The Broad is looking for exceptional candidates to join the Precision Cardiology Laboratory. The successful candidates will join an interdisciplinary team of computational biologists, laboratory scientists, and clinicians working together to identify and validate new molecular targets for cardiovascular disease, with the ultimate goal of advancing novel therapeutics to the clinic in collaboration with a strategic industry partner.  We are currently looking for candidates to take a lead on performing large-scale studies using single-cell RNA sequencing in normal and disease tissue samples from humans and animal models. The candidates will take oversee the design and processing of single-cell experiments, supervise a research associate, collaborate with data scientists on the analyses, and potentially lead a therapeutics project targeting cardiovascular disease.

Example workstreams include:

• Design and implement laboratory methods for single-cell analysis of biological data
• Collaborate with computational biologists to analyze single-cell data
• Integrate single-cell data with other available genetic, sequencing, and epigenetic datasets to help prioritize potential therapeutic targets and cell types
• Collaborate with Broad Institute single-cell analysis community, Human Cell Atlas group and the Data Sciences Platform
• Design and lead independent projects
• Create scientifically rigorous visualizations, communications, and presentations of results
• Contribute to generation of protocols, publications, and intellectual property
• Maintain and organize computational infrastructure and resources

REQUIREMENTS

• Ph.D. in Biology (Developmental, Molecular, Cellular Biology), Biochemistry, or related life science field
• 2+ years of research in an industrial or academic setting with a proven record of successful interaction with external customers, vendors, and team members
• Hands-on experience in with single cell analyses
• Experience with CRISPR targeting ES/iPS cells and imaging protocols preferred
• Ability to develop research plans for executing strategy, operate and maintain equipment, and perform laboratory work, with complete independence
• Track record of working on complex problems, and ability to integrate data from multiple disciplines
• Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
• Outstanding verbal and written communication abilities
• Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
• A passion for science and sense of urgency to find new medicines to benefit patients