A Postdoctoral Associate position is available in the laboratory of Alexey Terskikh, Development, Aging, and Regeneration Program. The position focuses on the novel approach to study the dynamics of 3D epigenetics landscape at a single cell level. The Postdoctoral Associate will explore the capability of Microscopic Imaging of Epigenetic Landscape (MIEL) and fluorescence-based reporters enabling live imaging of epigenetic modifications at a single cell level. MIEL combines fluorescence detection of epigenetic marks with automated cell imaging and machine learning to profile and quantify the “epigenetic signatures” of individual cells.

The candidate will investigate the epigenetic heterogeneity at the single cell level and the asymmetry during stem cell division in normal neurogenesis and in brain tumors. One of the long-standing question of this project is to determine whether the outcome of stem cell division is stochastic or deterministic and whether such outcome could be predicted based on the epigenetic signature of the mother cell.

Education and/or Experience:

Interested candidates must have a Ph.D. degree in any discipline of Biological Sciences. Skills in tissue culture, cell and molecular biology, fluorescent microscopy, computational biology and writing skills are required. Experience with transgenic mice model is highly desirable. Applications should be submitted online to the SBP career job site and should include a cover letter, CV, and references or publications as one PDF file.