Symposium Overview

Metabolism and epigenetics are intricately linked, playing a key role in development, cancer, immune signalling and ageing. This symposium brings together world-leading researchers exploring this nexus and will focus in particular on how metabolites and metabolic networks impact gene regulation, on recently discovered roles of metabolites in disease and how this opens novel therapeutic avenues. We will highlight enabling tools linking metabolites, their localisation within tissues and cells with the regulation of chromatin structure, gene activity and epigenetic inheritance.

Innovative molecular and computational tools that enable the detection of metabolites in time and space, as well as novel biology in powerful model organisms and clinical data have led to a renaissance of research on metabolism, especially in the context of epigenetics and gene regulation. The goal of our interdisciplinary symposium is to strengthen the connection between these fields, inspire novel ideas and enable collaborations at this frontier.

Session Topics

• Metabolic regulation of epigenetic marks
• Metabolic control of gene expression
• Metabolism in development and disease
• Systems analysis of metabolism
• Immunometabolism
• Cancer metabolism
• Immune cell metabolism
• Novel tools for metabolism and epigenetics

Speakers:

Asifa Akhtar
Max Planck Institute of Immunobiology and Epigenetics, Germany

Alexander Aulehla,
EMBL Heidelberg, Germany

Guoliang Cui
German Cancer Research Center, Germany

Anne-Claude Gavin
EMBL Heidelberg, Germany

Kai Johnsson
Max Planck Institute for Medical Research, Germany

Sue Kaech
Salk Institute for Biological Studies, USA

Susanne Mandrup
University of Southern Denmark

Ashby Morrison
Stanford University, USA

Mihai Netea
Radboud University Medical Center, The Netherlands

John O’Neill
MRC Laboratory of Molecular Biology, UK

Paola Picotti
ETH Zurich, Switzerland

John Andrew Pospisilik
Van Andel Research Institute, USA

Markus Ralser
The Francis Crick Institute, UK &
Charité -University Medicine, Germany

Matthias Tschöp
Helmholtz Zentrum München, Germany

Benjamin Tu
UT Southwestern Medical Center, USA

Kathryn Wellen
University of Pennsylvania, USA

Oscar Yanes
Rovira i Virgili University, Spain