Postdoctoral Scientist
April 25, 2019 - May 26, 2019
Dr. Wu’s lab in the Department of Medicine focuses on two epigenetic modulators and members of the AT-rich interaction domain family, ARID4A and ARID4B. Epigenetics plays an important role in human health and disease. Disruption of epigenetic modifications leads to dysregulation of gene function without altering the DNA sequence per se. A major challenge in understanding the importance of epigenetics in human health and diseases is to identify the specific epigenetic factors and the signaling involved.
Currently, we are investigating the role of ARID4A and ARID4B in development and cancer disease using state-of-the-art conditional knockout mouse models and genomic and proteomic approach. We also study the role of ARID4B in cancer stem cells that have been suggested as the major cause for therapy resistance and the driving force behind cancer metastasis and relapse. To investigate whether and how ARID4B drive cancer development, we evalute the underlying molecular mechanisms by which ARID4B promotes therapy resistance and aggressive cancer.
Dr. Wu’s lab in the Department of Medicine has an opening for a Postdoctoral Scientist.
- culture and transfection of mammial cells
- collection of samples for reporter gene assays
- western blooting to analyze protein expression
-cancer cell migration and invasion assays -human cancer xenogrant experiments using SCID/NOD mice.
- other duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position.
This post-doc scientist is also required to work with genetically modified mice and in a BSL2 laboratory setting.
Minimum Qualifications:
Qualified candidates will hold a PhD in a related discipline. Degree must be conferred by the start date of the position
Additional Required Licenses/Certifications/Posting Specific Minimum Qualifications: Preferred Qualifications:
Ph.D. degree, with experience in molecular and cellular biology.