Leukemia 2017-05-19T11:28:29+00:00

This dataset summarizes current cancer epigenetics research data on leukemic cell lines. The dataset is meant to help you choose cell lines suitable to investigate the oncogenic (EpiONC) or tumor suppressive (EpiTSG) activities of epigenetic modifiers in one or more leukemia. This page is periodically updated, so please check it again for new data that may be relevant to your research.

Most cell lines can be purchased from the American Type Culture Collection (ATCC) or from the Leibniz-Institut-German Collection of Microorganisms and Cell Cultures (Deutsche Sammlung von Mikroorganismen und Zellkulturen; DSMZ), and links to these repositories are provided whenever available.

Salient genetic characteristics such as chimeric fusion genes (e.g. E2A-PBX1 fusion), chromosomal deletions (e.g. del(6)(q21)) or mutations (e.g. p53 mutations), as well as the gender (F: female, M: male), or age (in years) of the patients from whom the cell lines were derived are whenever known also listed. Under “Tumor” is listed the nature of the tumor of origin as primary (Pri), relapse (Rel), or metastasis (Met).

Additional abbreviations used: EBV (Epstein-Barr virus).

This dataset is a work in progress and we rely on our members and readers to point us to data that ought to be herein included. We, therefore, welcome any information that you may provide that would help us make this dataset the most useful tool for your research. You may email us at info@ces.b2sg.org.

To cite this dataset: S. Winkler, S. Brandstetter, I.M. Bennani-Baiti. Leukemia, Cancer Epigenetics Cell Line Database (CECLD) v0.1, Cancer Epigenetics Society (http://ces.b2sg.org/cecld/leukemia/), 2016.

Cell line
Gender Age Tumor Notes
697 DOT1L (KMT4) B cell precursor leukemia E2A-PBX1; del(6)(q21) M 12 Rel EBV+
EOL-1 DOT1L (KMT4) Acute myeloid eosinophilic leukemia FIP1L1-PDGFRA; MLL partial tandem duplication M 33
Kasumi-1 DOT1L (KMT4) Acute myeloblastic leukemia AML1-ETO; KITN822mut M 7 Rel