The Postdoc Rsh Fellow, Epigenetic will function under the supervision of a Senior Scientist and Director of the Division of Genetics and Epigenetics. The laboratory has a long standing research program on epigenetics and DNA methylation in normal human development and in common diseases, including cancer, Down syndrome, Alzheimer’s disease and other neurodegenerative disorders, and autoimmune diseases. Areas of current emphasis include mechanistic studies on genetic-epigenetic interactions that occur in cis and in trans, using both human samples and mouse models, and the use of epigenomic mapping as a ‘post-GWAS’ method to identify genes and DNA variants that underlie disease susceptibility. We are also studying epigenetically-acting anti-cancer drugs, seeking to understand how these agents affect tumor cells and stromal and immune system cells in the tumor microenvironment. Opportunities for post-doctoral training in our group therefore encompass the areas of genome and epigenome analysis using whole genome and targeted approaches in human samples and informative mouse models, the development of useful bioinformatic methods, and pre-clinical studies of epigenetically-acting anti-cancer therapies and their effects on the tumor microenvironment in tumor-prone mouse models. 
1. May design and perform whole genome and epigenome analyses in human samples and appropriate mouse models, for understanding mechanisms of disease susceptibility. 
2. May develop and apply useful bioinformatic approaches to genomic and epigenomic data for testing mechanistic hypotheses. 
3. Present results in internal and external research forums. 
4. Participate in grant and manuscript writing, as appropriate. 
5. May design and conduct animal studies using murine models of cancer and Down syndrome. 
6. May design and conduct immunological profiling studies in mouse models of Down syndrome and cancer. 
Working Conditions: 
Education, Knowledge, Skills and Abilities Required: 
1. Hold a Ph.D. or M.D. Degree from an accredited medical school or graduate level institution. 
2. Minimum publication or in preparation of two articles as first author in high quality peer-reviewed scientific journals.