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Research Assistant
May 29, 2019 - June 30, 2019
The fundamental structure of chromatin suggests that all DNA-templated processes, including a wide range of epigenetic phenomena, are influenced by chromatin alterations with far-reaching implications for human biology and disease. Research in Dr. Allis’ laboratory is centered on chromatin and its regulation though post-translational modification of histone (and non-histone) proteins, ATP-dependent remodeling of chromatin, and the exchange of histone variants.
Detailed Description
This position will involve contributing directly to work by a physician scientist (MD, PhD) who specializes in medical oncology. The overall aim of the work is to understand the fundamental epigenetic mechanisms of cancer-associated mutations. Projects may also involve preclinical drug development of anticancer therapeutics. The Research Assistant will be responsible for performing cell culture, generation of cell lines harboring tumor-derived mutations, cell-based chromatin assays (eg. ChIP, DNA methylation and/or produce next-generation sequencing libraries), measurements of small molecule activity, and cellular differentiation assays. Will record data and analyze results, maintain and perform experiments with cells in tissue culture, and maintain inventory of frozen cell stocks.
Job Requirements
Bachelor’s degree in science required; Master’s degree preferred. Previous experience with cell culture, molecular biology and biochemical techniques strongly preferred. Must self-motivated, inquisitive, ambitious and enthusiastic about conducting research. Excellent verbal and written communication skills and the ability to thrive in a fast-paced environment necessary. Must be able to work both independently and as part of a team.