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Postdoctoral Fellow
January 30, 2019 - March 3, 2019
The Beckman Research Institute of City of Hope is looking for talented Postdoctoral Fellows who will be in the laboratory of Dr. Yilun Liu at the Department of Cancer Genetics and Epigenetics. The focus of the lab relates to the studies of the molecular functions of a group of tumor suppressors known as the human RECQ family helicases. Mutations in different RECQ proteins have been linked to distinct clinical syndromes with various developmental abnormalities, premature aging phenotypes and cancer predisposition.
Works from Dr. Liu’s laboratory have established novel models and important mechanistic insights into (a) how Rothmund-Thomson syndrome helicase, RECQ4, facilitates efficient nuclear and mitochondrial DNA replication; (b) how mutations in RECQ4 contribute to cancer pathogenesis; (c) how tumor suppressor RECQ5 avoids detrimental DNA damages caused by transcription; and (d) how RECQ5 provides chemo-resistance to Topoisomerase 1-targeting therapy. These findings were published in journals, including Nature Communications, Cell Reports, EMBO Journal and PNAS. Please click here for a full list of publications from Dr. Liu’s laboratory.