Focus: Chromatin and gene regulation in human disease

Kadoch Laboratory, Dana-Farber Cancer Institute/HMS/Broad Institute

The Kadoch Laboratory at the Dana-Farber Cancer Institute, Harvard Medical School, and Broad Institute is seeking a highly qualified post-graduate student (student graduating with BA/BS this Spring/Summer 2019 or in the previous year) to join our team as a Computational Biologist focused at the intersection of cancer biology, epigenetics, and chromatin regulation. Our lab uses multidisciplinary approaches including genomics and epigenomics, systems biology, functional genetic screening, biochemistry, structural biology, and chemical biology, to explore the mechanisms of chromatin remodeling complexes, which are frequently mutated in human cancers and other diseases. Our exciting and diverse set of projects involve collaborations across the Harvard and MIT centers in Boston and Cambridge.

This is a unique opportunity with significant potential for the student to work closely with the PI and carry forward independent projects resulting in presentations and publications. Computational Biologists in our laboratory participate in lab meetings and journal clubs, participate in subgroup meetings, work closely with graduate students and postdocs, and have typically authored several publications prior to entering PhD or MD/PhD programs following their time in our lab. The successful applicant will have advanced experience in R and/or Python and familiarity with genomics-centered approaches such as ChIP-seq, RNA-seq, ATAC-seq, Hi-C, and others through prior lab research experience as well as undergraduate coursework. The ideal candidate will also have some familiarity with chromatin biology and in reading and dissecting literature in this area. We are looking for candidates who can dedicate at least two years in the lab and who may be considering applying to graduate and/or medical school following their time in the lab. The ideal candidate will be exceptionally motivated, detailed, goal-oriented and will possess excellent organizational, communication, and analytical skills.

Please see http://www.kadochlab.org; twitter: @kadochlab; @ckadoch for more information, as well as PubMed for recent papers from our lab:https://www.ncbi.nlm.nih.gov/pubmed/?term=kadoch+c.