Dr. Hari’s laboratory at Huntsman Cancer Institute and College of Pharmacy under Therapeutics Accelerator program is seeking a highly motivated Research Technician with expertise in conducting various in vitro cancer biology and drug screening assay for the kinase, epigenetic and immune related protein targets. Interested candidate will be working on the biological evaluation of novel chemical entities (NCE) for use in cancers research and treatment. Research Technician, you will be technically responsible for working on the PI and his labs chemist fellows to support in vitro cell-free and cancer cell-based efficacy screening assays utilizing available compounds as and when made by chemist fellows. This will entail detailed reading of the literature reported assays, validation using reference control compounds, associated methods, existing assay protocols, and alos utilizing vendor specific reagents/kits etc., and then planning, execution, optimization and analysis of the assay results. The compound effects in those assays and presenting the results in group meetings, then supporting sections of grant proposals, publications, and lab supervision.

Responsibilities

• Cell-free target binding assays; kinase glo, thermal shift and FP, FRET, AlphaScreen, AlphaLisa,
• IC50, EC50, Ki, Kd, Km, substrate competitive, reversibility and time dependent read out data analysis and handling expertise
• Cell-based, cancer cellular profiling and synergy experiments handling expertise are part of the job description
• Additional experience in cancer biology investigations such as conducting standard biochemical/binding or other relevant target specific mechanistic assays such as Flow Cytometry, NK, B cell, immune cell killing, cytokine release, Macrophage, other immunoassays and working experience on radioligand binding assays is a plus.
• Ability to clearly communicate ideas verbally and through presentations.

Minimum Qualifications

Bachelor’s degree in biology, chemistry, or other scientific disciplines in a related field or equivalency required; knowledge of complex laboratory techniques, equipment, terminology, materials and substances. Skilled in the use of laboratory equipment, ability to create and analyze statistical calculations and prepare reports required; and demonstrated human relations and effective communication skills also required. OSHA training and certification in animal care and use or the willingness to complete the certification may be required by some departments.

Applicants must demonstrate the potential ability to perform the essential functions of the job as outlined in the position description.