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It is a great pleasure to announce that the 21st International Chromosome Conference edition will take place in Foz do Iguaçu, Brazil, on July 10-13, 2016. This will be the first time that the ICC will be held in South America. Foz do Iguaçu (Foz), is a desirable location in Brazil due to its beautiful nature, human cultural diversity, and easy access to several South American countries. Foz ICC 2016 is an excellent opportunity to bring exciting chromosome related topics and new technologies together for discussion under the view of the most outstanding chromosome biologists.