We are seeking a highly motivated, positive and engaged team player to join our Epigenetic Discovery group. The successful candidate will work on drug discovery projects focused on Epigenetic and Transcriptional targets. Specifically, the candidate will be expected to design, develop and execute experiments that include new target validation, identification of biomarkers, elucidation of mechanism of action, executing existing cell based assays, and evaluating regular lists of chemical matter to support ongoing SAR efforts. Experience with chromatin IP (ChIP) is highly desired. In addition, the candidate will assist in creating stable cell lines, and developing and optimizing new cell based assays to support drug discovery efforts.

Responsibilities will include, but are not limited to, the following

• Independently design, plan and execute scientific experiments
• Analyze and interpret scientific data, troubleshoot and suggest new directions
• Conduct routine assays to confirm hits from primary screens and support ongoing SAR efforts
• Develop, trouble shoot and optimize new cell based biomarker and functional assays
• Accurately maintain written reports and organize data
• Present projects in team, department and project review meetings
• Independently review current literature pertaining to oncology, epigenetics, transcriptional regulation and related assays

Experience/Skills/Knowledge Required

• Master’s degree in a scientific discipline with at least 6 years work experience, or Bachelor’s degree with at least 8 years work experience.
• In-depth knowledge of cancer biology and epigenetics
• Familiarity with drug discovery process for epigenetic and transcriptional targets in oncology
• Experience with target ID / validation efforts
• Experience in executing and developing cell-based assays, and small molecule hit confirmation efforts
• Experience in molecular and cell biology techniques including cell culture, transfection and transduction techniques (overexpression, RNAi, CRISPR), stable cell line generation/validation, viability assays, functional/phenotypic assays such as viability and apoptosis in 2D and 3D settings, real time PCR, protein assays such as immunoblotting and/or protein simple, RNA assays including qPCR and/or Nanostring, microscopy. Experience in ChIP assays is desired
• Highly motivated, positive, capable of multitasking, attention to detail, and innovative
• Excellent time management and organizational skills, strong written and oral communication skills, ability to think creatively and solve problems are essential