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A position is available for a Research Associate in the laboratory of Dr. Katherine Chiappinelli, Ph. D. at the George Washington Cancer Center (https://smhs.gwu.edu/cancercenter/) and the Department of Microbiology, Immunology, & Tropical Medicine (https://smhs.gwu.edu/microbiology/) at George Washington University in Washington, DC.

Dr. Chiappinelli’s laboratory focuses on the epigenetic control of gene expression in cancer, specifically of immune signaling in and from tumor cells. Our goal is to use epigenetic therapies to harness the power of the immune system to fight cancer. This position will aid the PI in the planning, execution and analysis of experiments designed to elucidate epigenetic control of the interferon response in cancer.

The incumbent will be responsible for the daily management of the lab’s activities, ordering reagents and personnel. These responsibilities include designing and performing experiments and assays, data analysis and organization, and the generation of Standard Operating Procedures (SOPs). He/she should be a clear communicator and organized thinker who is willing to collaborate with the head of the laboratory to develop and execute a diverse research program.

Duties include:
•Perform the following assays with optimization and troubleshooting if necessary:
PCR, basic molecular cloning techniques, and quantitative RT-PCR
-Western blots
-In vitro studies, including cell culture of human cancer cell lines and shRNA or CRISPR/Cas9 manipulation of specific genes 
-Assays to analyze DNA methylation, including pyrosequencing
-Assays to analyze chromatin structure, including chromatin immunoprecipitation
•Maintain laboratory inventory
•Manage ordering of supplies
•Manage equipment maintenance
•Development of organizational system to keep track of experimental data generated by all laboratory personnel
•Performs other duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position.

Incumbent is expected to have an enthusiasm for the practice of science and a passionate interest in the field of cancer epigenetics and/or immunology.