The successful candidate will work within a successful multidisciplinary research team that applies both computational and laboratory techniques to understand mechanisms responsible for epigenetic dysfunction in cancer. This project will have a particular emphasis on the use of assays to interrogate structural rearrangements and perform functional studies. We wish to use existing genomic data to inform laboratory experiments performing Hi-C to examine topologically associated domains (TADs) and their relationship to frequent translocations in myeloma including those involving the immunoglobulin loci and MYC. ChIP-seq and CRISPR/Cas9 experience or enthusiasm to develop new protocols would be advantageous, in order to determine functionality of discovered abnormalities. There will be a component of computational analysis which will be performed in association with our bioinformatics team.

(60%) – Design, execute and interpret experiments to investigate the extent of DNA rearrangements, topological domains and chromatin modifications in myeloma.

(10%) – Maintain accurate and up-to-date records to document the research progress.

(10%) – Take a lead role in writing up data for publication in peer-reviewed journals.

(15%) – Interact with bioinformaticians and instruct in data analysis and summarization.

(5%) – Present data ag group and section meetings.

(5%) – Contribute to the dissemination of research at national and international meetings (annually)

Establish and maintain knowledge relevant to epigenetics, genomics and biology of multiple myeloma (ongoing)

May perform other duties as assigned.

PhD in Molecular biology, genetics or oncology required.

Salary: Negotiable

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