City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

Requisition number 14254

Position Summary and Key Responsibilities:
Postdoctoral Research Fellow, Dr. David Chen Laboratory – Department of Systems Biology, Beckman Research Institute Dr. David Chen’s laboratory in Systems Biology is focused on the epigenetic mechanisms underlying the therapeutic resistance in cancers. This laboratory is skilled in high-throughput CRISPR genetic screens for de novo therapeutic target discovery. They also utilize next-generation sequencing (NGS) for epigenomic and transcriptomic analyses (ChIPseq, ATACseq, RNAseq, etc.), and the patient-derived xenograft (PDX) models for in vivo therapeutic efficacy assessments. In addition, Dr. Chen’s laboratory is involved in cutting-edge technology development including high-density CRISPR protein scan, and precision epigenome editing.Dr. Chen received his postdoctoral training from Dr. Scott Armstrong in Harvard Medical School. His laboratory in City of Hope currently consists 3 postdocs, 1 computational biologist, and 1 technician. The lab is well funded by a 5-year institutional start-up, an NIH K99/R00 Award, and an ASH Scholar Award. An additional NIH R01 Award (scored top 3%) is expected to start in 2019.

Qualifications:
PhD in cell or molecular biology, genuine enthusiasm for science, willingness to think beyond established concepts and to try and learn new experimental and analysis tools. The lab takes a team science approach, so being a nice person and enjoyable to work with is important as well.

Your application should include in one single PDF :
CV, brief motivation statement, coordinates of three references

Experience:
Mammalian cell culture, cell biology (required); Cancer/leukemia-related studies (preferred); Molecular biology, cloning, biochemistry (preferred); Animal model studies (preferred); High-throughput sequencing and computational analysis (preferred)