The Chandrasekharan Laboratory, in the Department of Radiation Oncology at the University of Utah and Huntsman Cancer Institute, is searching for a highly motivated and hardworking postdoctoral researcher with prior experience in gene transcription or genome stability and epigenetic mechanisms, and the use of genomics-bioinformatics methodologies and mammalian experimental systems (cell culture and mouse model). The Chandrasekharan laboratory is focused on understanding epigenetic histone modifying mechanisms. We are seeking a post-doc to study the regulation and functions of histone modifying enzymes and their potential therapeutic targeting in cancers.
Experimental duties include, but are not limited to: creating knockout or knockin cell lines using CRISPR genome-editing technology; performing functional genomics or proteomics experiments and use bioinformatics for data analyses; overexpressing and purifying proteins or protein complexes using chromatography for proteomic, structural and/or biochemical/biophysical characterization studies; evaluating histone modifying enzyme functions in vivo in genetic mouse models; and performing preclinical drug-dosing studies in cell culture and in xenograft mouse models
Please see specific research projects and additional information pertaining to lab research on our website at:
http://healthcare.utah.edu/huntsmancancerinstitute/research/labs/chandrasekharan/

Responsibilities

The preferred candidate should have a Ph.D. in biomedical sciences, molecular-cell biology, or an allied area. Previous laboratory experience in mammalian cell culture and mouse model system, chromatography, genome editing, genomics and bioinformatics are required. The applicant should have a good working knowledge of protein biochemistry, epigenetics and chromatin biology, as well as bioinformatics and scientific writing skills. The ideal candidate will have demonstrated initiative, curiosity and dedication to scientific research as well as the ability to work independently and in a team environment. Essential Functions
1. Create CRISPR-based knockin or knockout cell lines; perform epigenomics and bioinformatics, and conduct preclinical studies using in vitro or in vivo mammalian model systems.
2. Performs and directs specialized and complex lab tests, experiments and surgical procedures for studies.
2. Assists the Principal Investigator in the design, implementation and performance of new protocols and procedures as well as the modification of existing techniques.
3. Reviews scientific journals, abstracts and other literature for information concerning experimental procedures.
4. Makes advanced statistical calculations, analyzes data and prepares reports summarizing research results.
5. Operates complex and highly specialized laboratory and surgical instruments and equipment. Instructs others in their use.
6. Maintains an inventory of supplies, reagents, and samples used in procedures for the lab.
7. May supervise, train and review the work of laboratory personnel.
8. May prepare equipment and rooms for studies.
9. May assist with preparing grant proposals and budgets.
Problem Solving
Incumbents in this position work independently to review, analyze and interpret the results of the data collected and assist the principal investigator in getting the information presented to peers and published in appropriate journals. Incumbents in this position are responsible for addressing unusual or sensitive situations and for bringing them to resolution. If they are unable to bring them to resolution, they will consult with the principal investigator to obtain resolution.

This job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

Minimum Qualifications Preferences

Looking for a recent graduate with 0-1 year experience. Individuals from historically underrepresented groups, such as minorities, women, qualified persons with disabilities, and protected veterans are strongly encouraged to apply.