To cite this section of the Cancer Epigenetics Drug Database

Reference: A. Neudolt, S. Winkler, and I.M. Bennani-Baiti. Histone deacetylase inhibitors. Cancer Epigenetics Drug Database (CEDD) – Experimental dataset, Cancer Epigenetics Society (https://ces.b2sg.org/cedd/experimental_hdaci/), 2021.

Chemical structures of cancer epigenetics drugs

4SC-202
Abexinostat
Apicidin
AR-42
Cancer Epigenetics Society: Belinostat
Cancer Epigenetics Society: Butyrate
CAY10603
CBHA
Chidamide
CUDC-101
Dacinostat
Entinostat
EX-527
JQ12
Largazole
Oxamflatin
Panobisnostat
Romidepsin
Scriptaid
Tenovin-1
TMP269
TSA
Tubastatin A
Valproic acid
VNLG/124
Vorinostat

Brief description of cancer epigenetics drugs

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Drugs
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Cell lines
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Experiments

Apicidin is a fungal (Fusarium sp.) metabolite and cyclic peptide antibiotic with broad spectrum anti-Apicomplexan parasite activity. It exhibits potent cell permeable HDACi activity against parasitic histone deacetylase (IC50 = 0.7 nM) and against eukaryotic HDAC3 (IC50 ≈ 16 nM), while only moderately inhibiting HDAC6 (IC50 ≈ 665 nM).

Apicidin displays low hydrosolubility and requires warming up to 37C and sonication to be soluble in aqueous solutions. It is soluble at ~50 mg/ml in ethanol and in DMSO.

Apicidin chemical structure is cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]. It is also referred to as Apicidin Ia, Ccris 9163, and OSI 2040.

AR-42 is an hydroxamate-tethered phenylbutyrate derivative that displays broad-spectrum deacetylase inhibitor activity of both histone and non-histone proteins with IC50 ranging between 16 and 30 nM. AR-42 was shown to induce hyperacetylation of histone H3, α-tubulin, and p21.

The US Food and Drug Administration (FDA) has granted AR-42 orphan drug status for the treatment of two benign tumors, meningioma and schwannoma.

AR-42 is soluble in DMSO and ethanol at up to 63 mg/ml (201.69 mM) and is soluble in water at < 1 mg/ml. It is also soluble at up to 30 mg/ml in 0.5% methylcellulose + 0.2% Tween 80. Solubility is increased by warming up to 37C and with sonication. Store at -20C after use; stable for up to 6-12 month at -20C.

AR-42 chemical structure is N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide. AR-42 is also known as OSU-HDAC42.

Belinostat is an hydroxamate-type drug that targets histone deacetylases (HDAC) with an IC50 in HeLa cell extracts of 27 nM. Belinostat is approved by the US Food and Drug Administration (FDA) for the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL).

Belinostat is soluble in DMSO at up to 64 mg/ml (201 mM), and in water or ethanol at < 1 mg/ml. Belinostat is also soluble at up to 12 mg/ml in DMSO:polyethylene glycol:Tween 80 (1%:30%:1%; v/v/v/).

Belinostat chemical structure is (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. Belinostat is also known as 866323-14-0 (E Isomer), AN-1073, BCP9000386, Beleodaq, Beleodaq (TN), Beleodaqreg, Belinostat (E), Belinostat Ph3, CCG-208758, E-Belinostat, GTPL7496, NSC726630, OR190689, PX105684, PXD101, PXD-101, QCR-181, and ZINC3818726.

Butyrate is a short chain (4-carbon) fatty acid that competitively engages the zinc sites of class I and II histone deacetylases or HDACs, particularly HDAC1, HDAC2, HDAC3, and HDAC8.

Butyrate is also known as 156-54-7, butanoic acid sodium salt, butyric acid sodium salt, sodium butanoate, sodium propanecarboxylate.

CBHA is a potent hybrid polar compound HDAC inhibitor, exhibiting IC50 values of 10 and 70 nM for HDAC1 and HDAC3, respectively.

CBHA is soluble in DMSO and may be stored at -20C.

CBHA chemical structure is N-hydroxy-3-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-benzamide. It is also known as m-carboxycinnamic acid bis-hydroxamid, and as histone deacetylase inhibitor II.

Entinostat is a 2-aminophenyl benzamide derivative which inhibits class I HDAC1 (IC50 = 0.51 μM) and HDAC3 (IC50 = 1.7 μM), but not HDAC4, HDAC6, HDAC8, and HDAC10 (IC50 ≥ 100 µM).

Entinostat is soluble in water and ethanol at < 1 mM and in DMSO up to a maximum of 199 mM.

Entinostat chemical structure is carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl ester, and is also known as MS-275, MS27-275, and SNDX-275.

Largazole is isolated from the marine cyanobacteria Symploca sp. and acts as potent class I-selective HDACi with increased affinity for HDAC1 (IC50: 3.5 nM), and HDAC2 and HDAC3 (IC50: 10.5 nM), and low activity on HDAC6 (IC50: 200 nM).

Largazole is a 3-hydroxy-7-mercaptohept-4-enoic acid moiety-containing macrocyclic depsipeptide. To chelate the Zn2+ ion at the active site of HDACs, the octanoyl in largazole needs to be cleaved in cells to reveal the active thiol form of the prodrug.

Largazole can be dissolved in ethanol at 1 mg/ml.

The chemical structure of Largazole is Octanethioic acid, S-[(3E)-4-[(5R,8S,11S)-5-methyl-8-(1-methylethyl)-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.12,5]eicosa-2(20),16(19),18-trien-11-yl]-3-buten-1-yl] ester.

Oxamflatin is cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that binds to the zinc atom at HDACs’ catalytic sites, acting as potent HDACi (IC50 ≈ 16 nM).

Oxamflatin is of very limited solubility (and stability) in aqueous solutions. Its is soluble in ethanol at ~ 0.5 mg/ml, DMSO at ~ 5 mg/ml, and DMF at ~ 10 mg/ml. It is is light and moisture-sensitive and should be stored at -20C. It is also soluble in methanol and acetonitrile.

Oxamflatin chemical structure is N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-2E-penten-4-ynamide. It is also known as Metacept 3.

Panobinostat is a cinnamic hydroxamic acid analog that may impede metastasis as it suppresses expression of hypoxia-inducible factor-1α or HIF-1α as well as vascular endothelial growth factor or VEGF. It is also a potent pan-HDACi with an IC50 of ~ 5 nM.

Panobinostat is also known as LBH589 and is marketed under the brand names of Farydak® and Faridak®.

Romidepsin is a bicyclic depsipeptide antibiotic prodrug isolated from the bacterium Chromobacterium violaceum. Romidepsin is an HDAC1 (IC50: 1.6 nM), HDAC2 (IC50: 3.9 nM), HDAC4 (IC50: 25 nM), and HDAC6 (IC50: 790 nM), inhibitor that also inhibits hypoxia-induced angiogenesis and targets (Hsp90)-dependent oncoproteins.

Romidepsin is soluble at 18 mg/ml in DMSO:polyethylene glycol:Tween 80 (1%:30%:1%, v/v/v), 10 mg/ml in DMSO, and at less than 1 mg/ml in water or ethanol.

Romidepsin chemical structure is (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone. It is also known as chromadax, depsipeptide, FK228, FR901228, Istodax, and NSC-630176 .

Scriptaid is a hydroxamic acid-containing HDACi that displays an IC50 of about 0.6 µM toward HDAC1 and HDAC3, and an IC50 of about 1 µM for HDAC8.

Scriptaid is soluble in DMSO up to at least 10 mM (reportedly up to a maximum of 100-199.7 mM) and may be stored at -20C under inert gas. It is also soluble in ethanol (0.3 mg/ml) and in methanol. Solution ought to be warmed up to room temperature for no less than an hour before use. It is best to freshly dissolve it just prior to use rather than to use frozen solutions.

Scriptaid chemical structure is 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide. Is is also known as GCK 1026.

Tenovin-1 inhibits the NAD+-dependent class III histone deacetylases SIRT1 and SIRT2. Tenovin-1 induces both histone H4 and p53 acetylation, and leads to apoptosis.

Tenovin-1 is soluble in DMSO and DMPF (0.25 mg/ml). For increased water solubility, use the tenovin derivative Tenovin-6.

Tenovin-1 chemical structure is N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide.

Trichostatin A (TSA) is a natural derivative of dienohydroxamic acid isolated from the bacteria Streptomyces and is a potent and non-competitive reversible inhibitor of histone deacetylases HDAC1, HDAC4 and HDAC6. Trichostatin A also inhibits TERT.

Trichostatin A is soluble in ethanol (2 mg/ml), DMSO (20 mg/ml), and in DMF (30 mg/ml).

Trichostatin A chemical structure is 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo- 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide.

Valproic Acid is a synthetic derivative of propylpentanoic fatty acid with antiepileptic and mood stabilizing properties. It is mainly used for the treatment of epilepsy and bipolar disorders, though it can also be effective in migraines and in schizophrenia. Valproic Acid can act as a GABA inhibitor. It also inhibits histone deacetylases (HDACs) and nitric oxide synthase.

Valproic acid is soluble in water at 1.3 mg/ml and freely soluble (up to 0.1 – 1 g/ml) in 1N sodium hydroxide, acetone, benzene, chloroform, ethanol, ether, n-heptane, and methanol.

Valproic acid is also known as 99-66-1, 2-propylpentanoic acid, 2-propylvaleric acid, Avugane, calcium valproate, Convulex, Convulsofin, Delepsine, Depacon, Depakene, Depakine, Depakote, dipropyl Acetate, Divalproex, Divalproex sodium, Epical, Epidim, Epilimreg, Epival, Ergenyl, Eurekene, magnesium valproate, Mylproin, propylisopropylacetic acid, semisodium valproate, sodium valproate, Valdisoval, Vaplarin, valproate, and Vupral.

Vorinostat is a a second generation polar-planar synthetic hydroxamic acid derivative which binds to the catalytic domain of histone deacetylases (HDACs), whereby the hydroxamic moiety chelates the zinc ion located in the catalytic pockets of HDACs and blocks deacetylation. In addition to the hyperacetylation of histones, Vorinostat also leads to hyperacetylation of α-tubulin, heat-shock protein 90 (hsp90), and of the p53 tumor suppressor gene. Vorinostat crosses the blood-brain barrier.

Vorinostat is also known as 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide, MK0683, MK-0683, N1-hydroxy-N8-phenyl-octanediamide, N-hydroxy-N’-phenyl-octane-1,8-diotic acid diamide, N-hydroxy-N’-phenyloctanediamide, Octanediamide, N1-hydroxy-N8-phenyl-, Octanediamide, N-hydroxy-N’-phenyl-, QCR-121, SAHA, suberanilohydroxamic acid, suberoylanilide hydroxamic acid, Vorinostatum, Zolinza, Zolinzareg.

Functional assays used to assess the activity of cancer epigenetics drugs

A5A is a cell viability assay that relies on the premise that Annexin V, a cell-impermeable protein, binds with high affinity membrane phosphatidylserine phospholipids when exposed at the cell surface. Though phosphatidylserine phospholipids localize to the inner, cytoplasmic side of the plasma membrane in healthy cells, they translocate from the inner to the outer side of the plasma membrane early in apoptosis, and become accessible to Annexin V. Following staining with Annexin V and propidium iodide (see PIA), the assay allows to quantify: i. (Annexin V / PIA)– viable cells; ii. Annexin V+ / PIA– cells undergoing early apoptosis; iii. (Annexin V / PIA)+ dead cells and those in late apoptosis. Annexin V is usually labeled with a fluorochrome such as FITC as to analyze staining by flow cytometry.

Automated Cell Counting regroups a number of automated procedures including for example electrical impedance-based technologies (e.g Bio-Rad’s Coulter), or microscopy imaging-based methods (e.g. Beckman’s Vi-CELLâ„¢ Cell Counter) to assess cell viability and proliferation. These techniques are mostly automated versions of the trypan blue exclusion assay (see TBE).

BrdU Cell Incorporation Assay is used to quantify 5-bromo-2′-deoxyuridine or BrdU incorporation into DNA during DNA replication that occurs in the course of cellular proliferation. Cells in culture are incubated in the presence of large amounts of BrdU, which is incorporated into DNA instead of thymidine. Following cell fixation and DNA denaturation, a labelled monoclonal anti-BrdU antibody is used to quantify the amount of incorporated BrdU, which in turn reflects the extent of de novo replicated DNA / cell proliferation.

Caspase 3/7 Apoptosis Assay: the Caspase 3 and 7 cysteine protease family members are integral components of mammalian apoptosis. Several variants of this assay are available, including for example those that utilize caspase 3 and 7 substrates that emit light or fluorescence once cleaved by the caspases. The substrate being in excess, the amount of light/fluorescence is proportional to the amount of caspases, and by extension, to the number of apoptotic cells.

Calcein AM allows to assess cell metabolism, and consequently, cell viability. Calcein AM is a non-fluorescent, cell permeable hydrophobic compound that is hydrolyzed by intracellular esterases to produce Calcein, a hydrophilic, cytoplasm-contained fluorescent compound in metabolically active (live) cells. Spectrophotometry of Calcein AM-labeled cells with an excitation at 490 nm and emission at 520 nm permits the quantification of metabolically active cells.

Cell Cycle Analysis is carried out by flow cytometry analysis of cellular DNA content after staining of nuclei with a DNA binding dye (usually propidium iodide). Cells distributes into the G0/G1 phase (cells with about 1n DNA content), S phase (~1.5n), and G2/M phase (~2n). This assay allows to assess (and quantify) if a drug induces a cell cycle block at a given cell cycle phase/checkpoint.

Colony Formation Assay or Colony Forming Units is an assay that is usually carried out by visualizing colonies with the crystal violet dye (see CVA) and allows to assess a cell’s capacity to overcome contact inhibition by growing into a colony, usually in soft agar. This assay is considered to be an in vitro measure of cellular tumorigenicity. The assay is based on counting the number of colonies, their size, or both.

Crystal Violet Assay is a cell viability and proliferation assay based on crystal violet, a cell permeable tri-(dimethylaniline)-methane dye that binds to both DNA and proteins, thus allowing for the visualization of cells (e.g. see CFA), or their quantification by use of spectrophotometry at 570 nm. Since crystal violet stains equally well living and dead cells, this assay is appropriate only for adherent cells that detach after cell death. After the medium is discarded and the dead cells washed away, only the adherent cells remain and are stained.

CyQUANT is a cell proliferation assay that relies on a cell permeable green fluorescent nucleic acid dye (CyQUANT GR dye) and a fluorescence suppression dye that quenches background cellular fluorescence. This is a one-step assay whereby reagents are added directly to cells in culture, incubated 30-60min, and fluorescence is measured with an excitation at 485 ± 10 nm and emission at 530 ± 12.5 nm. The assay essentially measures the amount of nucleic acids in living cells in culture, and is linear over a range of 50 – 250,000 cells in a 200 µl volume.

4′,6-diamidino-2-phenylindole or DAPI is a fluorescent dye that stains the nucleus by binding to AT-rich DNA. Apoptosis can be assessed in fluorescent microscopy by counting the number of DAPIA-stained cell nuclei that show condensed and fragmented chromatin, two early signs of apoptosis.

Erythrosine B Exclusion assay is an alternative to trypan blue (see TBE) in quantifying cell viability and proliferation. Similarly to trypan blue, live cells are impermeable to Erythrosine B, whereas dead cells readily incorporate it.

CellTiter-Glo Luminescent Cell Viability Assay assesses the levels of cellular ATP as a gauge of cellular metabolism. The assay is based on luciferase, which requires ATP (and Mg2+) to convert luciferin into oxiluciferin, and which in the process emits luminescence. The intensity of luminescence signal is proportional to the amount of available cellular ATP, and is thus indicative of metabolic activity.

Guava Viability Assay allows to assess both total cell count and cell viability. The assay is based on quantifying two dyes, one that binds DNA in all cells, and a second dye that binds DNA in dead cells only.

Hemocytometer Cell Counting is based on counting the number of cells in visible light microscopy in multiple fields of a hemocytometer, and then calculating the average number of cells per field.

Lactate Dehydrogenase assay measures the amount of LDH, a non-secreted cytosolic enzyme, in cell culture media as an indicator of cytotoxicity. In cytotoxic conditions, the plasma membrane is damaged and LDH is released into the cell culture medium. The amount of LDH in the medium can be indirectly assessed using MTT type of assays that quantify the amount of NADH in the cell culture medium produced during the conversion of lactate into pyruvate by LDH.

Mitochondrial Membrane Potential assay: intact cells present with a mitochondrial membrane potential due to the differential in polarity between the overall electronegatively charged mitochondrial matrix and electropositively charged cytosol. In this assay, cells are incubated in the presence of cell permeable potential-sensitive fluorescent dyes such as JC-1, which accumulate into mitochondria and shift fluorescence emission from green to red (from about 529 to 590 nm). In cytotoxic conditions or apoptosis, mitochondrial membranes are damaged and mitochondrial membrane polarity is compromised, leading to a shift in the fluorescence emission ratio, which can be quantified and reflects cell viability.

A variation of the MTT assay (see below) that uses the MTS reagent (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) that also relies on formazan quantification to assess cellular metabolism, which may under certain conditions reflect cell number. Contrary to the multistep MTT assay, MTS involves a 1-step procedure.

Mosmann’s Thiazolyl blue Tetrazolium salt assay is a colorimetric assay to quantify cellular metabolic activity. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) is a yellow tetrazole that is metabolized into a non-hydrosoluble purple formazan by NADH/NADPH-dependent mitochondrial dehydrogenases. After solubilization in DMSO or SDS/HCl, formazan is spectrophotometrically quantified at 500-600 nm to assess the extent of tetrazole reduction, and by inference the activity of cellular dehydrogenases. Cellular metabolic activity may under certain conditions reflect cell number.

Neutral Red Method uses a vital dye, neutral red (a.k.a. Basic Red 5, Toluylene Red) that is actively uptaken by viable cells, whereby the dye accumulates in lysosomes, whereas non-viable cells remain impermeable to the dye. After washing out the excess of dye, the incorporated dye is released from the cells and is ionized following incubation in an acidified ethanol solution, which yields its characteristic red color. The amount of neutral red incorporated by the cells can then be quantified spectrophotometrically and is proportional to the number of viable cells.

Propidium Iodide (PI) Assay is a cell viability assay based on the fact that healthy cells are impermeable to PIA. Under certain cytotoxic conditions and during apoptosis, cell membranes are compromised and show increased permeability to PIA, which accumulates in the cell nuclei, wherein it intercalates into DNA. PIA is fluorescent and can therefore be quantified by fluorescence microscopy or spectrophotometry. Since PIA also binds RNA, cleaner results may be obtained by pretreating cells with RNAses.

RCA Conversion Assay is based on the reduction of the non-fluorescent RCA reagent into fluorescent resorufin by cellular dehydrogenases, and thus serves to measure the level of cellular metabolism (or as some interpret it, to assess the number of metabolically active -and thus viable- cells).

SAA Apoptosis Assay: Syto probes are cell permeable fluorescent compounds that bind to DNA and RNA. As cells undergo apoptosis, there is a caspase-dependent loss of fluorescence. The amount of fluorescence emitted by Syto is, therefore, proportional to the number of viable cells and inversely proportional to the number of apoptotic cells.

Spheroid Formation Assay is an assay that allows to assess a cancer cell’s capacity to grow in 3D, and thus to overcome contact inhibition. Cells are embedded in soft agar in the presence or absence of the drug, and spheroids are allowed to grow some 10-14 days depending on cell proliferation rates. The number of spheroids are counted at the end of the experiment for each test sample.

is a cell viability and proliferation assay that utilizes Sulforhodamine B, an anionic aminoxanthene dye that engages into electrostatic interactions with basic amino acids under moderately acidic conditions. The binding of Sulforhodamine B to cellular proteins is linearly dependent on the amount of proteins (and therefore cells), as measured spectrophotometrically at 560-580nm (after washing out the excess of non-bound dye and solubilization in SDS). Sulforhodamine B, however, permeates both living and dead cells, thus limiting the scope of the assay to adherent cells that detach after cell death.

Trypan Blue Exclusion Assay is based on counting in visible light microscopy the number of cells dyed in blue (trypan blue-permeable cells are cells whose membrane is no longer intact, which is indicative of cell death) and trypan blue-impermeable cells (viable cells). Trypan blue is also referred to as diamine blue or Niagara blue.

3H-Thymidine Incorporation assay allows to measure the amount of thymidine incorporated into de novo replicated DNA during cell proliferation. 3H-thymidine is added directly to the cell culture and permitted to incubate some 4-12 hours depending on cell division rates. Labelled DNA is next harvested onto glass fiber filter paper, which can be processed in a scintillation beta-counter. The amount of beta counts/amount of 3H-thymidine incorporated is proportional to the amount of replicated DNA and cell proliferation.

Terminal deoxynucleotidyl transferase (TdT) dUTP Nick End Labeling (TUNEL) allows the detection of DNA fragmentation that accompanies apoptosis. The assay takes advantage of the capacity of TdT to add labeled dUTPs to nicks in the fragmented DNA of cells undergoing apoptosis. The incorporation of dUTPs labeled with either a fluorochrome (e.g. fluorescein-dUTP) or a hapten (e.g. biotin-dUTP, BrdUTP) can be readily quantified and is proportional to the extent of apoptosis.

Transwell Assay, also referred to as the Boyden chamber transwell assay, can be used to quantify cellular motility, migration, chemotaxis, or invasion. The assay is based on the capacity of some cells to traverse a (usually 8 µm) porous membrane (motility / migration) that may in addition be coated with a basement membrane extract, Collagen I or IV, or Laminin I (invasion). The compartment to which the cells would migrate may contain a chemoattractant (e.g. SDF1α/CXCL12), thus allowing to assess chemotaxis. At the end of the experiments, cells that crossed the membrane are stained and counted.

The Wound Healing Assay, a.k.a Scratch Assay, is a technique to assess cell migration propensity in vitro. The assay relies on tracking cells movements on a slide onto which a gap (wound, scratch) is applied. While this method is widely accepted as a cell migration assay, we at the Cancer Epigenetics Society have concerns about its validity as its results may be compromised by the proliferation, or lack thereof, of the cells under investigation.

Water-soluble Tetrazolium salts assays utilize water-soluble dyes that yield formazans with different absorption spectra as an alternative to the water-insoluble and single-spectrum reagents of the MTT assay. Assay based on WST-1 (2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium) and perhaps more so on WST-8 (2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium) offer several advantages as they are reduced outside the cells, include 5-methyl-phenazinium methyl sulfate that serves as an electron transfer mediator, and yield a water-soluble formazan. Unlike MTT, WST assays are accompanied with lower cell toxicity, do not require a solubilization step, and emit stronger signals. WST assays allow to quantify cellular metabolism extracellularly. Cellular metabolic activity may under certain conditions reflect cell number.

A variant of the MTT, MTS and WST assays that relies on 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide as the tetrazole, and akin to WST, is reduced to a water-soluble formazan, thus eliminating the last solubilization step. XTT displays higher sensitivity and dynamic range than MTT, and as the latter, allows to quantify cellular metabolism. Cellular metabolic activity may under certain conditions reflect cell number.

A word about the Cancer Epigenetics Drug Database – HDACi section

Welcome to the Cancer Epigenetic Drug Database – Experimental dataset for histone deacetylase inhibitors (HDACi). The epigenetics drug database gives an overview of cancer cell lines sensitivity to HDACi in various functional assays (see assays abbreviations below). The page starts off with the chemical structures of the epigenetic drugs, a succinct description of the epigenetic drugs and functional assays used to test them in cancer cell lines, followed by Tables summarizing the data. Some of the epigenetic drugs also have clinical activities which are summarized in this page. Please note that the epigenetic drug solubility values provided here are only to be used as a guide, and that solubility depends on several variables such as the purity of the solute and solvent used, as well as the temperature used. Similarly, the IC50 values provided herein can be highly dependent on the type of functional assay used and length of incubation of cells with the epigenetic drugs.

The Cancer Epigenetics Drug Database is by definition a work in progress and we rely on our members and readers to bring to our attention data that ought to be included here. We, therefore, welcome any information that you may provide that would help us make this database as useful a tool for your research as possible. You may email us your suggestions at info@ces.b2sg.org, Subject line: CEDD – HDACi, Experimental dataset. The Cancer Epigenetics Drug Database is periodically updated, so please check it again for new data that may be relevant to your research.

Notes:

1Inc: Incubation of the cells in the presence of the drug in hours.
2Assay: Please see details on functional assays above.
3Gene vs protein expression: Symbols in plain text denote proteins (e.g. HDAC1), those in italics the mRNA (e.g. HDAC1), and those in bold (e.g. HDAC1) imply that both the mRNA and the protein are affected. ↑ indicates an increase, whereas ↓ indicates a decrease in mRNA or protein expression or in the levels of an epigenetic mark. Example of an epigenetic mark: H2AK118ac stands for histone H2A acetylated at lysine 118.

Histone deacetylase inhibitor (HDACi) activities in cancer cells

Cell lineIC50 (µM)Inc1Assay2
Additional information3ID#
56370.1572MTT
639-V0.3872MTT
DLD1~ 0.772MTT
HBLAK0.3872MTT
HCT-116~ 572MTT
HCT-15~ 472MTT
HEK-2930.272MTT
Hep3B> 572MTT
HepG2~ 1-572MTT
HepG2~ 1-372TBE
HepG2~ 1240CFA
HepG2> 2548TTI
HepG2> 1-512MMP
HL-7702> 2572MTT
HT-29~ 748MTT
HT-29~ 3 72MTT
HT-29~ 0.1-172TBE
HT-29~ 1240CFA
RT-1120.472MTT
SMMC-7721< 572MTT
SW17100.4772MTT
T240.3672MTT
TERT-NHUC0.2772MTT
UM-UC-30.5172MTT
UM-UC-3< 0.548LDH
VM-CUB10.3872MTT
VM-CUB1~ 0.5-2.548LDH
VM-CUB1< 0.548GLO

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (nM)Inc1Assay2
Additional information3ID#
AGS31048MTS
HF1< 50048A5A
HGC-2735048MTS
HGC-27< 250240CFA
Hs 578T<  50072MTT
L428< 50048A5A
L428~ 200024MMP
LA1-55n122.648CAM
LAN2163.148CAM
MDA-MB231< 50072MTT
OCI-LY3< 50048A5A
Ramos< 50048A5A
Ramos> 100024MMP
SK-N-BE(2)-C196.448CAM
SMS-KCNR83.548CAM
SUDHL4~ 50048A5A
SUDHL4< 50048A5A
SUDHL6< 50048A5A
SUM 149> 50072MTT

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional information3ID#
A2058~ 148SRB
AGS~ 0.248SRB
Capan-1 > 5 24LDH
Capan-15.848LDH
Capan-11.172LDH
Capan-1> 524SRB
Capan-1~ 0.648SRB
Capan-1~ 0.672SRB
Capan-10.124MTT
Capan-10.648 MTT
Capan-10.772MTT
Capan-1~ 0.1524CVA
Capan-1~ 0.448CVA
Capan-1~ 0.572CVA
CCD-18Co~ 448SRB
HBEC30KT~ 0.196MTS
HBEC34KT~0.896MTS
HCC40170.1296MTS
HCC40180.0396MTS
HCT116-p53+ ~ 748PIA↓ p53, MDM2 & MDM4 
HCT116-p53+~ 0.9 48MMP↓ p53, MDM2 & MDM4 
HCT116-p53–~ 248PIA↓ p53, MDM2 & MDM4 
HCT116-p53–~ 1.5 48MMP↓ p53, MDM2 & MDM4 
HCT116172XTT
HEC1A~ 0.1 – 172WST-1
HEC1B> 172WST-1
HEK2931196XTT
HeLa272XTT
HeLa1.496XTT
HeLa~ 0.848SRBInduces long-term H4ac, p21, Gelsolin, causes G0/G1 arrest
HepG2>1021LDH
HHUA~ 172WST-1
HL60~ 0.396XTT
Ishikawa~ 272MTT↑ H3ac, H4ac, p16, p21, E-cadherin, causes G2/M arrest
Ishikawa> 172WST-1
Jurkat~ 0.896XTT
K5621.572XTT
KLE~ 0.1 – 172WST-1
KYO12.772XTT
MCF7~248SRB
MCF7572XTT
MCF76.896XTT
MCF10A1.424MTTArrest in G1 phase
MCF10A-ras0.224MTTArrest in G1 phase
MDA-MB-231> 0.424TWA
MG-63~ 348SRB
NCI-H460> 5 24TWACXCL12-driven assay; ↑ CXCR4 
P3HR1~ 0.2144TBE
Panc-1> 524LDH
Panc-1> 548LDH
Panc-1~ 572LDH
Panc-1> 524SRB
Panc-1~ 1.248SRB
Panc-1~ 3.472SRB
Panc-1> 524MTT
Panc-1> 548MTT
Panc-1> 572MTT
Panc-1> 524CVA
Panc-1~ 0.7548CVA
Panc-1~ 0.872CVA
RL952~ 0.1 – 172WST-1
SF295< 524TWA↑ CXCR4 
SKOV3~ 124TWA↑ HDAC3, ↓ HDAC4 & HDAC7
SKOV3~ 372MTT↑ H3ac, H4ac, p16, p21, E-cadherin
SW837~ 0.324MTT
SW1116~ 0.324MTT↓ HDAC activity, ↑ NFκB
UOK121< 524TWACXCL12-driven assay; ↑ CXCR4 
YD-15~ 1.548MTT↑ H3ac, H4ac, Bax, cPARP
ZR-75-1~ 248SRB

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
ID#
697 0.044
 72RCA
56370.14472SAA
201-T2.672SAA
22RV10.16872SAA
23132-870.42372SAA
42-MG-BA1.08
72SAA
451-Lu0.7472SAA
639-V2.7472 SAA
647-V3.972SAA
769-P0.2472SAA
786-00.44
72SAA
8305C45
72SAA
8505C44 72SAA
8-MG-BA0.4172SAA
A101D0.5672SAA
A1720.7172SAA
A2040.772SAA
A20584.472SAA
A2534.172SAA
A27800.3572SAA
A3750.3772SAA
A3883.572SAA
A3-KAW0.1272RCA
A4274.6172SAA
A4310.272SAA
A49814.672SAA
A4-Fuk8.5772RCA
A6730.7972SAA
ABC-10.4572SAA
ACHN1.172SAA
ACN2.3272SAA
AGS0.3872SAA
ALL-PO0.0372SAA
ALL-SIL0.0772SAA
AM-380.7872SAA
AMO-10.1872RCA
AN3-CA1.4672SAA
ARH-770.1372RCA
ASH-311.472SAA
AsPC-11.1672SAA
ATN-10.1772RCA
AU5650.3672SAA
BB30-HNC0.9972SAA
BB49-HNC13.172SAA
BB65-RCC0.5372SAA
BC-10.1872RCA
BC-20.3872RCA
BC-30.2172RCA
BCPAP0.2772SAA
BE-130.05872RCA
BE2-M170.972SAA
Becker1472SAA
BEN0.9572SAA
BFTC-9050.8972SAA
BFTC-9091.5372SAA
BHT-1010.17572SAA
BHY0.472SAA
BICR1013.272SAA
BICR22172SAA
BICR311.872SAA
BICR780.3472SAA
BL-410.0972RCA
BL-700.0472RCA
BOKU1.172SAA
BPH-10.1772SAA
BT-20372SAA
BT-4742.1772SAA
BT-48345272SAA
BV-1730.1172RCA
BxPC-30.81372SAA
C2BBe1172SAA
C3229.972SAA
C-33-A0.172SAA
C3A1.5872SAA
C-4-I18.272SAA
CA460.02772RCA
Ca9-220.172SAA
CADO-ES10.05972SAA
CAKI-10.3572SAA
CAL-1201.2572SAA
CAL-12T0.9572SAA
CAL-1480.2272SAA
CAL-270.3772SAA
CAL-290.6572SAA
CAL331.1772SAA
CAL-391.3672SAA
CAL-518.8872SAA
CAL-540.5272SAA
CAL620.6272SAA
CAL7228.172SAA
CAL-78972SAA
CAL-85-11.8972SAA
Calu-10.272SAA
Calu-32.672SAA
Calu-60.3272SAA
CAMA-11.872SAA
Caov-32.6872SAA
Capan-11.3372SAA
Capan-264.172SAA
CaR-10.972SAA
CAS-11.1672SAA
Ca-Ski0.4172SAA
CCF-STTG176.272SAA
CCK-810.2272SAA
CCRF-CEM0.0972RCA
CESS0.0772RCA
CFPAC-141.272SAA
CGTH-W-10.8772SAA
ChaGo-K-12.5472SAA
CHL-10.19272SAA
CHP-1264.172SAA
CHP-1340.18572SAA
CHP-2120.0672SAA
CHSA0011772SAA
CHSA01080.1172SAA
CHSA892616572SAA
CL-117.6972SAA
CMK0.06772RCA
COLO-2050.4572SAA
COLO-320-HSR0.27572SAA
COLO–6680.6472SAA
COLO-678972SAA
COLO-6791.6672SAA
COLO-680N93.172SAA
COLO-6842.5872SAA
COLO-7410.5772SAA
COLO-7830.72672SAA
COLO-7922.8572SAA
COLO-8005.4172SAA
COLO-8240.88372SAA
COLO-8291.2272SAA
COR-L1050.3672SAA
COR-L230.42572SAA
COR-L2790.09372SAA
COR-L3030.05472SAA
COR-L3210.04772SAA
COR-L950.6972SAA
CP50-MEL-B0.5572SAA
CP66-MEL2.5172SAA
CPC-N0.272SAA
CS10.7772SAA
CTV-10.2272RCA
CW-20.6172SAA
D-247MG0.5872SAA
D-263MG1.4572SAA
D-283MED58.972SAA
D-336MG0.6372SAA
D-392MG1.6172SAA
D-423MG0.3672SAA
D-502MG1.0572SAA
D-542MG0.5772SAA
D-566MG0.572SAA
DAN-G0.6172SAA
Daoy0.08572SAA
Daudi0.17572RCA
DB0.172RCA
DBTRG-05MG1.5372SAA
DEL0.2572RCA
Detroit5622.8672SAA
DG-750.9372RCA
DJM-133.872SAA
DK-MG2.572SAA
DMS-1142.2272SAA
DMS-1530.1672SAA
DMS-2730.1672SAA
DMS-538.7772SAA
DMS-791.2772SAA
DND-410.1472RCA
DOK2.5872SAA
DoTc2-45100.7472SAA
DOV1397.572SAA
DSH10.19872SAA
DU-1450.3472SAA
DU44750.1872SAA
DV-900.3872SAA
EB20.2272RCA
EB-30.6672RCA
EBC-11.3772SAA
ECC101.472SAA
ECC40.972SAA
EC-GI-103.6872SAA
EFM-190.572SAA
EFM-192A0.8972SAA
EFO-214.3872SAA
EFO-270.4172SAA
EGI-13.5572SAA
EJM0.1572RCA
EKVX8.1972SAA
EM-20.17572RCA
EMC-BAC-11.1272SAA
EM-BAC-20.4372SAA
EN0.7672SAA
EoL-1-cell0.0272RCA
EPLC-272H0.2472SAA
ES10.1672SAA
ES-20.12672SAA
ES30.2572SAA
ES42.2272SAA
ES50.0472SAA
ES61.2572SAA
ES70.172SAA
ES80.17572SAA
ESO260.2572SAA
ESO510.472SAA
ESS-10.4172SAA
ETK-10.6372SAA
EVSA-T0.1972SAA
EW-10.0972SAA
EW-110.17572SAA
EW-130.9872SAA
EW-160.2172SAA
EW-180.172SAA
EW-242.1572SAA
EW-30.27572SAA
EW-70.2272SAA
EW74760.2672SAA
FADU2.472SAA
Farage0.2172RCA
FLO-10.3772SAA
FTC-1332.972SAA
FU971.6572SAA
FU-OV-18.7472SAA
G-292-A141B111.172SAA
G-3610.2172SAA
G-4010.4772SAA
G-40210.372SAA
GAK0.6972SAA
GAMG0.2572SAA
GB-10.08472SAA
GCIY0.1972SAA
GCT17.772SAA
GDM-10.1172RCA
GI-10.2472SAA
GI-ME-N0.272SAA
G-MEL0.572SAA
GMS-1029.872SAA
GOTO0.7472SAA
GP5d0.672SAA
GRANTA-5191.1372RCA
GR-ST0.1772RCA
GT3TKB0.8972SAA
H23691.2772SAA
H23730.6272SAA
H24611.4172SAA
H25913.7572SAA
H25950.7572SAA
H25961.4472SAA
H27220.6672SAA
H27310.02872SAA
H27951.4772SAA
H28030.4872SAA
H28041.172SAA
H28181.8172SAA
H2869172SAA
H31180.17572SAA
H32553.1672SAA
H40.5172SAA
H51368.572SAA
H922.572RCA
HA7-RCC51.872SAA
HAL-010.0972RCA
HARA0.8472SAA
HC-10.1672RCA
HCC11431.6372SAA
HCC11872.7372SAA
HCC139511.872SAA
HCC14190.7872SAA
HCC14280.3572SAA
HCC-1513.372SAA
HCC15000.37872SAA
HCC15690.7972SAA
HCC15990.1372SAA
HCC18060.5872SAA
HCC19371.3572SAA
HCC19541.2872SAA
HCC2020.2372SAA
HCC21572.2272SAA
HCC22181.0572SAA
HCC29980.9672SAA
HCC-330.1472SAA
HCC380.6572SAA
HCC-440.2172SAA
HCC-560.3472SAA
HCC700.7872SAA
HCC-780.3972SAA
HCC-8270.7672SAA
HCE-413.272SAA
HCT-1160.1772SAA
HCT-151.4672SAA
HDLM-26.2572RCA
HD-MY-Z0.4472RCA
HDQ-P10.4472SAA
HEC-10.7872SAA
HEL0.0772RCA
HeLa1.3272SAA
H-EMC-SS27.972SAA
Hep3B2-1-70.5572SAA
Hey0.2772SAA
HGC-270.4972SAA
HH0.12572SAA
HL-600.12272SAA
HLE0.9772SAA
HMV-II172SAA
HN4.972SAA
HO-1-N-10.872SAA
HO-1-u-10.9172SAA
HOP-620.3872SAA
HOP-921.9772SAA
HOS14.272SAA
HPAC1.0572SAA
HPAF-II3.4872SAA
Hs-4450.4872RCA
Hs-578-T372SAA
Hs-633T0.27572SAA
Hs-6831.7672SAA
HS746T0.1272SAA
Hs-766T2.8272SAA
Hs-939-T1.6372SAA
Hs-940-T2.1772SAA
HSC-22.3272SAA
HSC-32.0572SAA
HSC-390.7772SAA
HSC-43.172SAA
HT0.1672RCA
HT-10801.6872SAA
HT-1150.4772SAA
HT-11970.672SAA
HT-13761672SAA
HT-14469.272SAA
HT-290.372SAA
HT-30.4872SAA
HT550.9572SAA
HTC-C30.2372SAA
HuCCT10.9172SAA
huH-1372SAA
HuH-70.3772SAA
HuO-3N15.6672SAA
HuO91.9572SAA
HuP-T30.7772SAA
HuP-T40.4772SAA
HUTU-800.1572SAA
IA-LM3.7372SAA
IGR-10.3472SAA
IGR-370.27472SAA
IHH-40.35572SAA
IM-950.4472SAA
IMR-50.1372SAA
IOSE-364(-)0.1672SAA
IOSE-3970.1172SAA
IOSE-523(-)0.1772SAA
IOSE-75-16SV400.9172SAA
IPC-2980.272SAA
Ishikawa-02ER-2.6872SAA
IST-MEL10.7172SAA
IST-MES10.7972SAA
IST-SL10.06672SAA
IST-SL272.572SAA
J826.2972SAA
JAR0.24472SAA
JEG-355.572SAA
JHH-10.0872SAA
JHH-20.5872SAA
JHH-40.13572SAA
JHH-61.6372SAA
JHH-70.8772SAA
JHOS-21.172SAA
JHOS-311.672SAA
JHU-0110.4572SAA
JHU-0222.8772SAA
JIMT-12.4972SAA
JiyoyeP-20030.272RCA
JJN-30.1672RCA
JM10.03972RCA
J-RT3-T3-50.2172RCA
JSC-10.06772RCA
JURL-MK10.272RCA
JVM-22.4372RCA
JVM-30.2772RCA
K0520.1272RCA
K1918.872SAA
K21.7272SAA
K49.8772SAA
K50.5772SAA
K5620.2172RCA
K816.172SAA
KALS-11.172SAA
KARPAS-2990.2172RCA
KARPAS-4220.3772RCA
KARPAS-450.04372RCA
KARPAS-6200.1172RCA
KCL-220.1272RCA
KE-370.172RCA
KELLY0.1772SAA
KG-10.1272RCA
KG-1-C1.972SAA
KGN0.2572SAA
KING-10.3272SAA
KLE1.472SAA
KM120.8972SAA
KMH-213.872SAA
KM-H224.572RCA
KMOE-20.1572RCA
KMRC-10.772SAA
KMRC-204.5572SAA
KMS-110.1172RCA
KMS-12-BM0.08472RCA
KNS-421.172SAA
KNS-81-FD0.7172SAA
KON11.372SAA
KOPN-80.05272RCA
KOSC-20.3872SAA
KP-20.5672SAA
KP-32.2372SAA
KP-40.5472SAA
KP-N-YN0.1572SAA
KP-N-YS0.3872SAA
KS-1172SAA
KU-19-190.4472SAA
KU8120.01872RCA
KURAMOCHI0.6672SAA
KY8210.4772RCA
KYAE-10.3572SAA
KYM-10.4372SAA
KYSE-1408472SAA
KYSE-1503.772SAA
KYSE-1800.3272SAA
KYSE-220172SAA
KYSE-2701.3772SAA
KYSE-4101.8472SAA
KYSE-4500.7972SAA
KYSE-501.7872SAA
KYSE-5101.2872SAA
KYSE-520272SAA
KYSE-701.172SAA
L-12360.1672RCA
L-3630.2472RCA
L-42837.672RCA
L-54022.772RCA
LAMA-840.272RCA
LAN-65.8272SAA
LB1047-RCC0.372SAA
LB2241-RCC2.372SAA
LB2518-MEL0.6172SAA
LB373-MEL-D0.4972SAA
LB647-SCLC12.472SAA
LB771-HNC1.1572SAA
LB831-BLC0.7272SAA
LB996-RCC1.7772SAA
LC-1F0.6172SAA
LC-1-sq0.5672SAA
LC-2-ad0.1972SAA
LC4-10.172RCA
LCLC-103H0.6172SAA
LCLC-97TM10.4372SAA
LK-20.3872SAA
LN-181.5872SAA
LN-2290.9772SAA
LN-4051.1572SAA
LNCap-FGC0.1172SAA
LNZTA3WT41.172SAA
LOUCY0.1972RCA
LOU-NH910.9872SAA
LoVo1.6272SAA
LOXIMVI0.772SAA
LP-10.1572RCA
LS-10340.4572SAA
LS-1230.7272SAA
LS-1800.9472SAA
LS-411N0.1272SAA
LS-5131.172SAA
LU-134-A0.2872SAA
LU-1350.3472SAA
LU-1390.272SAA
LU-1650.2972SAA
LU-650.9772SAA
LU-99A2.672SAA
LXF-2890.6472SAA
M059J0.7272SAA
M141.1672SAA
MC1160.1772RCA
MCAS0.4472SAA
MCC13872SAA
MCC2632.472SAA
MC-CAR0.1272RCA
MCF710.472SAA
MC-IXC0.28172SAA
MDA-MB-134-VI1.2672SAA
MDA-MB-1571.172SAA
MDA-MB-175-VII1.172SAA
MDA-MB-2310.58472SAA
MDA-MB-3300.3672SAA
MDA-MB-3610.2472SAA
MDA-MB-41522.572SAA
MDA-MB-4363.672SAA
MDA-MB-4530.05872SAA
MDA-MB-4682.7472SAA
ME-10.1772RCA
ME-1800.6872SAA
MEC-10.0972RCA
MEG-010.3872RCA
MEL-JUSO0.4272SAA
MES-SA5.6672SAA
Mewo0.9272SAA
MFE-2800.8172SAA
MFE-2966.8772SAA
MFE-3198.5772SAA
MFH-ino0.6672SAA
MFM-2230.58272SAA
MG-6310172SAA
MHH-ES-10.2272SAA
MHH-NB-110.07572SAA
MHH-PREB-10.0972RCA
MIA-PaCa-21.6772SAA
MKL-1-28.272SAA
MKL-20.0972SAA
MKN11.3872SAA
MKN282.372SAA
MKN4514.572SAA
ML-10.3472SAA
ML-20.3372RCA
MLMA0.09672RCA
MMAC-SF3.1572SAA
MN-600.1472RCA
MOG-G-CCM0.4272SAA
MOG-G-UVW0.2772SAA
MOLM-130.07572RCA
MOLP-80.04772RCA
MOLT-130.02472RCA
MOLT40.1272RCA
MONO-MAC-60.1772RCA
Mo-T0.1872RCA
MPP-890.0772SAA
MRK-nu-12.2672SAA
MS-10.1172SAA
MS7512.9572SAA
MSTO-211H0.6772SAA
MV-4-110.0772SAA
MY-M120.05672SAA
MZ1-PC0.02772SAA
MZ2-MEL1.9472SAA
MZ7-mel0.1372SAA
NALM-60.1172RCA
NAMALWA0.0272RCA
NB(TU)1-100.2172SAA
NB14.6672SAA
NB100.5472SAA
NB120.0772SAA
NB130.172SAA
NB174.172SAA
NB40.05672RCA
NB50.57572SAA
NB60.16472SAA
NB690.2372SAA
NB70.03672SAA
NBsusSR0.1672SAA
NCC0210.3272SAA
NCI-H10480.9172SAA
NCI-H10920.2872SAA
NCI-H11550.3772SAA
NCI-H11840.05872SAA
NCI-H12994.3772SAA
NCI-H13044.3172SAA
NCI-H135518.972SAA
NCI-H13850.45272SAA
NCI-H13952.3772SAA
NCI-H14170.172SAA
NCI-H14352.5572SAA
NCI-H14360.6372SAA
NCI-H14370.8772SAA
NCI-H15220.1672SAA
NCI-H15632.8672SAA
NCI-H156895.972SAA
NCI-H15730.6172SAA
NCI-H15810.272SAA
NCI-H16230.572SAA
NCI-H16480.2872SAA
NCI-H16510.5372SAA
NCI-H16660.8672SAA
NCI-H16882.1572SAA
NCI-H16930.2672SAA
NCI-H16940.272SAA
NCI-H17034.472SAA
NCI-H17340.6372SAA
NCI-H17550.1772SAA
NCI-H17700.3472SAA
NCI-H1781372SAA
NCI-H17923.8472SAA
NCI-H17935.7472SAA
NCI-H18360.7172SAA
NCI-H183814.772SAA
NCI-H18691.272SAA
NCI-H1870.3972SAA
NCI-H18760.6572SAA
NCI-H19150.3772SAA
NCI-H19260.6772SAA
NCI-H19440.2772SAA
NCI-H1960.1972SAA
NCI-H19634.472SAA
NCI-H19750.4872SAA
NCI-H19931.4272SAA
NCI-H20098.2972SAA
NCI-H20232.2372SAA
NCI-H20290.3872SAA
NCI-H2030172SAA
NCI-H205214.572SAA
NCI-H20812.2372SAA
NCI-H20852.6172SAA
NCI-H20870.7172SAA
NCI-H20982.572SAA
NCI-H2110.0772SAA
NCI-H21100.3572SAA
NCI-H21222.9672SAA
NCI-H21268.5472SAA
NCI-H21350.2172SAA
NCI-H21411.1972SAA
NCI-H21702.472SAA
NCI-H21710.2772SAA
NCI-H21721.7272SAA
NCI-H21960.372SAA
NCI-H2200.2872SAA
NCI-H22270.07572SAA
NCI-H22286.2272SAA
NCI-H2260.2672SAA
NCI-H22860.5472SAA
NCI-H229120872SAA
NCI-H230.6972SAA
NCI-H23425.572SAA
NCI-H23470.4672SAA
NCI-H24051.1472SAA
NCI-H24440.8672SAA
NCI-H245235.872SAA
NCI-H2815.872SAA
NCI-H2920.2972SAA
NCI-H31220.4472SAA
NCI-H322M1.5772SAA
NCI-H3450.2772SAA
NCI-H3580.3672SAA
NCI-H4412.7372SAA
NCI-H4460.1472SAA
NCI-H46011.972SAA
NCI-H510A0.07272SAA
NCI-H5200.4872SAA
NCI-H5220.1572SAA
NCI-H5240.8372SAA
NCI-H5260.2372SAA
NCI-H5960.8972SAA
NCI-H6300.8272SAA
NCI-H640.2472SAA
NCI-H6470.4872SAA
NCI-H6500.7372SAA
NCI-H6610.2672SAA
NCI-H7161.6672SAA
NCI-H72011.872SAA
NCI-H7275.2372SAA
NCI-H7470.8572SAA
NCI-H7480.05272SAA
NCI-H8100.07672SAA
NCI-H821.7472SAA
NCI-H8380.8572SAA
NCI-H8411.3272SAA
NCI-H8470.0672SAA
NCI-H8650.1472SAA
NCI-SNU-10.4172SAA
NCI-SNU-162.4172SAA
NCI-SNU-52.7672SAA
NEC80.08472SAA
NH-120.06572SAA
NKM-10.07572RCA
NMC-G11.4272SAA
no-101.8672SAA
no-115.1772SAA
NOMO-10.2172RCA
NOS-10.1472SAA
NTERA-S-cl-D10.6772SAA
NU-DUL-10.07672RCA
NUGC-31.3672SAA
NUGC-40.7372SAA
NY16.772SAA
OACM5-10.3672SAA
OACp4C0.07672SAA
OAW-280.2272SAA
OAW-421.3372SAA
OC-3140.3972SAA
OCI-AML20.1272RCA
OCI-AML30.1272RCA
OCI-AML50.07772RCA
OCI-LY-190.09572RCA
OCI-M10.05672RCA
OCUB-M0.2572SAA
OCUM-167.972SAA
OE192.3372SAA
OE211.6972SAA
OE330.8472SAA
OMC-10.8272SAA
ONC-760.3872SAA
OPM-20.1172RCA
OSC-190.472SAA
OSC-200.4972SAA
OS-RC-21.1772SAA
OUMS-230.2172SAA
OV-17R0.2472SAA
OV-560.7172SAA
OV-70.5572SAA
OV-901.172SAA
OVCA4200.1572SAA
OVCA4331.3672SAA
OVCAR-310172SAA
OVCAR-43.872SAA
OVCAR-50.2972SAA
OVCAR-80.172SAA
OVISE1.172SAA
OVK-1878.972SAA
OVKATE172SAA
OVMIU0.4172SAA
OVTOKO1.172SAA
P12-ICHIKAWA0.1172RCA
P30-OHK0.03872RCA
P31-FUJ0.4972RCA
P32-ISH0.1372RCA
P3HR-10.172RCA
PA-10.02972SAA
PANC-02-030.472SAA
PANC-03-271.172SAA
PANC-04-0314.572SAA
PANC-08-133.172SAA
PANC-10-050.5572SAA
PA-TU-89020.3972SAA
PA-TU-8988T2.3272SAA
PC-140.2872SAA
PC-30.5172SAA
PC-3_[JPC-3]0.5672SAA
PCI-15A71.572SAA
PCI-301572SAA
PCI-380.8172SAA
PCI-4B0.2872SAA
PCI-6A0.12572SAA
PE-CA-PJ151.7972SAA
PEO10.4172SAA
PF-3820.172RCA
PFSK-10.8972SAA
PL181.3772SAA
PL-210.22572RCA
PL41.6972SAA
PLC-PRF-53.5972SAA
PSN10.1172SAA
QGP-10.2872SAA
QIMR-WIL0.05572RCA
Raji0.2472RCA
Ramos-2G6-4C100.1572RCA
RCC10RGB5.472SAA
RCC-AB0.272SAA
RCC-ER3.9272SAA
RCC-FG20.872SAA
RCC-JF0.2372SAA
RCC-JW0.6872SAA
RCC-MF0.2372SAA
RC-K81.172RCA
RCM-10.6172SAA
RD0.6672SAA
RD-ES0.2672SAA
REH0.1672RCA
RERF-GC-1B6.3272SAA
RERF-LC-KJ8.7172SAA
RERF-LC-MS0.6672SAA
RERF-LC-Sq11.5872SAA
RF-480.05872SAA
RH-10.1272SAA
RH-411.4772SAA
RKN2.172SAA
RKO0.4872SAA
RL0.1872RCA
RL95-20.2772SAA
RMG-I0.6972SAA
RO82-W-10.8572SAA
ROS-500.4272RCA
RPMI-26500.2872SAA
RPMI-66660.07372RCA
RPMI-79510.5172SAA
RPMI-82260.1972RCA
RPMI-84020.0572RCA
RPMI-88660.1272RCA
RS4-110.05972RCA
RT-1120.4172SAA
RT40.1272SAA
RVH-4212.5672SAA
RXF3930.4872SAA
S-1171.3272SAA
Saos-212872SAA
Sarc93716.4272SAA
SAS0.5872SAA
SAT0.7972SAA
SBC-10.3372SAA
SBC-30.06772SAA
SBC-50.3872SAA
SCaBER0.9772SAA
SCC-151.1472SAA
SCC-250.3272SAA
SCC-30.3672RCA
SCC-41.172SAA
SCC-90.5272SAA
SCH28.172SAA
Sci-10.1372RCA
SCLC-21H0.1872SAA
SF1260.6972SAA
SF2680.2772SAA
SF2950.5572SAA
SF5390.6172SAA
SH-42.7472SAA
SHP-771.172SAA
SIG-M50.07372RCA
SiHa38.572SAA
SIMA1.172SAA
SISO1.6772SAA
SJRH300.3872SAA
SJSA-11.272SAA
SK-CO-10.6672SAA
SK-ES-10.7972SAA
SK-IIIa5.5772SAA
SK-GT-40.3572SAA
SK-HEP-10.8472SAA
SK-LMS-10.1272SAA
SK-LU-12.3972SAA
SK-MEL-11.272SAA
SK-MEL-20.8272SAA
SK-MEL-241.172SAA
SK-MEL-281.6872SAA
SK-MEL-30.6272SAA
SK-MEL-300.5172SAA
SK-MEL-583.572SAA
SK-MES-10.4572SAA
SK-MG-10.9272SAA
SK-MM-20.5472RCA
SKN0.8872SAA
SKN-3172SAA
SK-N-AS0.0972SAA
SK-N-DZ1.2272SAA
SK-NEP-10.1372SAA
SK-N-FI0.5472SAA
SK-N-SH0.2172SAA
SK-OV-30.3972SAA
SK-PN-DW0.1672SAA
SK-UT-119.172SAA
SLVL0.09372RCA
SN12C0.9172SAA
SNB753.6572SAA
SNU-104011972SAA
SNU-1750.2272SAA
SNU-1820.5172SAA
SNU-3870.2772SAA
SNU-3980.5972SAA
SNU-4070.5272SAA
SNU-4230.3372SAA
SNU-4492.2672SAA
SNU-4750.7372SAA
SNU-610.1172SAA
SNU-8111472SAA
SNU-C11.172SAA
SNU-C2B0.4272SAA
SNU-C50.9272SAA
SR0.03672RCA
ST4860.1372RCA
SU86862.4172SAA
SU-DHL-11.3272RCA
SU-DHL-100.0372RCA
SU-DHL-160.04772RCA
SU-DHL-40.08272RCA
SU-DHL-50.03872RCA
SU-DHL-60.07572RCA
SU-DHL-80.04272RCA
SUIT-20.3572SAA
SUP-B150.08472RCA
SUP-HD10.1772RCA
SUP-M20.08772RCA
SUP-T10.1272RCA
SW1088672SAA
SW11160.3372SAA
SW12710.672SAA
SW1336.372SAA
SW14170.672SAA
SW14632.1372SAA
SW1564.8672SAA
SW15732.3172SAA
SW17100.5672SAA
SW17830.9272SAA
SW199072.272SAA
SW480.9672SAA
SW6200.4572SAA
SW68476.572SAA
SW7566.8472SAA
SW78017.772SAA
SW8370.1772SAA
SW8720.4672SAA
SW9000.8172SAA
SW9480.5272SAA
SW9540.1672SAA
SW9620.9772SAA
SW9820.6372SAA
T-241.3572SAA
T47D0.2672SAA
T840.6972SAA
T98G0.9772SAA
TALL-10.3772RCA
TC-710.1872SAA
TCCSUP172SAA
TE-13572SAA
TE-1037.372SAA
TE-117.5372SAA
TE-1211272SAA
TE-150.4472SAA
TE-40.7772SAA
TE-524.672SAA
TE-691.372SAA
TE-87572SAA
TE-96472SAA
TF-10.272RCA
TGBC11TKB0.5572SAA
TGBC1TKB1.3372SAA
TGBC24TKB0.4572SAA
TGW0.05972SAA
THP-10.1472RCA
TK0.1872RCA
TK1047.272SAA
TMK-11.2472SAA
Toledo0.1272RCA
TOV-112D0.4372SAA
TOV-21G3.1572SAA
TT46.972SAA
T-T2.1472SAA
ZZ2609-CO20.3872SAA
TUR0.1772RCA
TYK-nu0.4772SAA
U0313.6872SAA
U-118-MG1.8872SAA
U2510.1472SAA
U-2 OS0.272SAA
U-698-M172RCA
U-87-MG4.5272SAA
UACC-2570.3472SAA
UACC-62172SAA
UACC-8120.972SAA
UACC-8934.5372SAA
UISO-MCC-149.772SAA
UMC-110.1272SAA
UM-UC-30.9472SAA
UWB1.2890.9672SAA
VA-ES-BJ2.8772SAA
VAL0.07572RCA
VCaP0.08572SAA
VM-CUB-11.4472SAA
VMRC-MELG0.2572SAA
VMRC-RCW0.97572SAA
VMRC-RCZ0.5972SAA
WIL2-NS0.04672RCA
WM-1150.7572SAA
WM11580.2572SAA
WM1552C0.6972SAA
WM239A0.9972SAA
WM2782.6672SAA
WM350.27572SAA
WM793B1.5472SAA
WM902B5.2472SAA
WSU-DLCL23.2272RCA
WSU-NHL0.33372RCA
YAPC7.5872SAA
YH-131.7572SAA
YKG-10.8372SAA
YMB-1-E4.3672SAA
YT0.08972RCA

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
ID#
697 0.09
 72RCA
56370.272SAA
201-T5.3172SAA
22RV10.2372SAA
23132-870.6872SAA
42-MG-BA1.45
72SAA
451Lu3.2572SAA
639-V2.9872 SAA
647-V8.3772SAA
769-P0.4672SAA
786-00.68
72SAA
8305C566
72SAA
8505C0.7672SAA
8-MG-BA0.8872SAA
A101D1.3272SAA
A1721.1172SAA
A2040.7772SAA
A20588.4972SAA
A2535.172SAA
A27800.4572SAA
A3750.4972SAA
A3883.4372SAA
A3-KAW0.3272RCA
A427772SAA
A4310.2672SAA
A49822272SAA
A4-Fuk6.8172RCA
A673172SAA
ABC-11.3272SAA
ACHN1.6672SAA
ACN1.1272SAA
AGS0.6772SAA
ALL-PO0.0672RCA
ALL-SIL0.1372RCA
AM-380.4572SAA
AMO-10.1972RCA
AN3-CA4.7772SAA
ARH-770.2772RCA
ASH-348.872SAA
AsPC-10.348MTT
AsPC-1272SAA
ATN-10.1772RCA
AU5650.5772SAA
BB30-HNC1.3172SAA
BB49-HNC5.9572SAA
BB65-RCC0.8572SAA
BC-10.3472RCA
BC-20.1172RCA
BC-30.472RCA
BCPAP0.3172SAA
BE-130.1372RCA
BE2-M171.2272SAA
BEN2.1772SAA
BFTC-9051.0972SAA
BFTC-909372SAA
BHT-1010.3172SAA
BHY0.5672SAA
BICR108.8872SAA
BICR223.2372SAA
BICR312.7872SAA
BICR780.5472SAA
BL-410.1372RCA
BL-700.0572RCA
BOKU2.3472SAA
BPH-10.1772SAA
BT-203.5672SAA
BT-4743.4772SAA
BT-48329972SAA
BV-1730.372RCA
BxPC-3148MTT
BxPC-31.172SAA
C2BBe10.9372SAA
C3216.872SAA
C-33-A0.1972SAA
C3A5.4972SAA
C-4-I4.5472SAA
CA460.03472RCA
Ca9-220.2772SAA
CADO-ES10.1872SAA
CAKI-10.6772SAA
CAL-1201.5972SAA
CAL-12T1.272SAA
CAL-1480.3172SAA
CAL-270.4572SAA
CAL-291.572SAA
CAL331.7572SAA
CAL-391.7272SAA
CAL-5122.972SAA
CAL-542.8772SAA
CAL620.7372SAA
CAL7216.172SAA
CAL-7815.572SAA
CAL-85-13.472SAA
Calu-10.6772SAA
Calu-35.3272SAA
Calu-60.4272SAA
CAMA-11.1172SAA
Caov-33.8672SAA
Capan-14.7272SAA
Capan-291.572SAA
CaR-11.5372SAA
CAS-11.9872SAA
Ca-Ski0.472SAA
CCF-STTG130172SAA
CCK-810.4572SAA
CCRF-CEM0.1372RCA
CESS0.1672RCA
CFPAC-144.472SAA
CGTH-W-11.7372SAA
ChaGo-K-1372SAA
CHL-10.1972SAA
CHP-1264.3472SAA
CHP-1340.2772SAA
CHP-2120.172SAA
CHSA001125.472SAA
CHSA01080.1472SAA
CHSA892620.972SAA
CL-113.8872SAA
CMK0.0972RCA
COLO-2050.9972SAA
COLO-320-HSR0.6872SAA
COLO–6681.2472SAA
COLO-6785.8572SAA
COLO-6798.2772SAA
COLO-680N53572SAA
COLO-6841.772SAA
COLO-7411.6572SAA
COLO-7836.8972SAA
COLO-7925.9172SAA
COLO-80012.472SAA
COLO-8241.2772SAA
COLO-8291.9772SAA
COR-L1050.7572SAA
COR-L230.672SAA
COR-L2790.7372SAA
COR-L3030.0672SAA
COR-L3210.1172SAA
COR-L880.5972SAA
COR-L950.7172SAA
CP50-MEL-B1.172SAA
CP66-MEL3.6572SAA
CPC-N0.5872SAA
CS11.3772SAA
CTV-10.572RCA
CW-21.172SAA
D-247MG0.8372SAA
D-263MG2.6972SAA
D-283MED10472SAA
D-336MG46.672SAA
D-392MG3.1172SAA
D-423MG0.5672SAA
D-502MG1.6272SAA
D-542MG0.6272SAA
D-566MG0.5472SAA
DAN-G1.2272SAA
Daoy0.1172SAA
Daudi0.2872RCA
DB0.0772RCA
DBTRG-05MG2.5672SAA
DEL0.3272RCA
Detroit5628.3972SAA
DG-751.0872RCA
DJM-127772SAA
DK-MG2.9772SAA
DMS-1143.9972SAA
DMS-1530.4272SAA
DMS-2730.272SAA
DMS-531272SAA
DMS-79172SAA
DND-410.1672RCA
DoTc2-45101.1872SAA
DOV1338072SAA
DSH10.3872SAA
DU-1450.4772SAA
DU44750.3272SAA
DV-902.4972SAA
EB20.3872RCA
EB-3172RCA
EBC-13.2372SAA
ECC102.1872SAA
ECC42.0772SAA
EC-GI-1011.472SAA
EFM-191.1772SAA
EFM-192A2.4272SAA
EFO-214.4572SAA
EFO-270.6372SAA
EGI-15.2472SAA
EJM0.472RCA
EKVX22.872SAA
EM-21.6772RCA
EMC-BAC-12.0772SAA
EM-BAC-20.6772SAA
EN0.8972SAA
EoL-1-cell0.272RCA
EPLC-272H0.2872SAA
ES10.3172SAA
ES-20.2772SAA
ES30.4672SAA
ES43.8772SAA
ES50.0772SAA
ES61.3972SAA
ES70.1172SAA
ES80.272SAA
ESO260.4972SAA
ESO510.872SAA
ESS-10.5172SAA
ETK-10.6772SAA
EVSA-T0.3272SAA
EW-10.2372SAA
EW-110.372SAA
EW-131.4972SAA
EW-160.3272SAA
EW-180.172SAA
EW-245.0972SAA
EW-30.4172SAA
EW-70.3672SAA
EW74760.5372SAA
FADU2.872SAA
Farage0.3372RCA
FLO-11.5672SAA
FTC-1333.8472SAA
FU971.4372SAA
FU-OV-111.772SAA
G-292-A141B13572SAA
G-3610.472SAA
G-4010.9672SAA
G-40210.772SAA
GAK1.6472SAA
GAMG0.2572SAA
GB-10.2172SAA
GCIY0.5572SAA
GCT45.572SAA
GDM-10.2572RCA
GI-10.2872SAA
GI-ME-N0.3272SAA
GMS-108.672SAA
GOTO1.3372SAA
GP5d0.7972SAA
GRANTA-5192.3472RCA
GR-ST0.5372RCA
GT3TKB1.8272SAA
H23692.4872SAA
H23731.0772SAA
H24613.3772SAA
H25915.3972SAA
H25950.9172SAA
H25962.3172SAA
H27220.9772SAA
H27310.0472SAA
H27952.1272SAA
H28030.9572SAA
H28041.3972SAA
H28189.1372SAA
H28691.4772SAA
H31180.2672SAA
H32554.2872SAA
H51312872SAA
H993.372SAA
HA7-RCC31672SAA
HAL-010.1572RCA
HARA1.2872SAA
HC-10.1772RCA
HCC11431.9372SAA
HCC11877.6572SAA
HCC139511.772SAA
HCC14193.5372SAA
HCC14280.6972SAA
HCC-1512.772SAA
HCC15000.8472SAA
HCC15691.6172SAA
HCC15990.372SAA
HCC1806172SAA
HCC19371.4472SAA
HCC19543.3372SAA
HCC2020.3572SAA
HCC21572.1272SAA
HCC22185.972SAA
HCC29982.1572SAA
HCC-330.2172SAA
HCC380.9172SAA
HCC-440.3572SAA
HCC-560.2472SAA
HCC700.5172SAA
HCC-780.472SAA
HCC-8271.2172SAA
HCE-447.772SAA
HCT-1160.2572SAA
HCT-152.1872SAA
HDLM-211.272RCA
HD-MY-Z0.6572RCA
HDQ-P10.6972SAA
HEC-11.2472SAA
HEL0.1272RCA
HeLa2.2672SAA
H-EMC-SS9.272SAA
Hep3B2-1-70.8172SAA
Hey0.4772SAA
HGC-270.8672SAA
HH0.4972SAA
HL-600.3672SAA
HLE0.4872SAA
HMV-II1.1272SAA
HN972SAA
HO-1-N-10.9172SAA
HO-1-u-10.7172SAA
HOP-620.5772SAA
HOP-924.8672SAA
HOS15172SAA
HPAC1.6672SAA
HPAF-II6.8572SAA
Hs-4450.3672RCA
Hs-578-T6.0972SAA
Hs-633T0.3472SAA
Hs-68315.872SAA
HS746T0.4172SAA
Hs-766T5.1272SAA
Hs-939-T5.5772SAA
Hs-940-T2.4372SAA
HSC-22.4772SAA
HSC-32.6172SAA
HSC-43.1472SAA
HT0.272RCA
HT-10801.5872SAA
HT-1150.8372SAA
HT-11970.7772SAA
HT-137615.572SAA
HT-14431172SAA
HT-290.5672SAA
HT-30.6172SAA
HT551.6472SAA
HTC-C30.272SAA
HuCCT1172SAA
huH-127472SAA
HuH-70.972SAA
HuO-3N16.572SAA
HuO9472SAA
HuP-T30.9572SAA
HuP-T40.5572SAA
HUTU-800.3172SAA
IA-LM6.0572SAA
IGR-10.2972SAA
IGR-370.5372SAA
IHH-41.1472SAA
IM-951.0172SAA
IMR-50.2272SAA
IOSE-364(-)0.1972SAA
IOSE-3970.4572SAA
IOSE-523(-)1.5672SAA
IOSE-75-16SV400.3972SAA
Ishikawa-02ER-4.8372SAA
IST-MEL10.6672SAA
IST-MES11.2172SAA
IST-SL10.172SAA
IST-SL226072SAA
J824.7772SAA
JAR0.5272SAA
JEG-321872SAA
JHH-10.0572SAA
JHH-20.7272SAA
JHH-40.3272SAA
JHH-61.8972SAA
JHH-71.8772SAA
JHOS-21.2572SAA
JHOS-315.372SAA
JHU-0110.4672SAA
JHU-0225.3372SAA
JIMT-13.172SAA
JiyoyeP-20030.3572RCA
JJN-30.2572RCA
JM10.0672RCA
J-RT3-T3-50.2372RCA
JSC-10.1372RCA
JURL-MK10.6272RCA
JVM-23.1472RCA
JVM-30.472RCA
K0520.3972RCA
K1938672SAA
K2672SAA
K422.772SAA
K51.3572SAA
K5620.4972RCA
K884.572SAA
KALS-12.0572SAA
KARPAS-2990.2272RCA
KARPAS-4220.4672RCA
KARPAS-450.0772RCA
KARPAS-6200.2372RCA
KCL-220.4372RCA
KE-370.1972RCA
KELLY0.2572SAA
KG-10.3372RCA
KG-1-C2.6972SAA
KGN0.3472SAA
KING-10.672SAA
KLE1.772SAA
KM120.9372SAA
KMH-28.8772SAA
KM-H217472RCA
KMOE-20.4972RCA
KMRC-1172SAA
KMRC-204.3872SAA
KMS-110.2472RCA
KMS-12-BM0.1772RCA
KNS-421.9972SAA
KNS-81-FD172SAA
KON11.872SAA
KOPN-80.1172RCA
KOSC-20.7772SAA
KP-21.8672SAA
KP-32.1672SAA
KP-40.8972SAA
KP-N-YN0.6372SAA
KP-N-YS0.4672SAA
KS-11.2472SAA
KU-19-190.8772SAA
KU8120.01672RCA
KURAMOCHI1.172SAA
KY8210.7372RCA
KYAE-10.672SAA
KYM-11.3272SAA
KYSE-14027172SAA
KYSE-1506.872SAA
KYSE-1800.4372SAA
KYSE-2201.8372SAA
KYSE-2701.4872SAA
KYSE-4102.4572SAA
KYSE-4500.8672SAA
KYSE-500.6772SAA
KYSE-5101.3672SAA
KYSE-5202.4872SAA
KYSE-701.8272SAA
L-12360.372RCA
L-3630.4872RCA
L-42819572RCA
L-54015972RCA
LAMA-840.5472RCA
LAN-68.4772SAA
LB1047-RCC0.4972SAA
LB2241-RCC3.0372SAA
LB2518-MEL1.8572SAA
LB373-MEL-D0.7872SAA
LB647-SCLC11.272SAA
LB771-HNC1.9272SAA
LB831-BLC0.6172SAA
LB996-RCC5.5472SAA
LC-1F1.1672SAA
LC-1-sq0.972SAA
LC-2-ad0.1672SAA
LC4-10.2472RCA
LCLC-103H0.9772SAA
LCLC-97TM10.6472SAA
LK-20.3972SAA
LN-182.4372SAA
LN-2291.7972SAA
LN-4051.7372SAA
LNCap-FGC0.1472SAA
LOUCY0.0872RCA
LOU-NH911.2672SAA
LoVo1.9272SAA
LOXIMVI1.1572SAA
LP-10.4172RCA
LS-10340.6572SAA
LS-1230.9572SAA
LS-411N0.1472SAA
LS-5131.8472SAA
LU-134-A0.4172SAA
LU-1350.172SAA
LU-1390.4672SAA
LU-1650.5772SAA
LU-651.2672SAA
LU-99A2.7872SAA
LXF-2890.9772SAA
M059J0.972SAA
M142.2772SAA
MC1160.1972RCA
MCAS0.672SAA
MCC1318.472SAA
MCC2657.772SAA
MC-CAR0.2472RCA
MCF728.772SAA
MC-IXC0.4472SAA
MDA-MB-134-VI2.1272SAA
MDA-MB-1571.6972SAA
MDA-MB-175-VII3.5672SAA
MDA-MB-3300.8672SAA
MDA-MB-3610.6572SAA
MDA-MB-41529.972SAA
MDA-MB-4366.172SAA
MDA-MB-4530.0772SAA
MDA-MB-4687.1972SAA
ME-10.5572RCA
ME-1800.6972SAA
MEC-10.1672RCA
MEG-010.7672RCA
MEL-JUSO0.6472SAA
MES-SA16972SAA
Mewo2.872SAA
MFE-2800.7772SAA
MFE-2961372SAA
MFE-31934.672SAA
MFH-ino1.7472SAA
MFM-223172SAA
MG-6339772SAA
MHH-ES-10.3472SAA
MHH-NB-110.1672SAA
MHH-PREB-10.1472RCA
MIA-PaCa-20.748MTT
MIA-PaCa-22.5272SAA
MKL-1-21672SAA
MKL-20.3172SAA
MKN11.5572SAA
MKN283.2772SAA
MKN4526.672SAA
ML-10.3672SAA
ML-20.9572RCA
MLMA0.1472RCA
MMAC-SF3.5172SAA
MN-600.2572RCA
MOG-G-CCM0.4472SAA
MOG-G-UVW0.3872SAA
MOLM-130.372RCA
MOLP-80.0872RCA
MOLT-130.0572RCA
MOLT40.1372RCA
MONO-MAC-60.5972RCA
Mo-T0.4372RCA
MPP-890.1572SAA
MRK-nu-13.6772SAA
MS-10.1872SAA
MS7513.8172SAA
MSTO-211H2.4772SAA
MV-4-110.1972RCA
MY-M120.0572RCA
MZ1-PC0.3372SAA
MZ2-MEL3.4372SAA
MZ7-mel0.2572SAA
NALM-60.1472RCA
NAMALWA0.0672RCA
NB(TU)1-100.3472SAA
NB112.572SAA
NB100.9772SAA
NB120.0572SAA
NB130.1372SAA
NB1716.172SAA
NB40.1672RCA
NB54.1872SAA
NB690.4972SAA
NB70.5272SAA
NBsusSR0.372SAA
NCC0210.4672SAA
NCI-H10481.2972SAA
NCI-H10920.5472SAA
NCI-H11550.672SAA
NCI-H11840.1872SAA
NCI-H12999.172SAA
NCI-H13046.7572SAA
NCI-H135590.172SAA
NCI-H13851.2872SAA
NCI-H13952.3772SAA
NCI-H14170.1872SAA
NCI-H143523772SAA
NCI-H14361.1872SAA
NCI-H14371.9272SAA
NCI-H15220.4372SAA
NCI-H15634.2172SAA
NCI-H156845272SAA
NCI-H15731.8572SAA
NCI-H15810.3772SAA
NCI-H16230.7972SAA
NCI-H16480.4172SAA
NCI-H16511.3272SAA
NCI-H16661.1372SAA
NCI-H16880.3472SAA
NCI-H16932.7272SAA
NCI-H16940.3272SAA
NCI-H170314.372SAA
NCI-H17340.8472SAA
NCI-H17550.1572SAA
NCI-H17701.172SAA
NCI-H17814.272SAA
NCI-H17923.572SAA
NCI-H179312.172SAA
NCI-H18360.4872SAA
NCI-H183831.272SAA
NCI-H18693.1272SAA
NCI-H1870.4472SAA
NCI-H18760.6672SAA
NCI-H19150.3672SAA
NCI-H19260.7972SAA
NCI-H19440.4972SAA
NCI-H1960.2572SAA
NCI-H196333.572SAA
NCI-H19750.6272SAA
NCI-H19935.8172SAA
NCI-H200941.472SAA
NCI-H20235.2572SAA
NCI-H20291.1572SAA
NCI-H20301.4972SAA
NCI-H205236.172SAA
NCI-H20853.3172SAA
NCI-H20871.1172SAA
NCI-H20925972SAA
NCI-H2110.172SAA
NCI-H21100.5272SAA
NCI-H21226.0572SAA
NCI-H212632.772SAA
NCI-H21350.2672SAA
NCI-H21411.9972SAA
NCI-H21703.972SAA
NCI-H21710.4772SAA
NCI-H21722.4972SAA
NCI-H21960.3872SAA
NCI-H2200.3872SAA
NCI-H22270.0772SAA
NCI-H22287.5772SAA
NCI-H2260.3972SAA
NCI-H22861.772SAA
NCI-H229142272SAA
NCI-H23172SAA
NCI-H234220.272SAA
NCI-H23471.2972SAA
NCI-H24053.8472SAA
NCI-H24440.9772SAA
NCI-H245289.472SAA
NCI-H282872SAA
NCI-H2920.2472SAA
NCI-H31220.5272SAA
NCI-H322M1.7572SAA
NCI-H3450.5772SAA
NCI-H3580.3872SAA
NCI-H4411072SAA
NCI-H4460.2872SAA
NCI-H46020.572SAA
NCI-H510A0.2572SAA
NCI-H5200.7372SAA
NCI-H5220.3772SAA
NCI-H52424.472SAA
NCI-H5260.3372SAA
NCI-H5960.9972SAA
NCI-H6301.1472SAA
NCI-H640.3372SAA
NCI-H6471.1272SAA
NCI-H6501.2372SAA
NCI-H6610.5172SAA
NCI-H7162.3172SAA
NCI-H72040.172SAA
NCI-H7276.7272SAA
NCI-H7471.2172SAA
NCI-H7480.2172SAA
NCI-H8100.1572SAA
NCI-H8381.172SAA
NCI-H8412.172SAA
NCI-H8470.172SAA
NCI-H8650.1472SAA
NCI-SNU-10.772SAA
NCI-SNU-165.9872SAA
NCI-SNU-56.7572SAA
NEC80.172SAA
NH-120.1972SAA
NKM-10.2372RCA
NMC-G11.4872SAA
no-102.172SAA
no-118.7872SAA
NOMO-10.5272RCA
NOS-10.3372SAA
NTERA-S-cl-D10.4572SAA
NU-DUL-10.172RCA
NUGC-32.3672SAA
NUGC-40.8572SAA
NY57.272SAA
OACM5-10.5372SAA
OACp4C0.1272SAA
OAW-280.2272SAA
OAW-422.1372SAA
OC-3141.1872SAA
OCI-AML20.2572RCA
OCI-AML30.5472RCA
OCI-AML50.1272RCA
OCI-LY-190.1972RCA
OCI-M10.172RCA
OCUB-M0.3472SAA
OCUM-118872SAA
OE1918.172SAA
OE212.1772SAA
OE332.6772SAA
OMC-11.0472SAA
OPM-20.3672RCA
OSC-190.4172SAA
OSC-200.7572SAA
OS-RC-21.7972SAA
OUMS-230.1972SAA
OV-17R0.3572SAA
OV-560.8972SAA
OV-70.872SAA
OV-904.8272SAA
OVCA4200.9372SAA
OVCA4331.5672SAA
OVCAR-339372SAA
OVCAR-413.872SAA
OVCAR-50.5572SAA
OVCAR-80.2172SAA
OVISE1.4672SAA
OVK-1837572SAA
OVKATE0.8372SAA
OVMIU0.672SAA
OVTOKO1.5272SAA
P12-ICHIKAWA0.1472RCA
P30-OHK0.172RCA
P31-FUJ1.1472RCA
P32-ISH0.1772RCA
P3HR-10.0972RCA
PA-10.0572SAA
PANC-1148MTT
PANC-1< 1168CFA
PANC-1< 136A5A
PANC-1102ROS
PANC-02-03~ 2248MTT
PANC-02-030.4872SAA
PANC-03-270.548MTT
PANC-03-271.5672SAA
PANC-04-03~ 148MTT
PANC-04-0339.372SAA
PANC-08-136.7872SAA
PANC-10-05~148MTT
PANC-10-050.4772SAA
PA-TU-8988T2.9672SAA
PC-140.4372SAA
PC-31.0672SAA
PC-3_[JPC-3]2.0672SAA
PCI-15A21172SAA
PCI-3012.972SAA
PCI-381.2172SAA
PCI-4B0.3872SAA
PCI-6A0.1772SAA
PE-CA-PJ151.872SAA
PEO10.7172SAA
PF-3820.1472RCA
PFSK-1472SAA
PL181.7372SAA
PL-211.4672RCA
PL44.6172SAA
PL45~ 2148MTT
PLC-PRF-57.2872SAA
PSN10.1772SAA
QGP-10.7972SAA
QIMR-WIL0.1272RCA
Raji0.3872RCA
Ramos-2G6-4C100.2472RCA
RCC10RGB19272SAA
RCC-AB0.1872SAA
RCC-ER37.372SAA
RCC-FG21.0572SAA
RCC-JF0.472SAA
RCC-JW0.9272SAA
RCC-MF0.3372SAA
RC-K81.9772RCA
RCM-11.2572SAA
RD0.8672SAA
RD-ES0.4972SAA
REH0.2372RCA
RERF-GC-1B8.2672SAA
RERF-LC-KJ11.872SAA
RERF-LC-MS0.9472SAA
RERF-LC-Sq12.1672SAA
RF-480.1372SAA
RH-10.1472SAA
RH-412.6672SAA
RKN1.2172SAA
RKO0.572SAA
RL0.3272RCA
RL95-20.4172SAA
RMG-I0.872SAA
RO82-W-11.3272SAA
ROS-500.4772RCA
RPMI-26500.4472SAA
RPMI-66660.1472RCA
RPMI-82260.2872RCA
RPMI-84020.1172RCA
RPMI-88660.1572RCA
RS4-110.1472RCA
RT-1120.6672SAA
RT40.472SAA
RVH-4214.972SAA
RXF3930.4572SAA
S-1171.2972SAA
Saos-275272SAA
Sarc937118.572SAA
SAS0.5672SAA
SAT1.0872SAA
SBC-10.2772SAA
SBC-30.1372SAA
SBC-50.5272SAA
SCaBER1.7472SAA
SCC-151.5272SAA
SCC-250.2772SAA
SCC-30.6672RCA
SCC-41.2672SAA
SCC-90.6172SAA
SCH14572SAA
Sci-10.1672RCA
SCLC-21H0.4872SAA
SF1260.7372SAA
SF2680.2872SAA
SF2950.9672SAA
SF5394.2472SAA
SH-46.1372SAA
SHP-770.5472SAA
SIG-M50.1272RCA
SiHa79.672SAA
SIMA1.9572SAA
SISO1.9172SAA
SJRH300.9472SAA
SJSA-11.772SAA
SK-CO-11.172SAA
SK-ES-10.1572SAA
SK-IIIa40.672SAA
SK-GT-40.4872SAA
SK-HEP-13.0872SAA
SK-LMS-10.2772SAA
SK-LU-12.3372SAA
SK-MEL-22.8372SAA
SK-MEL-241.0372SAA
SK-MEL-282.8672SAA
SK-MEL-300.8772SAA
SK-MEL-522972SAA
SK-MES-10.5672SAA
SK-MG-10.9772SAA
SK-MM-22.0872RCA
SKN0.9972SAA
SKN-31.3472SAA
SK-N-AS0.2372SAA
SK-N-DZ2.1772SAA
SK-NEP-10.272SAA
SK-N-FI0.972SAA
SK-N-SH0.3672SAA
SK-OV-30.472SAA
SK-PN-DW0.5272SAA
SK-UT-125.672SAA
SLVL0.0872RCA
SN12C2.3572SAA
SNB752.0472SAA
SNU-10409.1972SAA
SNU-1750.2972SAA
SNU-1820.5472SAA
SNU-3870.2572SAA
SNU-3980.772SAA
SNU-4070.972SAA
SNU-4230.3472SAA
SNU-4497.6572SAA
SNU-4750.5372SAA
SNU-610.2672SAA
SNU-8145772SAA
SNU-C12.0672SAA
SNU-C2B0.4972SAA
SNU-C51.272SAA
SR0.0372RCA
ST4860.2172RCA
SU8686372SAA
SU-DHL-11.3872RCA
SU-DHL-100.0372RCA
SU-DHL-160.0372RCA
SU-DHL-40.1772RCA
SU-DHL-50.0572RCA
SU-DHL-60.07572RCA
SU-DHL-80.0572RCA
SUIT-20.6972SAA
SUP-B150.2172RCA
SUP-HD10.372RCA
SUP-M20.1772RCA
SUP-T10.2472RCA
SW108810.972SAA
SW11161.8172SAA
SW12710.9172SAA
SW1332.572SAA
SW14171.4372SAA
SW14636.7372SAA
SW1568.0972SAA
SW15733.3772SAA
SW17100.8372SAA
SW17831.472SAA
SW199042672SAA
SW480.8572SAA
SW6200.5472SAA
SW68430272SAA
SW7565.3172SAA
SW78068.972SAA
SW8370.372SAA
SW8720.5572SAA
SW9001.5972SAA
SW9480.9372SAA
SW9540.2572SAA
SW962172SAA
SW9820.7272SAA
T-242.572SAA
T47D0.3372SAA
T841.4572SAA
T98G5.6872SAA
TALL-10.6472RCA
TC-710.2872SAA
TCCSUP1.2472SAA
TE-192.272SAA
TE-1023272SAA
TE-1154.272SAA
TE-1233672SAA
TE-150.4972SAA
TE-40.7272SAA
TE-527872SAA
TE-643672SAA
TE-831372SAA
TE-931272SAA
TF-10.3172RCA
TGBC11TKB1.0572SAA
TGBC1TKB1.3472SAA
TGBC24TKB1.0372SAA
TGW0.272SAA
THP-10.2672RCA
TK0.2972RCA
TK1013472SAA
TMK-110.672SAA
Toledo0.0872RCA
TOV-112D0.5372SAA
TOV-21G4.2872SAA
TT20772SAA
T-T1372SAA
ZZ2609-CO20.5372SAA
TUR0.372RCA
TYK-nu0.6472SAA
U0312.1772SAA
U-118-MG3.2972SAA
U2510.2472SAA
U-2 OS0.2172SAA
U-698-M1.6672RCA
U-87-MG5.4472SAA
UACC-2570.8772SAA
UACC-622.5472SAA
UACC-8121.8372SAA
UACC-8934.3972SAA
UISO-MCC-120372SAA
UMC-110.2272SAA
UM-UC-30.9272SAA
UWB1.2891.1972SAA
VA-ES-BJ3.3572SAA
VAL0.1172RCA
VCaP0.1272SAA
VM-CUB-11.472SAA
VMRC-MELG0.2172SAA
VMRC-RCW2.4672SAA
VMRC-RCZ0.8472SAA
WIL2-NS0.0472RCA
WM-1150.9172SAA
WM11580.3572SAA
WM1552C0.7472SAA
WM239A272SAA
WM350.3672SAA
WM793B1.7372SAA
WM902B7.4872SAA
WSU-DLCL24.7772RCA
WSU-NHL0.7572RCA
YAPC6.6272SAA
YH-131.9272SAA
YKG-16.8172SAA
YMB-1-E4.8772SAA
YT0.0872RCA

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (mM)Inc1Assay2
Additional informationID#
C666-1> 1018A5A
C666-1> 1024WHA
HCT-116> 572MTT
HEK293~ 2 – 896WST-8
HL-60~ 1 – 224TBE
HL-60~ 1 – 524TWA
HL-60> 148WST-1↑ HDAC1/2/4 
HT-29> 572MTT
LA1-55n5.348CAM
LAN23.848CAM
MCF 10A> 1048MTT
MCF 10A> 1048SRB
MCF7~ 0.5 – 296WST-8
MCF7~ 448MTT
MCF7~ 3 – 448SRB
MCF7~ 148WST-1↑ HDAC1/2/4 
MDA-MB-231~ 748MTT
MDA-MB-231~ 548SRB
P3HR11144TBE
Raji< 1018A5A
Raji< 0.524EBE
SK-N-BE(2)-C10.448CAM
SMS-KCNR~ 6.648CAM
T-47D~ 448MTT
T-47D~ 1 – 248SRB
THP-1> 1024TBE
THP-1~ 5 – 1024TWA
U-937~ 524TBE
U-937~ 1 – 524TWA

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
ID#
697 0.2
 72RCA
56370.5472SAA
201-T16.972SAA
22RV10.7772SAA
23132-871.3772SAA
42-MG-BA3.12
72SAA
451-Lu3.6272SAA
639-V5.2372 SAA
647-V7.0772SAA
769-P0.8772SAA
786-01
72SAA
8305C566
72SAA
8505C1.272SAA
8-MG-BA2.2772SAA
A101D1.9872SAA
A1721.4672SAA
A2041.4572SAA
A205812.472SAA
A2536.972SAA
A27800.9772SAA
A3750.9372SAA
A3888.4872SAA
A3-KAW0.572RCA
A4277.172SAA
A4310.5572SAA
A4983172SAA
A4-Fuk14.472RCA
A6731.1572SAA
ABC-11.4572SAA
ACHN2.9472SAA
ACN2.6872SAA
AGS1.372SAA
ALL-PO0.0772RCA
ALL-SIL0.2372RCA
AM-380.6272SAA
AMO-10.3872RCA
AN3-CA4.772SAA
ARH-770.572RCA
ASH-335.272SAA
AsPC-15.372SAA
ATN-10.3872RCA
AU5651.7572SAA
BB30-HNC2.6272SAA
BB49-HNC16.772SAA
BB65-RCC1.4372SAA
BC-10.6872RCA
BC-20.172RCA
BC-30.6272RCA
BCPAP0.4972SAA
BE-130.1172RCA
BE2-M172.3372SAA
Becker2.9672SAA
BEN8.3572SAA
BFTC-9052.3772SAA
BFTC-9094.3272SAA
BHT-1010.81372SAA
BHY1.4972SAA
BICR1011.272SAA
BICR228.3372SAA
BICR314.5772SAA
BICR781.7272SAA
BL-410.2672RCA
BL-700.11772RCA
BOKU4.2572SAA
BPH-10.572SAA
BT-207.672SAA
BT-4741.6272SAA
BT-48332.372SAA
BV-1730.3372RCA
BxPC-32.1672SAA
C2BBe12.7372SAA
C3223.572SAA
C-33-A0.3272SAA
C3A11.472SAA
C-4-I13972SAA
CA460.0572RCA
Ca9-220.4972SAA
CADO-ES10.4672SAA
CAKI-12.2172SAA
CAL-1201.472SAA
CAL-12T1.8472SAA
CAL-1481.1972SAA
CAL-271.2172SAA
CAL-292.0972SAA
CAL333.2472SAA
CAL-397.0872SAA
CAL-5125.572SAA
CAL-542.5272SAA
CAL624.0572SAA
CAL7297.972SAA
CAL-7822.672SAA
CAL-85-15.9872SAA
Calu-11.4272SAA
Calu-39.2672SAA
Calu-61.6372SAA
CAMA-11.7372SAA
Caov-35.2872SAA
Capan-18.6772SAA
Capan-229472SAA
CaR-14.2172SAA
CAS-14.0572SAA
Ca-Ski0.7972SAA
CCF-STTG120.672SAA
CCK-811.1672SAA
CCRF-CEM0.1972RCA
CESS0.1972RCA
CFPAC-166.672SAA
CGTH-W-13.8472SAA
ChaGo-K-17.1972SAA
CHL-10.5172SAA
CHP-1261.2272SAA
CHP-1340.4972SAA
CHP-2120.2872SAA
CHSA00110.8672SAA
CHSA010828.572SAA
CHSA892623.872SAA
CL-110.1572SAA
CMK1.5472RCA
COLO-2051.3672SAA
COLO-320-HSR1.572SAA
COLO–66830.972SAA
COLO-6789.172SAA
COLO-67940272SAA
COLO-680N1.1672SAA
COLO-6842.3272SAA
COLO-74115.372SAA
COLO-78319.172SAA
COLO-79210.972SAA
COLO-8002.5772SAA
COLO-8242.8872SAA
COLO-8290.8872SAA
COR-L1050.7972SAA
COR-L230.5572SAA
COR-L2790.2672SAA
COR-L3030.272SAA
COR-L3210.04772SAA
COR-L884.6672SAA
COR-L956.0472SAA
CP50-MEL-B1.5872SAA
CP66-MEL18.772SAA
CPC-N0.6872SAA
CS12.0872SAA
CTB-10.1472RCA
CTV-11.1372RCA
CW-23.4172SAA
D-247MG1.4272SAA
D-263MG3.3972SAA
D-283MED4.2272SAA
D-336MG272SAA
D-392MG4.4872SAA
D-423MG1.1572SAA
D-502MG3.8772SAA
D-542MG1.3372SAA
D-566MG0.8572SAA
DAN-G2.7872SAA
Daoy0.2772SAA
Daudi0.672RCA
DB0.1572RCA
DBTRG-05MG3.9872SAA
DEL0.4972RCA
Detroit5621572SAA
DG-752.0672RCA
DJM-12472SAA
DK-MG5.9172SAA
DMS-1149.1672SAA
DMS-1533.8172SAA
DMS-2730.5472SAA
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SW482.1872SAA
SW6200.9972SAA
SW62624.972SAA
SW68436172SAA
SW7568.8472SAA
SW78043.572SAA
SW8370.8372SAA
SW8721.2272SAA
SW9004.3172SAA
SW9482.9172SAA
SW9540.572SAA
SW9622.1372SAA
SW9822.3272SAA
T-244.6672SAA
T47D1.4872SAA
T844.3272SAA
T98G2.572SAA
TALL-11.6572RCA
TC-710.5472SAA
TCCSUP3.1472SAA
TE-117672SAA
TE-1014172SAA
TE-1122.972SAA
TE-1243972SAA
TE-150.8472SAA
TE-43.0772SAA
TE-529572SAA
TE-634372SAA
TE-831172SAA
TE-931272SAA
TF-10.4972RCA
TGBC11TKB3.0972SAA
TGBC1TKB3.8872SAA
TGBC24TKB7.3372SAA
TGW0.3872SAA
THP-10.4372RCA
TK0.4772RCA
TK1032072SAA
TMK-111.572SAA
Toledo0.1672RCA
TOV-112D1.1172SAA
TOV-21G5.9272SAA
TT17072SAA
T-T8.2172SAA
ZZ2609-CO21.0972SAA
TUR0.4672RCA
TYK-nu1.672SAA
U0314.472SAA
U-118-MG4.8172SAA
U2510.3272SAA
U-2 OS0.8572SAA
U-698-M1.6172RCA
U-87-MG4.572SAA
UACC-2571.3272SAA
UACC-624.4172SAA
UACC-8126.0872SAA
UACC-8937.7372SAA
UISO-MCC-120672SAA
UMC-110.7472SAA
UM-UC-32.1372SAA
UWB1.2893.6372SAA
VA-ES-BJ5.7572SAA
VAL0.1472RCA
VCaP0.6872SAA
VM-CUB-14.2672SAA
VMRC-MELG2.4672SAA
VMRC-RCW4.3472SAA
VMRC-RCZ1.8972SAA
WIL2-NS0.0472RCA
WM-1151.5872SAA
WM11582.1872SAA
WM1552C1.7872SAA
WM239A3.5772SAA
WM2782172SAA
WM350.6972SAA
WM793B4.6472SAA
WM902B10.672SAA
WSU-DLCL226.672RCA
WSU-NHL1.4472RCA
YAPC2272SAA
YH-133.9572SAA
YKG-11.9372SAA
YMB-1-E6.7972SAA
YT0.1872RCA

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional informationID#
DLD1> 148TBE↑ p21 & p27
HepG2> 1021LDH
KCN-69n~ 0.5 – 172TBE
LA1-55n~ 0.572TBE
MKN45~ 1648TBE
MKN45> 460TBE
SK-N-ER ~ 0.5 – 172TBE

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional informationID#
HEL~ 3.548WST-83 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
HEL~ 272WST-83 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
HEL3 – 1048A5A3 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
KG-10.25
72WST-8↑ p21, phospho-p53, ↓ CDK2
KG-1> 272A5A↑ p21, phospho-p53, ↓ CDK2
MUTZ-10.3
72WST-8↑ p21, phospho-p53, ↓ CDK2
MUTZ-1> 272A5A↑ p21, phospho-p53, ↓ CDK2
SKM-1~248WST-83 µM: G0/G1 arrest; ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
SKM-1~172WST-83 µM: G0/G1 arrest; ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
SKM-10.572WST-8↑ p21, phospho-p53, ↓ CDK2
SKM-13 – 548A5A3 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
SKM-1~ 2
72A5A↑ p21, phospho-p53, ↓ CDK2

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional informationID#
HCT116> 1048PIA↓ p53, MDM2, MDM4 
HCT116-p53+~ 448MMP
HCT116-p53–> 1048MMP
HCT116-p53+< 248MTT
HCT116-p53–> 248MTT
P3HR1< 1144TBE

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
ID#
697 93.3
 72RCA
563719272SAA
201-T46472SAA
22RV144972SAA
23132-872.9372SAA
42-MG-BA309
72SAA
451-Lu19272SAA
639-V96.972 SAA
647-V16172SAA
769-P25572SAA
786-0114
72SAA
8305C565
72SAA
8505C84.172SAA
8-MG-BA55.272SAA
A101D33172SAA
A17222772SAA
A20432472SAA
A205812872SAA
A25322072SAA
A278091.772SAA
A375> 5048MTT
A37577.872SAA
A38829972SAA
A3-KAW10572RCA
A42711672SAA
A43111972SAA
A49867972SAA
A4-Fuk26072RCA
A67316572SAA
ABC-120372SAA
ACHN34272SAA
ACN19472SAA
AGS16072SAA
ALL-PO99.672RCA
ALL-SIL12472RCA
AM-3828572SAA
AMO-199.172RCA
AN3-CA16572SAA
ARH-7719572RCA
ASH-316372SAA
AsPC-199072SAA
ATN-111772RCA
AU56534072SAA
BB30-HNC16172SAA
BB49-HNC33772SAA
BB65-RCC29172SAA
BC-17972RCA
BC-227772RCA
BC-315072RCA
BCPAP14272SAA
BE-1316372RCA
BE2-M1717672SAA
Becker35572SAA
BEN28972SAA
BFTC-90575.372SAA
BFTC-90917472SAA
BHT-10115472SAA
BHY26072SAA
BICR1036172SAA
BICR2235072SAA
BICR3117472SAA
BICR7831872SAA
BL-4169.672RCA
BL-7012972RCA
BOKU32372SAA
BPH-111972SAA
BT-2035472SAA
BT-47413472SAA
BT-48345272SAA
BV-17311372RCA
BxPC-335672SAA
C2BBe118972SAA
C3219672SAA
C-33-A11272SAA
C3A31072SAA
C-4-I14872SAA
CA4630772RCA
Ca9-2218972SAA
CADO-ES131272SAA
CAKI-136472SAA
CAL-12050072SAA
CAL-12T11472SAA
CAL-14812972SAA
CAL-2717972SAA
CAL-2919972SAA
CAL3315072SAA
CAL-3914572SAA
CAL-5111372SAA
CAL-5439872SAA
CAL6291.272SAA
CAL7239672SAA
CAL-7846472SAA
CAL-85-174.272SAA
Calu-133672SAA
Calu-349372SAA
Calu-615672SAA
CAMA-116972SAA
Caov-39772SAA
Capan-138672SAA
Capan-251472SAA
CaR-148372SAA
CAS-11.1672SAA
Ca-Ski25972SAA
CCF-STTG129572SAA
CCK-8125272SAA
CCRF-CEM12672RCA
CESS15172RCA
CFPAC-138772SAA
CGTH-W-123372SAA
ChaGo-K-143072SAA
CHL-121.972SAA
CHP-12616072SAA
CHP-13443772SAA
CHP-21215272SAA
CHSA001166672SAA
CHSA010836472SAA
CHSA892671572SAA
CL-1134172SAA
CMK85.472RCA
COLO-20519572SAA
COLO-320-HSR9672SAA
COLO–66830572SAA
COLO-67868972SAA
COLO-67932872SAA
COLO-680N52472SAA
COLO-68435172SAA
COLO-74121.472SAA
COLO-78311272SAA
COLO-79226972SAA
COLO-80019572SAA
COLO-82421372SAA
COLO-82929672SAA
COR-L10542472SAA
COR-L2312672SAA
COR-L27938.872SAA
COR-L30321772SAA
COR-L32125772SAA
COR-L8845072SAA
COR-L9547072SAA
CP50-MEL-B26572SAA
CP66-MEL27872SAA
CPC-N31372SAA
CS119472SAA
CTB-149372RCA
CTV-172.572RCA
CW-234372SAA
D-247MG40272SAA
D-263MG28672SAA
D-283MED20672SAA
D-336MG33172SAA
D-392MG21172SAA
D-423MG40172SAA
D-502MG17072SAA
D-542MG37772SAA
D-566MG16672SAA
DAN-G11772SAA
Daoy14472SAA
Daudi15372RCA
DB92.572RCA
DBTRG-05MG22072SAA
DEL3972RCA
Detroit56223272SAA
DG-7513372RCA
DJM-124272SAA
DK-MG48672SAA
DMS-11425372SAA
DMS-15383572SAA
DMS-27326072SAA
DMS-5338672SAA
DMS-7950972SAA
DOK69372SAA
DoTc2-451022372SAA
DOV1331572SAA
DSH125272SAA
DU-14533472SAA
DU447574.872SAA
DV-9023072SAA
EB214372RCA
EB-317072RCA
EBC-128472SAA
ECC1027572SAA
ECC483572SAA
EC-GI-1028472SAA
EFM-1976872SAA
EFM-192A38172SAA
EFO-2140072SAA
EFO-2740272SAA
EGI-138172SAA
EJM98.272RCA
EKVX75672SAA
EM-225872RCA
EMC-BAC-116672SAA
EM-BAC-23872SAA
EN33772SAA
EoL-1-cell17.672RCA
EPLC-272H13972SAA
ES176.372SAA
ES-218872SAA
ES318072SAA
ES489.672SAA
ES522172SAA
ES614172SAA
ES766.972SAA
ES813972SAA
ESO2618372SAA
ESO5140772SAA
ESS-119372SAA
ETK-132872SAA
EVSA-T12172SAA
EW-119572SAA
EW-1120972SAA
EW-1319272SAA
EW-1624672SAA
EW-1830872SAA
EW-2421872SAA
EW-325972SAA
EW-716972SAA
EW747622672SAA
FADU18072SAA
Farage14372RCA
FLO-154672SAA
FTC-13315072SAA
FU9721172SAA
FU-OV-154172SAA
G-292-A141B180072SAA
G-361> 5048MTT
G-36117572SAA
G-40112772SAA
G-40237872SAA
GAK16272SAA
GAMG28772SAA
GB-110.972SAA
GCIY20072SAA
GCT18972SAA
GDM-111472RCA
GI-111772SAA
GI-ME-N40972SAA
G-MEL18072SAA
GMS-1014372SAA
GOTO32072SAA
GP5d19872SAA
GRANTA-51916872RCA
GR-ST23372RCA
GT3TKB12472SAA
H236920272SAA
H237349572SAA
H246139372SAA
H259157672SAA
H259549772SAA
H259619772SAA
H272229372SAA
H273188.772SAA
H279525072SAA
H280344172SAA
H280436072SAA
H281822772SAA
H286952972SAA
H311829372SAA
H325543072SAA
H416472SAA
H51357772SAA
H912872RCA
HA7-RCC30472SAA
HaCaT> 2024CVA
HAL-0115872RCA
HARA31872SAA
HC-117272RCA
HCC114356572SAA
HCC118718172SAA
HCC139548672SAA
HCC141982372SAA
HCC142841672SAA
HCC-1537072SAA
HCC150028072SAA
HCC156946272SAA
HCC159931972SAA
HCC180613372SAA
HCC193742472SAA
HCC195436872SAA
HCC20250172SAA
HCC215731572SAA
HCC221839672SAA
HCC299824972SAA
HCC-3326772SAA
HCC3817372SAA
HCC-4497.172SAA
HCC-5629772SAA
HCC7023772SAA
HCC-7817672SAA
HCC-82731472SAA
HCE-410172SAA
HCT-11615972SAA
HCT-1520672SAA
HDLM-225672RCA
HD-MY-Z18572RCA
HDQ-P125872SAA
HEC-125272SAA
HEL11372RCA
HeLa> 2024CVA
HeLa33.672SAA
H-EMC-SS32572SAA
Hep3B2-1-712172SAA
Hey17272SAA
HGC-2785.672SAA
HH11772SAA
HL-6019072SAA
HLE63.472SAA
HMV-II27072SAA
HN21572SAA
HO-1-N-118372SAA
HO-1-u-123672SAA
HOP-6224772SAA
HOP-9227572SAA
HOS11172SAA
HPAC61572SAA
HPAF-II46572SAA
Hs-294-T> 5048MTT
Hs-44519472RCA
Hs-578-T23372SAA
Hs-633T88.172SAA
Hs-68329972SAA
HS746T60272SAA
Hs-766T70472SAA
Hs-939-T23972SAA
Hs-940-T47172SAA
HSC-221072SAA
HSC-313772SAA
HSC-3970.872SAA
HSC-438672SAA
HT11272RCA
HT-108017272SAA
HT-11596.672SAA
HT-119746572SAA
HT-137639272SAA
HT-14426472SAA
HT-2924772SAA
HT-328172SAA
HT5532172SAA
HTC-C315472SAA
HuCCT123972SAA
huH-134772SAA
HuH-715272SAA
HuO-3N160272SAA
HuO926872SAA
HuP-T329272SAA
HuP-T427972SAA
HUTU-8075.872SAA
IA-LM33072SAA
IGR-159.272SAA
IGR-371172SAA
IHH-470.572SAA
IM-9532872SAA
IMR-513572SAA
IOSE-364(-)14472SAA
IOSE-39727772SAA
IOSE-523(-)15572SAA
IOSE-75-16SV4014572SAA
IPC-29814772SAA
Ishikawa-02ER-19072SAA
IST-MEL137872SAA
IST-MES120272SAA
IST-SL127872SAA
IST-SL228472SAA
J8221372SAA
JAR17772SAA
JEG-314172SAA
JHH-132672SAA
JHH-230872SAA
JHH-497.672SAA
JHH-614772SAA
JHH-715972SAA
JHOS-239372SAA
JHOS-348472SAA
JHU-01123072SAA
JHU-02249472SAA
JIMT-125472SAA
JiyoyeP-200317972RCA
JJN-35672RCA
JM113972RCA
J-RT3-T3-515372RCA
JSC-115472RCA
JURL-MK115272RCA
JVM-220672RCA
JVM-3> 10024MTT
JVM-3> 10048MTT
JVM-3> 10072MTT
JVM-323572RCA
K05211472RCA
K1938672SAA
K250172SAA
K410972SAA
K511172SAA
K56213572RCA
K881.672SAA
KALS-140872SAA
KARPAS-29963.572RCA
KARPAS-42214072RCA
KARPAS-4583.472RCA
KARPAS-62015872RCA
KCL-2284.272RCA
KE-3781.672RCA
KELLY17572SAA
KG-113472RCA
KG-1-C29772SAA
KGN21872SAA
KING-138172SAA
KLE90772SAA
KM1216372SAA
KMH-287.272SAA
KM-H214372RCA
KMOE-212872RCA
KMRC-127872SAA
KMRC-2024772SAA
KMS-1114972RCA
KMS-12-BM73.672RCA
KNS-4211772SAA
KNS-81-FD37972SAA
KON17972SAA
KOPN-867.572RCA
KOSC-228272SAA
KP-232972SAA
KP-344772SAA
KP-423172SAA
KP-N-YN39372SAA
KP-N-YS62.672SAA
KS-140172SAA
KU-19-1918672SAA
KU81217172RCA
KURAMOCHI40772SAA
KY82110272RCA
KYAE-134172SAA
KYM-113872SAA
KYSE-14036072SAA
KYSE-15021172SAA
KYSE-18016472SAA
KYSE-22028872SAA
KYSE-27013172SAA
KYSE-41031172SAA
KYSE-45021372SAA
KYSE-5011072SAA
KYSE-51014872SAA
KYSE-52061172SAA
KYSE-7034172SAA
L-123615072RCA
L-36316172RCA
L-42818472RCA
L-54016872RCA
LAMA-8411772RCA
LAN-638572SAA
LB1047-RCC28672SAA
LB2241-RCC32872SAA
LB2518-MEL17972SAA
LB373-MEL-D21372SAA
LB647-SCLC40.972SAA
LB771-HNC24772SAA
LB831-BLC12572SAA
LB996-RCC36772SAA
LC-1F61872SAA
LC-1-sq38372SAA
LC-2-ad17572SAA
LC4-191.772RCA
LCLC-103H16772SAA
LCLC-97TM127972SAA
LK-222472SAA
LN-1813972SAA
LN-22919072SAA
LN-40551872SAA
LNCap-FGC35772SAA
LNZTA3WT425272SAA
LOUCY12472RCA
LOU-NH9136472SAA
LoVo27872SAA
LOXIMVI12372SAA
LP-19872RCA
LS-103426372SAA
LS-12337572SAA
LS-18032272SAA
LS-411N22872SAA
LS-51332572SAA
LU-134-A28172SAA
LU-13515072SAA
LU-13935772SAA
LU-16534772SAA
LU-6555672SAA
LU-99A25372SAA
LXF-28918472SAA
M059J10672SAA
M1429472SAA
MC1164972RCA
MCAS24672SAA
MCC1321572SAA
MCC2622572SAA
MC-CAR16672RCA
MCF721372SAA
MC-IXC77.772SAA
MDA-MB-134-VI19172SAA
MDA-MB-15726172SAA
MDA-MB-175-VII43172SAA
MDA-MB-23116672SAA
MDA-MB-33040372SAA
MDA-MB-36120672SAA
MDA-MB-41552472SAA
MDA-MB-43642472SAA
MDA-MB-45317572SAA
MDA-MB-46892.172SAA
MDS814372SAA
ME-142172RCA
ME-18027072SAA
MEC-124272RCA
MEC-2> 10024MTT
MEC-2> 10048MTT
MEC-2> 10072MTT
MEG-0111072RCA
MEL-JUSO29372SAA
MES-SA13872SAA
Mewo31672SAA
MFE-28011372SAA
MFE-29621372SAA
MFE-31925972SAA
MFH-ino24872SAA
MFM-22316372SAA
MG-6329272SAA
MHH-ES-121672SAA
MHH-NB-1135072SAA
MHH-PREB-110372RCA
MIA-PaCa-231272SAA
MKL-1-228972SAA
MKL-227372SAA
MKN129472SAA
MKN2824972SAA
MKN4543572SAA
ML-142772SAA
ML-217672RCA
MLMA16172RCA
MMAC-SF31572SAA
MN-6014472RCA
MOG-G-CCM21872SAA
MOG-G-UVW19972SAA
MOLM-1312972RCA
MOLP-813772RCA
MOLT-1310872RCA
MOLT411672RCA
MONO-MAC-654.972RCA
Mo-T18672RCA
MPP-8952672SAA
MRK-nu-122372SAA
MS-120772SAA
MS75121672SAA
MSTO-211H17272SAA
MV-4-1181.872RCA
MY-M1222272RCA
MZ1-PC40172SAA
MZ2-MEL27472SAA
MZ7-mel17072SAA
NALM-612272RCA
NAMALWA14972RCA
NB(TU)1-1020872SAA
NB115672SAA
NB1018672SAA
NB1222672SAA
NB1317972SAA
NB1418872SAA
NB1754.872SAA
NB480.272RCA
NB520272SAA
NB651372SAA
NB699972SAA
NB722372SAA
NBsusSR18172SAA
NCC02144772SAA
NCI-H104812872SAA
NCI-H109231872SAA
NCI-H115584.472SAA
NCI-H118419372SAA
NCI-H129937372SAA
NCI-H130423472SAA
NCI-H135560872SAA
NCI-H138535772SAA
NCI-H139548772SAA
NCI-H141732072SAA
NCI-H143513572SAA
NCI-H143654.772SAA
NCI-H143729472SAA
NCI-H152219372SAA
NCI-H156339.572SAA
NCI-H156843972SAA
NCI-H157330972SAA
NCI-H158115472SAA
NCI-H162353472SAA
NCI-H164819272SAA
NCI-H165137272SAA
NCI-H166617672SAA
NCI-H168833872SAA
NCI-H169359472SAA
NCI-H169424872SAA
NCI-H170341272SAA
NCI-H173429672SAA
NCI-H175530.572SAA
NCI-H177017372SAA
NCI-H178129772SAA
NCI-H179220272SAA
NCI-H179374772SAA
NCI-H183643372SAA
NCI-H183837372SAA
NCI-H186935072SAA
NCI-H18736172SAA
NCI-H187627572SAA
NCI-H191525572SAA
NCI-H192624972SAA
NCI-H194428272SAA
NCI-H19635872SAA
NCI-H196318572SAA
NCI-H197532072SAA
NCI-H199363772SAA
NCI-H200916872SAA
NCI-H202344272SAA
NCI-H202919072SAA
NCI-H203031672SAA
NCI-H205256172SAA
NCI-H208121872SAA
NCI-H208512972SAA
NCI-H208711972SAA
NCI-H20918972SAA
NCI-H21117072SAA
NCI-H211026672SAA
NCI-H212210372SAA
NCI-H212656972SAA
NCI-H213518972SAA
NCI-H214130872SAA
NCI-H217029872SAA
NCI-H217187.772SAA
NCI-H217236272SAA
NCI-H219623572SAA
NCI-H22034472SAA
NCI-H222741472SAA
NCI-H222872572SAA
NCI-H22620772SAA
NCI-H228619872SAA
NCI-H229146972SAA
NCI-H2324172SAA
NCI-H234231672SAA
NCI-H234732172SAA
NCI-H240534672SAA
NCI-H244453672SAA
NCI-H245243472SAA
NCI-H2853572SAA
NCI-H29235172SAA
NCI-H312222472SAA
NCI-H322M67172SAA
NCI-H34536172SAA
NCI-H35827572SAA
NCI-H44169372SAA
NCI-H44631572SAA
NCI-H46020572SAA
NCI-H510A57.372SAA
NCI-H52020572SAA
NCI-H52238372SAA
NCI-H52417172SAA
NCI-H52619472SAA
NCI-H59656572SAA
NCI-H63016472SAA
NCI-H6473.172SAA
NCI-H64727772SAA
NCI-H65026172SAA
NCI-H66123272SAA
NCI-H6931372SAA
NCI-H71632872SAA
NCI-H72025872SAA
NCI-H727105072SAA
NCI-H74730972SAA
NCI-H74838172SAA
NCI-H81017772SAA
NCI-H8224772SAA
NCI-H83821272SAA
NCI-H84127272SAA
NCI-H84783.972SAA
NCI-H86554672SAA
NCI-SNU-121272SAA
NCI-SNU-1615772SAA
NCI-SNU-527772SAA
NEC813772SAA
NH-1218072SAA
NKM-123672RCA
NMC-G120572SAA
no-1046972SAA
no-1143272SAA
NOMO-180.672RCA
NOS-138572SAA
NTERA-S-cl-D122072SAA
NU-DUL-190.972RCA
NUGC-335772SAA
NUGC-419672SAA
NY24272SAA
OACM5-139572SAA
OACp4C40572SAA
OAW-2851672SAA
OAW-4214972SAA
OC-31416272SAA
OCI-AML228.272RCA
OCI-AML310672RCA
OCI-AML517672RCA
OCI-LY-1915072RCA
OCI-M178.972RCA
OCUB-M79.372SAA
OCUM-126572SAA
OE1924472SAA
OE2144072SAA
OE3336172SAA
OMC-131872SAA
ONC-7627072SAA
OPM-215072RCA
OSC-1917772SAA
OSC-2031172SAA
OS-RC-265572SAA
OUMS-2310272SAA
OV-17R40372SAA
OV-5624072SAA
OV-770772SAA
OV-9026072SAA
OVCA42056972SAA
OVCA43325772SAA
OVCAR-329472SAA
OVCAR-448172SAA
OVCAR-541872SAA
OVCAR-816572SAA
OVISE56572SAA
OVK-1822972SAA
OVKATE88972SAA
OVMIU42172SAA
OVTOKO35272SAA
P12-ICHIKAWA40.672RCA
P30-OHK13472RCA
P31-FUJ11372RCA
P32-ISH88.372RCA
P3HR-19872RCA
PA-115.772SAA
PANC-02-0337272SAA
PANC-03-2718772SAA
PANC-04-0377072SAA
PANC-08-1355272SAA
PANC-10-0527372SAA
PA-TU-890297.172SAA
PA-TU-8988T11272SAA
PC-1417772SAA
PC-321972SAA
PC-3_[JPC-3]15672SAA
PCI-15A20672SAA
PCI-3050172SAA
PCI-3823472SAA
PCI-4B15772SAA
PCI-6A24872SAA
PE-CA-PJ1520872SAA
PEO125772SAA
PF-38217072RCA
PFSK-15772SAA
PL1819572SAA
PL-2119972RCA
PL427272SAA
PLC-PRF-511472SAA
PSN179.272SAA
QGP-173972SAA
QIMR-WIL19372RCA
Raji17072RCA
Ramos-2G6-4C1014072RCA
RCC10RGB98472SAA
RCC-AB36672SAA
RCC-ER40372SAA
RCC-FG240272SAA
RCC-JF26872SAA
RCC-JW27072SAA
RCC-MF47872SAA
RC-K817472RCA
RCM-135272SAA
RD31372SAA
RD-ES11572SAA
REH17672RCA
RERF-GC-1B11372SAA
RERF-LC-KJ30772SAA
RERF-LC-MS22072SAA
RERF-LC-Sq175572SAA
RF-4825272SAA
RH-112572SAA
RH-4114472SAA
RKN24072SAA
RKO97.372SAA
RL13972RCA
RL95-216672SAA
RMG-I32472SAA
RO82-W-152272SAA
ROS-5013272RCA
RPMI-265016372SAA
RPMI-666617572RCA
RPMI-795119672SAA
RPMI-822616772RCA
RPMI-840259.272RCA
RPMI-886683.372RCA
RS4-1115272RCA
RT-11225072SAA
RT434172SAA
RVH-42135272SAA
RXF39343472SAA
S-11754572SAA
Saos-276472SAA
Sarc937183772SAA
SAS26172SAA
SAT72472SAA
SBC-122372SAA
SBC-357.272SAA
SBC-513472SAA
SCaBER30872SAA
SCC-1548572SAA
SCC-2532572SAA
SCC-348.172RCA
SCC-433972SAA
SCC-939372SAA
SCH41572SAA
Sci-174.472RCA
SCLC-21H21372SAA
SF12628472SAA
SF26831072SAA
SF29525272SAA
SF53952.172SAA
SH-433672SAA
SHP-7715172SAA
SIG-M529.672RCA
SiHa> 2024CVA
SiHa40772SAA
SIMA23272SAA
SISO20172SAA
SJRH3016172SAA
SJSA-133172SAA
SK-CO-123172SAA
SK-ES-128272SAA
SK-IIIa68172SAA
SK-GT-446572SAA
SK-HEP-110772SAA
SK-LMS-120872SAA
SK-LU-127572SAA
SK-MEL-112072SAA
SK-MEL-214772SAA
SK-MEL-2427272SAA
SK-MEL-2822372SAA
SK-MEL-329.372SAA
SK-MEL-3029772SAA
SK-MEL-542472SAA
SK-MES-115272SAA
SK-MG-127372SAA
SK-MM-251.272RCA
SKN27872SAA
SKN-337372SAA
SK-N-AS40172SAA
SK-N-DZ16872SAA
SK-NEP-115272SAA
SK-N-FI29772SAA
SK-N-SH24772SAA
SK-OV-331172SAA
SK-PN-DW23872SAA
SK-UT-117472SAA
SLVL45.872RCA
SN12C29072SAA
SNB7545972SAA
SNG-M21472SAA
SNU-104042472SAA
SNU-17516172SAA
SNU-18230272SAA
SNU-38713972SAA
SNU-39886.972SAA
SNU-40725072SAA
SNU-42331972SAA
SNU-44937072SAA
SNU-47520072SAA
SNU-6174372SAA
SNU-8159072SAA
SNU-C167972SAA
SNU-C2B38872SAA
SNU-C537572SAA
SR42.672RCA
ST48670.572RCA
SU868628072SAA
SU-DHL-153.572RCA
SU-DHL-1059.972RCA
SU-DHL-1670.772RCA
SU-DHL-469.172RCA
SU-DHL-525.772RCA
SU-DHL-680.972RCA
SU-DHL-818372RCA
SUIT-230772SAA
SUP-B1518572RCA
SUP-HD122472RCA
SUP-M236.272RCA
SUP-T197.572RCA
SW108823772SAA
SW111658072SAA
SW127140272SAA
SW1324272SAA
SW141745272SAA
SW1463113072SAA
SW15626872SAA
SW157355572SAA
SW171024072SAA
SW178313372SAA
SW199025072SAA
SW4820172SAA
SW62014472SAA
SW62631972SAA
SW68471872SAA
SW75633172SAA
SW78028472SAA
SW83744872SAA
SW87216772SAA
SW90030872SAA
SW94876472SAA
SW95415372SAA
SW96233672SAA
SW98225072SAA
T-2423772SAA
T47D81772SAA
T8432372SAA
T98G13372SAA
TALL-120072RCA
TC-7110572SAA
TCCSUP39572SAA
TE-134472SAA
TE-1018072SAA
TE-1119872SAA
TE-1235172SAA
TE-1537072SAA
TE-422772SAA
TE-536172SAA
TE-641072SAA
TE-829972SAA
TE-920872SAA
TF-123772RCA
TGBC11TKB97.872SAA
TGBC1TKB26072SAA
TGBC24TKB23372SAA
TGW73.172SAA
THP-119672RCA
TK20972RCA
TK1024572SAA
TMK-121072SAA
Toledo14172RCA
TOV-112D12272SAA
TOV-21G17172SAA
TT57172SAA
T-T22972SAA
ZZ2609-CO228772SAA
TUR15172RCA
TYK-nu11972SAA
U03126372SAA
U-118-MG40772SAA
U25120972SAA
U-2 OS34172SAA
U-698-M20072RCA
U-87-MG41672SAA
UACC-25736772SAA
UACC-6219972SAA
UACC-81231472SAA
UACC-89366772SAA
UISO-MCC-120672SAA
UMC-1110272SAA
UM-UC-312972SAA
UWB1.28985972SAA
VA-ES-BJ27772SAA
VAL10372RCA
VCaP29.472SAA
VM-CUB-114772SAA
VMRC-MELG15272SAA
VMRC-RCW13172SAA
VMRC-RCZ24572SAA
WIL2-NS13072RCA
WM-11524072SAA
WM115879.472SAA
WM1552C17972SAA
WM239A17972SAA
WM27821272SAA
WM3514772SAA
WM793B16872SAA
WM902B23572SAA
WSU-DLCL214272RCA
WSU-NHL12172RCA
YAPC57872SAA
YH-1331972SAA
YKG-114672SAA
YMB-1-E51272SAA
YT84.472RCA

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (nM)Inc1Assay2
Additional information3ID#
P3HR1~ 100144TBE

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional informationID#
CCRF-CEM~0.07
72MTT 
CDD-19Lu~4.2
72MTT
HeLa~ 2.1
72MTT ↑ Cyclin E, Gelsolin, p21, p27
HT-29~ 1.3
72MTT
Lu-99~ 0.15
72MTT
P3HR1< 0.5
144TBE

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (nM)Inc1Assay2
Additional informationID#
69711.572-84GLO
563748.772-84GLO
1321N17572-84GLO
22Rv127.672-84GLO
42-MG-BA68.972-84GLO
639-V81.572-84GLO
769-P87.472-84GLO
786-O237.772-84GLO
8-MG-BA112.872-84GLO
8305C50.772-84GLO
8505C68.972-84GLO
A-20423.872-84GLO
A-25363.272-84GLO
A-37546.872-84GLO
A-67336.772-84GLO
A-172101.472-84GLO
A205868.772-84GLO
A278054.972-84GLO
A549~ 6072RCA Cells arrest in subG1, ↑ H3K10p
A5492072WST-1↑ H3K4me1, p21 & p53, ↓ pERK 
A54917.472WST-1↑ E cadherin & p21, ↓ pERK & pAKT 
A549> 1048GLO
A549~ 4048RCA
A549~ 4072RCA
A54948.672-84GLO
ACHN45.772-84GLO
ALL-SIL7.372-84GLO
AMO-113.372-84GLO
AN3 CA117.372-84GLO
AsPC-1~ 9548MTT
AsPC-137.972-84GLO
AU56532.472-84GLO
AZ-52136.772-84GLO
B-CPAP88.472-84GLO
BDCM83.572-84GLO
BFTC-90984.272-84GLO
BGC-82328.772-84GLO
BL-4141.272-84GLO
BL-7012.772-84GLO
BL-2057.172-84GLO
BT-47419.172-84GLO
BT-549114.872-84GLO
BT-549< 10024TWA
BxPc-3110.472-84GLO
BxPc-328448MTT↓ CHK1, H3S10p & CDK2 
C2BBe154.472-84GLO
C32597.372-84GLO
C3A33.272-84GLO
Caki-210372-84GLO
CAL 2751.872-84GLO
CAL-12T51.572-84GLO
CAL-7880.972-84GLO
CAL-85-128.772-84GLO
Calu-1154.372-84GLO
Calu-346.372-84GLO
Calu-675.972-84GLO
CAMA-129.672-84GLO
CaOv31572WST-1
Capan-2> 100048MTT
Capan-268.572-84GLO
CAS-195.672-84GLO
CCK-8138.172-84GLO
CFPAC1> 100048MTT
CHL-118.272-84GLO
CHP-2121372-84GLO
CI-142.572-84GLO
CMK-8612.372-84GLO
COLO 2013372-84GLO
COLO 20539.372-84GLO
COLO 741109.872-84GLO
COLO-3206772-84GLO
COLO-67729.372-84GLO
COLO-678149.572-84GLO
COLO-67929.672-84GLO
COLO-699109.672-84GLO
COR-L105270.672-84GLO
COR-L23124.272-84GLO
COV318158.172-84GLO
COV50410672-84GLO
Daoy37.372-84GLO
Daudi~ 1048TBE
DBTRG-05MG139.872-84GLO
DEL1772-84GLO
Detroit 56295.272-84GLO
DK-MG93.172-84GLO
DMS 11449.572-84GLO
DOHH-214.472-84GLO
DOV1352.672-84GLO
DU 14524.372-84GLO
DV-9042.972-84GLO
EB1211.272-84GLO
EB2291.272-84GLO
EBC-144.572-84GLO
EFE-184144.872-84GLO
EFM-1928.272-84GLO
EFO-21168.272-84GLO
EFO-2720.472-84GLO
EM-21672-84GLO
EN67.872-84GLO
ES-243.472-84GLO
ESS-149.772-84GLO
F-36P472-84GLO
FaDu73.972-84GLO
FU-OV-140.972-84GLO
FU9720.372-84GLO
G-36121.172-84GLO
G-4011372-84GLO
G-402111.672-84GLO
GAMG139.372-84GLO
GB-197.172-84GLO
GCIY65.672-84GLO
GCT63.572-84GLO
GI-156.672-84GLO
GLC-8230.372-84GLO
GMS-1020.572-84GLO
GRANTA-51932.272-84GLO
H469.372-84GLO
HARA133.472-84GLO
HCC-1543.172-84GLO
HCC-4468.972-84GLO
HCC-5654.672-84GLO
HCC-7896.472-84GLO
HCC1187103.972-84GLO
HCC1395539.572-84GLO
HCC156925172-84GLO
HCC180654.972-84GLO
HCC195491.772-84GLO
HCC2935116.672-84GLO
HCC40068072-84GLO
HCC7067.272-84GLO
HCC8271048WST-1↑ H3ac, p21
HCC8279.472WST-1↑ p21
HCC827109.672-84GLO
HCT 11640.472-84GLO
HCT-15224.372-84GLO
HD-MY-Z75.972-84GLO
HDQ-P142.672-84GLO
HEC-1-A46.772-84GLO
HEC-1-B32.572-84GLO
HEC-15123.672-84GLO
HEC-251106.472-84GLO
HEC-26563.472-84GLO
HEC-5967.172-84GLO
HEC-626.372-84GLO
HEL 92.1.759.272-84GLO
Hep 3B2.1-771.372-84GLO
Hep G233.972-84GLO
Hey-A859.672-84GLO
HGC-2738.972-84GLO
HH11.672-84GLO
HL50~ 3072XTT
HLE152.572-84GLO
HLF101.572-84GLO
HMC-1-8186.872-84GLO
HMCB43.272-84GLO
HOS6272-84GLO
HPAC~ 8248MTT
HPAC48.572-84GLO
HPAF-II376.872-84GLO
Hs 229.T40.872-84GLO
Hs 294T70.872-84GLO
Hs 578T< 5072MTT↓ Cyclin D1
Hs 578T72.172-84GLO
Hs 683164.372-84GLO
Hs 695T3772-84GLO
Hs 729112.672-84GLO
Hs 739.T155.572-84GLO
Hs 746T42.172-84GLO
Hs 766T134.272-84GLO
Hs 840.T39.272-84GLO
Hs 852.T6572-84GLO
Hs 895.T72.272-84GLO
Hs 936.T25.472-84GLO
Hs 939.T52.272-84GLO
Hs 944.T55.972-84GLO
HSC-2299.772-84GLO
HT8.772-84GLO
HT-108042.172-84GLO
HT-119763.772-84GLO
HT-1376101.672-84GLO
HT-1448872-84GLO
HT-2947.972-84GLO
HuCCT193.572-84GLO
huH-17072-84GLO
HUP-T391.972-84GLO
HUP-T425.872-84GLO
HuT 788.472-84GLO
IA-LM117.872-84GLO
IGR-375272-84GLO
IGR-3953.772-84GLO
IGROV195.472-84GLO
IM9545.372-84GLO
IMR-3233.772-84GLO
IPC-2985472-84GLO
Ishikawa 02 ER-21.272-84GLO
Ishikawa H< 20336CFA↓ H3K9me & ↑ H3K9ace at PGR promoter
IST-MES157.672-84GLO
IST-MES242.772-84GLO
J82156.472-84GLO
JHH-280.172-84GLO
JHH-471.172-84GLO
JHH-539.272-84GLO
JHH-6175.772-84GLO
JHH-756.772-84GLO
JHH-DIPG1~50-10048GLO
JHH-DIPG1~ 4072GLO
JHOS-2140.672-84GLO
JHOS-4163.3272-84GLO
JHUEM-219.872-84GLO
JM13272-84GLO
JMSU-155.972-84GLO
JURKAT22.372-84GLO
JVM-316.872-84GLO
JY~ 5048TBE
K029AX45.172-84GLO
K5625072XTT↓ Akt, p-Akt, BCR-Abl, ↑ HSP70
K562/IM-R15172XTT↓ Akt, p-BCR-Abl
KALS-1134.572-84GLO
KARPAS-29962.372-84GLO
KARPAS-42227.972-84GLO
KARPAS-62023.772-84GLO
KASUMI-27.772-84GLO
KCI-MOH170.672-84GLO
KCL-2214.872-84GLO
KE-3958.772-84GLO
KE-979.972-84GLO
KELLY38.872-84GLO
KG-118.672-84GLO
KHM-1B18.972-84GLO
KLE62.472-84GLO
KMBC-254.572-84GLO
KMJR13821.348A5A
KMM-118.772-84GLO
KMRC-1202.272-84GLO
KMRC-2166.772-84GLO
KMS-1118.872-84GLO
KMS-12-BM3.972-84GLO
KMS-264.572-84GLO
KMS-3413.572-84GLO
KNS-42202.472-84GLO
KNS-6039.772-84GLO
KNS-6279.772-84GLO
KNS-81148.572-84GLO
KO5213.672-84GLO
KP-1N179.972-84GLO
KP-1NL166.372-84GLO
KP-285.472-84GLO
KP-3164.572-84GLO
KP-N-SI9s30.372-84GLO
KP496.372-84GLO
KU81232.772-84GLO
KURAMOCHI118.372-84GLO
KYM-113.372-84GLO
KYSE-140117.672-84GLO
KYSE-150183.372-84GLO
KYSE-180102.972-84GLO
KYSE-30128.572-84GLO
KYSE-41013.572-84GLO
KYSE-450172.772-84GLO
KYSE-510152.872-84GLO
KYSE-520149.772-84GLO
KYSE-7049.772-84GLO
L-3638.372-84GLO
L-42858.372-84GLO
L3.365.672-84GLO
LC-1/sq-SF142.672-84GLO
LCLC-103H104.172-84GLO
LN-1872.672-84GLO
LN-22977.872-84GLO
LOU-NH91182.472-84GLO
LOX IMVI69.472-84GLO
LP-115.372-84GLO
LS12347.272-84GLO
LS411N35.972-84GLO
LS51353.872-84GLO
LU9963.572-84GLO
LUDLU-143.772-84GLO
M059J130.772-84GLO
M202~ 6972GLO
M22913472GLO
M233~ 5572GLO
M249~ 1872GLO
M263~ 3972GLO
M285~ 3472GLO
M308~ 1272GLO
M37067972GLO
M376124.572GLO
M395~ 3372GLO
M408~ 4472GLO
M417~ 6072GLO
Malme-3M40.872-84GLO
MB 15747.472-84GLO
MC11611172-84GLO
MCAS79.872-84GLO
MCF7> 10024TWA
MDA-MB-15785.672-84GLO
MDA-MB-175-VII93.472-84GLO
MDA-MB-231< 5072MTT↓ Cyclin D1 
MDA-MB-231~10 – 10072CVA
MDA-MB-231~ 10024TWA
MDA-MB-41551.972-84GLO
MDA-MB-435S5872-84GLO
MDA-MB-436145.172-84GLO
MDA-MB-45310.672-84GLO
MDA-MB-468282.772-84GLO
Me100716.848A5A
MEC-117.772-84GLO
MEG-0162.572-84GLO
MEL-HO31.672-84GLO
Mel-RM39.348A5A
MES-SA104.272-84GLO
MeWo106.572-84GLO
MFE-28045.572-84GLO
MFE-29660.572-84GLO
MFE-31959.772-84GLO
MG-63126.672-84GLO
MHH-ES-163.372-84GLO
MIA PaCa-21348MTT
MIA PaCa-219.672-84GLO
Mino10.172-84GLO
MJ13.372-84GLO
MKN-4553.472-84GLO
MKN714072-84GLO
MKN74152.372-84GLO
MOG-G-CCM206.872-84GLO
MOLM-131.317GLO
MOLP-81872-84GLO
MOLT-168.672-84GLO
MONO-MAC-17.972-84GLO
MOR/CPR3072-84GLO
MPP 8963.772-84GLO
MSTO-211H73.772-84GLO
MV4-111.77GLO
NCI-H104850.772-84GLO
NCI-H109266.672-84GLO
NCI-H115545.572-84GLO
NCI-H118424.872-84GLO
NCI-H1299> 1048GLO
NCI-H1299151.172-84GLO
NCI-H133972.472-84GLO
NCI-H134153.672-84GLO
NCI-H1355121.572-84GLO
NCI-H1373108.172-84GLO
NCI-H1563234.472-84GLO
NCI-H156858.872-84GLO
NCI-H157312272-84GLO
NCI-H15814672-84GLO
NCI-H164886.172-84GLO
NCI-H1650176.972-84GLO
NCI-H165166.872-84GLO
NCI-H166669.972-84GLO
NCI-H169358.972-84GLO
NCI-H16942372-84GLO
NCI-H1703216.272-84GLO
NCI-H1792107.672-84GLO
NCI-H1869133.872-84GLO
NCI-H191538.572-84GLO
NCI-H194472.172-84GLO
NCI-H19758572-84GLO
NCI-H200935.972-84GLO
NCI-H202393.372-84GLO
NCI-H2030140.372-84GLO
NCI-H2052101.472-84GLO
NCI-H208554.772-84GLO
NCI-H208711472-84GLO
NCI-H2111472-84GLO
NCI-H212230.472-84GLO
NCI-H217039.672-84GLO
NCI-H2172> 1048GLO
NCI-H222867.572-84GLO
NCI-H226264.472-84GLO
NCI-H228641.572-84GLO
NCI-H23> 1048GLO
NCI-H23~ 2572RCA↓ HDAC4 
NCI-H23~ 3048RCA ↓ HDAC4 
NCI-H2365.472-84GLO
NCI-H244478.272-84GLO
NCI-H2452136.572-84GLO
NCI-H2886.972-84GLO
NCI-H32289.572-84GLO
NCI-H325552.672-84GLO
NCI-H35891.272-84GLO
NCI-H441> 1048GLO
NCI-H441121.372-84GLO
NCI-H460~3572WST-1↑ p21, H3ac, H3K4me2 & H3K4me3 
NCI-H46098.772-84GLO
NCI-H52059.272-84GLO
NCI-H52283.472-84GLO
NCI-H647330.472-84GLO
NCI-H650145.772-84GLO
NCI-H6612.672-84GLO
NCI-H72776.172-84GLO
NCI-H74735.772-84GLO
NCI-H81011.972-84GLO
NCI-N8746.772-84GLO
NCO226.672-84GLO
NIH:OVCAR-348.572-84GLO
NUGC-373.472-84GLO
NUGC-49.772-84GLO
OC 31413872-84GLO
OC 31582.172-84GLO
OC 31612072-84GLO
OCI-AML220.372-84GLO
OCI-AML3> 1048MTT
OCI-AML511.472-84GLO
OCI-LY1017.172-84GLO
OCUM-116.772-84GLO
OE2155.272-84GLO
OE3335.472-84GLO
ONCO-DG-1102.772-84GLO
ONS-76123.672-84GLO
OPM-22.572-84GLO
OV-9029.872-84GLO
OVCAR-327.172SRB↓ BRCA1 & Cyclin E1 
OVCAR-4100.472-84GLO
OVCAR-825.272-84GLO
OVMANA166.772-84GLO
OVSAHO202.772-84GLO
OVTOKO148.672-84GLO
P12-ICHIKAWA10.872-84GLO
P31/FUJ11.972-84GLO
P3HR-163.872-84GLO
P3HR-1~ 50144TBE
PA-TU-890293.972-84GLO
Panc-1~57048MTT↓ CHK1, H3S10p & CDK1 
Panc 02.03> 100048MTT
Panc 02.0350.172-84GLO
Panc 03.27~ 0.548MTT
Panc 03.27137.872-84GLO
Panc 04.037.748MTT
Panc 04.0348.272-84GLO
Panc 05.04> 100048MTT
Panc 10.0526148MTT
Panc 10.0593.872-84GLO
PC-14> 1048GLO
PC-1478.172-84GLO
PC-382.772-84GLO
Pfeiffer20.372-84GLO
PK-194.472-84GLO
PK-45H85.472-84GLO
PK-59134.972-84GLO
PL45> 100048MTT
PL4587.972-84GLO
PLC/PRF/537.372-84GLO
PSN188.272-84GLO
QGP-15472-84GLO
Raji62.572-84GLO
RD26.372-84GLO
Reh31.472-84GLO
RERF-GC-1B57.172-84GLO
RERF-LC-AI59.672-84GLO
RERF-LC-MS162.972-84GLO
RKN153.272-84GLO
RKO49.872-84GLO
RL95-236.272-84GLO
RPMI-795143.772-84GLO
RPMI-840211.372-84GLO
RT-11243.172-84GLO
RT447.872-84GLO
RVH-42178.872-84GLO
Saos-27872-84GLO
SBC-522.772-84GLO
SCaBER32.172-84GLO
SCC-919.472-84GLO
SF-295106.972-84GLO
SF1269972-84GLO
SF7761~ 4072GLO
SF8657126.672-84GLO
SH-10-TC103.672-84GLO
SHP-7712772-84GLO
SIG-M5972-84GLO
SIMA58.772-84GLO
SJRH3025.872-84GLO
SJSA-1116.772-84GLO
SK-BR-331.872-84GLO
SK-CO-1135.472-84GLO
SK-ES-121.872-84GLO
SK-HEP-14172-84GLO
SK-LMS-163.872-84GLO
SK-LU-1146.372-84GLO
SK-MEL-233.372-84GLO
SK-MEL-2499.772-84GLO
SK-MEL-3013972-84GLO
SK-MEL-316972-84GLO
SK-MEL-534.472-84GLO
SK-MES-17472-84GLO
SK-MM-283.372-84GLO
SK-N-AS~ 3748MTT
SK-N-AS17.572-84GLO
SK-N-BE(2)10448MTTCells arrest in Sub-G1
SK-N-BE(2)22.472-84GLO
SK-N-DZ~ 1748MTT
SK-N-DZ12.972-84GLO
SK-N-FI52.272-84GLO
SK-N-SH22.772-84GLO
SKOV-3141.472-84GLO
SKOV-31572WST-1Cells arrest in G2/M
SKOV-36-1272CFA
SKOV-320.172SRB
SNG-M136.572-84GLO
SNU-175.672-84GLO
SNU-163672-84GLO
SNU-18296.672-84GLO
SNU-387146.672-84GLO
SNU-39854.172-84GLO
SNU-423221.472-84GLO
SNU-449203.872-84GLO
SNU-475145.872-84GLO
SNU-C2A120.372-84GLO
SNU-C2B73.472-84GLO
Sq-148.372-84GLO
SU-DHL-1018.172-84GLO
SU-DHL-413.672-84GLO
SU-DHL-68.572-84GLO
SU-DHL-811.672-84GLO
SU-DIPG-IV~ 10048GLO
SU-DIPG-IV~ 3072GLO
SU-DIPG-VI~ 100-50048GLO↑ H3K27me3
SU-DIPG-VI~ 15-5072GLO
SU-DIPG-XIII~ 100-50048GLO↑ H3K27me3 
SU-DIPG-XIII~ 7072GLO
SU-pcGBM-2~ 200072GLO
SU.86.86114.772-84GLO
SU.86.86> 100048MTT
SUIT-2156.972-84GLO
SUM 149~ 5072MTT↓ Cyclin D1, ESR1 
SUP-M213.472-84GLO
SUP-T192.272-84GLO
SW 1088202.472-84GLO
SW 1271118.972-84GLO
SW 13536672-84GLO
SW 157398.172-84GLO
SW 1990120.172-84GLO
SW 780111.672-84GLO
SW 9001140.772-84GLO
SW141757.672-84GLO
SW40324.872-84GLO
SW4839.272-84GLO
SW48048.572-84GLO
SW57958.872-84GLO
SW62032.972-84GLO
T-47D64.472-84GLO
T2466.272-84GLO
T3M-1073.772-84GLO
T84134.872-84GLO
T98G17772-84GLO
TC-7148.372-84GLO
TCCSUP61.672-84GLO
TE 617.T24.372-84GLO
TE-129.172-84GLO
TE-11163.872-84GLO
TE-1540.172-84GLO
TE-5170.772-84GLO
TE-997.572-84GLO
TEN127.772-84GLO
Toledo45.772-84GLO
TOV-112D60.872-84GLO
TOV-21G48.772-84GLO
TT2609-C0223.672-84GLO
TYK-nu36.772-84GLO
U-118 MG56.172-84GLO
U-2 OS34.572-84GLO
U-87 MG77.272-84GLO
U-93719.972-84GLO
UACC-25780.972-84GLO
UACC-6238.972-84GLO
UACC-81269.272-84GLO
UM-UC-3132.172-84GLO
VMRC-LCD8.172-84GLO
VMRC-RCW8.372-84GLO
VMRC-RCZ65.672-84GLO
WM-115170.272-84GLO
WM-266-435.272-84GLO
WM-79394.272-84GLO
WM-8895.372-84GLO
WM-983B121.572-84GLO
WM1799195.172-84GLO
YKG172.972-84GLO
ZR-75-15072-84GLO
ZR-75-3029.472-84GLO

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (nM)Inc1Assay2
Additional information3ID#
5637~ 5024MTS↑ H2AK118ac & H2BK34ac, ↓ HDAC1,2,3
5637172MTS
A549296MTS
DLD1>548TBE↑ p21, p27 
HBEC15KT2.596MTS
HBEC16KT~596MTS
HBEC30KT~ 196MTS
HBEC34KT1.396MTS
HBEC3KT196MTS
HC15001.596MTS
HCC156.496MTS
HCC1806 1.896MTS
HCC19541.596MTS
HCC3663.196MTS
HCC40176.596MTS
HCC40184.296MTS
LOXIMVI1.296MTS
M142.496MTS
MALME3M0.796MTS
MCF102.496MTS
MCF74.296MTS
MEL2701.896MTS
MKN45> 5048TBE
NCI-H1299~ 1296MTS
NCI-H13551.896MTS
NCI-H13955.396MTS
NCI-H14370.596MTS
NCI-H19931.296MTS
NCI-H20090.996MTS
NCI-H2073~ 3796MTS
NCI-H2085~ 796MTS
NCI-H2086~ 496MTS
NCI-H2920.796MTS
NCI-H3581.196MTS↑ H3 & H4, ↓ H3K9me3
NCI-H460< 524TWACXCL12-driven assay
NCI-H820496MTS
OCM15.596MTS
OCM31.596MTS
OMM2.32.796MTS
PEER10.848MTT↑ H3K9ac, H3K27me3, cPARP, ↓ Akt, HDAC3,4, DNMT1, Survivin
SF295< 524TWACXCL12-driven assay; ↓ pSTAT3, pSrc
SKMEL20.496MTS
SKMEL51.596MTS
SKMEL280.896MTS
SUPT17.948MTT↑ NF?B2, H3K9ac, H3K27me3, ↓ Akt, HDAC3,4, DNMT1, Survivin
UACC2571.696MTS
UACC62~ 196MTS
UOK121> 524TWACXCL12-driven assay; ↓ pSrc
VM-CUB1> 348GLO

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional information3ID#
MCF7< 348A5A
MCF7< 372A5A
MDA-MB-231< 348A5A
MDA-MB-231< 372A5A
MDA-MB-468> 1.518TBE
P3HR1~ 1-2144TBE
PANC-1~ 618TBE
SKBR3< 348A5A
SKBR3< 372A5A
SQ-20B~ 2.524CFA↓ Ku80; sensitizes cells to irradiation

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional information3ID#
A375< 2.548MTT ↑ p53 & p21 
A375> 2548TBE
A549 ~ 1072MTT↓ SIRT1, ↑ CDKN1A 
A549 < 10120MTT
ARN8 ~ 1-548MTTCells arrest in SubG0/G1
ARN8< 1048A5A
BL2 < 1048A5A
EW36< 1048A5A
G361> 2.548MTT↑ p53 
G361> 2548TBE
HCT116> 1048PIACells arrest in G1, ↑ p53, MDM2, p21, PIAG3, cPARP1
HCT116< 10 48A5A
HCT116-p53– > 1048A5A
HH > 2548GLO↑ FOXO3, ↓ SIRT1 
Hs294T~ 2.548MTT↑ p53 & p21, p53 activity
Hs294T> 2548TBE
HuT 78~ 2548GLO↑ cPARP, ↓ SIRT1 
MCF7~ 10 48CYQ
MDA-MB-231< 1048A5A
MDA-MB-468< 1048A5A
MyLa> 2524 GLO↑ cPARP & FOXO3, ↓ SIRT1 
NCI-H1299< 1072MTT
NCI-H1299< 10120MTT
NCI-H1299> 1048A5A
NCI-H157< 1072MTT
NCI-H157< 10120MTT
NCI-H358> 1072MTT
NCI-H358< 10120MTT
NCI-H460< 1072MTT
NCI-H460<10120MTT
NCI-H520~ 1072MTT
NCI-H520< 10120MTT
NHDF> 1048MTT
NTERA-2D< 1048A5A
NTERA-2D DNp53> 10 48A5A
SeAx> 2548GLO
SJSA~ 1048A5A
SZ4~ 2524 GLO
U-2 OS~ 1048A5A

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional information3ID#
MDA-MB-231> 10
72CVA

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (nM)Inc1Assay2
Additional information3ID#
563720024MTS↑ H2AK118ac & H2BK34ac
563710072MTS↑ H2AK118ac & H2BK34ac
A549~ 4096MTS
HBEC15KT29596MTS
HBEC16KT26096MTS
HBEC30KT28596MTS
HBEC34KT34696MTS
HBEC3KT31896MTS
HC15002996MTS
HCC15~ 896MTS
HCC1806 4196MTS
HCC19549196MTS
HCC36614796MTS
HCC40177396MTS
HCC40182396MTS
HEC1A~ 10072WST-1↓ Cyclin A
HEC1B~ 100072WST-1
HHUA~ 100072WST-1
Ishikawa~ 100 – 100072WST-1
KLE~ 100 – 100072WST-1
LOXIMVI5796MTS
M149896MTS
MALME3M24096MTS
MCF109696MTS
MCF79096MTS
MEL2706896MTS
NCI-H129915096MTS
NCI-H135510796MTS
NCI-H13954196MTS
NCI-H143719196MTS
NCI-H1993~ 9496MTS
NCI-H2009~ 3896MTS
NCI-H2073~ 6496MTS
NCI-H208539096MTS
NCI-H208627596MTS
NCI-H29222.596MTS
NCI-H3584096MTS↑ H3ac, H4ac
NCI-H8205596MTS
OCM118896MTS
OCM322096MTS
OMM2.38196MTS
RL952~ 10072WST-1
SKMEL233696MTS
SKMEL56696MTS
SKMEL2840096MTS
SQ-20B< 10024CFA
UACC25722296MTS
UACC6223896MTS

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (mM)Inc1Assay2
Additional information3ID#
A-375> 4024MTT
A-375> 4048MTT
BT-474> 1024MTS
BT-474~ 3.572MTS
BT-474~ 1.8120MTS
Caco-2> 148MTT
DU-145~ 172MTT
HCT116> 1048PIA
HCT116-p53+~ 1048MMP
HCT116-p53–> 1048MMP
HeLa148MTT
HepG2> 121LDH
HL-60~ 2 – 424TBE↓ CCL2
HL-601.748MTT
Hs 294T> 4024MTT
Hs 294T~ 4048MTT
HT-1080> 0.548TBE
HT-29> 148MTT
HuT 781.848MTT
K562> 148MTT
LA1-55n17.448CAM
LAN2248CAM
LNCaP~ 172MTT
MCF7> 1024MTS
MCF7~ 7.572MTS
MCF7~ 4120MTS
MCF70.2348MTT
MDA-MB-231> 1024MTS
MDA-MB-231~ 572MTS
MDA-MB-231~ 3.8120MTS
MES> 0.548TBE
P3HR1< 2144TBE
PC-3> 172MTT
Saos-2> 0.548TBE
SK-BR-3~ 524MTS
SK-BR-3~ 1.872MTS
SK-BR-3~ 1120MTS
SK-ES-1> 0.548TBE
SK-N-BE(2)-C3.148CAM
SMS-KCNR~ 2.448CAM
THP-1> 824TBE
U-937~ 224TBE↓ CCL2

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.

Cell lineIC50 (µM)Inc1Assay2
Additional information3ID#
56377.524MTS
56371.972MTS
A-427~ 2.572MTT
A549~ 1.572MTT
HCT116~ 248PIA
HCT116~ 1.848MMP
HCT116< 248MTT
HEK2931396XTT
HEL~ 0.848WST-83 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
HEL0.472WST-83 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
HEL1 – 348A5A3 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
HeLa2.596XTT
HL60~0.996XTT
Hs 578T< 572MTT
JHH-DIPG1~ 172GLO
Jurkat1.196XTT
LA1-55n123.348CAM
LAN218.448CAM
MCF78.696XTT
MDA-MB-231< 572MTT
MDA-MB-231~ 1 – 1072CVA
MOLM-130.147GLO
MV4-110.367GLO
NCI-H1299~ 6.572MTT
NCI-H1299> 1240-360CFA
NCI-H1944~ 272MTT
NCI-H1993~ 2.572MTT
NCI-H2126~ 1.572MTT
NCI-H226B~ 772MTT
NCI-H226B> 1240-360CFA
NCI-H226Br~ 1172MTT
NCI-H292~ 2.572MTT
NCI-H322~ 3.572MTT
NCI-H358~ 3.572MTT
NCI-H460< 524TWACXCL12-driven assay; ↑ CXCR4 
NCI-H460~ 772MTT
NCI-H460> 1240-360CFA
NCI-H596> 1240-360CFA
NCI-H596~ 972MTT
OVCAR-35.572SRB
P3HR1> 50144TBE
SF295< 524TWACXCL12-driven assay; ↑ CXCR4 
SF7761~ 572GLO
SK-N-BE(2)-C12.348CAM
SKM-10.3172GLO
SKM-1~ 148WTS-83 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
SKM-1~ 0.7572WTS-83 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
SKM-1~ 148A5A3 µM: ↑ p21, SOCS3, ↓ phospho-JAK2, phospho-STAT3
SKOV-32.772SRB
SMS-KCNR5.848CAM
SU-DIPG-IV~ 172GLO
SU-DIPG-VI~ 1-272GLO
SU-DIPG-XIII~ 1-272GLO
SU-pcGBM-2> 1072GLO
SUM 149> 572MTT
UM-UC-3< 2.548LDH
UM-UC-3~ 2.548MTT
UOK121< 524TWACXCL12-driven assay; ↑ CXCR4 
VM-CUB1> 2.548GLO
VM-CUB1> 2.548LDH
VM-CUB1< 2.548MTT

© CEDD, Cancer Epigenetics Society; all rights reserved, 2021. Data may be used in academic publications contingent on citation of the reference at the top of this page.