Center for Investigational Therapeutics (CIT) at Huntsman Cancer Institute program is seeking a highly motivated Research Technician with expertise in conducting various in vitro cancer biology and drug screening assay for the kinase, epigenetic and immune related protein targets. Interested candidate will be working on the biological evaluation of novel chemical entities (NCE) for use in cancers research and treatment. Research Technician, you will be technically responsible for working on the PI and his labs chemist fellows to support in vitro cell-free and cancer cell-based efficacy screening assays utilizing available compounds as and when made by chemist fellows. This will entail detailed reading of the literature reported assays, validation using reference control compounds, associated methods, existing assay protocols, and alos utilizing vendor specific reagents/kits etc., and then planning, execution, optimization and analysis of the assay results. The compound effects in those assays and presenting the results in group meetings, then supporting sections of grant proposals, publications, and lab supervision.

Responsibilities:
• Highly motivated and creative individual with a MS or related experience in cancer biology and immunology disciplines
• Cell-free target binding assays; kinase glo, thermal shift and FP, FRET, AlphaScreen, AlphaLisa,
• IC50, EC50, Ki, Kd, Km, substrate competitive, reversibility and time dependent read out data analysis and handling expertise
• Cell-based, cancer cellular profiling and synergy experiments handling expertise are part of the job description
• Additional experience in cancer biology investigations such as conducting standard biochemical/binding or other relevant target specific mechanistic assays such as Flow Cytometry, NK, B cell, immune cell killing, cytokine release, Macrophage, other immunoassays and working experience on radioligand binding assays is a plus.
• Ability to clearly communicate ideas verbally and through presentations
• Your application should include a CV with any publications list, two references, and a brief summary of your research experiences. The position is limited for 1 year and can be extended for second and third year as well