratory environment with a strong ability to develop and troubleshoot new experiments.\n\n\n\n\n 
URL:https://ces.b2sg.org/event/bcm-6dec19/
LOCATION:Baylor College of Medicine\, 1 Baylor Plaza\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/bcm-baylor-e1494304823632.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191122
DTEND;VALUE=DATE:20191224
DTSTAMP:20191122T230456Z
CREATED:20191122T230456Z
LAST-MODIFIED:20191122T230456Z
UID:21484-1574380800-1577145599@ces.b2sg.org
SUMMARY:Postdoc Scientist - Bioengineering
DESCRIPTION:We are seeking a Post-Doctoral Scientist – Multiple Postdoctoral Fellow Positions in Epigenetics\, human iPS cells\, 3D Bioprinting\, Hematopoietic Stem Cell Biology\, Bioengineering\, and Blood Cancers: Columbus\, OH\, United States. \nThe Shah laboratory provides a dynamic microenvironment that offers excellent opportunities for intellectual exchange and collaborations among investigators from diverse fields. We investigate the origin\, development\, and differentiation of hematopoietic stem cells (HSCs)\, and their utility in treating patients with blood and bone marrow diseases. \nWe have expertise in utilizing zebrafish\, mice\, and human induced pluripotent stem (iPS) cells to analyze novel genes and mechanisms important for blood formation. Our goals are to utilize our knowledge in developing cellular- and mechanism-based therapies as well as generating functional HSCs for the treatment of hematological diseases. \nResponsibilities\nWhy Nationwide Children’s Hospital? \nThe moment you walk through our doors\, you can feel it. When you meet one of our patient families\, you believe it. And when you talk with anyone who works here\, you want to be part of it\, too. Welcome to Nationwide Children’s Hospital\, where Passion Meets Purpose. \nHere\, Everyone Matters. We’re 12\,000 strong. And it takes every single one of us to improve the lives of the kids we care for\, and the kids from around the world we’ll never even meet. Kids who are living healthier\, fuller lives because of the knowledge we share. We know it takes a Collaborative Culture to deliver on our promise to provide the very best\, innovative care and to foster new discoveries\, made possible by the most groundbreaking research. Anywhere. \nAsk anyone with a Nationwide Children’s badge what they do for a living. They’ll tell you it’s More Than a Job. It’s a calling. It’s a chance to use and grow your talent to make an impact that truly matters. Because here\, we exist simply to help children everywhere. \nNationwide Children’s Hospital. A Place to Be Proud. \nQualifications\nWhat Are We Looking For? \nPosition # 2: Bioengineering of 4D Scaffold Development.\nThe ideal candidate will have Ph.D.\, M.D.\, or M.D./Ph.D. in Tissue Engineering\, Biomaterials\, Biophysics\, Machine Learning\, Systems Biology\, Chemical Engineering\, and/or Drug Development. This position offers an excellent opportunity to learn and apply skills in organoid development\, 3D bio-printing\, Bio-MEMS\, artificial intelligence\, microfluidics\, proteomics\, and/or medicinal chemistry.
URL:https://ces.b2sg.org/event/nat22nov19/
LOCATION:Nationwide Children’s Hospital Research Institute
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/03/nationwide-childrens-e1520166537688.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191120
DTEND;VALUE=DATE:20191124
DTSTAMP:20190414T135609Z
CREATED:20190414T135609Z
LAST-MODIFIED:20190414T135609Z
UID:21198-1574208000-1574553599@ces.b2sg.org
SUMMARY:Metabolism Meets Epigenetics
DESCRIPTION:Symposium Overview\nMetabolism and epigenetics are intricately linked\, playing a key role in development\, cancer\, immune signalling and ageing. This symposium brings together world-leading researchers exploring this nexus and will focus in particular on how metabolites and metabolic networks impact gene regulation\, on recently discovered roles of metabolites in disease and how this opens novel therapeutic avenues. We will highlight enabling tools linking metabolites\, their localisation within tissues and cells with the regulation of chromatin structure\, gene activity and epigenetic inheritance. \nInnovative molecular and computational tools that enable the detection of metabolites in time and space\, as well as novel biology in powerful model organisms and clinical data have led to a renaissance of research on metabolism\, especially in the context of epigenetics and gene regulation. The goal of our interdisciplinary symposium is to strengthen the connection between these fields\, inspire novel ideas and enable collaborations at this frontier. \nSession Topics\n\n\nMetabolic regulation of epigenetic marks\nMetabolic control of gene expression\nMetabolism in development and disease\nSystems analysis of metabolism\nImmunometabolism\nCancer metabolism\nImmune cell metabolism\nNovel tools for metabolism and epigenetics\n\n\nSpeakers: \nAsifa Akhtar \nMax Planck Institute of Immunobiology and Epigenetics\, Germany \nAlexander Aulehla\, \nEMBL Heidelberg\, Germany  \nGuoliang Cui\nGerman Cancer Research Center\, Germany  \nAnne-Claude Gavin\nEMBL Heidelberg\, Germany  \nKai Johnsson\nMax Planck Institute for Medical Research\, Germany  \nSue Kaech\nSalk Institute for Biological Studies\, USA  \nSusanne Mandrup\nUniversity of Southern Denmark \nAshby Morrison\nStanford University\, USA  \nMihai Netea\nRadboud University Medical Center\, The Netherlands \nJohn O’Neill \nMRC Laboratory of Molecular Biology\, UK  \nPaola  Picotti\nETH Zurich\, Switzerland \nJohn Andrew Pospisilik \nVan Andel Research Institute\, USA \nMarkus Ralser\nThe Francis Crick Institute\, UK &\nCharité -University Medicine\, Germany  \nMatthias Tschöp\nHelmholtz Zentrum München\, Germany  \nBenjamin Tu\nUT Southwestern Medical Center\, USA  \nKathryn  Wellen\nUniversity of Pennsylvania\, USA  \nOscar Yanes \nRovira i Virgili University\, Spain 
URL:https://ces.b2sg.org/event/embo-meeting20nov19/
LOCATION:EMBL Heidelberg\, Meyerhofstraße 1\, Heidelberg\, 69117 \, Germany
CATEGORIES:Meetings
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/05/EMBO_Logo_grey-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191110
DTEND;VALUE=DATE:20191212
DTSTAMP:20191110T214825Z
CREATED:20191110T214825Z
LAST-MODIFIED:20191110T214825Z
UID:21480-1573344000-1576108799@ces.b2sg.org
SUMMARY:Data analyst - Computational Biology
DESCRIPTION:The Lawrence Lab at the Massachusetts General Hospital Cancer Center seeks a data analyst to join an interdisciplinary team of computational biologists from MGH and the Broad Institute\, working at the forefront of cancer research and treatment. We use computation as a powerful microscope to study both the fundamental biology of cancer initiation and progression\, as well the diagnosis and treatment of cancer patients in the hospital setting. \nCurrent research interests of the Lawrence Lab: \nCancer evolution: We are using genomic profiling to observe the processes of clonal evolution during the course of a patient’s disease and treatment.\nResistance to targeted therapies: We are actively investigating mechanisms of drug resistance and how to combat it.\nSingle-cell sequencing: New approaches allow us to dissect a tumor down to single cells and investigate RNA expression\, DNA mutations\, and epigenetic changes all in single cells.\nLiquid biopsies: We work with state-of-the-art technologies that can monitor the progression of cancer through a simple blood draw.\nMutational processes: We are studying mutational background patterns to learn about DNA damage repair deficiencies\, which can be biomarkers for the use of genotoxic therapy.\nCancer driver genes: We are working to understand specific driver mutations that deactivate tumor suppressors or activate oncogenes.\nPrincipal Duties: \nApply existing computational pipelines\, and help develop novel pipelines\, for analyzing cancer data sets to assess data quality\, critically review and analyze results\, communicate results to biologists\, computational biologists\, software engineers and clinicians.\nExplore novel data visualization methods\, with emphasis on integrating diverse data types and extracting clinically relevant insights.\nWork with Cancer Center researchers to understand experimental procedures and the kinds of data produced (e.g. DNA sequencing\, RNA sequencing\, epigenetic readouts\, clinical outcome annotations). Meet and discuss with clinical and experimental colleagues to identify analytical challenges and goals.\nContribute to scientific writing and creation of data figures to be included in research publications reporting novel discoveries made in the lab and clinic. \nQualifications: \nB.A./B.S. (M.A./M.S. preferred) in one of Computational Biology\, Bioinformatics\, Biology\, Biochemistry\, Computer Science\, Mathematics\, Physics\, or a related field.\nAt least 2 years of experience in scientific research.\nIndependent\, self-motivated drive to push research forward.\nExcellent programming skills (using any of Matlab\, R\, Java\, Python\, Perl\, C\, etc.)\nNimble approach to programming and data analysis\, with an emphasis on simple\, intuitive\, reasoning: quickly open unfamiliar datasets\, generate simple visualizations to project the data onto our brains as usefully as possible\, to stimulate hypothesis generation and the next steps of the analysis.\nComfort using Word\, Excel\, Powerpoint to communicate results between team members.\nAbility to work together with multi-disciplinary teams comprising physicians\, biologists\, statisticians\, and software engineers.\nFluency in spoken and written English.\nExperience in machine learning\, cloud computing (e.g. Google Cloud) a plus.
URL:https://ces.b2sg.org/event/mass-10nov19/
LOCATION:Massachusetts General Hospital Cancer Cente\, 55 Fruit St\, Boston\, MA\, 02114\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/10/mgh-massachusetts-general-hospital-cancer-center.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191108
DTEND;VALUE=DATE:20191210
DTSTAMP:20191108T145425Z
CREATED:20191108T145147Z
LAST-MODIFIED:20191108T145425Z
UID:21478-1573171200-1575935999@ces.b2sg.org
SUMMARY:Research Technician
DESCRIPTION:Center for Investigational Therapeutics (CIT) at Huntsman Cancer Institute program is seeking a highly motivated Research Technician with expertise in conducting various in vitro cancer biology and drug screening assay for the kinase\, epigenetic and immune related protein targets. Interested candidate will be working on the biological evaluation of novel chemical entities (NCE) for use in cancers research and treatment. Research Technician\, you will be technically responsible for working on the PI and his labs chemist fellows to support in vitro cell-free and cancer cell-based efficacy screening assays utilizing available compounds as and when made by chemist fellows. This will entail detailed reading of the literature reported assays\, validation using reference control compounds\, associated methods\, existing assay protocols\, and alos utilizing vendor specific reagents/kits etc.\, and then planning\, execution\, optimization and analysis of the assay results. The compound effects in those assays and presenting the results in group meetings\, then supporting sections of grant proposals\, publications\, and lab supervision. \nResponsibilities:\n• Highly motivated and creative individual with a MS or related experience in cancer biology and immunology disciplines\n• Cell-free target binding assays; kinase glo\, thermal shift and FP\, FRET\, AlphaScreen\, AlphaLisa\,\n• IC50\, EC50\, Ki\, Kd\, Km\, substrate competitive\, reversibility and time dependent read out data analysis and handling expertise\n• Cell-based\, cancer cellular profiling and synergy experiments handling expertise are part of the job description\n• Additional experience in cancer biology investigations such as conducting standard biochemical/binding or other relevant target specific mechanistic assays such as Flow Cytometry\, NK\, B cell\, immune cell killing\, cytokine release\, Macrophage\, other immunoassays and working experience on radioligand binding assays is a plus.\n• Ability to clearly communicate ideas verbally and through presentations\n• Your application should include a CV with any publications list\, two references\, and a brief summary of your research experiences. The position is limited for 1 year and can be extended for second and third year as well
URL:https://ces.b2sg.org/event/u-8nov19/
LOCATION:University of Utah\, 201 Presidents Cir\, Salt Lake City\, 84112\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/png:https://ces.b2sg.org/wp-content/uploads/2017/08/university-of-utah_416x416.png
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191106
DTEND;VALUE=DATE:20191208
DTSTAMP:20191106T164128Z
CREATED:20191106T163612Z
LAST-MODIFIED:20191106T164128Z
UID:21476-1572998400-1575763199@ces.b2sg.org
SUMMARY:Junior Specialist - Epigenetic Programming
DESCRIPTION:A Junior Specialist position is available in Dr. Sha Sun’s laboratory in the Department of Developmental and Cell Biology at University of California Irvine. The Sun laboratory investigates mammalian long noncoding RNAs incorporating biochemistry\, molecular biology\, bioinformatics\, microscopy\, and using human cancer cell lines and mouse embryonic stem cells. Under general supervision\, the Junior Specialist will conduct scientific research using mammalian tissue cultures\, molecular and biochemical techniques\, sequencing and fluorescence imaging approaches. \nExperience in mammalian cell research\, bioinformatics analysis\, and molecular biology are highly preferred. The successful candidate will have a high level of organization and the ability to complete tasks on time. Proficiency with data management and computing software is desired. A Bachelor’s degree in a biological science major with prior experience in a laboratory setting is strongly preferred. \nQualified candidates should submit (1) Cover Letter (2) CV or Resume listing qualifications and experience and (3) Contact Information for three references to the following recruitment URL: https://recruit.ap.uci.edu/JPF05837
URL:https://ces.b2sg.org/event/uc-6nov19/
LOCATION:UC Irvine\, Irvine\, CA\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/01/ucirvine_-uc-irvine-cali.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191106
DTEND;VALUE=DATE:20191208
DTSTAMP:20191106T162805Z
CREATED:20191106T162805Z
LAST-MODIFIED:20191106T162805Z
UID:21474-1572998400-1575763199@ces.b2sg.org
SUMMARY:Assistant Professor-Toxicology & Cancer Biology
DESCRIPTION:The Department of Toxicology and Cancer Biology is recruiting an Assistant Professor who has expertise in epigenetics\, redox biology\, cell signaling pathways\, and/or metabolisms. This position will focus 80% on research\, 10% on teaching\, 5% on service and 5% on professional development initially. After tenured the candidate will be expected to support themselves 30% with research grants. \nPlease include a CV and cover letter along with application. In addition\, please provide the names and contact information for at least three references when prompted in the application. This information may be utilized to solicit recommendation letters from your references within the employment system. \nApplications will be reviewed immediately and continue until the position is filled. \nThe Department of Toxicology and Cancer Biology\, in the UKY College of Medicine\, has a long history of being an outstanding basic science department that interfaces closely with the Markey Cancer Center. Positions in the department include state-of-the-art research space and facilities\, strong institutional support and competitive salary and start-up packages. The Markey Cancer Center is an NCI-designated Cancer Center on the medical campus of the University of Kentucky. Situated on a campus with all six health profession colleges\, the cancer center is located within a vibrant and expanding basic and clinical research community with ample opportunities for collaboration within and across its research programs (see https://ukhealthcare.uky.edu/markey-cancer-center/research for more information).
URL:https://ces.b2sg.org/event/uk-6nov19/
LOCATION:University of Kentucky\, 410 Administration Drive\, Lexington\, KY\, 40506\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/06/Univ.-of-Kentucky-logo-e1508082584777.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191106
DTEND;VALUE=DATE:20191109
DTSTAMP:20190406T230434Z
CREATED:20190403T201519Z
LAST-MODIFIED:20190406T230434Z
UID:21161-1572998400-1573257599@ces.b2sg.org
SUMMARY:Epigenomics of Common Diseases
DESCRIPTION:Discussing the future of epigenomic studies of common diseases\nWe are pleased to announce the 8th Epigenomics of Common Diseases conference and invite scientists working on experimental and computational epigenomics and epigenetics to showcase the latest developments in the field and discuss epigenomic approaches in common human diseases. \nEpigenetic variation plays an important role in disease processes and provides a promising focus for disease prediction\, prevention and treatment. Technological advancements in the past few years have fuelled a dramatic increase in the scale\, breadth and availability of epigenomic reference maps\, including populational and environmental epigenomic datasets. \nThis year’s conference will cover a broad spectrum of epigenomic discoveries\, opportunities\, and also challenges\, in human normal biology and in disease. \nProgramme:  \nThe conference will start at 12.30 on Wednesday\, 6 November and close at 14.00 on Friday\, 8 November 2019. \nTopics will include: \n\nGenetic-epigenetic interactions\nOld and new roles of epigenomic factors\nEpigenomics in development and ageing\nEpigenomic misregulation in cancer\, brain and other diseases\nPopulational and environmental epigenomics\nMethodological challenges: epigenomic study design\, data analysis and interpretation\nThe future of epigenomic studies of common diseases\n\n  \nKeynote speakers \nCheryl Arrowsmith – University of Toronto\, Canada \nJohn Stamatoyannopoulos – University of Washington\, USA \n  \nConfirmed speakers \nDeborah Bourc’his – Institut Curie\, France \nJoseph Costello – UC San Francisco\, USA \nJohn Greally – Albert Einstein College of Medicine\, USA \nEilis Hannon – University of Exeter\, UK \nKristian Helin – Sloan Kettering Institute\, USA \nEva Jablonka – Tel Aviv University\, Israel \nViviane Labrie – Van Andel Institute\, USA \nStephanie London – NIEHS\, USA \nMathieu Lupien – University of Toronto\, Canada \nRaphäel Margueron – Institut Curie\, France \nKyung-Min Noh – EMBL\, Germany \nVardhman Rakyan – Queen Mary University of London\, UK \nClaire Rougeulle – CNRS / Université Paris Diderot\, France \nRichard Saffery – Murdoch Children’s Research Institute\, Australia
URL:https://ces.b2sg.org/event/6-8nov19-epigenomics/
LOCATION:Wellcome Genome Campus\, UK\, Wellcome Trust Genome Campus\, Hinxton\, CB10 1SA\, United Kingdom
CATEGORIES:Meetings
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2019/04/ECD_EarlyBird_Twitter.jpg
ORGANIZER;CN="Advanced Courses and Scientific Conferences%2C Wellcome Genome Campus":MAILTO:scientificconferences@wellcomegenomecampus.org
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191105
DTEND;VALUE=DATE:20191207
DTSTAMP:20191105T191830Z
CREATED:20191105T191735Z
LAST-MODIFIED:20191105T191830Z
UID:21472-1572912000-1575676799@ces.b2sg.org
SUMMARY:Professor
DESCRIPTION:The newly established Center for Precision Environmental Health (https://www.bcm.edu/centers/precision-environmental-health ) invites applications for an open-rank faculty search. Applications will be considered for tenured/tenure-track Assistant\, Associate or Full Professor. \nCenter faculty hold academic appointments in one or more of Baylor’s basic\, translational or clinical departments including Molecular & Cellular Biology\, Molecular & Human Genetics\, and Medicine. Ample opportunities exist for collaborations with faculty across the Texas Medical Center\, including U.T. MD Anderson Cancer Center\, UT Health\, Texas A&M University\, Texas Children’s Hospital\, Houston Methodist Research Institute\, University of Houston\, and Rice University. \nJob Duties:\nThe successful candidate will use innovative approaches to study important questions in cell and molecular biology and gene-environment interactions\, broadly defined. Applicants’ research programs should complement existing Center faculty strengths in environmental health\, cell and developmental biology\, genetics\, epigenetics\, cancer biology\, neurocognitive/neurodegenerative disease\, and model systems of human disease\, including vertebrate and invertebrate model organisms. The selected candidate will also be expected to advance Baylor’s strategic plan by contributing to initiatives in Population Health and Precision Medicine. \nMinimum Qualifications:\nCandidates must hold a doctoral degree (PhD\, MD\, or equivalent) with a strong record of scholarly activity. Candidates for appointment at the Associate or Full Professor levels should be nationally or internationally recognized scholars with consistent externally funded research programs.
URL:https://ces.b2sg.org/event/bcm-5nov19/
LOCATION:Baylor College of Medicine\, 1 Baylor Plaza\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/bcm-baylor-e1494304823632.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191105
DTEND;VALUE=DATE:20191207
DTSTAMP:20191105T172225Z
CREATED:20191105T171802Z
LAST-MODIFIED:20191105T172225Z
UID:21470-1572912000-1575676799@ces.b2sg.org
SUMMARY:Research Assistant II
DESCRIPTION:The Research Assistant II position provides technical and coordination skills to support core services in the Department of Epigenetics and Molecular Carcinogenesis at the Science Park campus. \nJOB SPECIFIC COMPETENCIES \nResearch Support \nPerform technical laboratory duties or experimental tasks to supply information as part of a research service core laboratory. Perform duties in accordance with general and/or specific plans. Assists in the design of laboratory experiments\, techniques\, and protocols. Processes\, organizes and summarizes data\, reporting experiment results using a variety of scientific\, word processing\, spreadsheet or statistical software applications or program platforms. Preparation of tissues\, cell cultures\, blood samples\, and perform other laboratory duties\, such as the handling of laboratory animals. Assist in general laboratory operation\, ensures the laboratory is prepared for experiments\, performs related laboratory maintenance such as maintaining and cleaning equipment and assisting with monitoring and stocking supplies\, preparation of stock solutions and other reagents. Collect and analyze data from experimental procedures and discuss results with the principal investigator. Document experimental results and maintain an organized laboratory notebook. Prepare materials for submission to granting agencies. May instruct other staff and students in basic laboratory techniques. \nExpertise and Specialization \nApply basic background and experience in science to the application of laboratory techniques\, using judgment\, analysis and evaluation. Read literature and confer with superiors regarding new procedures\, and modify them according to the needs of the project. Master complex skills and techniques used in the Core laboratory. Learn new skills or technology. \nLaboratory Organization \nCoordinate procedures\, assemble materials and contribute to the Core laboratory. Participate in ongoing learning and demonstrate application of it in carrying out assignments. Follow Core guidelines regarding order processing\, handling of rush orders and special jobs. Alert superiors to problems with orders or with the queue. Interact with client user groups and alert superiors to problems/concerns. Perform other duties as assigned.
URL:https://ces.b2sg.org/event/mda-5nov19/
LOCATION:MD Anderson Cancer Center\, 1515 Holcombe Blvd\, Houston\, TX\, 77030\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/MDAnderson.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191104
DTEND;VALUE=DATE:20191206
DTSTAMP:20191105T022229Z
CREATED:20191105T022229Z
LAST-MODIFIED:20191105T022229Z
UID:21468-1572825600-1575590399@ces.b2sg.org
SUMMARY:SR. Research Assistant - Surgery
DESCRIPTION:Under the direction of the Transplant Director of Research\, this position supports the Principle Investigators (PIs) and Research Associates in conducting clinical\, molecular biology\, or genomic research on epigenetics in ischemia reperfusion injury\, liver donor quality and mechanistic study\, mechanistic studies in liver cancer\, and maintenance of kidney biorepository collections and samples. \nDUTIES AND RESPONSIBILITIES: \nRuns quality control for reagents\, keeps track of and processes samples\, isolates nucleic acids and proteins and performs associated quality control.\nIsolates extracellular micro-vesicles. Performs RT and QPCR reactions and data analyses. Performs hands-on-bench laboratory activities.\nWorks with live tissue\, bodily fluids\, and cell cultures\, along with raw and isolated DNA/RNA samples. Analyzes samples using PCR\, microarrays\, and assays.\nMaintains sample collections and labeling.\nUses various analyses (Expressions Console\, IPA\, and MiScript PCR Analysis).\nSupports author or publishes one to three papers per year.\nProvides laboratory administrative support to PIs.\nOversees general lab maintenance and upkeep. Ensures laboratory supplies are available.\nOperates and maintains laboratory equipment\, ensuring clean working order such as performing instrumentation standardization.\nEnsures adherence to applicable UTHSC\, and governmental guidelines for the safe use and handling of toxic substances\, radioactive material\, dangerous chemicals and equipment.\nOversees student projects.\nTrains\, mentors\, and provides guidance to staff\, students\, and residents on an on-going basis.\nPerforms other duties as assigned.\nKNOWLEDGE\, SKILLS\, AND ABILITIES: \nAbility to work with little to no supervision.\nAbility to multi-task.\nSkill and ability to communicate effectively in person\, on the telephone\, and in writing with diverse people.\nKnowledge of IRIS system and Microsoft Office Suite – Word\, Power Point\, Excel.
URL:https://ces.b2sg.org/event/ut-4nov19/
LOCATION:University of Tennessee Health Science Center\, Memphis\, TN\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2018/05/uthsc-uni-tennessee.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191104
DTEND;VALUE=DATE:20191206
DTSTAMP:20191104T185302Z
CREATED:20191104T185302Z
LAST-MODIFIED:20191104T185302Z
UID:21466-1572825600-1575590399@ces.b2sg.org
SUMMARY:Research Assistant I
DESCRIPTION:JOB SPECIFIC COMPETENCIES \nResearch Support \nProvide experimental and technical support for Core laboratory services. Perform duties in accordance with general and/or specific plans. Assists in the design of laboratory experiments\, techniques\, and protocols. Processes\, organizes and summarizes data\, reporting experiment results using a variety of scientific\, word processing\, spreadsheet or statistical software applications or program platforms. Preparation of tissues\, cell cultures\, blood samples\, and perform other laboratory duties\, such as the handling of laboratory animals. Assist in general laboratory operation\, ensures the laboratory is prepared for experiments\, performs related laboratory maintenance such as maintaining and cleaning equipment and assisting with monitoring and stocking supplies\, preparation of stock solutions and other reagents. Collect and analyze data from experimental procedures and discuss results with the principal investigator. Document experimental results and maintain an organized laboratory notebook. Prepare materials for submission to granting agencies and foundations. May instruct other staff and students in basic laboratory techniques. \nExpertise and Specialization \nApply basic background in science to the application of laboratory techniques\, using judgment\, analysis and evaluation. Read literature and confer with superiors regarding new procedures. Master essential skills and techniques used in the Core laboratory. \nLaboratory Organization \nContribute to the Core laboratory. Pursue learning and self-development. Actively seek feedback. Transfer learning into next steps. Perform other duties as assigned.
URL:https://ces.b2sg.org/event/mda-4nov19/
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/MDAnderson.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191103
DTEND;VALUE=DATE:20191205
DTSTAMP:20191103T210436Z
CREATED:20191103T210336Z
LAST-MODIFIED:20191103T210436Z
UID:21460-1572739200-1575503999@ces.b2sg.org
SUMMARY:Scientist- Precision Informatics
DESCRIPTION:s person will be responsible for performing hands-on exploratory and regulatory related biomarker analysis\, large-scale genetic\, genomic\, and other ‘omic analyses\, with a primary goal of identifying and validating targets and biomarkers in preclinical studies and clinical trials for oncology. More specifically\, this person will participate the design of genomic studies in preclinical and clinical research\, implement cutting-edge informatics and statistical methods and tools to analyze the data including WGS/WES/targeted sequencing\, RNAseq\, epigenetic data\, etc\, and perform integrative analysis of genomic data and available clinical data in clinical trials. Furthermore\, the individual will leverage publicly available cancer genomic and pharmacogenomics data to integrate with Eisai internal data for biomarker analysis. All analysis work will be documented and will follow best practices for enabling reproducible research. \nPrincipal Duties and Responsibilities:\n• Perform data analysis activities including cleaning\, handling\, integration\, and analysis of small- and medium-scale experimental data generated from cell lines\, model organisms\, and human subjects\, including genotype\, mRNA\, protein\, and other data types.\n• Analyze large-scale analysis-ready datasets to answer specific focused questions of relevance to project teams.\n• Contextualize findings from internal experiments and generate hypotheses for new internal experiments by analyzing and interpreting externally available data.\n• Provide appropriate visualization and interpretation of results in preclinical experimental data to support decision making on drug development projects.\n• Contribute to preclinical experimental study design to generate statistically meaningful information.\n• Prepare and track documentation including analysis plans\, result reports\, and progress reports.\nJob Qualifications \n• Ph.D. degree in Biomedical Sciences\, Bioinformatics\, Computational Biology\, Biostatistics\, Statistical Genetics\, Genetic Epidemiology\, or closely related field. At least 5 years of experience in hands-on cancer genomic data analysis.\n• Must have analytic and statistical skills to conduct analysis of WGS/WES\, transcriptomic\, proteomic and epigenetic data. Must have experience in clinical outcome analysis.\n• Must have a good understanding of human biology. Experience in oncology is highly desirable. Must demonstrate good understanding of drug discovery requirements and processes.\n• Must have strong organizational skills and ability to prioritize work.\n• Must have excellent communication skills and the ability to act on cross-disciplinary teams; must have demonstrated ability in scientific publications.\n•Must have experience with R and Unix/Linux systems. Additional experience with languages/software including Spotfire\, Bioconductor\, Pipeline Pilot\, and SQL is strongly preferred. Ability to use Excel and Python may also be useful.
URL:https://ces.b2sg.org/event/eisai3nov19/
LOCATION:Eisai\, Woodcliff Lake\, NJ\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2019/11/eisai.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191103
DTEND;VALUE=DATE:20191205
DTSTAMP:20191103T205236Z
CREATED:20191103T205236Z
LAST-MODIFIED:20191103T205236Z
UID:21458-1572739200-1575503999@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:The primary purpose of the Postdoctoral Appointee position is to conduct research investigation into the characterization of oncogenic and tumor suppressor enhancer regions\, as well as on the dissection of the interplay between metabolism and epigenetics in T-cell Acute Lymphoblastic Leukemia (T-ALL) using mouse models under the supervision of the Principal Investigator. The Post Doc Fellow will perform research\, experiments\, and laboratory techniques of a specialized nature under direct supervision of the Principal Investigator. \nAmong the key duties of this position are the following:\n• Conducts research experiments to understand the role and mechanisms of SOD1 in oxidative stress resistance and cancer cell survival as well as the interplay between metabolism and redox regulation to unveil new therapeutic strategies.\n• Prepares written reports of the research experiments.\n• Prepares grant proposals based on the research conducted.\n• Gives oral presentations of the research.\n• Performs other related duties as assigned.
URL:https://ces.b2sg.org/event/3nov19/
LOCATION:Rutgers Cancer Institute of New Jersey\, 195 Little Albany St\, New Brunswick\, NJ\, 08903\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/07/rutgers.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190927
DTEND;VALUE=DATE:20191002
DTSTAMP:20181103T153555Z
CREATED:20181103T151702Z
LAST-MODIFIED:20181103T153555Z
UID:20799-1569542400-1569974399@ces.b2sg.org
SUMMARY:ESMO 2019 Congress
DESCRIPTION:ESMO is delighted to announce that the ESMO 2019 annual Congress will take place in partnership with the European Association for Cancer Research (EACR) from 27 September to 1 October 2019\, at the Fira Barcelona\, Spain. \nThe ESMO Congress is the appointment in Europe for clinicians\, researchers\, patient advocates\, journalists and the pharmaceutical industry from all over the world to get together\, learn about the latest advances in oncology and translate science into better cancer patient care. \nESMO 2019 will be the global stage for excellence in translational research\, presentation of practice-changing data and multidisciplinary discussions. \nWe invite you to save the date. \n  \nOnline registration will be available in January 2019
URL:https://ces.b2sg.org/event/esmo2019/
LOCATION:Gran Via venue\, Av. Joan Carles I\, 64\, Barcelona\, 08908\, Spain
CATEGORIES:Meetings
ATTACH;FMTTYPE=image/png:https://ces.b2sg.org/wp-content/uploads/2018/11/2019_esmo_inevidenza-e1541241108833.png
ORGANIZER;CN="Chantal Cornu%2C Valentina Allevato":MAILTO:congress@esmo.org
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190724
DTEND;VALUE=DATE:20190827
DTSTAMP:20190724T222412Z
CREATED:20190724T222412Z
LAST-MODIFIED:20190724T222412Z
UID:21338-1563926400-1566863999@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:Rutgers\, The State University of New Jersey is seeking a Post Doc Fellow for the Cancer Pharmacology Department at Rutgers Cancer Institute of New Jersey. \nThe primary purpose of the Postdoctoral Appointee position is to conduct research investigation into the characterization of oncogenic and tumor suppressor enhancer regions\, as well as on the dissection of the interplay between metabolism and epigenetics in T-cell Acute Lymphoblastic Leukemia (T-ALL) using mouse models under the supervision of the Principal Investigator. The Post Doc Fellow will perform research\, experiments\, and laboratory techniques of a specialized nature under direct supervision of the Principal Investigator. \nAmong the key duties of this position are the following:\n• Conducts research experiments to understand the role and mechanisms of SOD1 in oxidative stress resistance and cancer cell survival as well as the interplay between metabolism and redox regulation to unveil new therapeutic strategies. \n• Prepares written reports of the research experiments. \n• Prepares grant proposals based on the research conducted. \n• Gives oral presentations of the research. \n• Performs other related duties as assigned.
URL:https://ces.b2sg.org/event/r-24jul19/
LOCATION:Rutgers Cancer Institute of New Jersey\, 195 Little Albany St\, New Brunswick\, NJ\, 08903\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/07/rutgers.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190724
DTEND;VALUE=DATE:20190827
DTSTAMP:20190724T211654Z
CREATED:20190724T211654Z
LAST-MODIFIED:20190724T211654Z
UID:21336-1563926400-1566863999@ces.b2sg.org
SUMMARY:Postdoctoral Fellow
DESCRIPTION:Three postdoctoral positions are immediately available in the laboratory of Dr. Suyun Huang in the Department of Human and Molecular Genetics and the VCU Institute of Molecular Medicine at Virginia Commonwealth University\, School of Medicine. The ongoing studies in the laboratory focus on identification and functional validation of molecular determinants of glioblastoma and brain metastasis (from breast cancer). The research is fully funded by National Institutes of Health grants. Please refer to our recent publications for more information (Cancer Cell 2017\, Nature Cell Biology 2016\, Nature Communications 2016\, The Journal of Clinical Investigation 2014\, EMBO J. 2016\, & Cancer Cell 2011). \n\n\n\nRequired Qualifications\nDr. Huang’s laboratory is seeking highly qualified\, dedicated individuals with a commitment to research excellence. Candidates must have Ph.D. or M.D. degrees and with a solid publication record\, including first-authored publication(s) in respected journal. The candidate must also have strong organizational\, written\, and verbal communication skills in English. \n\n\n\nPreferred Qualifications\nCandidates are preferred with a Ph.D. degree in biochemistry\, molecular biology and molecular genetics and with experience in the areas of protein modification\, transcriptional control\, protein-protein interaction\, epigenetics and animal modeling.
URL:https://ces.b2sg.org/event/vcu-24jul19/
LOCATION:Virginia Commonwealth University\, 907 Floyd Ave\, Richmond\, VA\, 23284\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/09/VCU-virginia-commonwealth-e1506279590219.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190723
DTEND;VALUE=DATE:20190826
DTSTAMP:20190723T213831Z
CREATED:20190723T213752Z
LAST-MODIFIED:20190723T213831Z
UID:21334-1563840000-1566777599@ces.b2sg.org
SUMMARY:Research Investigator
DESCRIPTION:How to Apply\nSend CV to: \nDepartment of Pediatrics Division of Hematology/Oncology \nOffice of Faculty Affairs \nMedical Professional Building\, Room D3216 \nAnn Arbor\, MI  48109-5718 \nJob Summary\nThe University of Michigan\, Department of Pediatrics is seeking candidates for a Research Investigator position in the Division of Pediatric Hematology/Oncology. \nBasic functions and responsibilities \nUnder direct supervision of the Principal Investigator perform scientific research in the field of pediatric oncology. Participate in a leadership role supervising junior research staff and support personnel. Participate in extra-mural grant writing and academic authorship. \nDuties and responsibilities: \n\nIndependently implement technical procedures for assignments (50%)\, including:\n\nPerform genetic manipulation and genetic analysis of MSC’s and cancer cell lines. (CRISPR-Cas9\, CRISPR-I and RNAi) supervise/train lab members in these experiments\nPerform immunofluorescence and confocal microscopy\, supervise/train lab members in these experiments\nPerform RNA-seq\, ChIP-seq\, Mass spec\, Histone PTM and data integration analysis\, supervise/train lab members in these experiments\n\n\nParticipate in formulating research methods and suggest options for improving quality\nAssist other team members in their projects\nIndependently participate in academic authorship of manuscripts and grants related to lab work (25%)\nMake recommendations on best technical approaches to investigate a scientific problem\nIndependently implement technical procedures for assignments.\nParticipate in laboratory meetings\nResponsible for accurate record keeping\nInteract with collaborators as necessary to provide interpretation of study results\nCommunicate and make recommendations to other scientists in the team\nTrain personnel in existing laboratory techniques and procedures\, explain and demonstrate technology and equipment capabilities\, operation limitation and outcomes (25%)\n\nSupervision Received \nDirection is received from the Principal Investigator. Staff members in this classification are expected to work independently and in collaboration with other laboratory personnel\, regularly exercise good judgment in setting priorities\, resolving operational problems and the application of procedures\, methods and policies.  \n Supervision Exercised \nFunctional supervision may be exercised over lab assistant\, graduate students and other junior personnel \nRequired Qualifications*\nQualifications Required:  \n\nPhD degree and at least 3 years of postdoctoral experience in a recognized field of science directly related to the position\nExceptional work ethic in a highly competitive environment\nAbility to communicate clearly the results of his/her experiments to other team members\nStrong knowledge of molecular and cell biology\, especially in the field of epigenetics and oncology\nProficiency in Microsoft Word\, PowerPoint\, Excel\, and GraphPad Prism\nFamiliarity with basic laboratory instrumentation and maintenance of laboratory equipment \nProficient in record keeping\nA solid command of tissue culture and in conducting studies in an enhanced BSL-2 environment is necessary\nKnowledge of bioinformatics tools for data analysis and interpretation\nHands on skills and experience with all standard molecular and cell biology techniques (e.g. qPCR\, ChIP-PCR\, IP and Co-IP\, Cloning\, Western blot\, microscopy\, genetic modification)\nAdvanced skills in ChIP-seq and proteomics approaches\n\nQualifications Desired: \n\nMinimum seven years of directly related laboratory experience. Familiarity with University research administration policies and procedures\nFluorescence and Confocal microscopy experience\n\nEvidence of qualification is provided by previous employment\, references\, performance evaluations and/or personal interview
URL:https://ces.b2sg.org/event/m-23jul19/
LOCATION:University of Michigan\, 500 S State St\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/05/uni-michigan.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190723
DTEND;VALUE=DATE:20190826
DTSTAMP:20190723T190636Z
CREATED:20190723T190636Z
LAST-MODIFIED:20190723T190636Z
UID:21332-1563840000-1566777599@ces.b2sg.org
SUMMARY:Postdoctoral Research Fellow
DESCRIPTION:The Hackensack Meridian Health Center for Discovery and Innovation is offering a position for postdoctoral studies in the field of cancer signaling and gene expression in the laboratory of Dr. Byungwoo Ryu.  The goal of the laboratory’s research program is to unravel the cancer epigenome regulating mechanisms which can be targeted for the sensitization to the precision therapies in the hope of translating these therapeutic modalities to have long-term clinical benefit. The Ryu laboratory focuses on investigating chromatin remodeling enzymes\, such as histone and DNA modifiers and gene transcription factors as potential targets for overcoming the resistance of oncogene-targeting therapies and enhancing the objective therapy response rate of immune check-point blockade therapies.  The Ryu laboratory uses chemical genetics approaches including small molecule inhibitors\, genome/epigenome-wide profiling\, gene-editing technology\, and animal models. Successful postdoctoral candidate will have a strong interest in cancer biology\, epigenetics\, and immuno-oncology.  The candidate will perform in vivo animal models and in vitro analyses. The postdoctoral fellow is expected to understand the project and work independently taking responsibilities in the development and execution of experimental procedures to successfully advance the research project. The successful candidate will be responsible for preparing data for presentations\, progress reports\, and the preparation of manuscripts and posters. The post-doctoral fellow is anticipated to have good communication and writing skills. The successful candidate will have a team-oriented mindset and will provide guidance to junior members. \nResponsibilities \n\nProficient at most gold standard assays in molecular biology and genetics.\nDesign and conduct animal studies using a vast array of genetic models.\nPerform data analysis and interpretation.\nPresent results in internal and external research forums.\nParticipate in grant and manuscript writing\, as appropriate.\n\n  \nQualifications \nKnowledge\, Education and Skills Required: \n  \n\nHold a Ph.D. in Molecular Biology\, Biochemistry\, Cancer biology or equivalent from an accredited graduate level institution.\nMinimum publication or in preparation of one article as first author in a reputable peer-reviewed scientific journal.\nExcellent analytical and presentation skills.\nExpertise in cell culture\, flow cytometry\, mouse handling\, and basic cellular and molecular biology techniques required.
URL:https://ces.b2sg.org/event/h-23jul19/
LOCATION:Hackensack University Medical Center\, 30 Prospect Ave\, Hackensack\, NJ\, 07601\, United States
CATEGORIES:Jobs
ATTACH;FMTTYPE=image/jpeg:https://ces.b2sg.org/wp-content/uploads/2017/11/Hackensack-University-Medical-Center.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190722
DTEND;VALUE=DATE:20190825
DTSTAMP:20190723T003133Z
CREATED:20190723T003133Z
LAST-MODIFIED:20190723T003133Z
UID:21330-1563753600-1566691199@ces.b2sg.org
SUMMARY:Research Professional
DESCRIPTION:We are aiming to recruit a skilled and enthusiastic research professional to work on a newly funded research project in Dr. Jason Cheng’s laboratory\, section of Hematopathology\, Dept of Pathology\, University of Chicago. Dr. Cheng’s lab research is focusing on 1) illustrating the epigenetic and genetic mechanisms that control normal hematopoiesis and the pathogenesis of hematologic malignancies\, such as acute myeloid leukemia (AML)\, myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS); and 2) developing novel diagnostics and therapeutics for more effective of hematologic diseases. The successful applicants will have the opportunities to work with state-of-the-art molecular and imaging technologies\, such as single-cell DNA or RNA sequencing\, bisulfate RNA-seq (BS-RNA-seq) and super-resolution stimulated emission depletion (STED) imaging\, and the advanced core facilities in the University of Chicago and the University of Chicago Comprehensive Cancer Center. The applicants will also have the opportunities to collaborate with first-rate scientists and physicians. Interested individuals are encouraged to read more details about our recently published paper at https://www.nature.com/articles/s41467-018-03513-4). \nJob Family\nResearchResponsible for all aspects of research projects and research facilities. Plans and conducts clinical and non-clinical research; facilitates and monitors daily activities of clinical trials or research projects. Directs engineering and technical support activities to develop and maintain tools and computational methods needed to gather and analyze data. \nCareer Track and Job Level\nResearchOversees all aspects of management\, scientific technological development\, and operations for major research projects or research facilities. Ensures compliance of research activities with institutional\, state\, and federal regulatory policies\, procedures\, directives and mandates. Writes articles\, reports and manuscripts. Presents research findings at meetings and/or conferences.P1: Performs routine assignments in the entry level to a professional job progression. Typically requires a college or university degree or the equivalent work experience that provides knowledge and exposure to fundamental theories\, principles and concepts. Develops competence by performing structured work assignments. Uses existing procedures to solve routine or standard problems. Receives instruction\, guidance and direction from others. \nRole Impact\nIndividual Contributor \nResponsibilities\nThe job performs routine assignments related to scientific research projects. Ensures compliance of research activities with institutional\, state\, and federal regulatory policies\, procedures\, directives and mandates. Analyzes possible solutions using standard procedures. Writes articles\, reports and manuscripts. Assists in drafting presentations on research findings.1) Maintains technical and administrative support for a research project.\, 2) Analyzes and maintains data and/or specimens. Conducts literature reviews. Assists with preparation of reports\, manuscripts and other documents.\, 3) Installs\, sets up and performs experiments; interacting with students and other laboratory staff under the direction of the principal investigator.\, 4) Maintains recruiting and scheduling research subjects; assisting with developing or amending study protocols; assisting with developing data collection tools; assisting with building databases; and providing general administrative support. Has general awareness in research techniques or methods\, regulatory policies and procedures\, and relevant scientific field\, 5) Performs other related work as needed. \nUnit-specific Responsibilities \n1) Managing data files; and providing general administrative support. \n2) Assisting lab members in preparing and conducting experiments. \n3) Following established procedures or protocols. \n4) Provides assistance to supervisor with research projects. \n5) Performing basic laboratory techniques. \n6) Assisting with maintaining animals.
URL:https://ces.b2sg.org/event/uc-22jul19/
LOCATION:University of Chicago\, 5801 S Ellis Ave\, Chicago\, IL\, 60637\, United States
CATEGORIES:Jobs
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20190722
DTEND;VALUE=DATE:20190825
DTSTAMP:20190723T002549Z
CREATED:20190723T002549Z
LAST-MODIFIED:20190723T002549Z
UID:21328-1563753600-1566691199@ces.b2sg.org
SUMMARY:Research Fellow
DESCRIPTION:The Beltran laboratory at Dana-Farber Cancer Institute and Harvard Medical School is focused on the study of treatment resistance in prostate cancer. We utilize a variety of molecular biology and genomic and epigenomic approaches to understand prostate cancer disease progression\, therapy resistance\, and tumor heterogeneity both in patients and in preclinical models. We are particularly focused on the emerging subset of advanced prostate cancers that lose androgen receptor dependence as a mechanism of treatment resistance\, associated with lineage plasticity and a change in clinical and pathologic characteristics towards a small cell/neuroendocrine phenotype. Current projects include: 1) Defining and validating the essential genes during neuroendocrine prostate cancer progression using genome-scale CRISPR-Cas9 screening approaches to identify novel therapeutic targets; 2) Understanding the genetic\, epigenetic\, and phenotypic changes that drive cancer progression through bulk and single cell molecular analyses of tumor biopsies and patient-derived models; 3) Elucidating the mechanism\, timing\, and cooperation of identified drivers including MYCN\, AURKA\, EZH2\, RB1\, and others; 4) Characterization and preclinical testing of novel epigenetic and immune -based therapeutic approaches and combination strategies to treat\, revert\, or prevent non-AR driven resistance. Research in the laboratory ranges from basic mechanistic investigation of cancer gene function to highly translational genomic and functional studies of patient-derived tissues from clinical trials. Team members work in a highly collaborative environment that includes laboratory investigators\, clinical investigators\, and computational biologists. We are seeking an enthusiastic\, dedicated and hardworking post-doctoral scientist to join our team. The successful candidate will have a strong interest in cancer biology and therapeutics with experience in molecular biology\, biochemistry\, genetics/genomics or biochemistry. The Beltran lab recently relocated from Weill Cornell to DFCI. While the lab’s new DFCI website is still in development\, more information on the lab’s research may be found at beltranlab.weill.cornell.edu \n\nSpecific responsibilities include: \n\nPerforming cell and molecular biology research including but not limited to 2D and 3D cell culture\, genetic manipulation through shRNA/CRISPR\, protein/RNA/DNA analyses including Western blotting\, RNA-seq\, IP-MS\, and ChIP-seq.\nLentiviral transduction techniques for ORF-overexpression experiments or RNAi and CRISPR-Cas9 knockdown/knockout experiments.\nPerforming a variety of basic cancer biology assays\, including in vitro proliferation or apoptosis assays\, drug sensitivity assays\, soft agar assays and in vivo xenograft experiments.\nWorking with a team of experimental and computational biologists to analyze and interpret sequencing data as well as gain- and loss-of-function genetic or pharmacologic screening data.\nPerforming detailed characterization and cellular mechanism of action studies of genetic or pharmacologic screening hits.\nPerforming preclinical translational studies in mouse models of cancer.\nEffectively work with research technicians and cross-functional project teams\nMaintaining accurate records\, writing reports\, and preparing/giving presentations.\n\n\n\n\nQualifications\n\n\n\n\nMD\, PhD or MD/PhD in biological sciences or equivalent\nStrong work ethic\, positive attitude and team-centered mentality\nA strong background in molecular and/or cell biology\, biochemistry\, genomics or cancer biology.\nExperience with genomics\, functional genetic screens or mouse models of cancer (xenografts\, PDXs\, GEMMs) and/or computational skills including computer programming are of interest\nExcellent oral and written communication skills.\nThe ability to perform both self-directed and guided research is required. \nMust demonstrate outstanding ability to work effectively as part of an interdisciplinary team of scientists.
URL:https://ces.b2sg.org/event/df-22jul19/
LOCATION:Dana-Farber Cancer Institute\, 450 Brookline Avenue\, Boston\, MA\, 02215\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190722
DTEND;VALUE=DATE:20190825
DTSTAMP:20190723T002029Z
CREATED:20190723T002029Z
LAST-MODIFIED:20190723T002029Z
UID:21326-1563753600-1566691199@ces.b2sg.org
SUMMARY:Staff Scientist- Cell & molecular biology
DESCRIPTION:In the Kriwacki lab we are passionate about understanding how phase separation drives the condensation of biomolecules to create liquid-like bodies that mediate diverse biological processes. Importantly\, aberrant biomolecular condensation is associated with several devastating human diseases\, such as cancer and neurodegeneration.  A new initiative in the laboratory addresses the role of aberrant phase separation as a driver in cancer and we seek an analytical\, critical thinking\, self-driven cell biologist to join our team. The Staff Scientist will be responsible for conducting cutting edge research on phase separation by cancer-associated proteins in cells and their effects on chromatin structure and function\, contributing to the training of postdoctoral fellows and students\, and coordinating collaborative efforts. \nThe ideal candidate will have: \n\na PhD degree in Cell Biology\, Epigenetics or related field\na minimum of 5 years post-graduate experience with functional genomics methods (e.g.\, RNA-seq\, CHIP-seq\, 3C-based methods\, etc.)\, tissue culture (primary and immortalized cell lines)\, fluorescence microscopy and quantitative image analysis\nproject management experience\nscientific writing experience\nexcellent organizational and communication skills\nprior experience with biomolecular condensates is highly desired\, as also is experience with cellular models of cancer\n\n\nTo learn more about our work\, follow these links: \nHow does the most common ALS mutation doom cells? \nHow do molecular partners form dynamic scaffolding for protein machinery? \nKey inner control mechanism of cell’s “smart glue” \nProtein glue that holds biomolecules within the nucleolus \n\n\n\n\nMinimum Education\n\n\n\n\nA Ph.D. in an appropriate scientific field is required\n\n\n\n\nMinimum Experience\n\n\n\n\nA minimum of five (5) years of relevant and productive (combined) years postdoctoral research associate or five (5) years of combined academic experience at the postdoctoral level or above.
URL:https://ces.b2sg.org/event/stj-22jul19/
LOCATION:St. Jude Children’s Hospital\, 262 Danny Thomas Pl\, Memphis\, TN\, 38105\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190720
DTEND;VALUE=DATE:20190722
DTSTAMP:20190414T144413Z
CREATED:20190414T144212Z
LAST-MODIFIED:20190414T144413Z
UID:21200-1563580800-1563753599@ces.b2sg.org
SUMMARY:Dynamics of Epigenetic Regulation: Mechanisms and Beyond
DESCRIPTION:The Gordon Research Seminar on Epigenetics is a unique forum for graduate students\, postdocs\, and other junior scientists to present and exchange new data and cutting-edge ideas. The focus of this meeting is on recent advances in our understanding of the dynamic nature of epigenetic regulatory mechanisms across phyla. In particular\, we will focus on how epigenetic alterations can influence phenotypic plasticity\, development\, reprogramming\, and transgenerational inheritance. The GRS will include a keynote address by Dr. Bradley Cairns\, as well as a career panel discussion with panelists from academic and non-academic fields. \nApplication Instructions\nThe seminar will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS\, either by giving an oral presentation or presenting a poster. Therefore\, all applications must include an abstract. \nThe seminar chair will select speakers from abstracts submitted by April 20\, 2019. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate\, you must submit an application by the date indicated in the Application Information section above. \nProgram Format\nGordon Research Seminars are 2-day meetings which take place on the Saturday and Sunday just prior to the start of the associated GRC. The GRS opens with a 1-hour introductory session on Saturday afternoon\, followed by a poster session\, dinner and a 2-hour session in the evening. Sunday morning begins with breakfast and is followed by another 2-hour session\, a second poster session\, and lunch. A final 1-hour session takes place just after lunch\, and the associated GRC begins later that evening. \nAn outline of the program components for this GRS is displayed below. The seminar chair is currently developing their detailed program schedule\, which will include the speakers they select from submitted abstracts\, in addition to any additional components outlined below. The detailed program will be available by May 20\, 2019. Please check back for updates. \n\nKeynote Speaker\n\n\n\nBradley Cairns (University of Utah\, USA)\n\n\n\nSpeakers\n\n\n\nTo Be Selected from Submitted Abstracts\n\n\n\nDiscussion Leaders\n\n\n\nJulie Ahringer (University of Cambridge\, United Kingdom)\nAmander Clark (University of California\, Los Angeles\, USA)\n\n\n\n\nAdditional Discussion Leaders May Be Selected from Submitted Abstracts\n\n  \nApplications for this meeting must be submitted by June 22\, 2019. Please apply early\, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed\, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations. \nGRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above\, any applicants who wish to be considered for an oral presentation should submit their application by April 20\, 2019. Please refer to the application instructions in the Conference Description section below for more details (if available).
URL:https://ces.b2sg.org/event/grs-meeting20jul19/
LOCATION:Holderness School\, 33 Chapel Ln\, Holderness\, NH\, 03245\, United States
CATEGORIES:Meetings
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190702
DTEND;VALUE=DATE:20190805
DTSTAMP:20190702T220418Z
CREATED:20190702T220150Z
LAST-MODIFIED:20190702T220418Z
UID:21319-1562025600-1564963199@ces.b2sg.org
SUMMARY:Research Opportunities - Medical Oncology
DESCRIPTION:There is an opportunity for research in the laboratory of Dr. Jieya Shao. The central theme of the lab is unravelling novel cancer biology with the overarching goal of developing effective therapies. Two main projects are currently ongoing primarily in the context of breast cancer: \n1. “Moonlighting” functions of the actin-binding protein profilin-1 (Pfn1) in transcriptional and epigenetic regulation. As an essential eukaryotic protein\, the mechanisms behind the paradoxical anticancer effects of profilin-1 have remained mysterious for nearly two decades. Our recent studies suggest that the anticancer activities of Pfn1 may stem from its poorly understood nuclear functions which become deregulated in cancer due to an alteration of its nucleocytoplasmic trafficking. We are currently focusing on defining its novel roles in transcriptional control and epigenetic regulation in the context of both estrogen receptor positive and triple negative breast cancer by utilizing multidisciplinary approaches including biochemistry\, molecular and cellular biology\, proteomics\, mouse xenograft models\, and next generation sequencing.\n2. The role of VCP in protein homeostasis\, DNA damage response\, and chemotherapy efficacy of cancer. Valosin-containing protein (VCP) is an evolutionarily conserved and highly abundant AAA+ ATPase involved in diverse cellular processes. Functioning as a “segregase”\, VCP maintains protein homeostasis by extracting polyubiquitinated proteins from various cellular locations or complexes for turnover. Numerous studies have now linked VCP to chromatin-associated protein degradation and genome stability maintenance particularly in the context of DNA damage response. Nevertheless\, detailed understanding of its mechanism of action\, its mode of (de)regulation in cancer\, and its relevance to chemotherapy response is lacking\, and we are currently investigating all these questions. \n\n\nPreferred Qualifications\n\n\n\n\n\n\n\n\nCandidates with general understanding of biochemistry\, molecular and cellular biology and prior experience in mammalian cell culture\, Western blotting\, DNA/RNA isolation\, mouse handling and surgery are preferred.\nKnowledge in genetics/epigenetics and experience in quantitative PCR and chromatin immunoprecipitation (ChIP) is a plus\, so is the skill in data mining and computational analysis.\nMust have troubleshooting skills\, independent analytical thinking and research planning skills.\nDemonstrated ability to work independently and communicate with the laboratory staff and investigators.\nAbility to maintain complete and organized records/reports.\nWorking knowledge of computer software and general lab equipment.
URL:https://ces.b2sg.org/event/2jul19/
LOCATION:Washington University in St. Louis\, 1 Brookings Dr.\, St. Louis\, MO\, 63130\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190626
DTEND;VALUE=DATE:20190729
DTSTAMP:20190626T211757Z
CREATED:20190626T211757Z
LAST-MODIFIED:20190626T211757Z
UID:21316-1561507200-1564358399@ces.b2sg.org
SUMMARY:Lab Assistant I
DESCRIPTION:The proposed position will be located at the Dermatology Research labs\, specifically in the DiNardo Lab. The dermatology labs are located at the Altman Clinical and Translational Research Institute (ACTRI) at UC San Diego\, established in 2010 as part of a national consortium of 60 medical research institutions created to energize bench-to-bedside efforts. The structure was opened in 2016 and encompasses 359\,000 square feet of offices\, state-of-the-art laboratories and clinical space (including a research pharmacy) and houses a multitude of distinct research endeavors as described before. \nThe Lab Assistant will engage in assisting postdoctoral fellow and senior scientists working on skin innate immune projects related to microbiome and immune-tolerance. Under supervision\, the lab assistant will assist with preparation and execution of experiments using biological and chemical materials. Tasks will include preparation of standardized media and reagents; upkeep of laboratory apparatus and facilities; ordering and organization of laboratory supplies; record-keeping and organization of experimental outputs on the laboratory computer notebook and databases. \nThe assistant will have an opportunity to observe and aid senior laboratory members with experiments involving cell culture\, PCR\, specimen sectioning\, molecular cloning\, genotyping and gel electrophoresis. \nMINIMUM QUALIFICATIONS\n\nGraduation from high school or a GED and one (1) year of laboratory experience or two (2) years of college including courses in the biological sciences; or an equivalent combination of education and experience.\nPossess the knowledge and abilities essential to the successful performance of the duties assigned to the position.\nProven experience doing standard and routine laboratory tasks. Skill to accurately organize\, store\, and retrieve samples\, chemicals\, and supplies.\nSolid organizational skills to order and maintain lab reagents and supplies\, and keep accurate lab records and computer files using Excel.\nDemonstrated ability to follow written and verbal protocols\, techniques\, and instructions.\nWillingness to work with small animals (mice) and to assist in procedures in compliance with standards and protections (ACP and IACUC).\nStrong experience making decisions\, analyzing situations\, problem solving\, and initiating action for laboratory maintenance.\nAbility to read\, comprehend\, discuss\, and present research materials.\nWillingness to convey skin specimens between nearby facilities (short walking distance).\nWillingness to learn new theory\, techniques\, and tasks and share knowledge.\n\nPREFERRED QUALIFICATIONS\nA Bachelor’s Degree in Biological Science discipline.
URL:https://ces.b2sg.org/event/ucsd-26jun19/
LOCATION:UC San Diego Health – Moores Cancer Center\, 3855 Health Sciences Drive\, La Jolla\, CA\, 92037\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190625
DTEND;VALUE=DATE:20190728
DTSTAMP:20190625T183214Z
CREATED:20190625T183214Z
LAST-MODIFIED:20190625T183214Z
UID:21314-1561420800-1564271999@ces.b2sg.org
SUMMARY:Faculty Position
DESCRIPTION:The Department of Urology and the Robert H. Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine are leading the search for a full-time tenure track Investigator up to the rank Professor in the area of prostate cancer biology. \nQualified candidates will have a PhD or MD or dual degree and an outstanding record of research in prostate cancer biology. The successful applicant will have experience in the field of cancer biology\, which could include cancer genetics and proteomics\, cancer cell biology\, tumor microenvironment\, cancer stem cells\, metastasis\, tumor immunology\, chemical biology\, cancer metabolism\, oncogenic signal transduction pathways\, genome integrity\, and cancer epigenetics.  We are seeking an individual with an established program in prostate cancer who is drawn to the broad opportunities at Northwestern with its collaborative clinical programs at Northwestern Memorial Hospital. The Center for Genetic Medicine houses the NUgene biobank and the Robert H. Lurie Comprehensive Cancer Center offers a robust research infrastructure for translation. \nThe start date is negotiable and the position will remain open until filled. When applying\, please upload this completed list of references form to suggest the names of individuals who could write letters of reference on your behalf.  \nPlease read ALL instructions and make preparations before proceeding to the application page: \n\nApplications will only be accepted via online submission (see link below).\nPlease prepare all documents in advance as Adobe PDF files\, and please be sure all information is entered correctly and accurately (especially names and email addresses)\, as there will be no opportunity for online revision after your application has been submitted.\nAll required fields in the application form are marked with an asterisk and must be filled before clicking the “Submit” button.\nBe aware that incomplete applications cannot be saved.\n\nApplications accepted here: Apply for Job
URL:https://ces.b2sg.org/event/nwu-25jun19/
LOCATION:Northwestern University\, 633 Clark St\, Evanston\, IL\, 60208\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190624
DTEND;VALUE=DATE:20190727
DTSTAMP:20190624T213706Z
CREATED:20190624T213706Z
LAST-MODIFIED:20190624T213706Z
UID:21312-1561334400-1564185599@ces.b2sg.org
SUMMARY:Post Doctoral Scientist
DESCRIPTION:We are seeking a Post-Doctoral Scientist –  Multiple Postdoctoral Fellow Positions in Epigenetics\, human iPS cells\, 3D Bioprinting\, Hematopoietic Stem Cell Biology\, Bioengineering\, and Blood Cancers: Columbus\, OH\, United States. \n   \nThe Shah laboratory provides a dynamic microenvironment that offers excellent opportunities for intellectual exchange and collaborations among investigators from diverse fields. We investigate the origin\, development\, and differentiation of hematopoietic stem cells (HSCs)\, and their utility in treating patients with blood and bone marrow diseases. \n\nWe have expertise in utilizing zebrafish\, mice\, and human induced pluripotent stem (iPS) cells to analyze novel genes and mechanisms important for blood formation. Our goals are to utilize our knowledge in developing cellular- and mechanism-based therapies as well as generating functional HSCs for the treatment of hematological diseases. \n\n\n\n\n\n\n  \n\n\n\nQualifications\n\n\n\nWhat Are We Looking For? \n\nPosition # 1: Epigenetics of Hematopoietic Stem Cell Development and Disorders. \nThe ideal candidate will have Ph.D.\, M.D.\, or M.D./Ph.D. in Regenerative Medicine\, Stem Cells\, Immunotherapy\, Hematology\, Oncology\, and/or Biology. This position offers an excellent opportunity to learn and apply skills in epigenetics\, directed differentiation of human induced pluripotent stem cells (iPSCs)\, HSC transplant\, xenograft\, computational biology\, high-throughput screening\, gene-editing\, and/or molecular and cellular biology techniques. \n\n\nMinimum Physical Requirements: \n  \n\nSitting Constantly (67-100%)\nTalking on phone/in person constantly (67-100%)\nTyping on a keyboard occasionally (0-33%)\nStanding/walking occasionally (0-33%)\n\n\nThe above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individual so classified\, nor is it intended to limit or modify the right of any supervisor to assign\, direct\, and control the work of employees under his/her supervision.
URL:https://ces.b2sg.org/event/nc-24jun19/
LOCATION:Nationwide Children’s Hospital Research Institute\, 700 Children's Dr\, Columbus\, OH\, United States
CATEGORIES:Jobs
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190624
DTEND;VALUE=DATE:20190727
DTSTAMP:20190624T211941Z
CREATED:20190624T211941Z
LAST-MODIFIED:20190624T211941Z
UID:21310-1561334400-1564185599@ces.b2sg.org
SUMMARY:Research Specialist
DESCRIPTION:The Department of Nutritional Sciences at The University of Arizona leads in cutting-edge Research\, outstanding Undergraduate and Graduate Programs\, Cooperative Extension Programs and Continuing Professional Education that advance the discovery and translation of the roles of nutrition and physical activity in optimizing health and wellness for people in Arizona and beyond. The Department of Nutritional Sciences announces the availability of a Research Specialist position under the supervision of Dr. (Ski) Floyd H. Chilton.\nThese position’s duties include performing a wide variety of standard laboratory experimental procedures\, analyzing data\, assisting with writing will manuscripts for publication\, and possibly leading and coordinating the work of other staff.\nThe successful candidates will possess resourcefulness and adaptability in order to address the special and changing needs of research in one specialized field. They will also have the ability to modify and adapt standard procedures to meet the needs of the project while performing preliminary analysis. These positions may require work with potentially hazardous materials such as toxic chemicals\, radiation and/or disease-causing organisms. \nDr. Chilton’s research focuses on how genetic and epigenetic variations interact with human diets (especially the modern Western diet) to drive inflammation and inflammatory disorders (including cardiovascular disease and cancer)\, as well as psychiatric/developmental disorders (ADHD\, autism spectrum disorder\, and depression). \nFunding for these positions is contingent on research grants and will be renewed annually. The individual will be expected to work collaboratively with Dr. Chilton to support research carried out in his laboratory and with his collaborators at the University of Arizona\, University of Arizona Health Sciences\, and affiliated institutions\, including Wake Forest School of Medicine\, Johns Hopkins School of Medicine\, and the University of Virginia.
URL:https://ces.b2sg.org/event/az-24jun19/
LOCATION:University of Arizona\, Tuscon\, AZ\, 85721\, United States
CATEGORIES:Jobs
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