A postdoctoral scholar position in the areas of genomics, stem cell biology, and leukemia is available in the laboratory of Dr. Grant Challen at Washington University School of Medicine in St. Louis. The Challen lab studies the epigenetic regulation of normal and malignant hematopoiesis. The successful applicant will be responsible for characterizing the roles of epigenetics in stem cell differentiation and blood cancer transformation. Our lab uses a variety of cutting edge technologies coupled with traditional cell culture, molecular biology and mouse genetic models. The Hematopoietic Development and Malignancy (HDMP) program of the Siteman Cancer Center at Washington University in St. Louis provides us access to a variety of specialized research cores to facilitate our projects. Motivated candidates with a PhD or MD with a strong background in molecular and cellular biology, cancer research and epigenetics are encouraged to apply. For the latest updates about our lab research, please visit our lab website (www.challenlab.com) and lab Twitter feed (@challenlab).

PRIMARY DUTIES & RESPONSIBILITIES:

• Design, plan, execute and interpret complex experiments integrating cell culture, mouse models, and genome sequencing data.
• Ability to independently generate testable hypotheses.
• Integrated analysis of molecular data.
• Analyze and interpret results to communicate with others and produce presentations and scientific publications is required.
• Assist in grant preparation and reporting.
• Maintain conformity with ethical standards in research.
• Maintain compliance with good laboratory practice including the maintenance of adequate research records
• Collegial conduct towards co-trainees, staff members and members of the research group.

The appointee has earned a Ph.D., M.D. or equivalent terminal or doctoral degree.

• Applicants should have a graduate degree in developmental biology, genetics, or related field.
• Previous experience with mouse models, flow cytometry, cancer genomics, and next-generation sequencing applications would be an advantage but is not essential.
• The successful candidate will be self-motivated, eager to acquire new knowledge and skills on a regular basis, and must demonstrate critical thinking skills.
• The ability to analyze and interpret results to communicate with others and produce scientific publications is required.