The Disease Biology Group in the Protein Homeostasis Thematic Center of Excellence (PH TCOE) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a highly motivated Research Associate with experience in molecular biology and state-of-the-art techniques of epigenetic profiling such as ATAC-seq and ChIP-seq. The successful candidate will work collaboratively in a multi-disciplinary environment to further our understanding of the molecular mechanism of action of our novel compounds and targets. Responsibilities will include to design and execute genetic and epigenetic studies in multiple disease models to support drug target validation, mechanism of drug action, biomarker discovery and potential drug combination strategies.  The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Protein Homeostasis at Celgene

The PH TCoE at Celgene is one of the fundamental research and early development engines delivering therapeutics to patients.  As a thematic center, the PH TCoE is agnostic to therapeutic modality or disease area. The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company’s most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.

Responsibilities will include, but are not limited to the following:

Work independently to design, execute, analyze, interpret and troubleshoot scientific experiments in molecular and cell biology, cellular biochemistry and assay development Accurately maintain written reports and present results in an organized and timely manner to supervisor and colleagues Communicate with peers and supervisors, foster teamwork and contribute to collaborative efforts Strong commitment to quality and demonstrate adaptability

Skills/Knowledge Required:

• Bachelor’s degree in molecular biology, cell biology, or related scientific discipline with at least 2 years laboratory experience.
• Hands-on experience with molecular biology techniques including but not limited to, quantitative PCR, ATAC-seq and ChIP-seq and manipulation/editing of gene/message/protein via RNAi and/or CRISPR methods
• Experience with mammalian cell culture and cell-based assays to analyze compound effects (Western blot, ELISA, immunoprecipitation, immunofluorescence and functional assays such as cell cycle and apoptosis)
• Excellent communication, presentation and organizational skills are required as well as the ability to independently design, execute, and troubleshoot experiments through completion
• Data analysis skills and experience with a variety of scientific software applications are required
• Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.