Postdoctoral Associate
April 26, 2018 - May 27, 2018
A post-doctoral position is available in the laboratory of Alexey Terskikh, Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California. The position focuses on the novel approaches to study epigenetics at a single cell level. A candidate will explore the capability of Microscopic Imaging of Epigenetic Landscape (MIEL) and fluorescence-based reporters enabling live imaging of epigenetic modifications at a single cell level. MIEL combines fluorescence detection of epigenetic marks with automated cell imaging and machine learning to profile and quantify the “epigenetic signatures” of individual cells.
A candidate will investigate the epigenetic heterogeneity at the single cell level and the asymmetry during stem cell division in normal neurogenesis and in brain tumors. One of the long-term goals of this project is to determine whether the outcome of stem cell division is stochastic or deterministic and thus could be predicted based on the epigenetic signature of mother cell.
Required Experience
The candidate must have a Ph.D. degree in any discipline of Biological Sciences. Skills in tissue culture, cell and molecular biology, fluorescent microscopy, computational biology and writing skills are required. Experience with transgenic mice model is highly desirable.