Epigenetics is a major mechanism in human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have uncovered altered epigenomes arising from mutations, altered expression and/or copy number alterations of numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide analyses have illustrated the relationship between altered epigenetic states (e.g., modified DNA, histones and chromatin packaging) and disease onset and progression. Furthermore, both local and long-range nuclear chromatin architecture are increasingly recognized as major contributors to normal and pathologic epigenetic states.

This meeting, held jointly with “3D genome”, will cover the most current knowledge of epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to normal and disease models. In addition, this meeting will highlight the impact that preclinical and clinical epigenetic therapeutics have on multiple diseases including cancer, immunology, and neurological disorders. An interdisciplinary panel of speakers including both thought leaders in the field as well as young investigators will survey the latest research results and conceptual understanding of fundamental mechanisms of epigenetic signaling, especially as relates to regulation of gene expression programs. Presentations and workshops will highlight the latest technologies and methodologies for studying epigenetic states and 3D chromatin architecture in cells, tissues and organisms.

The meeting will begin on Sunday, March 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 21 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 22 in order to fully experience the meeting. 

Program:

– 3D Epigenome/Epigenetics and Disease

-Workshop: 4DN Nucleome Consortium Resources

-Epigenetic Dysregulation in Neurobiology 

-Single Cell Analysis of Genome Architecture 

-Understanding and Targeting Epigenetic Dysregulation

-Analysis of 3D Genome with Advanced Microscopy 

– Workshop: ENCODE Consortium Resources

-Infectious Diseases and Autoimmunity 

-Chromatin and Epigenetics 

-Chromatin Signaling and Epigenetic Mechanisms

-3D Genome and Gene Regulation

-Workshop: International Human Epigenome Consortium 

-Metabolic Diseases and Aging

-Genome Architecture and Development

-Epigenetic Regulation in Immunoncology and Cancer Therapeutics 

-Computational Analysis of 3D Genome

-3D Genome and Disease

Deadlines:

Scholarship Deadline: Nov 15, 2018 
Discounted Abstract Deadline: Nov 15, 2018
Abstract Deadline: Dec 12, 2018
Discounted Registration Deadline: Jan 22, 2019