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The 2016 Midwest Chromatin and Epigenetics Meeting (MCEM) will bring together more than 200 scientists from the American Midwest who study transcription, chromatin and epigenetics. The meeting provides an excellent opportunity to share scientific insight, foster the exchange of new ideas and to enhance collaboration. The meeting will be held from June 5–June 7, 2016 at Van Andel Institute in Grand Rapids, Michigan.