We’re seeking a highly motivated and technically proficient laboratory Scientist with a strong enzymology background to join our dynamic biochemistry team. The successful candidate will provide biochemistry solutions across multiple projects in all therapeutic areas in a high-visibility, highly-matrixed environment. Creativity, enthusiasm, organization, and excellent communication skills a must. Excellent development and advancement potential.

Job Responsibilities

• Conceptual design and execution of novel biochemical assays to kinetically characterize enzyme targets
• Develop strategies to ensure quality expression, purification, and biophysical characterization of enzymes produced from multiple expression systems
• Interact with exploratory cell biologists to help elucidate relevant intracellular biochemistry, genetic and epigenetic regulation of our targets and advance them through validation
• Interact closely with medicinal chemistry to guide small molecule drug discovery through the execution of inhibitor or activator mechanism of action studies
• Dual leadership from bench and in CRO management; manage external FTE resources; transfer and validate assays to external partners

Qualifications

• PhD in Enzymology, Biochemistry or related field with 0-5+ years industry research experience or an MS or BS degree with 7-10 years of industry research experience in the context of small-molecule drug discovery
• A strong background in steady-state enzymology with emphasis on mechanism of action and kinetic studies with (UV/VIS, TR-FRET, FP) readouts. Past experience with coupled enzyme assay systems, transient kinetics, KNIME informatics environment, and LCMS-based enzyme assays is a plus.
• In-depth understanding of recombinant protein expression and purification from bacterial, insect, and yeast systems.
• A proven history of effective team work with excellent collaborative and communication skills is required