This senior scientist will join the Integrative Biotechnology Group of the Pfizer Oncology Research Department where s/he will apply functional genomics to study cellular mechanisms that impact tumor response to late stage oncology pipeline assets.

The qualified candidate should be a highly motivated, creative, and collaborative individual with strong interest and publication record relevant to tumor intrinsic / extrinsic signaling regulating cell cycle progression, epigenetics, and/or senescence response. The candidate must be flexible to study novel mechanisms underlying tumor vulnerabilities discovered from functional genomics screening efforts. This role includes developing and applying flow cytometry based biological endpoint assays to enable prioritization of screen hits that elicit desired outcome.

The successful candidate must have strong communication skills and will be expected to present their research to multidisciplinary teams, senior management, and at external scientific meetings.

ROLE RESPONSIBILITIES

• Develop and execute assays for in vitro / in vivo synthetic lethal functional genomics screens in relevant cancer models to discover genes that impact sensitivity or resistance to late stage oncology compounds.
• Prioritize drug discovery opportunities by integrating screen results with knowledge gained from publicly available datasets and multi-omics profiling of tumor response to small molecule inhibitors.
• Collaborate with a diverse team of cancer and molecular biologists to validate and determine the mechanism of action of prioritized targets.
• Incorporate advances in CRISPR/RNAi technologies to maintain cutting edge functional genomics platform.
• Present key findings that highlight research progress and opportunities to senior management and at internal meetings.
• Continue excellent publication and presentation record by publishing research discoveries in high impact journals and presenting at external scientific conferences.

BASIC QUALIFICATIONS

• Ph.D. in Cell Biology or related discipline and 3+ years of academic experience at the postdoctoral level or 2+ years of industry experience in cancer research.
• Broad understanding of and advanced technical expertise in research of signaling pathways that underlie cell cycle progression, epigenetics, and/or mechanisms that govern senescence.

PREFERRED QUALIFICATIONS

• Experience executing pooled CRISPR/RNAi screens in cancer models in vitro and / or in vivo.
• Strong technical expertise in flow cytometry / sorting.
• Developed/applied biological endpoint assays to gain mechanistic insights into the consequences of gene knockdown or inhibition.
• Experience working with 2D and 3D mammalian cell culture systems.
• Expert molecular biology skills as well as expertise in immunofluorescence, immunoprecipitation, transgene mutagenesis / expression, western blot, and Q-PCR.
• Significant impact in field of study as demonstrated by publications in top tier peer-reviewed research journals.