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The Simone Laboratory in the Radiation Oncology Department at Thomas Jefferson University Hospital in Philadelphia, PA is seeking an outstanding post-doctoral fellow to work in the area of cancer and radiation biology. Our laboratory focuses on using metabolic manipulation such as dietary alterations, to improve standard cancer therapy such as radiation and chemotherapy. Mechanistically, our focus is on microRNA alterations and downstream effectors. Our laboratory has a focus on hormonally responsive cancers such as breast and prostate cancer using both in vitro and in vivo models. From the pre-clinical data generated in the Simone Laboratory, we have now opened multiple clinical trials with hormone-driven cancer patients which allows for the laboratory to evaluate translational endpoints of our basic science research.

Experience Required : The candidate must be highly motivated, independent and interested in our projects. The candidate must have PhD in molecular biology, cell biology or a cancer related field. Although not absolutely necessary, the ideal candidate will preferably have some experience with caloric restriction, epigenetics, microRNA or radiation biology. Expertise in microarray analysis, RT-PCR, ChIP, cloning, mouse husbandry, in vivo tumor experiments are also a plus. The successful candidate will of course have mentoring so that career goals can be achieved, but must be able to independently generate hypotheses, design experiments to test the hypothesis, performs routine and more difficult procedures, analyze data and coherently present results in the form of presentations, abstracts, manuscripts and the basis for grant writing, preparation and submission. In addition, qualified candidates should have strong verbal and written communication skills, and a demonstrated record of scientific achievement through peer-reviewed publications. Successful, well-motivated candidates will join a highly interactive, interdisciplinary team of researchers with diverse backgrounds and expertise in a collaborative scientific environment. Preference will be given to individuals with these skill sets who are now completing their thesis work and have at least one high-impact publication.