We seek an accomplished Scientist level oncologist/immunologist to join the in vivo pharmacology group within the Oncology Research Unit (ORU) of Pfizer’s Worldwide Research & Development (WRD) division in La Jolla, California. The successful candidate will join a dynamic team of scientists in the Oncology In Vivo Pharmacology Group, playing a leading role in the characterization of models of cancer and evaluating new drug candidates.

Participate in pre-clinical drug discovery and development projects with a focus on targeted therapeutics, epigenetics and the tumor microenvironment. Characterize and develop small molecules in close collaboration with partner lines as an integral member of drug discovery teams. Evaluate anti-tumor effects in combination with biologics. Employ and develop new cutting-edge in vivo mouse and human cancer models. Provide technical and scientific expertise in in vivo pharmacology to the tumor cell biology department to enable target identification, validation, prioritization and efficient drug discovery of small molecules.

The candidate must have a strong background in hands-on laboratory based experimentation.   Experience with scRNA sequencing technologies (10X Genomics) is required. Knowledge in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20, Cytobank, FlowJo, FACS, MACS) is desired. Ideal applicants will have excellent communication and organizational skills, critical problem-solving abilities, and a commitment to excellence.

ROLE RESPONSIBILITIES

• Execute and analyze cells within the tumor microenvironment by multi-parameter flow cytometric and RNAseq studies.
• Characterize new in vivo mouse models, including syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel therapies.
• Conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
• Interpretation, presentation and documentation of experiments.
• Presentation of results within a multidisciplinary team environment.

BASIC QUALIFICATIONS

• BS/MS in Cancer Biology, Immunology or equivalent experience in a related discipline.
• > 6 years of laboratory work experience in academia or industry
• Hands on laboratory skills. In vivo skills (IV, PO dosing), blood/tissue collection is a plus.
• Ability to follow novel scientific or technological developments, and to implement them in the laboratory.
• Excellent written and oral communication and presentation skills in English.
• Strong ability to multi-task and work productively in a fast-paced, highly collaborative, and diverse team environment. Capability to contribute to a vivid and challenging intellectual environment.

PREFERRED QUALIFICATIONS

• Expertise in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Fortessa-X20, Cytobank, FlowJo, FACS, MACS) or scRNA sequencing technologies (10X Genomics) preferred
• Experience with animal models of human cancers preferred.