Dr. Adams’ lab investigates the impact of chromatin and epigenetics on cellular senescence, aging and cancer. In particular, the lab hypothesizes that age-associated changes in chromatin and epigenetic programming contribute to the dramatic age-associated increase in incidence of cancer. While age is the biggest single risk factor for most cancers, the reason for this is current poorly understood.

The lab strives to be highly collaborative with other labs in San Diego, the US and elsewhere, for example collaborating with computational biologists, immunologists, experts in specific mouse models of cancer and aging, and surgeons, pathologists and clinical oncologists.

Summary

Applications are invited from ambitious, independent and motivated postdoctoral associate candidates to join the lab of Professor Peter D. Adams investigating the epigenetics of aging and cancer. The specific project in the broad epigenetics-cancer-aging area can be discussed, but we are particularly interested in investigating aspects of epigenetic dysregulation in Acute Myeloid Leukemia that can be exploited for development of novel therapies.

The project can employ state-of-the-art molecular and cellular biology approaches, including ChIP-seq, RNA-seq, ATAC-seq, DNA methyl-seq and other large-scale epigenomic and chromatin analyses, including at the single-cell level; high throughput chemical and RNAi/CRISPR phenotypic screens; cell imaging; state-of-the-art gene manipulations using RNAi and CRISPR technology. In addition, we routinely employ sophisticated mouse models and human tissues.

San Diego has an outstanding scientific environment and a fabulous place to live.

TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments.

Duties and Responsibilities

• Pro-actively and semi-independently lead a project focused on epigenetics of aging and/or cancer, e.g. epigenetic mechanisms underlying acute myeloid leukemia
• Perform cell and molecular biology experiments
• Work with mouse models of cancer and aging
• Generate hypotheses, design experiments, interpret data, trouble shoot and optimize experiments
• Collaborate and synergize with other members of the lab to promote lab synergies
• Present results to lab members at weekly lab meetings
• Present results and data within SBP, local La Jolla meetings and national and international meetings, as appropriate
• Maintain and initiate collaborations between Adams lab and other labs in SBP, San Diego, US and worldwide

Required Skills

Required Experience

• Ph.D. degree or equivalent in biological science is required
• Experience and/or expertise in an aspect of cell and/or molecular biology and/or animal models is highly desired

Other Knowledge, Skills and/or Abilities

• Knowledge of molecular biology of chromatin and/or epigenetics is ideal
• Knowledge of statistical methods applied to biology
• Familiarity with public bioinformatics databases and resources
• Computational expertise is an advantage
• Communicates effectively and collaborates well with Principal Investigators and their team members
• Have strong organizational and problem-solving skills
• Possess strong attention to detail, analytical and time management skills
• Excellent data presentation, communication and interpersonal skills
• Embody the Institute’s core values of Commitment, Collaboration, Communication, Community and Compassion