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Applications are invited from ambitious, independent and motivated candidates to work with Professor Peter D. Adams to investigate the epigenetics of aging and cancer at Sanford Burnham Prebys Medical Discovery Institute, San Diego. Specific projects in the lab range from development of novel epigenetic therapies to combat cancer (for example, epigenetic therapies to synergize with immune therapies), to investigation of epigenetic mechanisms that contribute to age-associated increase in cancer. A long-term goal of the lab is to develop epigenetic-based approaches for cancer chemoprevention.

The project will employ state-of-the-art molecular and cellular biology approaches, including ChIP-seq, RNA-seq, ATAC-seq, DNA methyl-seq and other large-scale epigenomic and chromatin analyses, including at the single-cell level; high throughput chemical and RNAi/CRISPR phenotypic screens; cell imaging; state-of-the-art gene manipulations using RNAi and CRISPR technology. In addition, we routinely employ sophisticated mouse models and human tissues.

The lab strives to be highly collaborative with other labs in San Diego, the US and elsewhere, for example collaborating with computational biologists, immunologists, experts in specific mouse models of cancer and aging, and surgeons, pathologists and clinical oncologists. San Diego is an outstanding scientific environment and a fabulous place to live.

Required Experience

Candidates should have, or be working towards, a PhD or equivalent degree in a biological science. Expertise in an aspect of cell and/or molecular biology and/or animal models is essential. The lab has dedicated computational biology support for data analysis, so computational expertise is an advantage, but not essential. Successful applicants will be able to learn computational approaches for analysis of large datasets, a big advantage in a competitive job market.

Interested candidates should submit one PDF with a summary of achievements and research interests, updated CV and contact information for 3 letters of references.